Searchable abstracts of presentations at key conferences in endocrinology
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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Oral Communications

Calcium and Bone

ea0063oc1.1 | Calcium and Bone | ECE2019

Genetic testing for hereditary hyperparathyroidism in a large UK cohort

Mariathasan Sashi , Andrews Katrina , Thompson Edward , Armstrong Ruth , Park Soo-Mi , Casey Ruth

Primary hyperparathyroidism (PHPTH) is a common endocrine disorder and it is estimated that 10% of cases are hereditary, related to syndromes including; multiple endocrine neoplasia (MEN) type 1, MEN type 4, MEN2A and hereditary hyperparathyroidism jaw tumour syndrome. Further hereditary cases can occur in the absence of syndromic features such as familial hypercalcemia hypocalcuria. Identifying cases of hereditary PHPTH enables a personalised medicine approach. Current guidel...

ea0063oc1.2 | Calcium and Bone | ECE2019

Urinary magnesium as predictor of nephrolithiasis in patients with asymptomatic primary hyperparathyroidism

Saponaro Federica , Cetani Filomena , Giulio Marina Di , Giulio Francesco Di , Mazoni Laura , Apicella Matteo , Scalese Marco , Pardi Elena , Borsari Simona , Marcocci Claudio

The 4th International Workshop for the management of asymptomatic PHPT included the presence of hypercalciuria (dUCa> 400 mg/day) and increased stone risk by biochemical stone risk profile as criteria for surgery. Our aim was to evaluate the complete stone risk profile in 176 consecutive patients with asymptomatic PHPT. We recorded clinical and biochemical data, including 24 hours urinary measurements of the following parameters: volume and pH, creatinine, calcium, magnesi...

ea0063oc1.3 | Calcium and Bone | ECE2019

Menin and EZH2 activities modulate the expression of the long non-coding RNA HAR1B in parathyroid tumors

Morotti Annamaria , Verdelli Chiara , Guarnieri Vito , Muscarella Lucia Anna , Silipigni Rosa , Guerneri Silvana , Vicentini Leonardo , Vaira Valentina , Corbetta Sabrina

Epigenetic deregulation is emerging as a component of the parathyroid tumorigenesis. We identified a long non-coding RNA (LNCRNA) signature clearly distinguishing parathyroid adenomas (PAds) and carcinomas from normal glands. Among the deregulated LncRNAS, HAR1B was upregulated in PAds harboring the common chromosome 11q loss of heterozygosity (Chr11q-LOH; n=10) compared with PAds harboring normal chromosome 11 haplotype (Chr11q-WT; n=12; P&...

ea0063oc1.4 | Calcium and Bone | ECE2019

Risk of sepsis, respiratory infections, and kidney or other genitourinary (GU) infections in patients with chronic hypoparathyroidism (HypoPT): a retrospective cohort study

Chen Kristina , Curhan Gary , Gosmanova Elvira , Mu Fan , Briggs Allison , Pajerowski William , Sherry Nicole , Ketteler Markus , Rejnmark Lars

Background: Prior small studies have suggested increased risk of infections in patients with hypoparathyroidism (HypoPT). This study using a large managed care cohort evaluated whether chronic HypoPT is associated with increased risk of sepsis, respiratory infections, and kidney or other genitourinary (GU) infections.Methods: A retrospective cohort study using a US commercial claims database (Q1 2007–Q2 2017) was conducted to examine the association...

ea0063oc1.5 | Calcium and Bone | ECE2019

Renal function in 711 patients with hypoparathyroidism during more than 4 years of therapy

Siggelkow Heide , Stamm Bettina , Stamm Niklas , Blaschke Martina , Gruszendorf Martin

Patients (pts) with hypoparathyroidism (HypoPT) are at risk to develop renal failure possibly caused by hypercalciuria and nephrocalcinosis. We retrospectively evaluated the data of 711 Patients with HypoPT in 3 endocrine centres in Germany.Methods: Records of 711 pts with HypoPT were reviewed. Patients were predominantly female (n=592, male: n=119; age 50.9±14.1 years, range 12 – 99 years). The following parameters were docum...