Endocrine Abstracts

Kiss1 neurons are essential elements in the central pathways controlling the reproductive axis. In rodents, two major hypothalamic populations of Kiss1 neurons exist, in the arcuate nucleus (ARC) and in the rostral periventricular area of the third ventricle (RP3V). The majority of ARC Kiss1 neurons express two others neuropeptides, neurokinin B (NKB; encoded by Tac2) and dynorphin (Dyn); hence, this population has been named KNDy. Yet, NKB-only and Kiss1-only neurons are also...

Context: Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, were long considered infertile. Testicular sperm extraction (TESE) now allows some of these patients to access fatherhood. The predictive factors for success, however, remain unknown.Patients and methods: Non-mosaic KS patients with azoospermia or severe cryptozoospermia on two semen analyses without any other spermatogenesis disorder were included. They were sorted into two age ...

Endocrine disruptors are a rising concern for public health due to their ubiquitous presence affecting reproductive development throughout generations. We aim at studying the transgenerational effect of an EDC mixture on female sexual development and reproduction. Female rats (F0 generation) were orally exposed to a mixture of 14 anti-androgenic and estrogenic EDCs or corn oil for 2 weeks before and throughout gestation and until weaning. The mixture was composed of plasticize...

Reproduction is tightly coupled to body energy and metabolic status. GnRH neurons, the final output pathway for the brain control of reproduction, directly or indirectly receive and integrate multiple signals, including metabolic cues regulating reproductive function. Yet, the molecular underpinnings of such phenomenon remain largely unfolded. AMP-activated protein kinase (AMPK), a fundamental cellular sensor that becomes activated in conditions of energy deficit, has a key ro...

Background: The brain’s thermoregulatory center is stimulated by activation of neurokinin 3 receptor (NK3R) and inhibited by estrogen. In menopause, declining estrogen disturbs this balance, producing vasomotor symptoms (VMS). This study assessed response to the NK3R antagonist fezolinetant in women with menopausal VMS.Methods: This phase 2b, double-blind trial (NCT03192176) randomized menopausal women (age >40−65 y) with moderate/severe V...