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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Oral Communications

Reproduction 1

ea0063oc8.1 | Reproduction 1 | ECE2019

Dissecting the roles of KNDy-derived kisspeptins in the control of reproduction: Generation and characterization of the Tac2-specific Kiss1 KO (TaK-KO) mouse

Franssen Delphine , Velasco Inmaculada , Ruiz-Pino Francisco , Torres Encarnacion , Ruohonen Suvi , Roa Juan , Poutanen Matti , Tena-Sempere Manuel

Kiss1 neurons are essential elements in the central pathways controlling the reproductive axis. In rodents, two major hypothalamic populations of Kiss1 neurons exist, in the arcuate nucleus (ARC) and in the rostral periventricular area of the third ventricle (RP3V). The majority of ARC Kiss1 neurons express two others neuropeptides, neurokinin B (NKB; encoded by Tac2) and dynorphin (Dyn); hence, this population has been named KNDy. Yet, NKB-only and Kiss1-only neurons are also...

ea0063oc8.2 | Reproduction 1 | ECE2019

AMH is a predictive factor for successful sperm retrieval in non-mosaic Klinefelter syndrome patients

Renault Lucie , d'Estaing Sandrine Giscard , Cuzin Beatrice , Benchaib Medhi , Lornage Jacqueline , Soignon Gaelle , Dijoud Frederique , Lejeune Herve , Plotton Ingrid

Context: Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, were long considered infertile. Testicular sperm extraction (TESE) now allows some of these patients to access fatherhood. The predictive factors for success, however, remain unknown.Patients and methods: Non-mosaic KS patients with azoospermia or severe cryptozoospermia on two semen analyses without any other spermatogenesis disorder were included. They were sorted into two age ...

ea0063oc8.3 | Reproduction 1 | ECE2019

Endocrine Disruptors transgenerationally alters pubertal timing through epigenetic reprogramming of the hypothalamus

Rodriguez David Lopez , Francisco Aylwin Carlos , Gerard Arlette , Blacher Silvia , Tirelli Ezio , Bourguignon Jean-Pierre , Lomniczi Alejandro , Parent Anne-Simone

Endocrine disruptors are a rising concern for public health due to their ubiquitous presence affecting reproductive development throughout generations. We aim at studying the transgenerational effect of an EDC mixture on female sexual development and reproduction. Female rats (F0 generation) were orally exposed to a mixture of 14 anti-androgenic and estrogenic EDCs or corn oil for 2 weeks before and throughout gestation and until weaning. The mixture was composed of plasticize...

ea0063oc8.4 | Reproduction 1 | ECE2019

Conditional ablation of AMP-Activated Protein Kinase (AMPK) in GnRH neurons reveals specific roles in reproductive and metabolic homeostasis

Roa Juan , Franssen Delphine , Barroso Alexia , Ruiz-Pino Francisco , Vazquez Maria Jesus , Garcia-Galiano David , Castellano Juan Manuel , Gaytan Francisco , Dieguez Carlos , Pinilla Leonor , Lopez Miguel , Tena-Sempere Manuel

Reproduction is tightly coupled to body energy and metabolic status. GnRH neurons, the final output pathway for the brain control of reproduction, directly or indirectly receive and integrate multiple signals, including metabolic cues regulating reproductive function. Yet, the molecular underpinnings of such phenomenon remain largely unfolded. AMP-activated protein kinase (AMPK), a fundamental cellular sensor that becomes activated in conditions of energy deficit, has a key ro...

ea0063oc8.5 | Reproduction 1 | ECE2019

The neurokinin 3 receptor antagonist, fezolinetant, is effective in treatment of menopausal vasomotor symptoms: responder analysis results from a randomized, placebo-controlled, double-blind, dose-ranging study

Fraser Graeme , Lederman Samuel , Waldbaum Arthur , Young James , Skillern Laurence , Ramael Steven

Background: The brain’s thermoregulatory center is stimulated by activation of neurokinin 3 receptor (NK3R) and inhibited by estrogen. In menopause, declining estrogen disturbs this balance, producing vasomotor symptoms (VMS). This study assessed response to the NK3R antagonist fezolinetant in women with menopausal VMS.Methods: This phase 2b, double-blind trial (NCT03192176) randomized menopausal women (age >40−65 y) with moderate/severe V...