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Endocrine Abstracts (2019) 63 P971 | DOI: 10.1530/endoabs.63.P971

ECE2019 Poster Presentations Diabetes, Obesity and Metabolism 3 (112 abstracts)

Are fast insulin analogues fast enough? Switching to faster aspart may reduce glycemic variability and the risk of hypoglycemia in type 1 diabetic patients on sensor-augmented insulin pump therapy

Manuel Esteban Nivelo-Rivadeneira 1 , Agnieszka Kuzior 1 , Paula Maria Fernandez-Trujillo-Comenge 1 , Ana Delia Santana-Suarez 1 , Carmen Acosta-Calero 1 , Macarena Diaz-Moreno 2 , Almudena Medina-Sanchez 3 & Francisco Javier Martinez-Martin 4

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1Endocrinology and Nutrition Dpt, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain; 2Guanarteme Primary Healthcare Center, Las Palmas de Gran Canaria, Spain; 3Escaleritas Primary Healthcare Center, Las Palmas de Gran Canaria, Spain; 4Outpatient Hypertension Clinic, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain.


Aim: Comparing the effect of Faster Aspart insulin (Fiasp®) with previous insulin analogues (aspart, lispro) in type I diabetic patients with sensor-augmented pump therapy.

Methods: Patients with Minimed Paradigm® insulin pumps, Enlite® sensors and Guardian® software (able to automatically stop the pump infusion to prevent hypoglycemia) were switched from previous insulin to Faster Aspart. Data from the previous 3 months and 3 months afterwards were obtained from the Guardian® software and compared by Student’s paired t-test. Satisfaction data were obtained by analogic scales. Data are given as mean±S.D.

Results: Sixteen patients (age 23±6.8 years, 69% female) were switched to Faster Aspart from lispro (25%) and aspart (75%). Their glycemic variability coefficient (100 x mean glucose/S.D.) was significantly reduced from 41.3±9.2% to 34.2+8.9% (P=0.0342). Time on glucose <70 mg/dl was significantly reduced from 3.8±1.3% to 2.9+0.9% (P=0.0301), Time on glucose >180 mg/dL was reduced from 6.7±1.9% to 5.5+1.8% (P=0.0766), HbA1C decreased from 7.3±0.9% to 6.9+0.8% (P=0.1940). On a 0–10 visual analogical scale, patient satisfaction was significantly increased from 6.3±1.8 to 7.8+1.4% (P=0.0133). No unexpected adverse effects were reported.

Conclusions: In this open, uncontrolled study, switching from previous insulin analogues to Faster Aspart was well-tolerated and significantly reduced glycemic variability and time on hypoglycemia; patient satisfaction was significantly increased, and trends for lower time on hyperglycemia and lower HbA1C were found. We conclude that Faster Aspart is an advantageous alternative to the classic fast-acting insulin analogues for patients on sensor-augmented insulin pump therapy.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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