Diabetes, Obesity and Metabolism 3

Objective(s): Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms can be associated with atherogenic lipid profile. The results of recent studies in different populations are contradictory. The aim of study was to assess serum lipids in women with different vitamin D status carrying various VDR gene variants.Materials and methods: We examined 697 women aged 35 to 55 y.o. (mean 43.4±0.3). Anthropometric parameters (...

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ea0063p883 | Diabetes, Obesity and Metabolism 3 | ECE2019

Impact of the overweight and fatty liver in chronic hepatitis B treatment

Kallel Roua , Akkari Imen , Mrabet Soumaya , Jemni Imen , Jezia Elhem Ben

Background: More than 1.9 billion people in the world are suffering from overweight. Damages can be caused to the liver such as fatty liver or even Cirrhosis. The aims of this study are to determine the prevalence and the impact of steatosis and overweight on therapeutic response in chronic hepatitis B.Methods: This is a descriptive transversal study enrolled from 01/2010 to 09/2018. All patients with chronic hepatitis B investigated by liver biopsy were...

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ea0063p884 | Diabetes, Obesity and Metabolism 3 | ECE2019

Development of diabetes after pancreatic resection

Montoro Jose Ignacio Martinez , Vega Maria Molina , Perez Ana Maria Gomez , Cea Yolanda Eslava , Almeida Jose Manuel Garcia , Munoz Miguel Angel Suarez , Madueno Francisco Jose Tinahones

Introduction: The development of diabetes is common after pancreatic surgery, so a close follow-up is essential in order to make an early diagnosis and start treatment as soon as possible.Material and methods: Data from 56 patients subjected to pancreatic surgery between 2013 and 2018 are presented. Demographic and clinical-analytical characteristics are also described. We analyzed the incidence of diabetes during the follow-up (one month after surgery [...

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ea0063p885 | Diabetes, Obesity and Metabolism 3 | ECE2019

Threatening hypertriglyceridemia during pregnancy revealing laminopathy and genetic susceptibility in a patient with type 1 diabetes

Nativel Mathilde , Flaus-Furmaniuk Anna , Debussche Xavier , Nobecourt Estelle

Background: Severe hypertriglyceridemia (HT) increases the risk of pancreatitis, whereas mild HT may be a risk factor for cardiovascular disease. The variety of hypertriglyceridemia origins often makes the etiological diagnosis complex.Case report: A 24-year-old female G3P0Ab2 with type 1 diabetes mellitus (T1DM) was referred at 27th week of gestation to the Endocrinology Department in July 2017 for glycemic instability and severe hypertriglyceridemia. T...

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ea0063p886 | Diabetes, Obesity and Metabolism 3 | ECE2019

Perforating necrobiosis lipoidica: a new case report

Maghfour Soukaina , Abed Yosra Hasni El , Gammoudi Rima , Boussofara Lobna , kahla Marwen Ben , Aouinallah Amina , Mokni Sana , Ghariani Najet , Belajouza Colandane , Denguezli Mohamed

Introduction: Necrobiosis lipoidica (NL) is a rare, chronic granulomatous cutaneous disease that most often affects the lower extremities. The etiology of the condition is unknown but there appears to be some association with diabetes mellitus. Perforating necrobiosis lipoidica (PNL) is a very rare variant of NL characterized by trans-epidermal collagen elimination. We present a case of type II diabetes patient with disseminated perforating necrobiosis lipoidica (PNL).<p c...

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ea0063p887 | Diabetes, Obesity and Metabolism 3 | ECE2019

Management of hyperglycaemia risk in patients on medium or long-term glucocorticoid treatment: a retrospective pilot study

Greenfield Helen , Kumar Mohit

Background: Glucocorticoids are used medium and long-term for a variety of inflammatory and autoimmune conditions, with increasing use in the UK. The management of their potential side effects, however, remains suboptimal, and guidelines are not comprehensive. Our institute has had cases of patients presenting with hyperglycaemic emergencies due to steroid induced diabetes.Aims: 1) To obtain an estimate of the frequency of the use of medium and long term...

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ea0063p888 | Diabetes, Obesity and Metabolism 3 | ECE2019

Maturity onset diabetes of the young type 5 – report of one phenotype

Roque Catarina , Ferrinho Catia , Cunha Clara , Oliveira Manuela

Introduction: MODYs are being identified more frequently but the rarity of some types still precludes in-dept knowledge of their natural course of disease. One of this rare forms is MODY 5, the result of a mutation on the hepatocyte nuclear factor 1 beta (HNF-1B) gene that associates with genitourinary and pancreatic malformations/dysfunction.Case report: A 24-year-old female was referred to the Endocrinology clinic due to hyperglycaemia identified on pr...

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ea0063p889 | Diabetes, Obesity and Metabolism 3 | ECE2019

Radiation-induced loss of glycemic control in a patient with refractory lymphoma

Adamidou Fotini , Komzia Paraskevi , Georgiou Thomas , Tsoutsas Georgios , Panagiotou Athanasios , Kita Marina

Introduction: PD-1 inhibitors are powerful disruptors of self- tolerance and autoimmune diabetes develops in up to 0.9% of patients. Lipodystrophic insulin reactions, although uncommon with human insulin analogs, are a recognized cause of impaired insulin delivery in patients on intensive insulin regimens. We describe a patient with resistant lymphoma and nivolumab-induced autoimmune diabetes, who suffered loss of glycemic control due to early radiation-induced subcutaneous fi...

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ea0063p890 | Diabetes, Obesity and Metabolism 3 | ECE2019

Auto immune hypoglycemia in individuals with type 1 diabetes, from a patient case report

Louzolo-Kimbembe Rolly Junior , Mghari Ghizlane El , Ansari Nawal El

Introduction: Hypoglycemia is a severe complication of diabetes mellitus characterized by blood sugar levels lower than 0.7 g/L in individuals with diabetes. Several symptoms can be related to hypoglycemia and severe cases can be lethal. Individuals with type 1 diabetes and on insulin therapy may also experience hypoglycemic episodes but their frequency and late occurrence might indicate the presence of autoantibodies to insulin, if no other causes suggest otherwise. This cond...

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ea0063p891 | Diabetes, Obesity and Metabolism 3 | ECE2019

Scleredema adultorum of buschke: a case report

Maghfour Soukaina , Abed Yosra Hasni El , Kahla Marwen Ben , Gammoudi Rima , Boussofara Lobna , Aouinallah Amina , Mokni Sana , Ghariani Najet , Belajouza Colandane , Denguezli Mohamed

Introduction: Scleredema is a rare connective-tissue disorder characterized by diffuse, non-pitting induration of the skin. Scleredema is divided into three types. Pathogenesis is largely unknown. We present a case of a 56-year-old woman with non insulin-dependent diabetes mellitus who presented with a progressive history of thickening of the skin on her back.Case report: A 56-year-old woman, suffered from type 2 diabetes diagnosed 15 years ago, presente...

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ea0063p892 | Diabetes, Obesity and Metabolism 3 | ECE2019

An investigation into the relationship between plasma concentrations of cortisol, testosterone, blood pressure and blood glucose levels in diabetic hypersensitive cardiovascular patients

Ullah Safir , Rafi Muhammad , Akram Maleeha , Kazmi Ali Raza , Tahir Fahim , Jahan Sarwat , Afshan Kiran , Naseem Afzaal Ahmed , Qayyum Mazhar , Rizvi Syed Shakeel Raza

Diabetes mellitus type 2 (DM-2) occurs when pancreas fails to produce enough insulin or when the body cannot effectively make use of the insulin produced by the pancreas. Among other factors causing DM-2, stress is increasingly regarded as one of the causative agents that make the blood glucose levels rise, and cause DM-2. It has also been reported that DM-2 may be one of the commonest cause of hypogonadism, a lack of function in the testes, which adversely affects testosteron...

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ea0063p893 | Diabetes, Obesity and Metabolism 3 | ECE2019

Necrosis of the nasal pyramid in a type 1 diabetic after prolonged intubation: in the light of a case

Askaoui Sara , Lmghari Guizlane , Ansari Nawal El

Introduction: Necrosis of the nasal pyramid is mainly of traumatic origin, among the other possible causes, those induced by systemic diseases, in particular Wegeners granulomatosis…We report a case of necrosis of the nasal pyramid secondary to prolonged intubation in a type 1 diabetic.Observation: Patient T.T, 28 years old, followed for a poorly balanced type 1 diabetes, admitted to a blood clot in a table of diabetic ketoacidosis. The patie...

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ea0063p894 | Diabetes, Obesity and Metabolism 3 | ECE2019

Revelation modalities of latent autoimmune diabetes of adults

Zaher Fatima Zahra , Bouizammarne Ilham , Rafi Sana , Elmghari Ghizlane , Elansari Nawal

Introduction: Latent autoimmune diabetes in adults (LADA) is autoimmune diabetes occurring in a subject over 30 years of age with positive anti-island antibodies and insulin therapy after 6 months. Inaugural ketosis is an unusual presentation at the time of diagnosis due to the slow progression of beta cell destruction. The purpose of this work is to point out the different revelation modalities of LADA patientsPatients and methods: A cross-sectional des...

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ea0063p895 | Diabetes, Obesity and Metabolism 3 | ECE2019

Neuroendocrine neoplasia and obesity

Nunes Adriana , Medeiros Gertrudes M , Velloso Renata N , Gurjao Edmar C , Nunes Adriana B , Barbosa Paulo E S

Neuroendocrine neoplasia (NENs) are rare tumours that show features of neuroendocrine differentiation. Generally, NENs can be subdivides into high-grade neuroendocrine carcinomas (NECs) and low-to-intermediate grade neuroendocrine tumours (NETs). The most common Endodermal NETs localisations are the lungs, ileum, appendix, and rectum. Neuroectodermal NETs include medullary thyroid cancer (MTC), pheochromocytoma (PHEO), and paraganglioma (PGL). Nets are estimated to occur...

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ea0063p896 | Diabetes, Obesity and Metabolism 3 | ECE2019

NME7 gene is associated with the shape of glucose curves during oral glucose tolerance test

Bendlova Běla , Vejražkova Daniela , Šedova Lucie , Šeda Ondrej , Včelak Josef , Vaňkova Marketa

Introduction: The shape of the glucose curve during oral glucose tolerance test (OGTT) reflects the dynamic of the glucose stimulus-response, and it can be considered as predictor of the impaired glucose tolerance and Type 2 Diabetes (T2D). Nucleoside diphosphate kinase 7, non-metastatic cells 7 (NME7) is an acknowledged member of ciliome and is involved in the biogenesis or function of cilia. Due to the fact that obesity and T2D are common in several ciliopathies, we enrolled...

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ea0063p897 | Diabetes, Obesity and Metabolism 3 | ECE2019

From the glucocentric model to new opportunitiesmetabolic control

Iurova Olga , Marchenkova Larisa

Objective: To study the parameters of carbohydrate and fat metabolism, electrolytes of urine against the background of taking SGLT-2 (i-SGLT-2) inhibitors in patients with type 2 diabetes mellitus with a GFR more than 60 ml/minMaterials and methods.: In the study, patients with newly diagnosed type 2 diabetes mellitus with excess weight and obesity (15 people) were prescribed drugs of group-i-SGLT-2 at the initial minimum dose. The level of HbA1c, the ma...

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ea0063p898 | Diabetes, Obesity and Metabolism 3 | ECE2019

Does diabetes expose to multidrug-resistant urinary tract infections?

Jemai Chaima , Islem Stambouli , Hajer Moalla , Nadia Alaya , Faten Mahjoub , Olfa Berriche , Henda Jamoussi

Introduction: Urinary tract infection is worrying in diabetic patients especially unbalanced. Contracting a multidrug-resistant bacterium is even more alarming since it narrows the therapeutic means in a patient whose immune system is already weakened by the diabetes. The objective of this study is to describe the clinical and metabolic characteristics of a population of diabetic patients with urinary tract infection.Methods: This is a retrospective stud...

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ea0063p899 | Diabetes, Obesity and Metabolism 3 | ECE2019

Impact of hypomagnesemia in type 2 diabetes mellitus

Driouich Yasmine , El Aziz Siham , Chadli Asma

Introduction: Magnesium is the fourth most abundant cation in the body and plays an important physiological role in many of its functions. However, an association between hypomagnesemia and insulin resistance (IR) in diabetes has recently been found.Objective: To determine the correlation between hypomagnesemia, glycemic imbalance and the degenerative complications of type 2 diabetes.Materials and methods: We conducted a prospectiv...

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ea0063p900 | Diabetes, Obesity and Metabolism 3 | ECE2019

The results of diabetic foot syndrome screening among rural patients with diabetes in Uzbekistan

Ibragimova Nilufar , Shakirov Khamidulla , Babakhanov Bakhodir , Kokareva Lyudmila , Platonova Oksana

Diabetic foot syndrome (DFS) is currently considered the most severe of all late diabetes complications, resulting in deteriorating health outcomes, increased disability and reduced life expectancy.Aim: To study the frequency of occurrence of DFS in rural peoples with diabetes in Uzbekistan.Methods: Upon the international project WDF08-379 Prevention of lower limb amputations in people with diabetes in Uzbekistan, imple...

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ea0063p901 | Diabetes, Obesity and Metabolism 3 | ECE2019

The role of ‘Diabetic Foot’ rooms in the organization of specialised help to patient with diabetic foot syndrome in Uzbekistan

Ibragimova Nilufar , Kamalov Telman , Shakirov Khamidulla , Kokareva Lyudmila , Platonova Oksana

Of all the late complications of diabetes, foot lesions are the most preventable. The multidisciplinary approach to providing specialized help for people with diabetes can prevent the amputations in 4985% diabetic foots.Aim: The organization of specialized help to patient with diabetic foot syndrome (DFS) by the establishing the network of Diabetic foot rooms and training of multidisciplinary team of specialists (endocrinologist, surgeo...

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ea0063p902 | Diabetes, Obesity and Metabolism 3 | ECE2019

Corticoid induced diabetes: where? when?

Driouich Yasmine , El Aziz Siham , Chadli Asma

Introduction: Corticosteroid-induced diabetes (CID) is a common and potentially harmful problem in clinical practice. Its pathophysiological mechanisms are multiple, from increased hepatic neoglucogenesis to peripheral insulin resistance or direct toxic effect on the β cell. The aim of our study was to study the clinical profile of patients who developed corticosteroid-induced diabetes and its factors of occurrence.Method: We report a retrospective ...

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ea0063p903 | Diabetes, Obesity and Metabolism 3 | ECE2019

Short term metabolic outcome following bariatric surgery; A single center experience from Asia

Gunatilake Sonali , Weerakoon Diana , Subasinghe Chandrika , Bulugahapitya Uditha , Wijerathna Thejana

Background: Obesity and related co-morbidities have become an emerging major health concern in South Asia. In addition to the efficacy in weight control, bariatric surgery improves metabolic disorders, thus is a recognized mode of treatment in obesity.Objectives: To review the outcome of metabolic disorders in a group of obese patients in Sri Lanka following bariatric surgery.Methods: Patients who underwent bariatric surgery at Pro...

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ea0063p904 | Diabetes, Obesity and Metabolism 3 | ECE2019

Case report: Bullous pemphigoid in a patient with type 2 Diabetes on treatment with linagliptin

Gonzalez Lazaro Paloma , Contreras Pascual Cristina , del Val Zaballos Florentino , Silva Fernandez Julia , Torres Arroyo Belvis , Javier Gomez Alfonso Francisco , Garcia Manzanares Vazquez de Agredos Alvaro , Gomez Garcia Ines

Introduction: The association of bullous pemphigoid (BP) with the use of dipeptidyl-peptidase 4 (DPP-4) inhibitors among patients with diabetes has recently emerged. The risk of developing BP during treatment with new DPP-4 inhibitor agents like linagliptin is yet to be established. The clinical features and the prognostic outcomes of patients with DPP-4 inhibitor-associated BP are yet to be established.Objective: To report a case of BP on a patient with...

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ea0063p905 | Diabetes, Obesity and Metabolism 3 | ECE2019

Epidemiological research on diabetic rethynopatia prevalence in newly diagnosed people with type 2 diabetes in Uzbekistan

Normatova Nargiza , Ibragimova Nilufar , Djalalov Sherzod

Diabetic retinopathy (DR) is one of the most frequent and serious complications of diabetes and the leading cause of blindness worldwide. Nevertheless, in Uzbekistan there is no precise statistical data on the prevalence of DR in patients with newly diagnosed diabetes mellitus.Purpose: To study the incidence of DR in newly diagnosed people with type 2 diabetes in Uzbekistan.Materials and methods: Within the framework of the grant &...

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ea0063p906 | Diabetes, Obesity and Metabolism 3 | ECE2019

Gestational Diabetes in Early Pregnancy – what does fasting glucose tell us?

Rosinha Patricia , Dantas Rosa , Alves Marcia , Azevedo Teresa , Inacio Isabel , Ferreira Sara Esteves , Pedrosa Carla , Albuquerque Isabel , Garrett Ana Catarina , Guimaraes Joana

Introduction: The association of fasting glucose (FG) in early pregnancy (EP) with adverse outcomes for the mother and her offspring is well known, although the best cut-offs for diagnosis of Gestational Diabetes (GD) are not consensual.Objetive: Evaluate the impact of FG in EP in the management of pregnant women and obstetric and fetal outcomes.Methods: Retrospective cohort of pregnant women with GD diagnosed before 24 weeks of ge...

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ea0063p907 | Diabetes, Obesity and Metabolism 3 | ECE2019

Weight change of a population of diabetic patients previously educated and having fasted the month of Ramadan

Jemai Chaima , Faika Ben Mami , Awatef Mouelhi , Imen Kakhri , Imen Ksira , Nadia Ben Amor , Arwa Temessek , Hajer Tertek , Mariem Zarrouk

Introduction: The objective of our study was to study the evolution of the weight of a population of diabetic patients previously educated and having fasted the month of Ramadan.Methods: This is a prospective study that involved 140 patients who wish to fast the month of Ramadan (2016) and who have presented themselves at consultations dedicated to preparing diabetic patients wishing to fast, organized at the National Institute of Nutrition of Tunis (Dep...

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ea0063p908 | Diabetes, Obesity and Metabolism 3 | ECE2019

Association of dipeptidyl peptidase 4 inhibitor use with risk of bullous pemphighoid

Damas-Fuentes Miguel , Gomez-Perez Ana , Munoz-Garach Araceli , Mancha-Doblas Isabel , Tinahones-Madueno Francisco

Introduction: Recent studies suggest that the use of dipeptidyl peptidase 4 inhibitors (DPP-4i) may be associated with an increased risk of developing bullous pemphigoid; which has led to publication of several pharmacovigilance alerts.Objectives: To characterize the potential association between the use of DPP-4i and the risk of developing bullous pemphigoid.Material & methods: Observational, retrospective study based on clini...

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ea0063p909 | Diabetes, Obesity and Metabolism 3 | ECE2019

Circulating microRNAs expression profile in individuals with obesity compared to healthy controls

Assmann Tais Silveira , Milagro Fermin I , Cuervo Marta , Riezu-Boj Jose I , Martinez J Alfredo

Context: Obesity is a global epidemic and an independent risk factor for several metabolic disorders. Emerging evidence suggests a role for epigenetic factors, such as microRNAs (miRNAs), in the development of obesity. MiRNAs are small non-coding RNAs that regulate gene expression. Moreover, circulating miRNAs are potential noninvasive biomarkers because they are stable in body fluids and can be detected using validated techniques, such as quantitative PCR. However, the identi...

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ea0063p910 | Diabetes, Obesity and Metabolism 3 | ECE2019

Gestational Diabetes: what to say about body mass index and outcomes? The influence of prepregnancy body mass index on obstetric and neonatal outcomes of women with gestational diabetes

Ferreira Sara Esteves , Rosinha Patricia , Inacio Isabel , Alves Marcia , Azevedo Teresa , Dantas Rosa , Pedrosa Carla , Ferreira Marilia , Albuquerque Isabel , Fonseca Catarina , Jesus Andreia , Guimaraes Joana

Introduction: Due to the growing prevalence of obesity, more women are overweight in early pregnancy, leading to adverse neonatal and obstetric outcomes.Objective: To evaluate the influence of maternal prepregnancy body mass index (BMI) on blood glucose levels at diagnosis of gestational diabetes (GD), obstetric and neonatal outcomes.Methods: Retrospective observational study including women with GD and singleton pregnancy, with fo...

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ea0063p911 | Diabetes, Obesity and Metabolism 3 | ECE2019

Assessement of magnesemic status in patients with metabolic syndrome

Driouich Yasmine , El Aziz Siham , Mjabber Amal , Chadli Asma

Introduction: The association between hypomagnesemia and insulin resistance in diabetes and arterial hypertension has been strongly found, but its role in the metabolic syndrome has not been established.Objective: To determine the magnesium status of patients with metabolic syndrome.Materials and methods: We conducted a prospective study on patients followed in the service of Endocrinology-Diabetology since September 2018 including...

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ea0063p912 | Diabetes, Obesity and Metabolism 3 | ECE2019

1,25-dihydroxyvitamin D₃ (1,25-(OH)₂D₃) and lipid accumulation in liver cells: A role for epigenetic mechanisms?

Perez Francisca Salas , Martinez J Alfredo , Milagro Fermin I

Context: Vitamin D is a fat-soluble vitamin which requires the hydroxylation into 1,25-dihydroxyvitamin D (1,25-(OH)2D3) to be fully active. Vitamin D deficiency is a worldwide health problem associated to a wide range of acute and chronic diseases. On other hand, vitamin D supplementation has been proposed to reduced the risk of metabolic dysfunctions including obesity, type 2 diabetes and cardiovascular disease. Vitamin D interacts with the epigenetic m...

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ea0063p913 | Diabetes, Obesity and Metabolism 3 | ECE2019

Blood pressure objectives in diabetic patients: about 588 cases

Fennoun Halima , Outtaleb Fatima-Zahra , El Aziz Siham , Chadli Asma

Introduction: Hypertension (HTA) is a common condition in patients with type 2 diabetes and is associated with a high risk of cardiovascular disease. Optimal control is the major goal of clinicians to reduce cardiovascular risk. The objective of this study is to determine the prevalence of blood pressure goals in hypertensive diabetic patients.Methods: Retrospective descriptive study including 588 diabetic patients hospitalized in the endocrinology depar...

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ea0063p914 | Diabetes, Obesity and Metabolism 3 | ECE2019

miRNAs-target genes, miRNA-lncRNA, and miRNA-small molecules interactions involved in metabolic diseases

Assmann Tais Silveira , Milagro Fermin I , Martinez J Alfredo

Context: Metabolic diseases affect millions of people in both developed and transition countries. In addition to genetic inheritance of risk alleles, emerging evidence has shown that these diseases are also linked to lifestyle and inherited epigenetic pattern interactions. The strong link between epigenetics and metabolism may offer attractive clinical applications to counteract and manage the escalating prevalence of metabolic diseases, such as obesity, type 2 diabetes mellit...

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ea0063p915 | Diabetes, Obesity and Metabolism 3 | ECE2019

Profile of patients using continuous subcutaneous insulin infusion in portugal

Osorio Ana Sofia , do Vale Sonia , Cruz Diogo

Introduction: Continuous subcutaneous insulin infusion (CSII) represents a treatment option that helps patients with type 1 diabetes (PwT1D) to achieve better glycemic control, reduces hypoglycemia and improves quality of life. In Portugal, the National Health System (SNS) affords CSII treatment to PwT1D, according to certain criteria. Over the years, the number of patients treated with CSII devices supported by SNS has grown exponentially. We analyzed these patients pro...

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ea0063p916 | Diabetes, Obesity and Metabolism 3 | ECE2019

Genetic variants of TCF7L2 gene in Lithuanian women population with previously diagnosed Gestational Diabetes Mellitus compared to General Population

Francaite-Daugeliene Migle , Lesauskaite Vaiva , Tamosiunas Abdonas , Jasukaitiene Aldona , Velickiene Dzilda

Introduction: TCF7L2 is a commonly investigated gene in women with gestational diabetes mellitus (GDM). TCF7L2 different SNPs are associated with GDM risk in women of different races and ethnicities, however, the relationship between the genetic variants of TCF7L2 and GDM has not been completely evaluated.Objective: To determine the association of genetic variants rs7901695, rs7903146, rs7895340, rs11196205, rs12255372 of...

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ea0063p917 | Diabetes, Obesity and Metabolism 3 | ECE2019

Angiotensin-converting enzyme (ACE) gene I/D polymorphism and angiotensin II type 1 receptor (AGTR1) gene A1166C polymorphism and diabetic kidney disease

Vasilkova Volha , Pchelin Ivan , Borovets Yana , Naumenko Elena , Filiptsova Natallia , Mokhort Tatsiana

Background: Polymorphisms in angiotensin-converting enzyme (ACE) gene and angiotensin II type 1 receptor (AGTR1) gene have been assessed in previously multiple studies for association with diabetic nephropathy (DN), but results are still controversial.Aim: The aim of our study was to find out the role of ACE (I/D) and AGTR1 (A1166C) in genetic susceptibility of diabetic nephropathy in Belarusian population.Methods: The present case...

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ea0063p918 | Diabetes, Obesity and Metabolism 3 | ECE2019

Risk factors for diabetic retinopathy: About 454 patients

Boulbaroud Zineb , El aziz Siham , Bensbaa Salma , Chadli Asma

Introduction: Diabetic retinopathy (DR) is a common and serious complication of diabetic microangiopathy. The aim of our study was to evaluate the frequency of DR and to analyze the various factors associated with its development and progression.Patients and methods: Analytical prospective study including 454 diabetic patients requiring an eye examination, hospitalized at the endocrinology-diabetology department of the University Hospital of Casablanca b...

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ea0063p919 | Diabetes, Obesity and Metabolism 3 | ECE2019

Diabetes Eruditus: Characteristics of type 1 diabetes of long duration

Duarte Diana Borges , Amaral Claudia , Amado Ana , Teixeira Sofia , Carvalho Andre , Vilaverde Joana , Freitas Claudia , Palma Isabel , Dores Jorge , Carvalho Rui , Bacelar Conceicao , Ramos Helena , Cardoso Helena

Introduction and aim: Type 1 diabetes mellitus (T1DM) presents as a challenge for both health care providers and patients looking to avoid chronic complications and early mortality. Clinical features of patients with long duration T1DM are still poorly studied and debated. The aim of our work was to describe the clinical features of subjects with long duration T1DM.Methods: Cross-sectional study of patients with T1DM with more than 40 years of evolution ...

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ea0063p920 | Diabetes, Obesity and Metabolism 3 | ECE2019

The Soft tissue infections in diabetic patients

Kibhat Odiki Lygie Sephora , El Aziz Siham , Mjabber Amal , Chadli Asma

Introduction: The diabetic patient in times of imbalance is susceptible to infections with a risk five times higher than non-diabetics. The aim of our work was to determine the clinical and paraclinical manifestations of soft-tissue infections in diabetic patients, to identify contributing factors and etiologies.Patients and methods: Prospective study, conducted from October 2017 to September 2018, in the endocrinology department of Ibn Rochd University ...

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ea0063p921 | Diabetes, Obesity and Metabolism 3 | ECE2019

Diabetic foot education: patient satisfaction (about 151 cases)

Faiz Hajare , El Aziz Siham , Mjabber Amal , Chadli Asma

Introduction: Therapeutic education is the cornerstone of foot care for the diabetic patient. The purpose of this work was to evaluate the satisfaction of patients who have benefited from diabetic foot education sessions.Methods: This is a prospective study involving 151 patients with risky feet who benefited from the diabetic foot awareness and education day in our service during the following period (January 2018 to December 2018). For this work, we us...

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ea0063p922 | Diabetes, Obesity and Metabolism 3 | ECE2019

The cardio-metabolic profile of elderly patient with diabetes mellitus type 2 (about 300 case)

Ballaziri Hasna , El Aziz Siham , Chadli Asma

Objective: Old age represents a real factor for many co-morbidities dominated by metabolic disorders and cardiovascular disease and, which are the major challenges of health. Diabetes in the elderly is the sixth leading cause of mortality at this age. Our study has the objective to assess the Cardio Metabolic profile among patients with type 2 diabetes in hospital environment.Methods: It is a descriptive study conducted on 300 diabetics type 2, over 65 y...

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ea0063p923 | Diabetes, Obesity and Metabolism 3 | ECE2019

Flash glucose monitoring system in children under 18 years old with diabetes mellitus type 1 in the southern hospital area of Granada: preliminary results

Utrero Sara Leon , Ponce Maria Hayon , Laguna Ma Del Carmen Serrano , Torres Elena Lopez-Mezquita , Charneco Miguel Quesada , Vela Elena Torres

Objective: To evaluate the baseline characteristics and their evolution three months after implantation of the Flash glucose monitoring System (Freestyle Libre), after financing by the Andalusian Health Service in patients under 18 years old with type 1 diabetes mellitus (DM1) in our hospital area.Material and Methods: A descriptive observational and retrospective study that includes patients with DM1 under 18 years old from the southern hospital area of...

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ea0063p924 | Diabetes, Obesity and Metabolism 3 | ECE2019

Candidiasis infections in the diabetic About 307 cases

Dinghat Ornella Marline Yvonne , Mjabber Amal , El Aziz Siham , Chadli Asma

Introduction: Unbalanced diabetes mellitus predisposes to bacterial and fungal infections especially candidiasis. Candidiasis can have several localizations including digestive, genitourinary or mucocutaneous. The purpose of this work was to analyze the characteristics of candidiasis in all these forms in the patient.Materials and Methods: Descriptive cross-sectional study from January 2012 to December 2018, including 307 diabetic patients presenting wit...

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ea0063p925 | Diabetes, Obesity and Metabolism 3 | ECE2019

The diabetes mellitus type 2 in elderly patients: comorbidities and polymedication (about 300 cases)

Ballaziri Hasna , El Aziz Siham , Chadli Asma

Objective: Polymedication is particularly common among elderly diabetes patients because of the frequency of co-morbidities, of certain chronic diseases and disabilities, of the growing demand for care, therapeutic progress, but also of some of the excess of requirements. The objective of our study is to assess the frequency of comorbidities in a population of elderly diabetic type 2, analyze the drug consumption.Methods: It is a descriptive study conduc...

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ea0063p926 | Diabetes, Obesity and Metabolism 3 | ECE2019

Factors influencing the practice of physical activity in youth with type 1 diabetes mellitus

Boulbaroud Zineb , Aziz Siham El , Chadli Asma

Introduction: Physical activity (PA) improves physical performance and glycemic control in type 1 diabetes mellitus (T1D). Many factors determine access to a normal sporting life and therefore its benefits. The aim of this study was to evaluate the practice of PA in T1D and the factors influencing it.Patients and methods: Descriptive and analytical cross-sectional study including any patient with T1D admitted to the Endocrinology-Diabetology department a...

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ea0063p927 | Diabetes, Obesity and Metabolism 3 | ECE2019

Reasons for consultation in diabetological emergencies

Biona Martella Bouka , Aziz Siham El , Chadli Asma

Goal: Diabetes is a common condition, affecting the young and the elderly, which can lead to acute accidents such as ketoacidosis, diabetic ketosis, hypoglycemia and hyperglycemia with various decompensation factors, which may be of cardiac origin, neurological or infectious. The objective of the study was to clarify the epidemiological and clinical profile of diabetic patients, to establish the reasons for urgent consultations in diabetic patients.Metho...

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ea0063p928 | Diabetes, Obesity and Metabolism 3 | ECE2019

Assessment of therapeutic education in diabetes patients on insulin at the pharmacy

Odiki Lygie Sephora Kibhat , Aziz Siham El , Jamjam Siham , Chadli Asma

Introduction: Increasing the prevalence of chronic diseases, including diabetes, is an important public health issue. Beyond the actions already carried out in pharmacies, the place of the pharmacist is essential in the therapeutic education (ETP) and the actions of accompaniment of the patients. The objective of our work was to evaluate the level of education of patients in insulin therapy at the pharmacy level and to deduce the reasons for poor compliance.<p class="abste...

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ea0063p929 | Diabetes, Obesity and Metabolism 3 | ECE2019

Idiopathic versus autoimmune type 1 diabetes – long-term differences

Catarino Diana , Silva Diana , Pereira Claudia , Ribeiro Cristina , Ruas Luisa , Cunha Nelson , Fadiga Lucia , Guiomar Joana , Lavrador Mariana , Vieira Ines , Cardoso Luis , Paiva Isabel , Bastos Margarida

Introduction: The American Diabetes Association proposed two subcategories for type 1 diabetes: autoimmune type 1 diabetes (ADM) and idiopathic type 1 diabetes (IDM). The absence of β-cell autoimmune markers and lack of association with HLA haplotypes define the second category, whose pathogenesis remains unclear. Only a minority of patients with type 1 diabetes fall into this subcategory which is considered by several authors similar to type 2 diabetes.<p class="abst...

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ea0063p930 | Diabetes, Obesity and Metabolism 3 | ECE2019

Whole body cryotherapy effect on weight gain and metabolic parameters of metabolic and type 2 diabetic patients

Lushchyk Maxim , Danilova Larisa , Tuzava Hanna , Dudzik Natallia , Zhauneryk Sviatlana

Introduction/Aim: The incidence of type 2 diabetes in Belarus continues to grow. Alongside with the standard treatment search for the new methods of intervention still continued. Whole body cryotherapy appears to be a promising method of metabolic correction. Study aim was the estimation of various low-temperature regimen influence on biochemical parameters and BMI characteristics of patients with metabolic syndrome and type 2 diabetes and selection the optimal low-temperature...

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ea0063p931 | Diabetes, Obesity and Metabolism 3 | ECE2019

Sexual dimorphism in the mechanisms for insulin resistance

Hiriart Marcia Velasco Myrian , Hiriart Marcia

Insulin resistance (IR) is a condition where beta cells are producing insulin, sometimes in large amounts, but the peripheral targets develop an inadequate response to the hormone. Classically insulin resistance has been associated with pathologic conditions. However, there is also physiological IR, associated with the last period of pregnancy and in different moments of the development. We have previously characterised a period of physiological IR, around the ablactation peri...

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ea0063p932 | Diabetes, Obesity and Metabolism 3 | ECE2019

Glucosuric drugs + immune checkpoint inhibitors: A recipe for diabetic ketoacidosis?

Kuzior Agnieszka , Fernandez-Trujillo-Comenge Paula Maria , Nivelo-Rivadeneira Manuel Esteban , Santana-Suarez Ana Delia , Acosta-Calero Carmen , Pedrianes-Matin Pablo Benito , Zajac Marta Agata , Martinez-Martin Francisco Javier

Introduction/Aim: Diabetic ketoacidosis is a rare complication in type 2 diabetic patients treated with SGLT2 inhibitors; usually there is a triggering factor (major trauma or surgery, sepsis) or misdiagnosis (type 1 diabetes or LADA). Nivolumab is an anti-CD279 monoclonal antibody used as a second-line immunotherapy in non-small cell lung carcinoma; its use has been associated with fulminant type 1 diabetes and other autoimmune endocrine diseases. We hereby present a case of ...

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ea0063p933 | Diabetes, Obesity and Metabolism 3 | ECE2019

The Oral status of elderly patient with diabetes mellitus type 2: a real factor of risk of malnutrition (about 300 cases)

Ballaziri Hasna , Aziz Siham El , Chadli Asma

Introduction: Oral disorders are quite frequent in patients with diabetes mellitus type 2 in particular elderly patients. Their presence at this type of persons may influence the glycemic balance and entail a reduction of the masticatory potential with a risk of malnutrition. The purpose of the work is to establish the relationship between the oral disorders and the nutritional status of the elderly subjects with diabetes mellitus type 2.Patients and Met...

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ea0063p934 | Diabetes, Obesity and Metabolism 3 | ECE2019

Glycemic equilibrium of cancer patients with diabetes

Odiki Lygie Sephora Kibhat , Aziz Siham El , Mjabber Amal , Chadli Asma

Introduction: Diabetes and cancer are common, chronic and life-threatening diseases that coexist frequently. In addition, many cancer patients are already diabetic or are developing hyperglycemia as a result of a tumor or anti-cancer therapies. The aim of our work was to evaluate the glycemic balance of diabetic patients with cancer and its impact on the prognosis of the disease. Patients and methods: This are a prospective study carried out within the endocrinology department...

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ea0063p935 | Diabetes, Obesity and Metabolism 3 | ECE2019

Management of diabetic patients with cancer

Odiki Lygie Sephora Kibhat , Aziz Siham El , Mjabber Amal , Chadli Asma

Introduction: Managing people with diabetes and cancer during palliation is a major challenge. The aim of our work was to study the specific characteristics of diabetic people with cancer, to identify management modalities of management during cancer treatment.Patients and methods: Prospective study including 100 diabetic patients with cancer followed in the different services of Ibn Rochd University Hospital of Casablanca between 2017 and 2018. Variable...

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ea0063p936 | Diabetes, Obesity and Metabolism 3 | ECE2019

Let use results of foot examination for guiding diabetes mellitus therapy

Tesic Dragan S , Mitrovic Milena , Ljikar Jelena , Andric Dragica , Tomic Mirjana

Background and aims: After two decades of silence in classification system od type 2 diabetes there are some indices that the dibebtic retinopathy might be the sign for introduction of insulin therapy. The aim of this study was to examine associations between measures of diabetic foot in people with diabetes complicated by nonproliferative retinopathy (NPDR), maculopathy and proliferative retinopathy (PDR).Materials and methods: People were included had ...

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ea0063p937 | Diabetes, Obesity and Metabolism 3 | ECE2019

MicroRNA-26a, microRNA-33a, and microRNA-33b in patients with obesity: association with coronary artery disease

Shvangiradze Teona , Bondarenko Irina , Troshina Ekaterina , Karpukhin Aleksandr

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are commonly associated with coronary artery disease (CAD). Recent studies demonstrated that microRNAs (miRNAs) are involved in the pathogenesis of CAD.Aim: To study miRNA-26a, microRNA-33a and microRNA-33b expression in patients with obesity.Methods: MiRNAs were detected in peripheral blood samples of 66 patients, aged 4865 years. Patients with BMI 30.039.9 kg/m...

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ea0063p938 | Diabetes, Obesity and Metabolism 3 | ECE2019

Transition of young adults with type 1 diabetes

Kibhat Lygie , El Aziz Siham , Chadli Asma

Introduction: The transition period to young adult counseling is a crucial period for the diabetic patient. A poor transition exposes them to a risk of disengagement from the health system and mismanagement of diabetes. The objective of this work is to describe the progress of the transition and to deduce the facilitating and restraining elements.Patients and methods: This were a retrospective study of 120 referred diabetic type 1 patients from the pedia...

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ea0063p939 | Diabetes, Obesity and Metabolism 3 | ECE2019

Prevalence and predictive factors of advanced fibrosis in type 2 diabetic patient in a majoritally abstinent population of alcohol

Fennoun Halima , El Mansouri Souhaila , Tahiri Mohamed , El Aziz Siham , Haddad Farid , Hliwa Wafaa , Badr Wafa , Chadli Asma

Introduction: Metabolic steatopathy is frequently associated with type 2 diabetes, which may progress to advanced fibrosis. The objectives of this study were to evaluate the prevalence and predictors of the severity of hepatic impairment in this population.Methods: A cross-sectional study involving 281 type 2 diabetic patients followed in the endocrinology department in collaboration with the Hepato-Gastroenterology department of Ibn Rochd University Hos...

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ea0063p940 | Diabetes, Obesity and Metabolism 3 | ECE2019

The metabolic profile of diabetic patients during the month of Ramadan

Kibhat Lygie Sephora , El Aziz Siham , Chadli Asma

Introduction: Diabetes is considered by some to be a burden, it is common to meet diabetic Muslims who wish to observe the fast of the month of Ramadan. The objective of our work was to observe the effect of Ramadan fasting on clinical and metabolic parameters in type 2 diabetics.Patients and methods: Prospective study including 160 diabetic patients, within the Endocrinology department from May to August 2018. The participants benefited from a pre (T0),...

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ea0063p941 | Diabetes, Obesity and Metabolism 3 | ECE2019

Increased serum resistin levels in metabolically unhealthy compared to metabolically healthy obese individuals; correlation with circulating white blood cell subpopulations

Christou Konstantinos , Christou Georgios , Karamoutsios Achilleas , Vartholomatos Georgios , Gartzonika Konstantina , Tsatsoulis Agathocles , Tigas Stelios

Background: Obesity is associated with chronic low-grade inflammation that contributes to the development of metabolic syndrome (MS). Resistin, produced by neutrophils and monocytes, displays potent proinflammatory properties and has been associated with cardiometabolic disease. The aim of this study was to (a) determine serum resistin levels among obese patients with or without MS and (b) explore the role of the subsets of circulating white blood cells as potential determinan...

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ea0063p942 | Diabetes, Obesity and Metabolism 3 | ECE2019

Discharge in the diabetic foot: means, indications and observance: about 102 cases (preliminary results)

Pangui-Ntsam Henricia Laurinda , El Aziz Siham , Mjabber Amal , Chadli Asma

Introduction: The diabetic foot is a major public health problem with a significant socio-economic impact. In the presence of a trophic disorder land filling is a key element of care. The objective of our study is to identify the means and indications, to evaluate the contribution of the discharge in the prevention and the cicatrization of lesions of the diabetic foot.Methods: This was a prospective study conducted from September 2017 to July 2018. Inclu...

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ea0063p943 | Diabetes, Obesity and Metabolism 3 | ECE2019

Drug interactions in diabetic patients

Kibhat Lygie Sephora , El Faiz Imad , El Aziz Siham , Chadli Asma

Introduction: The frequent polypharmacy in diabetic patients, because of the complications of the disease, drug interactions can occur when two or more drugs are taken in combination. The objective of our work was to determine the relative frequency of these drug interactions, to identify the types and to evaluate the impact or the repercussion of these in the diabetic, in order to deduce the practical behaviors.Patients and methods: Prospective study, c...

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ea0063p944 | Diabetes, Obesity and Metabolism 3 | ECE2019

The impact of cigarette smoking on metabolic syndrome in diabetic patients type 2: about 322 cases

Iftahy Fatima Zahra , El Aziz Siham , Mjabber Amal , Chadli Asma

Introduction: Cigarette smoking is a modifiable cardiovascular risk factor, inducing and aggravating insulin resistance and metabolic disorders, especially in patients with type 2 diabetes (DT2). Our objective was to study the prevalence of the different components of the metabolic syndrome in patients with comparing with a group of non-smoking diabetics.Patients and methods: This was a cross-sectional study conducted in the Diabetology, Endocrinology an...

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ea0063p945 | Diabetes, Obesity and Metabolism 3 | ECE2019

The association between glycemic control and hip fracture risk – a retrospective Cohort study

Yoel Uri , Zimhony-Nissim Noa , Novack Victor , Fraenkel Merav

Introduction: Fragility fractures are increasingly recognized as a complication of diabetes mellitus (DM). Disease duration, poor glycemiccontrol, diabetes complication, and glycemic variability may be associated with increased risk.Aim: To investigate the association between glycemic control and hip fracture (HF) risk in a cohort of diabetic patients.Methods: This retrospective cohort study included all patients 50 years and older...

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ea0063p946 | Diabetes, Obesity and Metabolism 3 | ECE2019

Screening of abnormal glucose metabolism in cystic fibrosis could there be a place for DPP-4 inhibitors in early stages?

Peris Begona Pla , Sanchez Clara Marijuan , Moreno Nerea Aguirre , Alday Inigo Hernando , Blanco Sara Jimenez , Nunez Miguel Sampedro , Moreno Rosa Giron , Azpiroz Monica Marazuela , Martin Alfonso Arranz

Introduction: Abnormal glucose metabolism (AGM) is the most common extra-pulmonary comorbidity in people with cystic fibrosis (CF) and has a high negative impact on the underlying disease. Elevated postprandial glucose level is usually the first manifestation, which is traditionally detected by 75-gram oral glucose tolerance test (OGTT). The aim of this study was to evaluate glycemic pattern during continuous glucose monitoring (CGM) in patients with impaired glucose metabolis...

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ea0063p947 | Diabetes, Obesity and Metabolism 3 | ECE2019

Autoimmune diabetes mellitus versus idiopathic: differences at diagnosis

Silva Diana , Catarino Diana , Pereira Claudia , Ruas Luisa , Ribeiro Cristina , Cunha Nelson , Fadiga Lucia , Guiomar Joana , Cardoso Luis , Paiva Isabel , Carrilho Francisco

Introduction: The American Diabetes Association proposed two categories for the classification of type 1 diabetes mellitus (DM): autoimmune (AI) and idiopathic (ID). The absence of autoimmune markers or association with HLA haplotypes defines the second category. Only a small minority of patients with type 1 diabetes fall into this category.Objective: To evaluate the clinical characteristics of both categories and to analyze the differe...

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ea0063p948 | Diabetes, Obesity and Metabolism 3 | ECE2019

The relationship of vitamin D status, adherence to the Mediterranean diet and physical activity in obese children and adolescents

Simunovic Marko , Supe-Domic Daniela , Karin Zeljka , Degoricija Marina , Paradzik Martina , Bozic Josko , Unic Ivana , Skrabic Veselin

Background: Vitamin D deficiency has been associated with a wide range of chronic diseases, including childhood obesity. Prevalence of vitamin D deficiency in obese children and adolescents ranges from 6.5% to 57% depending on the population and criteria.Subjects and methods: This cross-sectional clinical study included 92 obese patients with BMI z score <2 and 39 healthy normal-weight subjects in the control group who were matched with the study gro...

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ea0063p949 | Diabetes, Obesity and Metabolism 3 | ECE2019

Detection of metabolic hepatic steatosis in type 2 diabetic patient: about 281 cases

Fennoun Halima , Mansouri Souhaila El , Tahiri Mohamed , Aziz Siham El , Haddad Farid , Hliwa Wafaa , Badr Wafa , Chadli Asma

Introduction: Metabolic liver steatosis is frequently associated with type 2 diabetes with an increased risk of progression to advanced fibrosis. Objective of this study was to estimate the prevalence of hepatic steatosis in patients with type 2 diabetes.Methods: A cross-sectional study including 281 type 2 diabetic patients followed at the Department of Endocrinology in collaboration with the Hepato-Gastroenterology Department of Ibn Rochd University Ho...

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ea0063p950 | Diabetes, Obesity and Metabolism 3 | ECE2019

Relative fat mass correlates better than BMI with total body fat – experience of an obesity clinic

Ferrinho Catia , Bello Carlos , Santos Francisco Sousa , Capitao Ricardo , Ferreira Rute , Limbert Clotilde , Duarte Joao Sequeira , Oliveira Manuela

Introduction: A simple linear anthropometric linear equation for total body fat quantification in adults was recently selected as the best of 365 anthropometric indexes in the American population. The authors intend to evaluate the correlation between the relative fat mass (RFM) equation and body fat determination by electric bioimpedance (EB) and compare it with BMI.Material/methods: Retrospective, cross-sectional, observational study that selected all ...

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ea0063p951 | Diabetes, Obesity and Metabolism 3 | ECE2019

Characterisation of Turner syndrome glucose homeostasis; autoimmunity, adiposity and insulin sensitivity

Cameron-Pimblett Antoinette , Attard Carol Cardona , Conway Gerard S

Introduction: Women with Turner syndrome (TS) have an increased risk of diabetes mellitus (DM) the pathogenesis of which is not well understood. International guidelines for TS recommend oral glucose tolerance tests (OGTT) but the utility of this test has not been determined. We sought to establish the rate of IGT and DM and characterise the DM-phenotype in adult women with TS.Methods: We performed OGTTs in 37 adults with TS and obtained an additional fa...

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ea0063p952 | Diabetes, Obesity and Metabolism 3 | ECE2019

Autotaxin level in patients with type 2 diabetes mellitus or cardiovascular disease

Duran Iffet Dağdelen , Gulcelik Neşe Ersoz

Introduction: Autotaxin (ATX)[Ectonucleotide Pyrophosphatase /Phosphodiesterase family member 2 (ENPP2)] is a lysophospholipase D stimulating cell migration, metastasis and angiogenesis. ATX hydrolizes lysophosphatidylcholine (LPC) and produces bioactive lysophosphatidic acid(LPA). There are some clues about ATXLPA pathway modulation may unlock the gate of metabolic derangement including diabetes formation or may impact formation of cardiovascular diseases via LPAs...

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ea0063p953 | Diabetes, Obesity and Metabolism 3 | ECE2019

Hepatic steatosis and cardiovascular risk in diabetic patient type 2

Fennoun Halima , Mansouri Souhaila El , Tahiri Mohamed , Aziz Siham El , Haddad Farid , Hliwa Wafaa , Badr Wafa , Chadli Asma

Introduction: Metabolic hepatic steatosis is a common condition in patients with type 2 diabetes, increasing the risk of cardiovascular morbidity and mortality in the absence of early and adequate management. The objective of this study was to evaluate cardiovascular risk in this population by comparing it with diabetic patients without fatty liver disease.Methods: We conclucted a cross-sectional study including 281 type 2 diabetics followed in Endocrino...

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ea0063p954 | Diabetes, Obesity and Metabolism 3 | ECE2019

Doege-potter syndrome in patients with malignant extrapleural solitary fibrous tumor: a single center experience

Peiro Inmaculada , Iglesias Pedro , Diez Juan Jose , Martin-Liberal Juan , Garcia-del-Muro Xavier , Serrano Teresa , Villabona Carles

Introduction: Doege-Potter syndrome (DPS) is a rare paraneoplastic syndrome consistent in non-islet-cell tumor hypoglycemia associated with solitary fibrous tumor (SFT). Pathogenesis of hypoglycemia has been attributed to the production of insulin-like growth-factor-2 (IGF-2) by tumor cells. We report two DPS patients with metastatic extrapleural SFT.Case 1: A 42-year-old man with SFT of the mesocolon that had been operated in 2010, presented with metast...

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ea0063p955 | Diabetes, Obesity and Metabolism 3 | ECE2019

Transgenic production of endogenous n-3 PUFA levels compared to fish oil intake differentially improve obesity-related metabolic disorders: role of the gut microbiota

Barz Melanie Le , Daniel Noemie , Varin Thibault V , Mitchell Patricia , Pilon Genevieve , Gauthier Josee , Garofalo Carole , Kang Jing X , Roy Denis , Jobin Christian , Levy Emile , Marette Andre

Previous studies demonstrated that n-3 polyunsaturated fatty acids (PUFA) reduce insulin resistance and non-alcoholic fatty liver disease (NAFLD). However, we previously reported that transgenic expression of the fat-1 n-3 desaturase, inducing the endogenous production of n-3 PUFA, improved insulin resistance but not hepatic steatosis in a mouse model of obesity. Thus, we compared the effects of increasing n-3 PUFA levels through oral or endogenous approaches in diet-...

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ea0063p956 | Diabetes, Obesity and Metabolism 3 | ECE2019

Clinical particularities of acute pancreatitis in diabetic patients: about 60 cases

Fennoun Halima , El Aziz Siham , Chadli Asma

Introduction: Acute pancreatitis is a common disease of simple evolution in 80% of cases, but burdened with increased morbidity and mortality especially in the diabetic patient because of his atypical symptomatology delaying his diagnosis. The objective of this study is to evaluate the clinical features of acute pancreatitis in diabetic patients.Methods: Retrospective descriptive study including 60 patients followed in the endocrinology department of Cas...

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ea0063p957 | Diabetes, Obesity and Metabolism 3 | ECE2019

Impact of bariatric techniques in the long-term weight loss

Angelica Herraiz Lorea , Torrego Macarena , Barabash Ana , Matia Pilar , Perez-Ferre Natalia , Marcuello Clara , Jimenez-Varas Ines , Sanchez-Pernaute Andres , Jose Torres Antonio , Angel Rubio Miguel

Introduction: Bariatric surgery (BS) has emerged as the most effective treatment for severe obesity, but weight regain after surgery is an important issue. The aim of this study was to evaluate the impact of different surgical techniques on long-term dynamic weight loss pattern.Materials and methods: We retrospectively included 444 patients with BMI > 35 kg/m2 who underwent different BS techniques: Sleeve gastrectomy (SG; n: 80), ...

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ea0063p958 | Diabetes, Obesity and Metabolism 3 | ECE2019

Ramadan fasting effects on the clinical and metabolic parameters of a previously educated population of diabetic, hypertensive and dyslipidemic patients

Jemai Chaima , Mami Faika Ben , Amel Loukil , Neila Fendri , Mohamed Rayene Ben , Senda Sellami , Arwa Temessek , Hajer Tertek , Mariem Zarrouk

Introduction: Several studies have been conducted to study the effect of fasting on the clinical and metabolic parameters of patients with multiple cardiovascular risk factors, particularly diabetes, hypertension, and dyslipidemia. Our aim was to study the effect of Ramadan fasting on the clinical and metabolic parameters of a previously educated population of diabetic, hypertensive and dyslipidemic patients.Methods: This is a prospective study that invo...

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ea0063p959 | Diabetes, Obesity and Metabolism 3 | ECE2019

Different pattern of clinical presentation between newly onset ketone prone diabetes and type 1 diabetes in a tertiary hospital

Martinez Garcia Maria , Elena Lopez Alaminos Maria , Trincado Aznar Pablo , Gonzalez Fernandez Mikel , Alvarado Rosas Almendra , Sanz Paris Alejandro , Acha Perez Javier

Introduction: A new subtype of diabetes, ketosis-prone diabetes (KPD) has been described in the last years among African, Asian and Hispanic population with characteristics similar to type 1 diabetes (DM1) such as cardinal symptoms, tendency to ketosis and decreased pancreatic reserve at onset, but with negative autoimmunity. The aim of this study was to compare this type of patients with those with type 1 diabetes at onset and their evolution.Material a...

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ea0063p960 | Diabetes, Obesity and Metabolism 3 | ECE2019

Prevalence of postprandial hyperinsulinemic hypoglycaemia in a random population after primary Roux-en-Y gastric bypass during a mixed meal tolerance test

Emous Marloes , Wijma Ragnhild , van den Broek Merel , de Heide Loek , van Dijk Gertjan , Wolthuis Albert , Totte Erik , Laskewitz Anke , Wolffenbuttel Bruce , van Beek Andre

Context: Roux-en-Y Gastric bypass (RYGB) is an effective way to induce sustainable weight loss. This operation can be complicated by late dumping, also known as postgastric bypass hyperinsulinemic hypoglycemia. Much is still unknown on its prevalence and its pathophysiology.Objective: To study the prevalence and the main driving mechanisms behind the occurrence of hypoglycemia after a mixed meal tolerance test (MMTT) in patients with primary RYGB. Design...

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ea0063p961 | Diabetes, Obesity and Metabolism 3 | ECE2019

The prevalence of impaired cognitive function and depression in patients with type 2 diabetes mellitus and severe insulin resistance

Šimonienę Diana , Veličkienę Džilda

Aims were: 1. To evaluate the prevalence of impaired cognitive functions and depression in patients with type 2 diabetes mellitus (T2DM) and compare between groups.2. To evaluate the association of cognitive functions and depression with age, gender, BMI, insulin dose, marital status and education in patients with T2DM.Methods: Case-control study of T2DM where patients with high insulin doses (>1U/kg/24 hrs) and uncontrolled di...

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ea0063p962 | Diabetes, Obesity and Metabolism 3 | ECE2019

Gender differences in patients with coronary heart disease and diabetes: A multicentric retrospective study

Tome Fernandez-Ladreda Mariana , Isabel Jimenez Millan Ana , Garcia Doncel Lourdes , Belen Ojedad Schuldt Maria

Introduction: There are known biological differences between men and women in coronary heart disease. It is important to know these differences in order to avoid inequalities in prevention, diagnosis and treatment of this pathology.Methods: We designed a retrospective, descriptive study in which we included all diabetic patients admitted to 3 different hospitals in Cádiz province with acute coronary syndrome and diabetes in 2016. Demographic data an...

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ea0063p963 | Diabetes, Obesity and Metabolism 3 | ECE2019

Delayed menarche, oligomenorrhea and hyperandrogenism in type 1 diabetes mellitus

Paschou Stavroula A , Vryonidou Andromachi , Melissourgou Marina , Kosteria Ioanna , Anagnostis Panagiotis , Goulis Dimitrios G. , Chrousos George P , Kanaka-Gantenbein Christina

Aim: To investigate reproductive function disorders in young women with type 1 diabetes mellitus (T1DM).Patients and methods: We studied 53 women with T1DM (duration 8.0±5.6 y) and 51 healthy controls with normal menstrual cycles and no clinical hyperandrogenism, matched for age (19.4±4.3 vs 20.8±3.1 years, P=0.063) and body mass index (BMI) (22.2±2.7 vs 21.4±1.9 kg/m2, P=0.088). T1DM (insulin regimen...

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ea0063p964 | Diabetes, Obesity and Metabolism 3 | ECE2019

‘Development of new dietetic approach for obese and overweight adults without metabolic factors for cardiovascular disease: preliminary results’

Balamoti Christina , Bargiotta Alexandra

Context: Developing reliable diet methods for facilitating long term weight loss outcomes my help to decrease obesity rates. It is then of paramount importance to investigate the potential benefits of the use of new dietetic approaches aiming at weight loss.Objective: To determine the clinical efficacy of two different dieting methods.Materials and methods: This was a randomized clinical study of dietary intervention. In total 40 h...

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ea0063p965 | Diabetes, Obesity and Metabolism 3 | ECE2019

Prediabetes: expectations and attitudes

Ivo Catarina , Duarte Vitoria , Verissimo David , Silva Joao , Lopes Luis , Passos Dolores , Jacome de Castro Joao , Marcelino Mafalda

Introduction: Prediabetes is a very prevalent disease. About 27.4% of Portuguese adults suffer from this condition. Prediabetes is defined as intermediate hyperglycemia state associated with the simultaneous presence of insulin resistance and β-cell dysfunction as diabetes, with increased risk of developing macro and microvascular complications. Approximately 7% of individuals with prediabetes will progress to diabetes per year. This study aims to characterize a populatio...

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ea0063p966 | Diabetes, Obesity and Metabolism 3 | ECE2019

The level of the vitamin D, osteoprotegerin and metabolic status in children with obesity

Mikhno Hanna , Solntsava Anzhalika , Dashkevich Helena

Objective: Determination of changes in metabolic status and vitamin D, osteoprotegerin concentrations in obese children.Methods: We examined 212 children in the University Hospital from 2016 to 2018 yrs. Their anthropometric parameters (body mass index (BMI)) were determined. Blood levels of vitamin D, OPG, insulin were determined. In the biochemical blood test, the parameters of uric acid, glucose were evaluated. All children were divided into 2 groups:...

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ea0063p967 | Diabetes, Obesity and Metabolism 3 | ECE2019

Assessment of the educational level of diabetics regarding their foot

Elfekih Hamza , Amor Bilel Ben , Hasni Yosra , Maaroufi Amel , Khochtali Ines , Ach Koussay

Introduction: Diabetic foot is known to represent a serious complication of diabetes mellitus, responsible for significant morbidity, disability and considerable financial implications. The prevention of this complication requires, first and foremost, a good patient education.Objective: To evaluate the current state of knowledge and practices of foot care in diabetic patients and to identify factors associated with a good educational level.<p class="...

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ea0063p968 | Diabetes, Obesity and Metabolism 3 | ECE2019

Diabetic foot: Assessment of the diabetic patient’s knowledge before and after a day of education

Kaidi Fatimazahra , El Aziz Siham , Mjabber Amal , Chadli Asmaa

Introduction: Diabetic foot problems are generally poorly understood by patients, yet they represent a major health problem. The aim of this study was to assess diabetes patients knowledge of preventive foot care before and after a diabetic foot day.Patients and methods: It was a prospective and descriptive study conducted in the service from January to December 2018, including 108 type 2 or type 1 diabetic patients, at risk of podiatry grade 1, 2 ...

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ea0063p969 | Diabetes, Obesity and Metabolism 3 | ECE2019

Knowledge and practices of diabetic patients during Ramadan

Ijdda Sara , Zaher Fatima Zahra , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: The month of Ramadan is characterized by abstaining from drinking and eating from sunrise to sunset. This exposes to an increased metabolic risk in diabetics. However, even if religiously diabetics could be exempt from fasting, a large number of them practice it.Materials and methods: We conducted a cross-sectional study and interviewed diabetic patients about their practices during Ramadan and about the presence or absence of complications...

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ea0063p970 | Diabetes, Obesity and Metabolism 3 | ECE2019

Late diarrhea in diabetic patients under metformin: An undesirable effect of the molecule appearing late?

Jemai Chaima , Islem Stambouli , Senda Sellami , Nadia Alaya , Faten Mahjoub , Olfa Berriche , Henda Jamoussi

Introduction: Diarrhea is an undesirable effect that affects almost one third of patients on metformin.When it appears late, it becomes difficult to attach it to metformin, especially in polymedicated patients or with complicated diabetes. The purpose of this study was to describe the clinical and biological characteristics of a population with chronic metformin-induced diarrhea and to characterize this diarrhea.Methods: This is a prospective study inclu...

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ea0063p971 | Diabetes, Obesity and Metabolism 3 | ECE2019

Are fast insulin analogues fast enough? Switching to faster aspart may reduce glycemic variability and the risk of hypoglycemia in type 1 diabetic patients on sensor-augmented insulin pump therapy

Nivelo-Rivadeneira Manuel Esteban , Kuzior Agnieszka , Fernandez-Trujillo-Comenge Paula Maria , Santana-Suarez Ana Delia , Acosta-Calero Carmen , Diaz-Moreno Macarena , Medina-Sanchez Almudena , Martinez-Martin Francisco Javier

Aim: Comparing the effect of Faster Aspart insulin (Fiasp®) with previous insulin analogues (aspart, lispro) in type I diabetic patients with sensor-augmented pump therapy.Methods: Patients with Minimed Paradigm® insulin pumps, Enlite® sensors and Guardian® software (able to automatically stop the pump infusion to prevent hypoglycemia) were switched from previous insulin to Faster Aspart. Da...

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ea0063p972 | Diabetes, Obesity and Metabolism 3 | ECE2019

The effects of metformin monotherapy on lipid profile in patients with type 2 diabetes mellitus

Borozan Sanja , Vujosevic Snezana , Kavaric Sreten , Boskovic Olivera , Krnjevic Djordjije , Cikic Elzana , Muzurovic Emir , Bjeladinovic Igor , Radovanic Snezana , Sparavalo Rada , Vukicevic Violeta , Ivanovic Suzana , Pupovic Enisa

Background: Due to its efficacy and safety, metformin is the most commonly used drug in a single-agent therapy of type 2 diabetes mellitus (T2DM), after lifestyle modifications failed to obtain a desirable effects. Despite his main effects in improving glycemic control, it is also stated that it has a beneficial effects on lipid profile, which may be attributable to improved insulin sensitivity, weight loss and reduction of irreversibly glycated low density lipoprotein cholest...

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ea0063p973 | Diabetes, Obesity and Metabolism 3 | ECE2019

Effects of diabetes mellitus on female sexual function

Gaju Yvette Moigny , Lmidmani Fatima , El Fatimi Abdellatif

Objective: The purpose of the present investigation was to evaluate sexual function among diabetic womenMethods: In this study, diabetic women with stable partner were requested to fill out the Brief Index of Sexual Functioning for Women(BISF-W) and a general demographic questionnaire containing personal and partner data.Results: A total of 60 women with mean 42.8±10.4 years were surveyed. The prevalence of sexual dysfunction ...

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ea0063p974 | Diabetes, Obesity and Metabolism 3 | ECE2019

Canagliflozin: Ankle-Brachial index (ABPI) and risk of amputations

Laguna Ma del Carmen Serrano , Ponce Maria Hayon , Utrero Sara Leon , Perez Luisa Sebastian , Torres Enrique Redondo , Charneco Miguel Quesada , Vela Elena Torres

Objectives: Assess the canagliflozin effect on the ABPI in patients without previous treatment with iSGLT-2 as a possible etiology of tissue hypoperfusion and a risk factor for amputations.Material and methods: Prospective observational study where we analyzed patients diagnosed of type 2 diabetes mellitus (DM2) with poor metabolic control and without prior treatment with iSGLT-2, which is initiated treatment with canagliflozin. Clinical, biochemical par...

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ea0063p975 | Diabetes, Obesity and Metabolism 3 | ECE2019

Impact of diabetes on professional activity

Mizouri Ramla , Rezgani Imen , Sebai Imen , Boukhayatia Fatma , Zahra Hajer , Khiari Marwa , Hatira Yosra , Temessek Aroua , Ben Mami Faika

Introduction: Diabetes is a chronic metabolic disease that can have a significant impact on fitness for work. The aim of our study was to study the impact of diabetes on work activity in diabetics.Methods: It was a descriptive and analytical study. It was conducted in 200 diabetic patients at the National Institute of Nutrition in Tunis. Patients received a clinical examination and standard biological assessment.Results: We include...

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ea0063p976 | Diabetes, Obesity and Metabolism 3 | ECE2019

Clinical characteristics of human POMC, PCSK1, and LEPR deficiencies

Argente Jesus , Rosenberg Allison , Rodeberg Deirdre , Stumpf Jeffrey , Baver Scott , Segal Scott

Background: Rare genetic disorders of obesity result from an impaired central melanocortin pathway, comprised of multiple genes, including POMC, PCSK1, and LEPR. Because of their rarity and the difficulty in identifying individuals with pathogenic mutations in these genes, a complete understanding of these disorders remains unclear. We reviewed previous case reports of individuals with POMC, PCSK1, or LEPR deficiencies to understand their cl...

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ea0063p977 | Diabetes, Obesity and Metabolism 3 | ECE2019

Association between physical inactivity and socioeconomic factors and lifestyle among Tunisian adolescents

Fredj Sihem Ben , Ghammem Rim , Maatoug Jihen , Zammit Nawel , Hasni Yosra , Chelly Souhir , Ghali Hela , Amor Bilel Ben , Ghannem Hassen

Background: Physical activity is associated with several health benefits, including lower obesity and diabetes risk. Many different factors influenced physical activity patterns of adolescents in a complex interactive way. The aim of this study was to assess association between physical inactivity and socioeconomic factors and lifestyle among Tunisian adolescents.Methods: A cross-sectional study was carried out in Sousse, Tunisia during the school year 2...

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ea0063p978 | Diabetes, Obesity and Metabolism 3 | ECE2019

Doctor, is it cancer? A rock-hard breast lump in an anxious type 1 diabetic male-to-female transgender patient

Gonzalez-Diaz Paula , Kuzior Agnieszka , Fernandez-Trujillo-Comenge Paula Maria , Rivadeneira Manuel Esteban Nivelo , Acosta-Calero Carmen , Santana-Suarez Ana Delia , Martin-Perez Marta , Martinez-Martin Francisco Javier

Introduction/Aim: Transgender people often worry about side effects of their hormonal therapy, including breast cancer, which is an exceedingly rare occurrence. Hereby we present the case of a patient with an uncommon metadiabetic complication that can be easily confused with breast cancer, with the aim of raising awareness on this condition.Material and Methods: Review of the Clinical Record of the patient and of the relevant literature.<p class="ab...

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ea0063p979 | Diabetes, Obesity and Metabolism 3 | ECE2019

Hypoglycemia: a major problem in diabetics

Mizouri Ramla , Rezgani Imen , Sebai Imen , Khiari Marwa , Boukhayatia Fatma , Hatira Yosra , Temessek Aroua , Mami Faika Ben

Introduction: Hypoglycaemia is the most serious side effect inherent in the search for good glycemic control in diabetic patients, which can be fatal and often cause significant physical and psychosocial morbidity.Aim: The aim of our study was to estimate the frequency of hypoglycaemia and to determine the factors associated with their occurrence.Methods: This was a retrospective descriptive study. The study is conducted in 200 dia...

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ea0063p980 | Diabetes, Obesity and Metabolism 3 | ECE2019

The influence of the prediabetes phenotype on the efficacy of lifestyle interventions to improve glycemia, insulin resistance and postprandial hyperinsulinaemia

Asimi Zelija Velija , Dzuvo Almira Hadzovic , Al-Tawil Djinan

Three phenotypes of prediabetes are known: impaired fasting glucose (IFG), Impaired glucose tolerance (IGT), and combined IFG/IGT. IFG is associated with impaired early phase and normal second-phase of insulin secretion. IGT is associated with both impaired early and late phase of insulin secretion. Numerous studies have demonstrated efficacy of lifestyle intervention in improving 2-hr oral glucose tolerance and fasting plasma glucose (FPG) in individuals with prediabetes, whi...

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ea0063p981 | Diabetes, Obesity and Metabolism 3 | ECE2019

Effectiveness and tolerance of liraglutide and bupropión/naltrexone: clinical experience

Cardenas-Salas Jersy Jair , Luca Bogdana Luiza , Aliaga-Verdugo Alberto , Montoya-Alvarez Teresa , Gutierrez-Medina Sonsoles , Sierra-Poyatos Roberto , Sanz-Pastor Maria Alba Galdon , Martinez Clotilde Vazquez

Introduction: Different pharmacological therapies for obesity have become available in the last years. It is important to know their effectiveness in real-world practice and their acceptance among patients.Objectives: To analyze the anthropometric changes, daily dosis, side effects and treatment withdrawal in patients treated with Liraglutide or Naltrexone/Bupropion in clinical practice.Material and methods: Retrospective descripti...

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ea0063p982 | Diabetes, Obesity and Metabolism 3 | ECE2019

The incidence of pancreatic cancer in diabetic patients

Puca Entela , Bitri Sonla , Dyrmishi Blertina , Lumi Ema , Puca Edmond

Introduction: Diabetes mellitus has been claimed to be a risk factor for pancreatic cancer. CA 19-9 is known as a tumor marker for pancreatic cancer upper gastrointestinal tract, ovarian hepatocellular, and colorectal cancers, as well as in inflammatory conditions of the hepatobiliary system, biliary obstruction and in thyroid diseases.Aim of the study: To evaluate the level of Ca19-9 in diabetic patients and the incidence of pancreatic cancer.<p cla...

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ea0063p983 | Diabetes, Obesity and Metabolism 3 | ECE2019

GLP-1 Agonist as an effective add-on basal-bolus therapy in type 2 diabetic patients

Maric Andreja , Jambrovic Martina , Tkalec Ivana , Toplek Goran , Kiric Maja Mikolaj

Introduction: Despite basal-bolus regime many type 2 diabetic patients do not achieve good glycemic control. Obesity and a large number of insulin units per day, even in combination with metformin and/or SGLT-2 inhibitors, are challenge in treatment of those patients.Aim: To assess changes of glycemia, body weight and daily dose of insulin in a group of type 2 diabetic patients treated with basal-bolus scheme (with/without peroral agents), starting with ...

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ea0063p984 | Diabetes, Obesity and Metabolism 3 | ECE2019

The relation between HbA1c, glucose management indicator and average glucose parameters

Hansen Klavs Wurgler

Conflicting results of estimated average glucose (eAG) calculated from HbA1c and average glucose values (AG) derived from continuous glucose monitoring (CGM) are a very frequent source of confusion and frustrations in the dialogue with patients. Recently the term glucose management indicator (GMI) has been coined to describe HbA1c estimated from AG. The aim of this presentation is to elucidate the relation between calculated and estimated HbA1c and average glucose values on th...

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ea0063p985 | Diabetes, Obesity and Metabolism 3 | ECE2019

An overview of urinary tract infection in diabetic patients

Puca Entela , Bitri Sonila , Puca Edmond

Diabetic patients have higher risk of urinary tract infection (UTI). Increasing of infections in patients with diabetes mellitus is conditioned by an immunosuppressive condition resulting from immune damage.Objective: To give some dates about urinary infection in patients with diabetes mellitus, that are presented for consultation at the service of Endocrinology in the American Hospital, Tirana, AlbaniaMaterial: This study was cond...

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ea0063p986 | Diabetes, Obesity and Metabolism 3 | ECE2019

Weight loss in PCOS - benefits of Metformin and Liraglutide - a single institution experience

Griffin Ciara , McGowan Elaine , Griffin Margaret

Obesity commonly occurs in PCOS and contributes to increased metabolic risk and low self esteem. Advice on weight loss underpins all management strategies in the obese lady with PCOS but weight loss can remain elusive despite best efforts. We wished to determine how diet advice alone compared to metformin and/or liraglutide in our patients.Methods: We conducted an observational retrospective anonymized review of patients attending an endocrinology clinic...

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ea0063p987 | Diabetes, Obesity and Metabolism 3 | ECE2019

Epidemiological, clinical and biochemical characteristics of metabolic syndrome in adults living in South of Tunisia

Chabchoub Ghazi , Gargouri Imene , Kacem Faten Hadj , Charfi Nadia , Mnif Mouna , Keskes Leila , Abid Mohamed

The metabolic syndrome (MetS) is a constellation of physiological and biochemical abnormalities characterized by obesity, hyperglycaemia, elevated triglycerides and decreases in high density lipoprotein cholesterol (HDL-C), and hypertension. The MetS promotes atherosclerosis, and increases the risk of developing diabetes and cardiovascular disease (CVD), as well as rates of mortality. Thus, it has become one of the major public health challenges worldwide. In Tunisia, few stud...

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ea0063p988 | Diabetes, Obesity and Metabolism 3 | ECE2019

Effect of high protein diet over caloric expenditure and thermogenesis in individuals with obesity

Lopez Itzel , Figueroa Nicte , Perez Elva , Ibarra Lorena , Martinez Claudia , Malacara Juan

Introduction: The caloric expenditure and thermogenesis are very important aspects in the obesity problem, mostly underestimated. The Protein Leverage Hypothesis (PLH) promotes the effect of satiety, delaying the hunger sensation; thus entails the regulation of caloric intake and body weight, as well as, the modification of thermogenic activity and energy expenditure. However, the effect of high protein diet over the physiological components of energy expenditure h...

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ea0063p989 | Diabetes, Obesity and Metabolism 3 | ECE2019

Metformin and Vitamin B12 deficiency: evaluation of vitamin B12, homocysteine and methylmalonic acid levels in type 2 diabetics

Inacio Isabel , Azevedo Teresa , Alves Marcia , Dantas Rosa , Balsa Ana Margarida , Ferreira Sara , Rosinha Patricia , Gomes Fernanda , Fonseca Catarina , Garret Ana , Jesus Andreia , Guimaraes Joana

Introduction: The American Diabetes Association guideline states that the long-term use of metformin may be associated with biochemical vitamin B12 (B12) deficiency and periodic measurement should be considered, although isolated serum B12 measurement has low sensitivity and specificity. Homocysteine (Hcy) and methylmalonic acid (MMA) are more sensitive biomarkers, the latter being more specific.Objectives: To estimate B12 deficiency in type 2 diabetics ...

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ea0063p990 | Diabetes, Obesity and Metabolism 3 | ECE2019

What is the factor that most influences perinatal outcomes in pregnant women with Gestational Diabetes Mellitus: Country of origin or previous Gestational Diabetes?

Ferrinho Catia , Matos Ana Catarina , Cordeiro Maria Carlos , Bastos Filipa , Ferreira Rute , Duarte Joao Sequeira , Oliveira Manuela , Portugal Jorge

Introduction: Gestational Diabetes Mellitus (GDM) is one of the pregnancy diseases with the highest rate of complications, influenced by several factors. Its prevalence has increased, with a prevalence of 7.2% in Portugal.Objective: Characterize pregnant women with GDM and evaluate the perinatal outcomes according to the country of origin and previous GDM.Material and methods: Cross-sectional and retrospective study. We collected c...

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ea0063p991 | Diabetes, Obesity and Metabolism 3 | ECE2019

Neuroimaging in the diagnosis of neuroplasticity in patients with diabetes mellitus

Matveeva Mariia , Zhukova Natalie , Tolmachov Ivan , Ermak Elena , Babenko Sergey

The goal was to study neuroplasticity in patients with diabetes mellitus using neuroimaging techniques. We examined 80 patients with diabetes mellitus type 1 and 2. All were conducted general clinical examination, neuropsychological testing - MoCa test, test 12 words. All patients underwent continuous glycemic monitoring and HbA1c assessment. An MRI study was also performed on Siemens 1.5 T, the protocol included a standard examination of the brain, a proton spectroscopy, and ...

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ea0063p992 | Diabetes, Obesity and Metabolism 3 | ECE2019

IN-FOCUS France: an epidemiological survey on severe hypertriglyceridaemiae assessing the comparative burden of illness of familial chylomicronaemia syndrome (FCS) and multifactorial chylomicronaemia syndrome (MCS)

Moulin Philippe , Bouquillon Benoit , Valero Rene , Krempf Michel , Rigalleau Vincent , Ziegler Olivier , Verges Bruno , Lecerf Jean-Michel , Verdier Edouard , Charriere Sybil , Bruckert Eric

Background: Familial chylomicronaemia syndrome (FCS) is a rare, inherited disorder characterised by impaired clearance of triglyceride (TG)-rich lipoproteins from plasma, leading to severe hypertriglyceridaemia (HTG), which have major effects on both physical and mental health, and a markedly increased risk of acute pancreatitis. A large overlap in the phenotype between FCS and multifactorial chylomicronaemia syndrome (MCS) contributes to the inconsistency in how patients are ...

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ea0063p993 | Diabetes, Obesity and Metabolism 3 | ECE2019

Abstract Unavailable....

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21st European Congress of Endocrinology

BiosciAbstracts