Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 63 | ECE2019 | Next issue

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

Card image cap
18-21 May 2019, Lyon, France

Poster Presentations

Adrenal and Neuroendocrine Tumours 3

ea0063p812 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Robotic-assisted interaortocaval dissection of an extra-adrenal paraganglioma in supine position via a trans-peritoneal approach

Quackels Thierry , Albisinni Simone , Lucidi Valerio , Dessars Barbara , Driessens Natacha

Introduction: Pheochromocytoma and paraganglioma (PPGLs) are rare neuroendocrine tumors. Some of them are catecholamine-secreting tumors responsible for hypertension or adrenergic symptoms. Among 10% are malignant with a higher rate of malignancy in the inherited syndromes. Management of patients with hereditary pheochromocytoma and PPGLs is well defined and standard treatment is surgical resection.Case report: We report the case of a 53-year-old man who...

ea0063p813 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Pituitary metastasis of Neuroendocrine Carcinoma – a rare case report

Castro Raquel , Macedo Daniel , Coiteiro Domingos , Vilela Pedro , Mafra Manuela , Pinto Cristina , Loewenthal Cristina , Nave Monica , Rosario Francisco

The authors report the clinical case of a 59-year old female who had vague complaints of impaired vision, fatigue and diffuse pain for more than a year before medical evaluation at our hospital. At the ophthalmology appointment, bitemporal hemianopsia was evident. Brain MRI was the diagnostic test of choice and revealed a mass involving de sellar and suprassellar space, causing compression of the optic chiasm, as well as osteolytic lesions in cranial vault. The patient was the...

ea0063p814 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Abnormal serotonin regulatory loop in adrenals of patients with Cushing’s syndrome and 21-hydroxylase deficiency

Le Mestre Julie , Duparc Celine , Reznik Yves , Bonnet-Serrano Fideline , Touraine Philippe , Chabre Olivier , Young Jacques , Sibony Mathilde , Gobet Francoise , Raverot Gerald , Bertherat Jerome , Louiset Estelle , Lefebvre Herve

In the human adrenal gland, serotonin (5-HT), released by subcapsular mast cells stimulates corticosteroid secretion through activation of type 4 serotonin receptors (5-HT4R) positively coupled to cAMP/proteine kinase A (PKA) signaling pathway and calcium influx. The 5-HT4R is principally expressed in zona glomerulosa cells explaining why 5-HT strongly stimulates aldosterone production but only exerts a modest stimulatory action on cortisol. Interestingly, in primary pigmented...

ea0063p815 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Insulinoma: Diagnosis and surgical management retrospective analysis of 9 cases

Elleuch Mouna , Boujelben Khouloud , Kacem Faten Hadj , Ben Salah Dhouha , El arbi Kaouthar , Charfi Nadia , Rekik Nabila , Mnif Mouna , Abid Mohamed

Introduction: Inslinomas are the most common cause of hypoglycemia resulting from endogenous hyperinsulinism. Although rare, they have the potential to produce metabolic derangements, necessitating early diagnosis. The aim of our study was to determine the clinical manifestations, diagnostic methods, treatments used and results of patients with insulinoma.Patients and methods: It’s a retrospective study including 9 patients with insulinoma, diagnose...

ea0063p816 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

A case of pheochromocytoma diagnosed with maternal lung edema and fetal mortality

Bayraktaroglu Taner , Ugur Emre Ali , Akdemir Adile Yesim , Erdemir Rabiye Uslu

Aim: Pregnancy and pheochromocytoma are an important clinical picture in which the mother and fetus are under threat. Herein, we present a case diagnosed with pheochromocytoma in the follow-up of fetal mortality and maternal pulmonary edema after emergency postnatal caesarean section.Case Report: Our case was a 32-year-old female, fetal distress was determined after hypertension and maternal hypoxemia in 26 weeks of gestation and emergency caesarean sect...

ea0063p817 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

A case of bilateral pheochromocytoma presenting with peritoneal metastasis after 12 years of primary diagnosis

Cankurtaran Yılmaz , Oruk Guzide Gonca , Cağlar Sevinc , Karslı Tuğce Yuksel , Pamuk Barış Onder , Gur Ozgur , Akkalp Aslı Kahraman

Introduction: Ten per cent of pheochromocytomas are malignant. Malign pheochromocytoma could cause metastasis, relapse and local invasion. The most common sites of metastasis for pheochromocytoma or extra-adrenal paraganglioma are lymph nodes, bones, lungs, and liver. Here, we present a case who had pheochromocytoma relapse and unusual peritoneal metastasis after 12 years of left adrenalectomy.Case presentation: A 38 year-old woman, who had left adrenale...

ea0063p818 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Adrenal oncocytic pheochromocytoma with probable malignant potential: a case report

Driouich Yasmine , Kyabaambu Ben , Aziz Siham El , Chadli Asma

Introduction: Adrenal tumors present with clinical features and signs unique to their specific hormonal hypersecretion. Among adrenal tumors, oncocytic pheochromocytomas are exceedingly rare tumours. We report an unusual clinical presentation of an adrenal cortical tumor with histologic features of an oncocytic pheochromocytoma.Case Report: We present a case of a 64-year-old man with moderate hypertension, type 2 diabetes and an incidental adrenal mass o...

ea0063p819 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

A novel pathogenic mutation in neurofibromatosis type 1

Fischler Rebecca , Vandernoot Isabelle , Brouckere Veronique de , Lucidi Valerio , Corvilain Bernard , Driessens Natacha

Introduction: Neurofibromatosis type 1 (NF1) is one of the most frequent genetic dominant syndrom in men with a prevalence of 1 in 2600 to 3000 individuals worldwide. NIH NF1 diagnostic criteria are driven by the most frequent manifestations of the disease (‘café au lait’ macules (CAL), neurofibromas, freckling, optic glioma, Lisch nodules and bone lesions). There are many clinical manifestations of NF1 (neurological, cardiovascular, gastrointestinal, endocrine ...

ea0063p820 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Clinical, hormonal and histopathological evaluation of adrenal incidentalomas: About 45 cases

Driouich Yasmine , Aziz Siham El , Chadli Asma

Introduction: Given their prevalence of up to 5% of the general population, A discovery of an asymptomatic adrenal mass (incidentaloma) during the investigation of an unrelated condition is relatively common. The issue of crucial importance is the histopathological differentiation between benign lesions and malignant tumours of the adrenal gland.Objective: To evaluate the secretory or non-secretory profile and the benign and malignant nature of incidenta...

ea0063p821 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

The malignant potential of oncocytic adrenal tumours should not be underestimated

Fontaine Benedicte , Flaus-Furmaniuk Anna , Jelloul Emna , Mosbach Helena , Maione Luigi , Chanson Philippe , Debussche Xavier

Background: Oncocytic neoplasms are rare adrenal tumours usually considered as benign and non-functional. Conversely, in recent large nationwide study from COMETE network over 50% of the oncocytic adrenocortical tumours were diagnosed as carcinoma according to Lin Weiss-Bisceglia-score. However, until now only 11 cases of metastatic oncocytoma were reported in English literature.Case report: A 54-year-old man with history of abdominal pain and weight los...

ea0063p822 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Melasma as a sign of Addison’s disease: case report

Maghfour Soukaina , Abed Yosra Hasni El , Gammoudi Rima , Boussofara Lobna , Kahla Marwen Ben , Aouinallah Amina , Mokni Sana , Ghariani Najet , Belajouza Colandane , Denguezli Mohamed

Introduction: Addison’s disease was first described in 1855 by Thomas Addison as a result of adrenal insufficiency. It is most common in females aged 30–50 years. Symptoms are often non specific.Weakness and weight loss are universal features of Addison’s disease. It can present to a dermatologist in different ways. We present a case of a young female who reported to dermatology outdoor with a typical melasma-like eruption over her face.Ca...

ea0063p823 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Pheochromocytoma affecting Pregnancy: still searching the needle in the haystack?

Langton Katharina , Constantinescu Georgiana , Richter Susan , Gieldon Laura , Lenders Jacques , Eisenhofer Graeme

Introduction: Pheochromocytoma associated with pregnancy carries a great risk for adverse fetal and maternal outcome, especially when the diagnosis is missed. Symptoms can present in a wide variety regarding intensity and duration, making it difficult for the treating midwife or obstetrician to draw correct conclusions.Clinical Case: We present a case of a 29 years old patient whose third pregnancy was complicated by short, but frequent and intense spell...

ea0063p824 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Laparoscopic adrenalectomy for adrenocortical carcinoma is not inferior to open adrenalectomy

Kraljevic Ivana , Knezevic Nikola , Kakarigi Luka , Kastelan Marko , Dusek Tina , Solak Mirsala , Polovina Tanja Skoric , Balasko Annemarie , Alduk Ana-Marija , Zidanic Martina , Kastelan Darko

Background: Laparoscopic adrenalectomy (LA) is the standard treatment for benign adrenal tumours but its role in the surgical management of adrenocortical carcinoma (ACC) is controversial. Therefore, the aim of this study was to compare long-term outcome between open adrenalectomy (OA) and LA in the treatment of primary ACC.Methods: This retrospective cohort study included patients with ACC ENSAT stage I-III referred to the Croatian referral centre for a...

ea0063p825 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Prevalence of adrenal glands lesions and correlation with radiological findings

Azorin Maria Isabel Tercero , Lopez Angela Fernandez , Jimenez Santiago Atienzar , Juan Maria Del Rosario Pastor

Objectives: To evaluate the prevalence in our work center of pathology of adrenal glands and to assess the efficacy of the radiology imaging in the detection of especific features and to exclude malignancy lessions.Material and Methods: We included patients who presented some adrenal lesion with histological study after surgerie between January 2010 and December 2015 in the hospitals of Albacete, Almansa and Villarrobledo. We use the Pathological Anatomy...

ea0063p826 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

The French COMETE-Cancer network for adrenal cancer: 10 years of activity as part of a national plan for clinical care of rare cancers

Libe Rossella , Tabarin Antoine , Chabre Olivier , Laboureau Sandrine , Goichot Bernard , Vezzosi Delphine , Lefebvre Herve , Verges Bruno , Niccoli Patricia , Vanthyghem Marie-Christine , Baudin Eric , Bertherat Jerome

Introduction: The French National Institute of Cancer (INCa) launched supported by the Ministry of Health in 2008 a program for the recognition of national networks for the management of rare cancers. Among the 23 selected networks COMETE-Cancer was recognized by INCa in 2009 for Adrenocortical carcinoma (ACC) and malignant pheochromocytoma/paraganglioma (MPP). At that time 60–120 new ACC/year and 30 new MPP/year were expected at the national level....

ea0063p827 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Congenital adrenal hyperplasia: clinical and hormonal presentation about a Tunisian serie

Hajji Ekram , Hasni Yosra , Othmen Wafa Ben , Abdelkarim Asma Ben , Kacem Maha , Chaieb Molka , Maaroufi Amel , Ach Koussay

Introduction: Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders that result from the deficiency of one of several enzymes involved in the steroidogenic pathway for cortisol biosynthesis. The most common cause of CAH, accounting for 90% of cases, is 21-hydroxylase deficiency. The symptoms of disease very depending on the nature and severity of the enzyme deficiency as well as the sex of the individual. Non-classical CAH is generally late onset. Ho...

ea0063p828 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Nonfunctioning adrenal incidentaloma associated with diabetes: about 40 cases

Driouich Yasmine , El Aziz Siham , Chadli Asma

Introduction: Adrenal incidentalomas are frequent, their prevalence reaches 5% of the general population, incidental diagnosis from an imaging examination motivated by an extra-adrenal sign is common. Diabetes may be present in patients with adrenal incidentaloma, it is often diabetes secondary to secretion of cathecholamines, mineralocorticoids and cortisol.Objective: To evaluate the clinical-biological profile of adrenal incidentalomas, as well as thei...

ea0063p829 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Multiple endocrine neoplasia type 2 family case in Belarussian population

Danilova Larisa , Grigorovitch Artur , Lushchyk Maxim

Multiple endocrine neoplasia type 2 (MEN2) is a rare hereditary autosomal dominant syndrome, caused by activating germline mutations in the RET proto-oncogene. Medullary thyroid carcinoma (MTC) remains the most common and aggressive manifestation of MEN2. The family case of MEN 2 syndrome in Belarussian population is analyzed. During the analysis of the records of clinical case of patient’s death in the reginal hospital because of thrombosis of mesenteric vessels and acut...

ea0063p830 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

An uncommon case of a large adrenal cyst

Sakali Anastasia-Konstantina , Thoda Pinelopi , Pappa Dimitra , Georgiou Eleni , Gountios Ioannis , Bargiota Alexandra

Introduction: Adrenal cystic lesions are rare. Differential diagnoses include pseudocysts, echinococcal cysts, hemangiomas, cystic pheochromocytomas, adrenal hematomas and lymphangiomas. We present here a rare case of an adrenal lymphangioma.Case report: A 35-year old man was referred to our department for investigation of a right adrenal cystic mass, incidentally found during an abdominal ultrasound. The patient was completely asymptomatic and had a med...

ea0063p831 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Catecholamine-secreting tumor and pancreatic tumor fibrosis – a coincidence?

Pascu Raluca Cristina , Popa Miruna Maria , Sirbu Anca Elena , Fica Simona

Introduction: Cells of the neuroendocrine system are spread throughout the body, and they can give rise to various neuroendocrine tumors with unpredictable evolution. It has been observed that they are often associated with the development of fibrosis, both local and distant.Case presentation: We present the case of an 81 year-old, normal-weight woman, who firstly presented in our clinic in 2014 for multinodular goiter (normal calcitonin). Fine needle as...

ea0063p832 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Addison disease in a patient with familial mediterranean fever

Ince Nurcan , Ceylan Ahmet , Erden Abdulsamet , Ersoy Reyhan , Cakir Bekir

Introduction: Familial Mediterranean Fever (FMF) is an autosomal recessive hereditary disease characterized by fever and inflammation of serous membranes. The most important complication of FMF is amyloidosis which has significant role in the prognosis. It is unclear how endocrine system hormones are affected in FMF. We present adrenal insufficiency in a an FMF patient without amyloidosis.Case: A 39 years old male patient who had been diagnosed with FMF ...

ea0063p833 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

The role of somatostatin analogs in the control of carcinoid syndrome: systematic review and meta-analysis

Alexandraki Krystallenia , Angelousi Anna , Chatzellis Eleftherios , Chrisoulidou Alexandra , Kalogeris Nikolaos , Kanakis Georgios , Savvidis Christos , Vassiliadi Dimitra , Toulis Konstantinos , Tsagarakis Stylianos , Kaltsas Gregory

Introduction: Somatostatin analogues (SSAs) are the mainstay of treatment for carcinoid syndrome (CS)-related symptoms. Controversy still exists regarding the extent of the efficacy of this intervention. The purpose of the systematic review and meta-analysis was to evaluate the percentage of patients achieving partial (PR) or complete response (CR) with the use of SSAs (lanreotide, octreotide, pasireotide) in patients with CS. Due to lack of uniformity and established criteria...

ea0063p834 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Familial multiple endocrine neoplasia type 1 revealed by a maxillary swelling

Salah Dhouha Ben , Gargouri Imen , Mnif Fatma , Elleuch Mouna , Charfi Nadia , Mnif Mouna , Rekik Nabila , Abid Mohamed

Introduction: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal dominant disorder caused by mutations in the MEN1 tumor suppressor gene and is characterized clinically by tumors in two or more endocrine glands, such as the pituitary gland, parathyroid glands or pancreatic islets. We describe an atypical presentation of familial hyperparathyroidism evoking the diagnosis of MEN1 in the first place.Observations: We report a three-member family....

ea0063p835 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Bilateral adrenal masses in Addison’s disease: primary tumors or tuberculosis?

Protop Mădălina , Alexandra Ambărus Popovici Ioana , Bianca Ioan , Alina Chelaru , Andreea Rosu , Georgiana Neagu , Cătălina Bilha Stefana , Laura Feraru , Cristina Preda , Letitia Leustean

Introduction: Addison’s disease is a rare disorder, described mainly in isolated cases. The two most common cause of primary adrenal insufficiency are autoimmune adrenalitis and adrenal tuberculosis, which is still the primary cause of primary adrenal insufficiency (PAI) in developing countries. Adrenal tuberculosis is difficult to diagnose, the classic presentation with non specific symptoms delay the diagnosis. In some cases, the background of tuberculosis and hyperpigm...

ea0063p836 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

A germline ARMC5 mutation in a patient with adrenal adenoma and multiple colonic polyps: a case report

Sparavalo Rada , Borozan Sanja

Background: Functional studies demonstrate that Armadillo repeat-containing 5 (ARMC5) gene, controls apoptosis and steroid synthesis. A germline mutations in ARMC5 are recently been associated with Cushing syndrome and possibly can be responsible for a broader tumor predisposition.Case presentation: A 51-year-old woman presented with intermittent rectal bleeding. A colonoscopy revealed multiple colonic polyps, histopathological analysis showed tubular ad...

ea0063p837 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Metastatic adrenal cortical carcinoma presenting with cervical mass and subclinical Cushing: a case report

Cankurtaran Yılmaz , Oruk Guzide Gonca , Karslı Tuğce Yuksel , Kocaayan Hasan , Pamuk Barış Onder

Introduction: Adrenocortical carcinoma (ACC) is a rare tumor with an aggressive prognosis of 1–2 people per million per year. They are functional tumors which mostly occur with virilization and/or Cushing syndrome. Metastatic ACC has a dismal prognosis and the most common sites of metastases are the lung, liver, lymph nodes and bones. Herein, we present metastatic ACC patient without Cushing clinic at the time of diagnosis.Case presentation: A 48-ye...

ea0063p838 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

(131) I-MIBG therapy in metastatic paraganglioma and phaeochromocytoma: a 4-year single centre experience

Mazo Estefania Santos , Lanchas Isabel , Begona Miguel , Barrio Javier Pi , Crespo Guillermo , Moreira Manuela , Garcia-Hierro Victor , Manuel Javier Sanchez

Retrospective study of patients with metastatic/progressive pheochromocytoma (PCC) and paraganglioma (PGL) treated with (131) I MIBG in our hospital during 2015–2018 period.Methods: There are no established criteria for establishing PCC/PGL as malignant apart from de presence of metastases at diagnosis. Radionuclide therapy (131) I-metaiodobenzylguanidine (MIBG) is frequently used in this patients when surgery is not possible. Indication of MIBG tre...

ea0063p839 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

When MAX runs in the family

Duarte Diana Borges , Pereira Catarina A , Palma Isabel , Carvalho Rui , Cardoso Helena

Introduction: Recent advance of genetic testing has contributed to the diagnosis of hereditary pheochromocytoma and paraganglioma (PPGL). Germline mutations in MYC associated factor X(MAX) are responsible for 1.1% of these PPGL; the median age at onset is 33 years and no reliable penetrance estimation is available for MAX-carriers. The authors present the case of a synchronous bilateral pheochromocytoma that prompted the discovery of a proband of MAX mutation and three other r...

ea0063p840 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Adrenal incidentalomas – from diagnosis to follow-up

Cunha Clara , Capitao Ricardo , Bello Carlos Tavares , Santos Francisco Sousa , Roque Catarina , Saraiva Catarina , Duarte Joao Sequeira , Oliveira Manuela

Introduction: Adrenal incidentalomas (AIs) are defined as adrenal masses measuring 10 mm or more in diameter, incidentally discovered on imaging exams performed for a non-adrenal disorder. The aim of this study is to provide a clinical and imagiological characterization of patients diagnosed with AIs followed in our institution.Methods: We conducted an observational and retrospective study that included patients with AIs evaluated at our institution betw...

ea0063p841 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Malignant paraganglioma of the urinary bladder-diagnosis and management – a case report

Gilis-Januszewska Aleksandra , Rzepka Ewelina , Paczkowska Katarzyna , Bryk Agata , Walczyk Joanna , Morawiec-Sławek Karolina , Pantofliński Jacek , Sowa-Staszczak Anna , Opalińska Marta , Pach Dorota , Hubalewska-Dydejczyk Alicja

Introduction: Paragangliomas (PGL) are rare tumours of neuroendocrine origin. Those localized in urinary bladder account for 10% of all PGL. They arises from chromaffin tissue of the sympathetic nervous system that is embedded in the muscle layer of the bladder wall. Approximately 10% of urinary bladder paragangliomas are malignant.Case presentation: A 76-year-old female presented with a history of haematuria, hypertension, headaches and excessive sweati...

ea0063p842 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Hypothalamic-pituitary-adrenal axis dysfunction in drug-naive schizophrenic patients

Naifar Manel , Maalej Manel , Ellouze Ahmed Slim , Guidara Wassim , Jmal Khalil , Maalej Mohamed , Charfi Nada , Hajkacem Faten , Abid Mohamed , Thabet Jihen Ben , Ayadi Fatma

Introduction: Hypothalamic-pituitary-adrenal axis dysfunction (HPA) has been reported in patients with schizophrenia and bipolar disorders but findings are inconsistent and few studies have conducted direct comparaisons of HPA biomarkers in drug native patients. We aimed to assess serum and salivary cortisol in the morning in drug-naive schizophrenic patients compared to controls.Methods: This was a cross-sectional case-control study conducted between Ju...

ea0063p843 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Efficacy of somatostatin analogues in managing hypercalcaemia due to PTHrP in a well differentiated metastatic pancreatic neuroendocrine tumour and discussion of modern treatment options: A clinical case

Uchambally Manjima , Munir Alia , Wadsley Jonathan , Lorenz Eleanor

Pancreatic neuroendocrine tumours are rare with an incidence of 5 per million. Of these tumours, 75% maybe hormonally functioning. They carry a better prognosis than adenocarcinoma of the pancreas. Parathyroid Hormone related peptide hypersecretion in PNETs is uncommon and is solely associated with metastatic PNETs. 31 cases are reported of PTH-rPoma in the literature. Here we describe a novel case presenting with cough. A previously well 56-year-old female presented to the ac...

ea0063p844 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Association of neurofibromatosis type 1 and neuroendocrine tumor

Kacem Faten Hadj , Zargni Asma , Mnif Fatma , Rekik Fatma , Elleuch Mouna , Salah Dhouha Ben , Charfi Nedia , Mnif Mouna , Rekik Nabila , Abid Mohamed

Introduction: Pheochromocytoma occurs in 0.1–5.7% of patients with Neurofibromatosis type 1(NF1). We report two cases of adrenal pheochromocytoma in patients with NF1.Observation: A 46 year-old male was admitted to our department for further examinations of an adrenal mass. The CT-scan showed two well-defined right adrenal masses measuring each 128×87×86 mm and 60×52×37 mm with central necrosis and calcifications in the biggest o...

ea0063p845 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Iatrogenic Cushing syndrome due to use of intranasal betamethasone – two case reports

Popa Miruna Maria , Pascu Raluca Cristina , Poterasu Mihaela , Sirbu Anca Elena , Fica Simona

Background: Iatrogeny is the most common cause of Cushing syndrome (CS), with most reported cases due to prolonged use of oral, parenteral or, rarely, topical corticosteroid preparations. Few cases of CS (and consecutive adrenal insufficiency (AI)) due to intranasal corticoids have been reported and the vast majority were documented in pediatric patients.Case reports: We present two cases of iatrogenic CS due to chronic intranasal administration of over-...

ea0063p846 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Adrenal lipoma: about two cases

Aouinati Yousra , Atraki Sara , El Aziz Siham , Mjaber Amal , Chadli Asmaa

Introduction: Adrenal myelolipoma is a rare, benign, non-secreting tumor, often found incidentally or in the context of abdominal pain. We report the cases of two patients with adrenal myelolipoma hospitalized at the endocrinology department of diabetology and metabolic diseases of Ibn Rochd University Hospital in Casablanca.Case 1: This is a 30-year-old patient, hospitalized for adrenal mass, revealed by right lower back pain, radiating to the right hyp...

ea0063p847 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

A Adrenocortical carcinoma (ACC) presenting with episodes of intermittent hypertension: Sarcomatoid type adrenocortical carcinoma

Gulec Yazır Merve , Cankurtaran Yılmaz , Gonca Oruk Guzide , Onder Pamuk Barış , Arıkan Etit Demet

Introduction: Adrenocorticalcarcinoma (ACC) is a rare malignancy with an aggressive prognosis, an incidance of 1–2 cases/million/year. It is the cause of 0.2% of all cancer deaths. It is seen in the 4th and 5th decades in adults and mostly unilateral and sporadic. Herein, we present a case of sarcomatoid type ACC which is symptomatic with mass compression and hypertansive attacks.Case presentation: A-52-year-old male was referred to our endocrinolog...

ea0063p848 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Synchronous tumours: Neuroendocrine Tumours and Breast cancer

Mnif Fatma , El Arbi Kawthar , Hadj Kacem Faten , Zargni Asma , Elleuch Mouna , Ben Salah Douha , Charfi Nedia , Mnif Mouna , Rekik Nabila , Abid Mohamed

Introduction:: The association of breast cancer and neuroendocrine tumours, in particular pheochromocytoma, is rarely described in the literature. We report a case in a particular context.Observation: This is a 53-year-old patient treated with 6 courses of chemotherapy for T2N3cM0 infiltrating breast carcinoma. She was admitted to our endocrinology department for exploration of a left adrenal incidentaloma, objectified in the extension assessment, measur...

ea0063p849 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Cervical paraganglioma: about one case

Aouianti Yousra , El Aziz Siham , Mjaber Amal , Chadli Asmaa

Introduction: Paragangliomas are rare neuroendocrine tumors usually Benign, developed at the expense of sympathetic ganglia, and whose treatment is essentially surgical. We report the case of a patient presenting a cervical paraganglioma hospitalized to the endocrinology department of diabetology and metabolic diseases of Ibn Rochd University Hospital in Casablanca.Observation: A 57 years old women, not known hypertensive, presenting a mandibular mass ev...

ea0063p850 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Measurement of androstenedione levels in adrenal veins for calculation of the selectivity index in adrenal venous sampling

Miren Azcutia Ane , Angelica Herraiz Lorea , Gonzalez Natalia , Jurado Purificacion , Abad Maria , Cuesta Martin , Mendez Jose , Calle Alfonso , Jose Torrejon Maria , Runkle Isabelle

Introduction: Primary hyperaldosteronism (PH) is characterized by autonomous adrenal aldosterone (A) hypersecretion. Unilateral adrenalectomy is the treatment of choice, when adrenal vein sampling (AVS) indicates lateralization of A secretion. To assure that each adrenal vein (AV) has been correctly sampled, cortisol levels in each adrenal vein must be higher than in the inferior vena cava. The adrenal gland cortisol/vena cava cortisol ratio is referred to as the selectivity i...

ea0063p851 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

True silent pheochromocytoma: description of a rare entity

Adamidou Fotini , Komzia Paraskevi , Mpatsi Ourania , Georgiou Thomas , Kita Marina

Introduction: With the advent of modern imaging, up to 30% of adrenal pheochromocytomas are discovered incidentally in asymptomatic patients. Smaller tumors may be ‘pre-biochemical’ in their secretory capacity, but truly nonfunctioning tumors over 3 cm are exceedingly rare. We describe a case of a clinically and biochemically silent pheochromocytoma.Case report: A 65-year-old woman was found to have a left adrenal incidentaloma on an abdominal ...

ea0063p852 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Multiple paragangliomas (PGs) of head and neck and middle mediastinum: report of an apparently sporadic case

Maria Baranga Iuliana , Vladan Andreea , Vasilescu Alexandru , Serban Marinela , Stoleru Liviu , Radian Serban , Poiana Catalina

Introduction: PGs are rare neuroendocrine tumours (NETs), slowly growing, derived from the neural crest cells of the autonomous nervous system. Presenting symptoms are related to catecholamine hypersecretion or to mass effect. The optimal approach is dictated by size, symptoms and anatomical relationship of tumours with neurovascular structures.Aim: To describe a patient with bilateral carotid body and mediastinal carotid body PGs....

ea0063p853 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Your young patient has severe, resistant hypertension? Do not treat her without a workup!

Esteban Nivelo-Rivadeneira Manuel , Kuzior Agnieska , Maria Fernandez-Trujillo-Comenge Paula , Delia Santana-Suarez Ana , Acosta-Calero Carmen , Perdomo-Herrera Esperanza , Lucia Tocino-Hernandez Alba , Javier Martinez-Martin Francisco

Introduction/Aim: Secondary hypertension is often undiagnosed or misdiagnosed as essential in young people. We hereby present a challenging case, in order to raise awareness about this problem.Material and methods: Review of the patient’s clinical record and of the relevant literature.Results: A previously healthy 22 year old woman complained of frequent non-pulsatile holocraneal headaches for 6 months; they were attributed to...

ea0063p854 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Uncontrolledhighblood pressure in pregnancy: the pheochromocytoma is not to be ignored

Meryam Elbahi , Sana Rafi , Ghizlane Elmghari , Nawal Elansari

Introduction: The discovery of a pheochromocytoma during pregnancy is very rare. The diagnostic and therapeutic approach determines the maternal and fetal prognosis. We present the case of a pheochromocytoma discovered during a pregnancy of 16 weeks of amenorrhea.Case report: Mrs. A.H 29 years old, primigravida, presented at 6 weeks of amenorrhea with hypertension, she was treated by alpha methyl dopa 500mg and nicardipne 20 mg; at 16 weeks she was hospi...

ea0063p855 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Adrenal surgical series - radiologic-pathological correlation

Carvalho Ferreira Paulo , Castelo Diogo , Mota Filipe , Sanches Agostinho , Portugal Pedro

Introduction: Adrenal surgical series are scarce in the literature. We aim to present a single institution consecutive case series and to establish a radiologic-pathological correlation.Material and methods: A retrospective, observational and descriptive study was conducted by searching the Pathology database for surgically removed adrenal lesions. Cases were matched with the Imagiology database. Ultrasound, CT and MRI images were then reviewed by the sa...

ea0063p856 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Von hippel-lindau disease associated with bilateral pheochromocytoma and cerebellous hemangioblastoma

Sekkat Kenza , El Aziz Siham , Chadli Asma

Introduction: Von Hippel-Lindau disease (VHL) is a hereditary condition that predisposes to the development of benign and malignant tumors due to mutations in the VHL gene. Several clinical manifestations can be observed including the development of hemangioblastomas of the central nervous system and the retina, renal or pancreatic cysts or cancers, or more rarely pheochromocytomas. These affect 10 to 25% of patients, are frequently bilateral and often reveal the disease.<...

ea0063p857 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Bilateral primary adrenal lymphoma

Kebapci Medine Nur , Dağdemir Arzu , Akalın Aysen , Kebapci Mahmut , Canaz Funda

Introduction: Adrenal gland involvement can be seen in about 25% of lymphomas. However, primary adrenal lymphomas (PAL) are rare. The most common is diffuse large B-cell lymphoma (DLBCL). It is seen usually after the age of 60 years as bilateral, large masses.Case report: A 64-year-old woman with a complaint of abdominal pain was referred to our clinic after bilateral surrenal masses were detected upon abdominal ultrasonography (USG) and computed tomogra...

ea0063p858 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Prevalence of autonomous cortisol secretion as defined in ESE guidelines in a Swedish cohort of patients diagnosed with adrenal incidentaloma: A prospective study in regional Sweden

Sahlander Fredrik , Bensing Sophie , Falhammar Henrik

Background: Resource-saving and medically safe investigations of adrenal incidentaloma (AI) is one of the challenges in modern endocrinology. The absolutely majority of AIs are benign and hormonally inactive. Mild hypercortisolemia is the most common finding in hormonally active AI and is often referred to as subclinical Cushing syndrome (SCS). SCS is associated with increased risk of type 2 diabetes, poorly regulated hypertension, osteoporosis and cardiovascular disease. Ther...

ea0063p859 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Phaeochromocytoma in pregnancy

Araujo Alexandra , Silvestre Catarina , Marcalo Jose , Gomes Ana Raquel , Carvalho Raquel

Phaeochromocytoma in pregnancy is an extremely rare condition. Early recognition can largely decrease maternal and fetal mortality rates. As symptoms of phaeochromocytoma are similar to those of other more common causes of hypertension during pregnancy, timely diagnosis is a challenge. There is no consensus in literature about the specific treatment nor about the optimal delivery timing or route. Case of a 32 years old woman with a single pregnancy of 30 weeks and 3 days admit...

ea0063p860 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Clinical presentation and management of primary aldosteronism in late childhood and adolescence: Experience in an outpatient hypertension clinic

Gonzalez-Diaz Paula , Fernandez-Trujillo-Comenge Paula Maria , Kuzior Agnieszka , Nivelo-Rivadeneira Manuel Esteban , Acosta-Calero Carmen , Santana-Suarez Ana Delia , Martin-Perez Marta , Martinez-Martin Francisco Javier

Aim: Description of a series of children and adolescents with Primary Aldosteronism (PA) diagnosed and treated in our Outpatient Hypertension Clinic from 1994 to 2018.Methods: Review of the clinical records and of the relevant literature. Values are given as mean +s.d.Results: 16 of a total of 49 patients younger than 20 years of age referred to our Hypertension Clinic from 1994 to 2018 were diagnosed of PA (33%), while 27 (55%) we...

ea0063p861 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Neuroendocrine neoplasms: experiences of a single tertiary referral endocrine centre in Hungary

Tőke Judit , Pocsai Karoly , Major Judit , Kollar Reka , Szatmari Reka , Stark Julia , Molnar Agnes , Szucs Nikolette , Reismann Peter , Nagy Geza , Pusztai Peter , Sarman Beatrix , Lohinszky Julia , Uhlyarik Andrea , Borka Katalin , Sapi Zoltan , Huszty Gergely , Varga Zsolt , Dabasi Gabriella , Igaz Peter , Toth Miklos

Introduction: Clinicopathological characterisation ofneuroendocrine neoplasms could provide improved prognostic information even at the time of the diagnosis.Objectives: The aim of this study was to characterise the clinicopathological features of a large cohort of patients with neuroendocrine neoplasms (NENs).Patients and methods: The study included 210 patients (95 men and 115 women) with histologically confirmed and verified neu...

ea0063p862 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Asymptomatic pheochromocytomas-an unelucidated physiopathology pattern

Burciulescu Sofia Maria Lider , Gheorghiu Monica Livia , Dumitrascu Anda , Hortopan Dan , Schipor Sorina , Badiu Corin

Introduction: Pheochromocytomas (PHEOs) are tumors arising from medulla chromaffin cells. Their diagnosis is challenging due to a large clinical spectrum – from classical crisis to completely asymptomatic. Approximately 5.0–6.5% of adrenal incidentalomas are pheochromocytomas, and 8% of pheochromocytomas are completely asymptomatic, usually in a familial form.Aim: To compare biochemical and imagistic features of symptomatic/asymptomatic PHEOs.<...

ea0063p863 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

A rare case of primary hyperaldosteronism associated with chronic kidney disease-difficulties in diagnosis and treatment

Leuştean Letiţia , Bălineanu Ginuţa Marcela , Rimbu Cosmina , Hrişcă Anamaria , Luminiţa Voroneanu Elena , Ungureanu Maria-Christina

Introduction: Primary aldosteronism (PA) accounts for 20% of patients with resistant hypertension and is one of its leading causes. Options of treatment include adrenalectomy and mineralocorticoid receptor antagonists (MRAs). Latest studies suggest that both may paradoxically lead to a decline in estimated glomerular filtration rate (eGFR), explained by the masked glomerular hyperfiltration associated to PA before treatment.Case report: A 56 years old ma...

ea0063p864 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

X-linked adrenoleukodystrophy phenotype evolution - is family history important?

Matos Tania , Jorge Zulmira , Costa Cristiana , do Vale Sonia

X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder of peroxisomal metabolism, characterized by deficient beta-oxidation of saturated very long chain fatty acids (VLCFA). The accumulation of VLCFAs is associated with demyelination of the nervous system, and impairment of steroid hormone synthesis in the adrenal cortex and the testis. The range of phenotypic expression is wide and dynamic. The three presentations most commonly seen are the childhood cerebral forms, a...

ea0063p865 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Iatrogenic secondary adrenal insuficiency due to ritonavir therapyand inhaled budesonide

Maldonado David Males , Gonzalez Alba Martin , Librizzi Maria Soledad , Mattei Isabella , Gutierrez Maria Calatayud

Introduction: The widespread use of highly-active antiretroviral therapy (HAART) has drastically improved the life expectancy of patients with human immunodeficiency virus (HIV) infection. However, many of these drugs show multiple interactions with other treatments; protease inhibitors (PI) are especially troublesome as they interact with the hepatic cytochrome P450. There have been previous reports of both Cushing’s syndrome and adrenal insufficiency in patients treated...

ea0063p866 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Primary adrenal lymphoma: a rare cause of adrenal insufficiency

Maciel Joana , Simoes Helder

Background: Primary adrenal Non Hodgkin Lymphoma (NHL) accounts for less than 1% of all NHL cases. Among them, Diffuse Large B Cell Lymphomas (DLBCL) are the most commonly identified. Seventy percent of cases are bilateral and adrenal insufficiency usually occurs. Here we describe a case of a DLBCL with bilateral adrenal involvement and adrenal insufficiency.Clinical case: A 68 years male with a personal history of malaria, asthma, hypertension and chole...

ea0063p867 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Associated factors with blood pressure outcome in 75 patients after adrenalectomy for primary hyperaldosteronism

Delattre-Willerval Sophie

Context: Surgery performed in primary hyperaldosteronism (PAH) can achieve biological healing in almost all cases, but blood pressure healing is only obtained in 20 to 55% of cases. The aim of our study is to identify the anthropometric, biological and pathological factors that would be statistically associated with blood pressure outcome in patients after unilateral adrenalectomy for primary aldosteronism between 1996 and 2016.Method: This is a monocent...

ea0063p868 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Uncontrolledhighblood pressure in pregnancy: the pheochromocytoma is not to be ignored

Meryam Elbahi , Sana Rafi , Ghizlane Elmghari , Nawal Elansari

Introduction: The discovery of a pheochromocytoma during pregnancy is very rare. The diagnostic and therapeutic approach determines the maternal and fetal prognosis. We present the case of a pheochromocytoma discovered during a pregnancy of 16 weeks of amenorrhea.Case report: Mrs. A.H 29 years old, primigravida, presented at 6 weeks of amenorrhea with hypertension, she was treated by alpha methyl dopa 500mg and nicardipne 20mg; at 16 weeks she was hospit...

ea0063p869 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

An unusual case of classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency diagnosed in the adulthood

Gonzalez Cristina Lorenzo , Arranz Maria Teresa Herrera , Marquez Maria Pilar Olvera , Huerta Yolanda Zambrano , Fernandez Javier Garcia , Mesa Elena Marquez , Abizanda Jose Enrique Palacio

Introduction: Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (classic 21-OHD CAH) is the most common form of congenital adrenal hyperplasia, characterized by simple virilizing or salt wasting forms. The saline loss picture develops after birth and it can evolve in a short time to a severe picture of hypotonic dehydration and hypovolemic shock with lethal consequences if not diagnosed and treated. Herein we present an unusual case of classic 21-OHD CAH ...

ea0063p870 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Successful percutaneous radiofrequency ablation of a secreting juxtaglomerular cell tumour

Barraud Sara , Merzeau Nicolas , Diallo Alpha , Job Louis , Delemer Brigitte

Introduction: Juxtaglomerular cell tumour (JCT) or Reninoma, is a rare cause of curable secondary hypertension, usually presented as a small renal tumour and treated by tumorectomy or partial nephrectomy (PN). Minimally invasive treatment such as percutaneous radiofrequency ablation (PRFA) has gained popularity over the last decade to treat small tumors. We report the case of a woman with secondary hypertension due to JCT, successfully treated with PRFA....

ea0063p871 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

A misleading presentation of auto-immune diabetes associated with somatostatinoma: a case report

Galvez Thierry , Gilly Olivier , Cour Bernadette Ginert , Verbeke Elodie , Prudhomme Michel , Guedj Anne-Marie

Somatostatinomas are rare neuroendocrine tumors diagnosed at a rather young age (mean age at diagnosis from 40 to 60 years). Non-auto-immune diabetes may associate with somatostatinoma as a result of abnormal somatostatin secretion, which inhibits insulin release. Steatorrhea and cholelithiasis are two other classical symptoms of these tumors. Here we report a case of somatostatinoma discovered while exploring a recently diagnosed diabetes, whose clinical and biological featur...

ea0063p872 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Adrenocortical cancer: our experience in a tertiary center of endocrinology

Lazar Elena , Caragheorgheopol Andra , Tomulescu Victor , Badiu Corin

Adrenocortical cancer is a rare, aggressive disease, requiring a fast and multidisciplinary approach. The genetics is heterogeneous so is also the clinical course. In the last 10 years, we have diagnosed and treated a number of 20 cases, aged at diagnosis between (34–74 years) (mean 55.9±12.87), followed up between (2–77 months) (mean 25.75±23.58). The maximal diameter of the tumor was (5.5–25) (mean 10.95±5.43). The secretion profile was Cushing ...

ea0063p873 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Immunohistochemical expression of ephrines A2 and A4 receptors in neuroendocrine neoplasms: preliminary results

Alexandraki Krystallenia , Antonopoulou Ioanna , Karaflou Maria , Christakou Charikleia , Mavroeidi Vasiliki , Karapanagioti Aggeliki , Lekkakou Maria , Anagnostou Elli , Tsoli Marina , Angelousi Anna , Delladetsima Ioanna Kassiani , Felekouras Evangelos , Sotiropoulos Georgios , Kaltsas Gregory , Theocharis Stamatios

Introduction: Ephrin receptors (EPHs) have a role in tumor growth, invasion, angiogenesis and metastasis of several neoplasms. Aim of the study was to investigate the expression and possible clinical significance of EPH-A4 and EPH-A2 protein expression in the pathophysiology of neuroendocrine neoplasms (NENs).Methods: EPH-A4 and -A2 protein expression was assessed by immunohistochemical analysis along with Ki-67 proliferation index (%) on 28 paraffin emb...

ea0063p874 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Molecular diagnosis of multiple endocrine neoplasia type 1 (MEN 1): a single-center experience

Gonzales Maria Santamaria , Toro Jose Jorge Ortez , Fernandez Elena Llorente , Miranda Carlos Miguel Peteiro

Background: Multiple endocrine neoplasia type 1 (MEN1) (OMIM 131100) is an autosomal dominant disorder associated with a high risk of developing parathyroid hyperplasia (90%), digestive neuroendocrine tumors (30–70%) and pituitary adenomas (30-40%). Prevalence of MEN1 is 2-10/100.000, there are no differences between men and women and usually, it is diagnosed before 40 years old. It is related to different mutations of the MEN1 tumour-suppressor gene (OMIM: 613733) which ...

ea0063p875 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Clinical spectrum of MEN1: what about other non-endocrine neoplasias?

Marques Bernardo , Martins Raquel G , Elvas Ana Rita , Couto Joana , Santos Jacinta , Martins Teresa , Rodrigues Fernando

Introduction: Multiple endocrine neoplasia type 1 syndrome (MEN1) is a hereditary autosomal dominant disorder caused by germline mutations in the MEN1 tumour-suppressor gene and is typically characterized by parathyroid adenomas, duodenopancreatic neuroendocrine tumors (NETs) and pituitary adenomas. Breast cancer has recently been identified as manifestation of MEN1 and female patients have early onset elevated breast cancer risk.Case report: Female pati...

ea0063p876 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

An interesting case of a familial insulinoma

McCarthy Aisling , Newman Christine , O'Keeffe Derek , O'Shea Paula , Bell Marcia

A 42 year old lady presented to the Endocrinology clinic with a longstanding history of exertional dizziness, increasing in frequency over the preceding two months. She reported marginal symptomatic improvement with the introduction of frequent carbohydrate rich meals. She was asymptomatic in the post-prandial period. She had no associated nausea, confusion, palpitations, diaphoresis, collapse or weight gain. She was on medication (SSRI) for anxiety. Her father and paternal gr...

ea0063p877 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Accuracy of adrenal imaging studies in predicting histological tumor dimension following adrenalectomy

Alexandraki Krystallenia , Aggeli Chrysanthi , Antonopoulou Ioanna , Parianos Christos , Ntokos George , Pateas Konstantinos , Kaltsas Gregory , Zografos Georgios

Introduction: Although computed tomography (CT) is the best mean to identify adrenal neoplasms there is still controversy of the concordance of the estimated radiological and histological size of the lesion. Since the size of adrenal tumours is a major criterion for surgical excision, we investigated whether recent and more sophisticated imaging techniques, can more accurately predict tumor’s size.Methods: We have retrospectively analyzed a series o...

ea0063p878 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Metabolic profile of non-functional adrenal adenomas

Batman Adnan , Yener Ozturk Feyza , Masum Canat Muhammed , Erol Rumeysa Selvinaz , Sen Esra Cil , Yıldız Duygu , Altuntas Yuksel

Aim: Metabolic syndrome rates have been studied especially in adrenal gland secreting cortisol and studies on nonfunctional adenomas are limited. In this study, we investigated metabolic parameters and metabolic syndrome frequency in non-functional adrenal adenomas (NFA).Materials and methods: In our study, 55 patients (15 men (27.3%), 40 women (72.7%) who were diagnosed incidentally, unilateral or bilateral localized, hormone-inactive, and with adenoma-...

ea0063p879 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

The role of selected adipokines as predictors of excessive secretion of cortisol in patients with incidental adrenal tumors

Reślińska Katarzyna , Kuligowska-Prusińska Magdalena , Junik Roman

The diagnosis of subclinical hypercortisolemia in patients with incidental adrenal tumors remains a challenge, as there are no unambiguous criteria for diagnosis. The discovery of a substance whose secretion increases under the influence of cortisol would make it easier to make therapeutic decisions. Hypercortisolism causes a change in the distribution of adipose tissue, so it can be assumed that it also affects secretion of proteins secreted by adipocytes (adipokines). The ai...

ea0063p880 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Cardiovascular and metabolic risk factors in children and adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Paredes Silvia , Alves Marta , Carvalho Fabia , Gomes Maria Miguel , Martins Sofia , Marques Olinda , Antunes Ana

Background: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is associated with an increased cardiometabolic risk in adult life. Nevertheless, data regarding pediatric age is scarce. We aimed to evaluate cardiometabolic risk factors in patients with CAH due to 21-hydroxylase deficiency in pediatric age.Methods: We reviewed the clinical records of patients with CAH evaluated in a Pediatric Endocrinology Unit in a central hospital. Pat...

ea0063p881 | Adrenal and Neuroendocrine Tumours 3 | ECE2019

Epidemiology and evolution data on gastroenteropancretic and pulmonary neuroendocrine tumors

Olariu Cristina , Mirela Gherghe , Badiu Corin

Neuroendocrine tumors (NETs) includes a broad family of tumors, the most frequent ones are in the gastrointestinal tract, lung, thymus, and pancreas. Gas-trointestinal and Pulmonary NETs may present with symptoms attributable to hormonal hypersecretion, which include intermit-tent flushing and diarrhea, or symptoms related to Cushing Syndrome. The variability of clinical manifestation may lead to late referral or misdiagnosis. In this retrospective study we analyzed 27 patient...