Endocrine Abstracts

Endocrine disrupting chemicals (EDCs) harm human health both as single molecules and as mixtures. Most research on EDCs is done on individual chemicals whereas we are exposed to mixtures of numerous and possibly interacting molecules. This discrepancy presents a dilemma for risk assessment and legislation. Thyroid hormones are essential for normal brain development where they influence, through specific embryonic and post-natal periods all the steps of brain development. In ad...

Type 2 diabetes (T2D), results from a deficiency in insulin action on peripheral tissues together with a lack of compensatory insulin production and release by pancreatic beta cells. The etiology of T2D involves both, genetic predisposition and environmental factors. Bisphenol-A (BPA) is a widespread endocrine disrupting chemical that modify pancreatic beta cell function and induce insulin resistance in rodents after treatment during different timing of exposure, including pre...

Obesity is commonly ascribed to an imbalance between caloric intake and energy expenditure, but a growing body of evidence underscores the contributions of other factors in the obesity epidemic. We found that exposure of F0 animals to TBT throughout pregnancy and lactation predisposed male F4 descendants of TBT-treated animals to obesity when challenged with a higher fat diet. The TBT group showed impaired ability to mobilize fat during fasting and elevated serum leptin levels...