Endocrine Abstracts

Background: The epidemic of obesity, together with its associated health burden, continues to spread globally. It is estimated that approximately 2.1 billion adults worldwide are now classified as overweight or obese. Thus, there is an urgent need to develop more effective strategies for preventing and managing obesity. Most population strategies to reduce the rising prevalence of non-communicable diseases (NCDs) have used a ‘one size fits all’ public health recommen...

Food restriction and weight-management strategies have been at the forefront of most efficient strategies to prevent and reduce the risk of type 2 diabetes and cardiovascular disease (CVD). However, when people find themselves in an increasingly obesogenic environment it becomes challenging to achieve and maintain successful behavioral changes. Fasting protocols such as intermittent energy restriction (IER) and time-restricted feeding (TRF), or restricting food consumption to ...

The PREDIMED trial showed that long-term adherence to an ad libitum Mediterranean diet (MeDiet) supplemented with extra-virgin olive oil (EVOO) or mixed nuts reduced incident cardiovascular disease (CVD) in older subjects at high risk. No clinical trials have been conducted to demonstrate whether weight loss sustained over time with an energy-restricted healthy diet plus increased physical activity (PA) reduces CVD risk. We designed the PREDIMED-PLUS study, a 6-year, multicent...