Endocrine Abstracts

Microbiota plays a major role in health and disease in humans. Sex hormones influence the diversity and composition of the gut microbiota. Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age (6–20%). PCOS is characterized by the association of androgen excess with oligomenorrhea, anovulatory infertility, and increased metabolic risk factors. The study of the interaction between gut microbiota and sex hormones in PCOS coul...

Insulin resistance and androgen excess, alongside anovulatory infertility, are the cardinal clinical and biochemical features of polycystic ovary syndrome (PCOS). Circulating androgen burden and metabolic dysfunction in PCOS are closely correlated, but an independent contribution of androgens perseto metabolic and other complications of PCOS remains poorly characterised. My work focuses on delineating the distinct impact of androgens on metabolic function, with a part...

Background: Cardiometabolic polycystic ovary syndrome (PCOS) phenotype is predominantly characterized by obesity. It is clearly associated with impaired metabolic and reproductive health, whereas implications on cardiac health are mostly limited with the exploration of cardiovascular risk factors without actual cardiovascular endpoints. There is a relative lack of systematic prospective studies investigating long-term effects of different treatment options that include phenoty...