Endocrine Abstracts

Thyroid autoimmunity (TAI) is the most frequent autoimmune disorder in women of childbearing age and increases the risk of thyroid dysfunction. TAI has been shown to be more common in women seeking counselling for infertility. The underlying causal mechanism that may account for any possible detrimental effect of TAI on fertility aspects remains hypothetical. In general, increased levels of anti-thyroid peroxidase abs (TPO-abs) have been defined as the most sensitive marker of...

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In humans, brain developmental processes start already around week 5 of gestation and continue throughout pregnancy and postnatal life. The migration, differentiation, proliferation, and myelination of neurons are thyroid hormone dependent processes, as shown in animal studies. The fetal thyroid gland is not functionally mature before week 18–20 of gestation. During this period the fetus acquires thyroid hormone for the most part via placental transfer from the mother. Th...