Endocrine Abstracts

Objective: Diagnosis of primary hyperaldosteron in patients with malignant arterial hypertension.

Materials and methods: The study included 125 patients with hypertension (68 men, 57 women, ages 16–74). All patients underwent biochemical hormonal analyzes of blood and ECG, MSCT. All patients tested ARS, out of 125 in 18 patients with ARS> 30. Patients with primary hyper aldosteronism 18 of them women 7, men 11, patients age 34±8.8 years, hypertension for 3.9 years (1–23), SBP-189.5±22.3 mm.rt.st. DBP-118.5±19.1 mm.rt.st, in all these patients, ARS averaged 74.6 (31.16–330.6), from the biochemical indicators of blood potassium 3.75±0.33, creatine blood-92.8±10.3 (mmol/l). In our sample of patients with hypertension, the prevalence of PGA was found to be 14.4%. Of 18 patients, 60% were diagnosed with left ventricular hypertrophy on ECG and 5 patients with Q-T lengthening at leads V1 and V2. Also in 5 patients, the level of potassium concentration in the blood plasma was <3.6 mmol/l. Regression analysis showed a linear dependence of the increase in SBP from the level of aldosterone, so when the level of aldosterone in the blood increases by 10 pg/ml, SBP increases 2.37 mm Hg. Pearson’s correlation analysis revealed a strong statistical significance of SBP from aldosterone level: r=0.5211 (P<0.05).

Conclusion: 1. When determining potassium in the blood showed that of 18 patients in 5 with hypokalemia, hyperaldosteronism was detected, in 13 patients with normalization there was hyperaldosteronism. A reliable method of diagnosing PHA is the determination of APC.

2. Regression analysis showed a linear dependence of the increase in SBP from the level of aldosterone, so when the level of aldosterone in the blood increases by 10 pg/ml SBP, 2.37 mm Hg raises.