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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

ePoster Presentations

Adrenal and Neuroendocrine Tumours

ea0063ep1 | Adrenal and Neuroendocrine Tumours | ECE2019

Pheochromocytoma in the setting of a neurofibromatous type 1

Askaoui Sara , Lmghari Guizlane , El Ansari Nawal

Introduction: Neurofibromatosis type 1 (NF1) is the most common autosomal dominant disease. The endocrine manifestations of NF1 are represented by pubertal abnormalities and pheochromocytoma. We report a case.Observation: Mr. G.A, age 28, consulling for a grade 2 HTA evolving for 3 years. The anamnesis notes paroxysmal crises made of Ménard triad. The exam notes a correct blood pressure, 18 coffee latte tasks, lentiginous tasks. Two neurofibromas of...

ea0063ep2 | Adrenal and Neuroendocrine Tumours | ECE2019

Congenital adrenal hyperplasia (salt wasting form) with central precocious puberty: A combined therapeutic approach using a nighttime glucocorticoid dose, an aromatase inhibitor and a gonadotropin-releasing hormone analogue

Barbacariu Ioana-Cristina , Cristea Cristina , Dragoman Paula-Maria , Pavăl Cristina Victoria , Siriteanu Andreea-Mariana , Cretu Cristina , Preda Cristina

Congenital adrenal hyperplasia (CAH) describes a group of autosomal recessive disorders where the cortisol biosynthesis is impaired. There are two forms of CAH: the classic form, which includes the salt-wasting and the simple virilizing forms, and the nonclassic form. CAH due to 21-hydroxylase deficiency accounts for 95% of cases. Treatment of the classic form of CAH is targeted at replacing cortisol and aldosterone and effectively controlling excess androgen symptoms by using...

ea0063ep3 | Adrenal and Neuroendocrine Tumours | ECE2019

Depression and anxiety are positively correlated with higher concentrations of cortisol and blood pressure in hypertensive cardiovascular disease patients

Unab Shiza , Akram Maleeha , Tahir Fahim , Jahan Sarwat , Kazmi Ali Raza , Afshan Kiran , Naseem Afzaal Ahmed , Qayyum Mazhar , Rafi Muhammad , Rizvi Syed Shakeel Raza

Hypertension or high blood pressure (HBP) has been counted as the chief cause and most significant factor in the development of cardiovascular diseases (CVDs) worldwide. Stress has been defined as an inner process that happens when a person is faced with an ordinant dictation that is perceived to go beyond the resources available to efficaciously respond to it. Cortisol is a hormone released from the zona fasciculata of the adrenal cortex during the times of stress. This biolo...

ea0063ep4 | Adrenal and Neuroendocrine Tumours | ECE2019

Metrorrhagia as first manifestation of adrenocortical carcinoma – case report

Čikić Elzana , Pekić Sandra , Vujošević Snežana , Čikić Majda , Đešević Enra , Čikić Amil

Introduction: Adrenocortical carcinoma is a rare tumor with an incidence of 1 per million per year. It occurs in two age groups: in children under 5 years old and in adults from 4th to 6th decade of life. It is potentially curable at an early stage, unfortunatelly, about 70% of these tumors are detected late. Functional carcinomas are present with about 60% with endocrine syndrom: Cushing syndrome (30%); Virilization and premature puberty (22%); Feminization (10%); Primary hyp...

ea0063ep5 | Adrenal and Neuroendocrine Tumours | ECE2019

Low blood glucose, but why?

Oukit Loubna , Rafi Sana , El Mghari Ghizlane , El Ansari Nawal

Introduction: Hypoglycaemia in non diabetic patients is a decrease of blood glucose below a threshold of 0.5 g/l, corresponds to a pathological situation, with many etiologies and whose management constitutes a real challenge, both symptomatic and etiological. The purpose of this study is to highlight the profile of these hypoglycaemia and their management.Patients and method: We have collected cases of hypoglycaemia in non-diabetic subjects encountered ...

ea0063ep6 | Adrenal and Neuroendocrine Tumours | ECE2019

A case of Cushing syndrome due to primary bilateral macronodular adrenal hyperplasia caused by ARMC5 mutation and concomitant primary hyperparathyroidism

Mamedova Elizaveta , Vasilyev Evgeny , Petrov Vasily , Izmailova Natalya , Buryakina Svetlana , Rozhinskaya Liudmila , Tiulpakov Anatoly , Belaya Zhanna

Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of Cushing syndrome and in 25–55% of cases is caused by mutations in ARMC5 gene. A 37 y.o. female was referred to our center with a diagnosis of ACTH-independent Cushing syndrome. Laboratory testing confirmed endogenous hypercortisolism (urinary free cortisol 5063.5 nmol/24 h (60–413), midnight salivary cortisol 56.6 nmol/l (0.5–9.4), midnight serum cortisol 1427 nmol/l (46–...

ea0063ep7 | Adrenal and Neuroendocrine Tumours | ECE2019

Adrenal carcinoma presenting as suicidal depression

Petrescu Denisa , Georgescu Carmen Emanuela , Crisan Catalina , Silaghi Horatiu , Suciu-Petrescu Malina , Lungu Ionela , Silaghi Cristina Alina

Depression can be an early manifestation of Cushing Syndrome (CS) and found to correlate with the severity of the clinical presentation. Rates for major depression vary from 12% to 50–70%. A 37-year-old male was admitted for sad mood, affective lability, suicidal ideation without a plan and micromanian incurability ideation. The medical history of the patient revealed an old anterior-lateral myocardial infarction last year, with percutaneous coronary intervention on diago...

ea0063ep8 | Adrenal and Neuroendocrine Tumours | ECE2019

Characteristics of factors affecting the survival of patients with adrenal cortical carcinoma treated with mitotane

Stępiński Kamil , Jurecka-Lubieniecka Beata , Michalik Barbara , Kotecka-Blicharz Agnieszka , Gawlik Tomasz , Soczomski Przemysław , Jarzęb Barbara

Introduction: Adrenal cortical carcinoma (ACC) is a rare malignant neoplasm of epithelial origin, derived from the adrenal cortex, with a high tendency to local invasion and distant metastases.Aim: The aim was to assess the effect of serum mitotane concentration during mitotane therapy and identify prognostic factors on the survival of ACC patients.Material and methods: It was a multifactorial analysis of patients from a single end...

ea0063ep9 | Adrenal and Neuroendocrine Tumours | ECE2019

Singultus persistens as a presentation of addisonian crisis

Pandurevic Srdjan , Marina Ljiljana , Ivovic Miomira , Tancic-Gajic Milina , Arizanovic Zorana , Sojat Antoan Stefan , Kendereski Aleksandra , Vujovic Svetlana

Introduction: It is presumed that hiccups are a vestigial reflex in mammals. They are rather common in healthy subjects. Persistent hiccups (lasting >48 h) are a serious clinical sign, and documented in a number of debilitating conditions. According to the available literature persistent hiccups in Addisonian crisis have been previously documented in only two patients.Case report: In July 2018, a 39 year old man checked into the ER complaining of nau...

ea0063ep10 | Adrenal and Neuroendocrine Tumours | ECE2019

Acquired intermittent long QT syndrome might be challenging in substitution dosing in adult patient with Addison disease: case report after 3 years follow up

Tesic Dragan , Andric Dragica , Somer Dalibor , Mitrovic Milena

Introduction: Acquired modifible long QT syndrome (LQTS) might be caused by hypocortisolism but also drug-induced. Unique genetic association between them is the background of both. The aim of this case report is to present the patient with Addison disease and LQTS not responding on increased dosage of hydrocortison susbstitution therapy.Case report: We report a female patient, 65 years old (1950y.). At the age of 34y. (1984y.) Morbus Addisoni was diagno...

ea0063ep11 | Adrenal and Neuroendocrine Tumours | ECE2019

Adrenal hematoma: two cases report

Guiomar Joana Reis , Moreno Carolina , Paiva Isabel , Cardoso Luis Miguel , Saraiva Joana , Rodrigues Dircea , Cunha Nelson , Catarino Diana , Fadiga Lucia , Silva Diana Festas , Figueiredo Arnaldo , Martins Maria Joao , Bastos Margarida

Introduction: Adrenal hematomas are a relatively rare clinical condition and its prevalence has been reported to be about 1%. Although various causes have been proposed, the ethology and pathophysiology are still not fully understood, and the symptoms range is very variable, from asymptomatic situations to haemorrhagic shock. Imaging is a challenging method to establish the diagnosis of adrenal hematomas, and in most cases, it is only possible after surgery. Surgery is routine...

ea0063ep12 | Adrenal and Neuroendocrine Tumours | ECE2019

Lost to follow-up in classic congenital adrenal hyperplasia: a case report

da Costa Cristiana Gomes , Matos Tania , do Vale Sonia

Introduction: Classic congenital adrenal hyperplasias (CAH) are mostly diagnosed in the first months/years of life and require a lifetime follow-up.Case report: A 33-year-old Caucasian man was admitted twice in the previous year to the emergency department; the first episode due to an acute tonsillitis, the second episode due to a lower respiratory tract infection, both associated with hyponatremia (125 mmol/l). Common causes of hyponatremia were exclude...

ea0063ep13 | Adrenal and Neuroendocrine Tumours | ECE2019

Adrenocortical carcinoma - single center experience

Zwolak Agnieszka , Tywanek Ewa , Świrska Joanna , Dudzińska Marta , Matyjaszek-Matuszek Beata , Tarach Jerzy

Adrenocortical carcinoma is an aggressive tumor of endocrine system with an annual incidence of 1–2 cases per million. The most significant prognostic factors are tumor size, disease stage at the time of putting the diagnosis and treatment method. Advanced age of the patient, and hormonal activity of the cancer are also related to poor prognosis.Materials and methods: In our study we collected data of 12 patients who were treated in Endocrinology Cl...

ea0063ep14 | Adrenal and Neuroendocrine Tumours | ECE2019

The diagnosis of Cushing’s syndrome in pulmonary adenocarcinoma associated with an unilateral adrenal mass - case report

Paval Cristina Victoria , Cristea Cristina , Siriteanu Andreea-Mariana , Barbacariu Ioana-Cristina , Dragoman Paula Maria , Cretu Cristina , Preda Cristina

Cushing’s syndrome is a collection of signs and symptoms due to prolonged exposure to cortisol. It can be difficult to diagnose, particularly endogenous Cushing’s syndrome, because other conditions share the same signs and symptoms. Diagnosing Cushing’s syndrome can be a long and extensive process, it’s treatment may be also an important challenge. We present the case of a 49-year-old man, with a history of asthma and pulmonary cribriform adenocarcinoma (ra...

ea0063ep15 | Adrenal and Neuroendocrine Tumours | ECE2019

Progress in the treatment of unresectable metastatic ileum-cecal NET - Peptide receptor radionuclide therapy (PRRT)

Terhes Lia , Baciu Elena , Curt Ana , Sazan Raul , Wollenweber Tim , Brad Cristian , Georgescu Carmen , Ilie Ioana

Neuroendocrine tumors (NETs) represent the second most common malignancy of the small bowel (SB) and despite their indolent nature, NET liver metastasis (NETLMs) will develop in 50 to 60% of patients. Although there have been recent advances in the therapeutic armamentarium in patients with advanced NETs, surgical resection remains the only potentially curative intervention for patients with NETLMs. However, patients whose liver has been significantly invaded by the tumour (mo...

ea0063ep16 | Adrenal and Neuroendocrine Tumours | ECE2019

Multiple endocrine neoplasia typu 2B – case report

Svilias Ioannis , Gabalec Filip , Cap Jan

Introduction: Multiple endocrine neoplasia type 2 (MEN2) is an autosomal dominant disorder with an estimated prevalence of 1 per 30,000 in the general population. MEN2 is subclassified into two distinct syndromes: types 2A (MEN2A) and 2B (MEN2B). MEN2A and 2B are inherited in an autosomal dominant pattern with very high penetrance. In both syndromes, there is an occurrence of multicentric tumour formation in all organs where the RET proto-oncogene is expressed.<p ...

ea0063ep17 | Adrenal and Neuroendocrine Tumours | ECE2019

A rare case of ectopic ACTH syndrome due to recurrence of olfactory neuroblastoma

Abe Hironori , Suwanai Hirotsugu , Ishikawa Takuya , Yakou Fumiyoshi , Hara Natsuko , Hirai Hideaki , Nagao Toshitaka , Miwa Takashi , Odawara Masato

We hereby report a rare case of ectopic adrenocorticotropic hormone (ACTH) syndrome due to recurrence of olfactory neuroblastoma which has few published reports. The female patient had surgery of olfactory neuroblastoma at 31 years old without the symptom of Cushing’s syndrome. Hypercortisolemia during treatment for recurrence of olfactory neuroblastoma were observed at 40 years old. The clinical findings were as followed; full moon face, central obesity, buffalo hump, an...

ea0063ep18 | Adrenal and Neuroendocrine Tumours | ECE2019

Characteristics, management and outcome of patients with adrenocortical carcinoma in a tertiary hospital: a retrospective study

Papanastasiou Labrini , Choreftaki Theodosia , Zografos George , Kapsali Chara , Kalantzi Athanasia , Monastirioti Nikoleta , Gravvanis Christos , Glykofridi Spyridoula , Tyfoxilou Ernestini , Vlaxou Sofia , Charalampidou Liana , Voulgaris Nikos , Markou Athina , Giagourta Irini , Piaditis George , Kounadi Theodora

Adrenocortical carcinoma (ACC) is a rare, aggressive tumor with poor prognosis, affecting 0.5–2 cases/106population/year.Objective: To analyse retrospectively characteristics, management and outcome of ACC patients, followed in our center between 2010–2018.Material and methods: The medical records related to diagnosis, treatment and follow-up of nine patients of 59.2±13.8 years with histological diagnosis ...

ea0063ep19 | Adrenal and Neuroendocrine Tumours | ECE2019

ACTH-Producing neuroendocrine cancer of the thymus with pancreatic metastasis, presenting with flush

Chang Ling-Kai , Wu Jer-Wei , Hsu Chia-Lin , Lin Chia-Chi , Cheng Mei-Fang , Chen Rou-He , Wang Hsiu-Po , Shih Shyang-Rong

Context: ACTH-producing neuroendocrine cancer (NEC) of the thymus is rare. Lymph nodes and bone are most common metastatic sites. ACTH-secreting thymic NEC with pancreatic metastasis was only reported in one case. Most cases presented with florid Cushing syndrome (CS). Our case had thymic NEC with pancreatic metastasis, presenting with intermittent flush instead of typical CS. We demonstrate the comprehensive information of somatostatin receptors (SSTR), three different kinds ...

ea0063ep20 | Adrenal and Neuroendocrine Tumours | ECE2019

Adrenocortical carcinoma: epidemiological, clinical and paraclinical profile: about 4 cases

Mnif Fatma , Elleuch Mouna , Sahnoun Randa , Saafi Wiem , Mnif Mouna , Charfi Nedia , Rekik Nabila , Abud Mohamed

Introduction: The adrenocortical carcinoma (ACC) is a primary malignant tumor developed in depends of the adrenal cortex, defined by a Weiss score ≥3. Despite the therapeutic progress, its prognosis is still severe.Patients and methods: This retrospective descriptive study evaluated 4 patients with adrenal corticosteroid followed in the endocrinology department of Sfax - Tunisia between 2010 and 2018.Results: There were 3 wom...

ea0063ep21 | Adrenal and Neuroendocrine Tumours | ECE2019

Primary hyperaldosteron detecting among the patients with essential hypertension

Dalimova Guzal , Khalimova Zamira

Objective: Diagnosis of primary hyperaldosteron in patients with malignant arterial hypertension.Materials and methods: The study included 125 patients with hypertension (68 men, 57 women, ages 16–74). All patients underwent biochemical hormonal analyzes of blood and ECG, MSCT. All patients tested ARS, out of 125 in 18 patients with ARS> 30. Patients with primary hyper aldosteronism 18 of them women 7, men 11, patients age 34±8.8 years, hyp...

ea0063ep22 | Adrenal and Neuroendocrine Tumours | ECE2019

The rare outcome of pituitary adenoma treatment

Mikadze Ketevan , Bostoganashvili Nestan , Kvanchakhadze Rusudan

Abstract: A 41-year-old woman admitted Ginekological Clinic to surgical intervention due to ovarial enlargement. It was suspected diagnoses of Acromegalia according to the clinical manifestations: amenorrhea, headache, dizziness, enlarged phalangeal digits. nose. The patient underwent laboratory and instrumental investigations. MRI showed the pituitary adenoma (1.4×1.0×1.0 cm), GH, Prolactin and TSH were sharply increased, Ultrasound revealed remarkably enlarged ovar...

ea0063ep23 | Adrenal and Neuroendocrine Tumours | ECE2019

Case report: patient presenting with tumor on the left adrenal gland

Muminova Sitora , Sharafutdinova Shakhnoza , Muratov Davron

The aim: To study the peculiarities of the clinical manifestations of hypercortisolism in the case of a mass formation in the adrenal gland.Materials and methods: Children’s Endocrinology of the Republican Specialized Scientific and Practical Medical Center of Endocrinology was hospitalized a boy 5 years old with a diagnosis of extensive tumor of the left adrenal gland.Results: At the time of the examination, the patient compl...