ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 OC1.5 | DOI: 10.1530/endoabs.63.OC1.5

Renal function in 711 patients with hypoparathyroidism during more than 4 years of therapy

Heide Siggelkow1,2, Bettina Stamm3, Niklas Stamm4, Martina Blaschke4,5 & Martin Grußendorf6

1Clinic for Gastroenterology and Endocrinology, Goettingen, Germany; 2MVZ Endokrinologikum, Goettingen, Germany; 3Medicover Saarbrücken MVZ, Saarbrücken, Germany; 4Clinic of Gastroenterology and Endocrinology, Goettingen, Germany; 5MVZ Endokrinologikum, Goettingen, Germany; 6Halblech, Halblech, Germany.

Patients (pts) with hypoparathyroidism (HypoPT) are at risk to develop renal failure possibly caused by hypercalciuria and nephrocalcinosis. We retrospectively evaluated the data of 711 Patients with HypoPT in 3 endocrine centres in Germany.

Methods: Records of 711 pts with HypoPT were reviewed. Patients were predominantly female (n=592, male: n=119; age 50.9±14.1 years, range 12 – 99 years). The following parameters were documented during treatment and follow-up (MW 52±40.9 months, time range 2–334 months): medication, calcium in serum and urine, phosphate, calcium-phosphate-product (CPP), glomerular filtration rate (GFR) calculated by CKD-EPI formula.

Results: Of these 711 pts. 29 had idiopathic HypoPT, 10 HypoPT after parathyroidectomy, 669 after thyroid operation. At first visit 4.0% of pts <40 years, 11.1% in the age group 40–59, 28.4% in the age group 60–69, and 49.0% in pts >69 years had a GFR < 60 ml/min. At the last visit no worsening of renal function was observed (GFR < 60 ml/min in 5.9% <40 years, 9.8% in the age group 40–59, 17.1% in the age group 60–69, 36.0% >69 years). An elevated CPP > 55 mg2/dl2 was found in 25 pts (3.5%). In these pts the proportion of GFR < 60 ml/min was 33.5% compared to 21.1% of those with normal CPP. In comparison of the therapeutic strategies pts treated exclusively with dihydrotachysterol renal function was the lowest (n=46; mean GFR 70.2±26.2 ml/min). In pts treated with calcitriol and calcium (n=226) mean GFR was better than in all other treatment groups (84.9±20.9).

Conclusion: We saw no worsening of renal function in a large cohort of patients with HypoPT during 4 years of therapy. High CPP was associated with lower GFR. Different treatment strategies of HypoPT seem to affect kidney function.

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