ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P1080 | DOI: 10.1530/endoabs.63.P1080

Impairment of glucose tolerance in children and adolescentstreated for medulloblastoma

Strebkova Natalia1, Alexey Kalinin1, Olga Vasyukova1, Pavel Okorokov1, Maria Kareva1 & Olga Zheludkova2

1Endocrinology Research Centre, Moscow, Russian Federation; 2Russian Research Center of Rentgenradiology, Moscow, Russian Federation.

Children and adolescents treated for solid brain tumors with chemotherapy and craniospinal irradiation are at increased risk of metabolic changes development. Current follow-up guidelines for cancer survivors recommend to monitor fasting glucose and HbA1 levels for diabetes/impaired glucose tolerance screening in these patients. The aim of our study was to evaluate metabolic changes in children treated for medulloblastoma with oral glucose tolerance test (OGTT). We examined 63 patients (40 males/23 females). Patients had a median age (range) of 11.3 (5.5–17.9) years. They were treated for medulloblastoma when aged 6.8 (1.2–16.2) years. The outcome measures were: BMI SDS, fasting glucose, HbA1c, OGTT (0, 30, 60, 90 and 120 min). We identified 4 patients with impaired glucose tolerance (120-min glucose ≥ 7.8 mmol/l). All patients with impaired glucose tolerance had normal values of fasting glucose (4.3 ÷ 5.04 mmol/l) and HbA1c (4.8 ÷ 5.8%). All these patients had normal BMI SDS (0.06 ÷ −1.7).

Conclusion: Children and adolescents treated for solid brain tumors by chemotherapy and craniospinal irradiation should be screened for glucose tolerance impairment by OGTT regardless of fasting glucose, HbA1c and BMI SDS values.

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