Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 63 | ECE2019 | Next issue

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

Card image cap
18-21 May 2019, Lyon, France

Poster Presentations

Pituitary and Neuroendocrinology 3

ea0063p1046 | Pituitary and Neuroendocrinology 3 | ECE2019

Recovery of the hypothalamic-pituitary-adrenal and gonadal axes following trans-sphenoidal adenomectomy, a single centre experience

Pofi Riccardo , Gunatilake Sonali , Macgregor Victoria , Cudlip Simon , Joseph Robin , Lenzi Andrea , Tomlinson Jeremy W , Jafar-Mohammadi Bahram , Isidori Andrea M , Pal Aparna

Hypopituitarism is a potential complication of trans-sphenoidal adenomectomy (TSA). Prediction of pituitary function (PF) recovery would inform hormonal replacement strategies. However, the frequency of re-testing of PF is variable across centres. The aim of this study was to determine rates, time and predictors of 6-weeks (6 w) recovery of hypothalamo-pituitary adrenal (HPA) and gonadal function after TSA.Methods: We performed a single-centre, retrospec...

ea0063p1047 | Pituitary and Neuroendocrinology 3 | ECE2019

Cerebrovascular events, secondary intracranial tumors and other neoplasia following radiotherapy for non-acromegaly pituitary tumors and craniopharyngiomas

Trifanescu Raluca , Smarandoiu Alexandra , Pascu Polina , Dumitrascu Anda , Pascu Alina , Trifanescu Oana , Anghel Rodica , Poiana Catalina

Background: Radiotherapy is part of the complex treatment of pituitary tumors; it is an effective treatment for residual postoperative tumors or recurrent tumors, but cerebrovascular events and secondary intracranial tumors may occur during long term follow-up.Aim: To assess prevalence of cerebrovascular events, secondary intracranial tumors and other neoplasia in patients with non-acromegaly pituitary tumors and craniopharyngiomas submitted to radiother...

ea0063p1048 | Pituitary and Neuroendocrinology 3 | ECE2019

Effectiveness of hight doses of cabergoline suppressive therapy in patients with prolactinoma

Khyzhnyak Oksana , Mykytyuk Miroslava , Gogitidze Teona , Nikolaiev Roman , Barabash Nadya , Manska Katerina

Aim: The aim of the study was to investigate the clinical and hormonal effectiveness of different modes of suppressive cabergoline (CAB) therapy during 12 months in patients with prolactinoma.Subjects and methods: It was examined and underwent a 12 month course of treatment by selective dopamine agonist CAB in 61 patients with prolactinoma (PROL) (9 male/ 52 female) aged 16–66 years. There were 40 women with microPROL, 12 with macro&giant PROL; ...

ea0063p1049 | Pituitary and Neuroendocrinology 3 | ECE2019

Expression of programmed death ligand 1 (PD-L1) in human pituitary adenomas

Suteau Valentine , Collin Alexandre , Menei Philippe , Rodien Patrice , Rousselet Marie-Christine , Briet Claire

Introduction: Pituitary adenomas, second most common brain tumors, are mostly well controlled after surgery. However, some pituitary tumors present an aggressive evolution and are resistant to standard management. Immunotherapy with inhibitors of T-cell checkpoints have shown durable efficacy in a variety of malignancies. Moreover, immunotherapy has been associated with treatment-related hypophysitis, suggesting that pituitary could be a target of these treatments. Recently, i...

ea0063p1050 | Pituitary and Neuroendocrinology 3 | ECE2019

RNASeq of Pituitary Adenomas reveals dysfunctional metabolic, secretory and differentiation molecular pathways

Formosa Robert , Vassallo Josanne

Pituitary adenomas consist of a group of highly heterogeneous intracranial tumours with variable presentation, clinical prognosis and management. High throughput sequencing was used in order to try and identify common de-regulated pathways and characterize tumours according to specific molecular behaviour. RNA sequencing (RNAseq) was chosen since it provides not only information regarding the expression profile but also the mutational load of each specific tumour analysed. 58 ...

ea0063p1051 | Pituitary and Neuroendocrinology 3 | ECE2019

A comparison of glucagon stimulation and insulin tolerance test in young adults followed craniospinal irradiation

Yudina Alla , Pavlova Maria , Sotnikov Vladimir , Mazerkina Nadezhda , Zheludkova Olga , Martynova Evgeniya

The glucagon stimulation test (GST) may be used as a good alternative to the insulin tolerance test (ITT) in the diagnosis of secondary adrenal insufficiency (SAI). The aim of the study was to compare the GST and ITT for diagnostic SAI, to define cortisol cut-off points and factors affecting the appearance of false positive results in young adults followed CSI.Subjects and Methods: A retrospective study of 28 patients (median age 19 [17; 23]) at least 2 ...

ea0063p1052 | Pituitary and Neuroendocrinology 3 | ECE2019

Long-term treatment of chronic refractory SIADH with tolvaptan in the elderly: A report of three cases

Stutz Beryl , Henzen Christoph , Fischli Stefan

Background: Hyponatremia due to the syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a very common electrolyte disorder in older patients leading often to hospital admissions. Symptoms can vary between mild disabilities (e.g. nausea, dizziness, attention deficits, gait disturbance) to severe life-threatening conditions (e.g. seizures, coma). Treatment of SIADH is challenging in particular when fluid restriction is limited or even not effective in restoring n...

ea0063p1053 | Pituitary and Neuroendocrinology 3 | ECE2019

Prolactinoma and elderly subject: which caracteristics?

Elleuch Mouna , Loukil Fatma , Mnif Fatma , Safi Wajdi , Zargni Asma , Salah Dhouha Ben , Hadjkacem Faten , Mnif Mouna , Rekik Nabila , Charfi Nedia , Abid Mohamed

Introduction: Prolactinoma is the most common secretory pituitary adenomas. It has clinical and biological characteristics that depend on age, gender and tumor size. Prolactinoma of the old subject is a rare clinical form that was not sufficiently treated in the literature.Materiels and methods: It is a retrospective study including 77 cases of prolactinoma among which 3 cases aged over than 65 years. The collection of data was made between 2000 and 2017...

ea0063p1054 | Pituitary and Neuroendocrinology 3 | ECE2019

Prolactinomas in women: clinical, neuroradiological and pathological predictive factors for efficacy of transphenoidal surgery

Witek Przemyslaw , Ozdarski Marcin , Maksymowicz Maria , Styk Andrzej , Szamotulska Katarzyna , Zielinski Grzegorz

Background: The treatment of choice in prolactinomas are dopamine agonists, with surgery reserved for cases refractory to or poorly tolerant of pharmacotherapy. Little is known on the associations between clinical, neuroradiological and pathological features influencing the efficacy of transphenoidal surgery.The Aim: To evaluate clinical, neuroradiological and neuropathological aspects of surgically treated prolactinomas in women, with a particular empha...

ea0063p1055 | Pituitary and Neuroendocrinology 3 | ECE2019

Quality of life in patients with acromegaly assessed by AcroQoL- first application in South Poland

Przybylik-Mazurek Elwira , Krolak Monika , Joanna Marchlewska , Szlauer Anastazja , Hubalewska-Dydejczyk Alicja

Introduction: Acromegaly is a disease associated with increased secretion of growth hormone and subsequent growth of bones, soft tissues and internal organs. An important factor influencing therapeutic treatment in recent years is the patient’s quality of life associated with the disease. In patients with acromegaly, it is significantly affected by the occurrence of depression and anxiety - agents undergoing treatment, which, however, still appear undiagnosed.<p class...

ea0063p1056 | Pituitary and Neuroendocrinology 3 | ECE2019

Pituitary stalk abnormalities: etiology aspects about 28 cases

Mnif Fatma , Safi Wajdi , Kacem Faten Hadj , Elarbi Kawthar , Khanfir Raoudha , Salah Dhouha Ben , Elleuch Mouna , Charfi Nadia , Rekik Nabila , Feki Mouna Mnif , Abid Mohamed

Introduction: The pituitary stalk is the target of various congenital or acquired pathologies. In this context we report a cohort of 28 patients with pathology of the pituitary stalk to analyze their clinical, hormonal and radiological characteristics.Results: The average age of our patients was 28 years with extremes ranging from (15 to 64); Male dominance was noted in 60% of cases. The reason for consultation was either a staturo delay or a pubertal de...

ea0063p1057 | Pituitary and Neuroendocrinology 3 | ECE2019

Differentially expressed miRNAs in spindle cell oncocytoma of the pituitary gland

Krokker Lilla , Nyirő Gabor , Reininger Lilla , Darvasi Otto , Szucs Nikolette , Czirjak Sandor , Toth Miklos , Igaz Peter , Patocs Attila , Butz Henriett

Introduction: Spindle cell oncocytomas (SCO) of the pituitary are rare tumors accounting for 0.1–0.4% of all sellar tumors. Due to its rarity, little information is available regarding its pathogonesis. The altered gene expression and the possible pathogenetic role of microRNAs (miRNAs) have been identified in many tumor types, however, until now ther is no data regarding their role in pituitary oncocytoma.Materials and methods: Total RNA was extrac...

ea0063p1058 | Pituitary and Neuroendocrinology 3 | ECE2019

Pituitary apoplexy: diagnosis, management and outcome in 44 patients

Gargouri Imen , Hadjkacem Faten , Mnif Mouna , Walha Mohamed , Rekik Nabila , Charfi Nadia , Ayadi Fatma , Abid Mohamed

Introduction: Pituitary apoplexy (PA) is a rare incident defined by the occurrence of necrosis and/or haemorrhage of the pituitary gland. PA is a clinical syndrome characterized by the sudden onset of headache, vomiting, visual impairment and decreased consciousness in some cases. The objectives of our study are to describe its clinical, biological and imaging features as well as the management of PA in the region of Sfax.Patients and methods: It is a re...

ea0063p1059 | Pituitary and Neuroendocrinology 3 | ECE2019

The expression of somatostatin receptor subtypes in immunohistochemistry and the response to somatostatin analogue therapy in non-functioning pituitary adenomas

Zawada Natalia Bozena , Kunert-Radek Jolanta

Introduction: Non-functioning pituitary adenomas (NFPA) are characterised by the expression of somatostatin receptors (SSTR), which is analysed using immunohistochemical investigations. The presence of SSTR forms the basis for the clinical use of somatostatin analogues (SSA) in the treatment of these tumours.Aim: The study was undertaken to provide immunohistochemical analysis of SSTR and to correlate it with tumoral response to SSA therapy in NFPA.<...

ea0063p1060 | Pituitary and Neuroendocrinology 3 | ECE2019

Isolated ACTH deficiency secondary to combined immunotherapy-induced hypophysitis: predilection for corticotrophs

Rajgopal Ranjith , Kumar Mohit

Immunotherapy targeting the CTLA-4 and PD-1pathways has revolutionised the treatment of several cancer types, and is under investigation in many others. However, its use is associated with a variety of side effects, many of which associated with immune system activation. In metastatic melanoma, the combination of ipilimumab (an anti-CTLA-4 antibody) and nivolumab (an anti-PD-1 antibody) has been shown to have greater efficacy than either drug as monotherapy, though as expected...

ea0063p1061 | Pituitary and Neuroendocrinology 3 | ECE2019

Clinical features and endocrine evaluation of non-functioning pituitary adenomas at a secondary level hospital

Pascual Cristina Contreras , Lazaro Paloma Gonzalez , Fernandez Julia Silva , del Val Zaballos Florentino , Alfonso Francisco Javier Gomez , Agredos Alvaro Garcia-Manzanares Vazquez-de , Garcia Ines Rosa Gomez

Introduction: Non-functioning pituitary adenomas are relatively common. A large number of these tumors are asintomathic pituitary microadenomas, that are increasingly detected because of sensitive imaging techniques improves. Those tumors that require treatment are generally macroadenomas and come to medical attention because of mass effect (visual field defects, headache, …) and/or hypopituitarism.Objective: To assess non-functioning pituitary ade...

ea0063p1062 | Pituitary and Neuroendocrinology 3 | ECE2019

Osteitis fibrosa cystica of the skull in a patient with primary hyperparathyroidism

Biban Georgiana Bianca , Baleanu Maria , Baculescu Nicoleta , Smarandache Romeo Marian , Corneci Cristina , Hortopan Dan , Poiana Catalina

Background: Overt parathyroid bone disease is a rare entity. We present a case of primary hyperparathyroidism (PHPT) and osteitis fibrosa cystica with involvement of multiple facial bones and neurocranium. Although the initial differential diagnosis was between acromegaly and bone malignancy, endocrine assessment demonstrated PHPT, with favorable outcome after parathyroidectomy.Case report: A 59-year-old woman referred to our clinic with painful swelling...

ea0063p1063 | Pituitary and Neuroendocrinology 3 | ECE2019

Cumulative GH exposure as risk factor for mortality and morbidity in patients with acromegaly

Galoiu Simona , Silea Simona , Mailat Monica , Baciu Ionela , Trifanescu Raluca Alexandra , Niculescu Dan Alexandru , Capatina Cristina , Radian Serban , Baculescu Nicoleta , Caragheoorgheopol Andra , Dumitrascu Anda , Poiana Catalina

Background: In patients with acromegaly, mortality depends most on achievement of control of GH/IGF1 levels. However, some of the complications of acromegaly still develop, despite successful control of disease. The aim of the study is to correlate mortality and morbidity with cumulative GH exposure in these patients compared to last GH/IGF1 level.Methods: We studied retrospectively 336 patients with acromegaly consecutively evaluated at least twice duri...

ea0063p1064 | Pituitary and Neuroendocrinology 3 | ECE2019

Nighttime serum cortisol level for diagnosis of hypercortisolism in hospitalized patients

Khatsimova Liana , Tsoy Uliana , Kuritsyna Natalia , Grineva Elena , Litvinenko Elena , Dalmatova Anna , Belousova Lidia

Purpose: According to modern guidelines late night serum cortisol measurement is not considered to be among the first steps for screening of hypercortisolism. But in some cases it may be useful as it allows identifying the loss of normal circadian rhythm of cortisol secretion. This test is not rarely used in hospitalized patients when Cushing’s syndrome is suspected. But the cutt-off point of nighttime serum cortisol level for the diagnosis of hypercortisolism is inconsis...

ea0063p1065 | Pituitary and Neuroendocrinology 3 | ECE2019

Graves dermopathy associating toes lesion, pretibial myxedema and acropachy, rare, but aggressive extrathyroidal manifestation of Graves’ disease

Marinescu Mihai Constantin , Baciu Ionela , Alexandrescu Daniela , Poiana Catalina

Introduction: Graves’ dermopathy (also known as pretibial myxedema, thyroid dermopathy, Jadassohn-Dösseker disease or myxedema tuberosum) is a rare extrathyroidal manifestation of Graves’ disease, which is almost always associated with Graves’ ophthalmopathy. Although pretibial myxedema is the most frequent localization of Graves’ dermopathy, the involvement of toes with or without the involvement of pretibial area may occur.Obje...

ea0063p1066 | Pituitary and Neuroendocrinology 3 | ECE2019

Reduction in serum biomarkers of acromegaly post-surgery and post-pharmacotherapy: are insulin-like growth factor (IGF)-1 and soluble (s)Klotho levels decreased to a similar extent?

Anand Gurpreet , Bernays Rene , Neidert Marian , Regli Luca , Sze Lisa , Tschopp Oliver , Zwimpfer Cornelia , Schmid Christoph

Background, aims: Acromegaly is caused by excessive growth hormone (GH) secretion, usually by a pituitary adenoma. Surgical removal of the GH-producing adenoma is the most effective treatment. Drug treatment is second-line option. Earlier work suggested Soluble (s)Klotho levels to be a supplementary biomarker to IGF-1. We tested whether IGF-1 and sKlotho serum levels show a concomitant reduction under medical treatment. If yes, is the extent of reduction in serum IGF-1 and sKl...

ea0063p1067 | Pituitary and Neuroendocrinology 3 | ECE2019

A closer look at pituitary deficiency in Ipilimumab-induced hypophysitis

Stormann Sylvere Schilbar Katharina , Kuppers Anna , Schopohl Jochen , Stormann Sylvere

Introduction: Ipilimumab is a monoclonal antibody directed against CTLA-4 used primarily in treatment of malignant melanoma. Immunological side effects are common, amongst others it may lead to hypophysitis. We studied clinical characteristics of IpiH and compared it to cases of primary hypophysitis (PH).Methods: We conducted a retrospective single centre study in 75 hypophysitis patients (60 primary, 15 Ipilimumab-induced in patients with melanoma). Gro...

ea0063p1068 | Pituitary and Neuroendocrinology 3 | ECE2019

Pituitary metastases of lung cancer in an elderly men mimiking pituitary apoplexy (3 cases)

Marmouch Hela , Mrabet Houssem , Jenzri Haythem , Fekih Hamza , Khochtali Ines

Introduction: Pituitary tumors are the most frequent intracranial neoplasm. However metastases in this location are rare and uncommon presentation of systemic malignancy. The clinical and radiologic features of most pituitary metastases can be characteristic and evocative but in no case pathognomic. The diabetes insipidus is the most common clinical manifestation of the disease. We report here four cases of pituitary metastases of lung cancer in an elderly patients mimiking pi...

ea0063p1069 | Pituitary and Neuroendocrinology 3 | ECE2019

Apelin, copeptin, aldosterone and renin in patients with hyponatremia after transnasal surgery for pituitary tumors

Pigarova Ekaterina , Zhukov Artem , Dzeranova Larisa , Malysheva Natalia , Nikankina Larisa , Melnichenko Galina , Dedov Ivan

Introduction: Hyponatremia after transnasal neurosurgery for pituitary adenomas is a serious and not so rare complication. It often occurs in a delayed manner after patient’s discharge and is a major cause of readmission. The pathogenesis of postneurosurgical hyponatremia is not clear yet.Aims: To study the role of posterior pituitary hormones (antidiuretic hormone (ADH) and apelin) and reaction of renin-aldosterone system (RAS) at hyponatremia mani...

ea0063p1070 | Pituitary and Neuroendocrinology 3 | ECE2019

Childhood-onset growth hormone deficiency: evaluation after reaching final adult height

Dobrovolskytę Radvilę , Navardauskaitė Rūta , Verkauskienė Rasa

Introduction: Growth hormone (GH) has multiple metabolic effects in adulthood, pointing to the need of identify those patients who would benefit of GH treatment after achievement of final height.Objective: To assess GH secretion, bone mineral density (BMD) and metabolic profile in patients with childhood-onset GH deficiency (GHD) after completion of recombinant GH (rGH) therapy for linear growth.Methodology: One hundred eleven pati...

ea0063p1071 | Pituitary and Neuroendocrinology 3 | ECE2019

A novel mutation in CHD 7 gene: hypogonadotropic hypogonadism without charge syndrome

Danda Vijay Sheker Reddy , Konda Chaithanya , Verupula Madhavi , Hyderabad Apsia Ruhi , Paidipally Srinivas Rao

Congenital isolated hypogonadotropic hypogonadism (CHH), is a condition characterized by a defect in development, migration and action of GnRH neurons. Numerous genes are involved in CHH. It can present with anosmia, hyposmia or normosmia. Two cases presented to our department with late onset delayed puberty. First case was a 29 year old with absence of secondary sexual characters along with micropenis and anosmia. His younger brother, 22 year old had similar complain...

ea0063p1072 | Pituitary and Neuroendocrinology 3 | ECE2019

Diabetes insipidus as first clinical manifestation of Xanthoma Disseminatum: a case report

Hajji Ekram , Ben Asma , abdelkrim , Marzouk Hajer , Hasni Yosra , Maaroufi Amel , Kacem Maha , Chaieb Molka , Ach Koussay

Introduction: Central diabetes insipidus (CDI) is a heterogeneous condition characterized by the presence of polyuria and polydipsia due to a deficiency of arginine vasopressin. Frequently, CDI is wrongly considered idiopathic if not associated with other signs and symptoms.Case report: We report the case of a 50-year-old woman diagnosed with idiopathic central diabetes insipidus at the age of 34. The MRI scan of the hypothalamus and pituitary gland was ...

ea0063p1073 | Pituitary and Neuroendocrinology 3 | ECE2019

Diagnostic challenges in Ectopic Cushing’s Syndome: report of 2 cases

Komzia Paraskevi , Efstathiadou Zoe , Karaiskos Theodoros , Tirkalas Sotiris , Gogakos Apostolos , Kita Marina

Introduction: Ectopic Cushing’s Syndrome (ECS) accounts for 5-10% of all cases of endogenous hypercortisolism. ACTH secreting intrathoracic masses is the most common cause of ECS. We present two patients with ectopic Cushing’s syndrome, with particularities in diagnosis.Case 1:: A 59-year-old female presented with arterial hypertension, and osteoporosis, along with weight gain and facial plethora, starting two years before. Screening tests were...

ea0063p1074 | Pituitary and Neuroendocrinology 3 | ECE2019

Local myofascitis: an unusual adverse reaction to lanreotide autogel injections

Hage Mirella , Marin Cristi , Bakopoulou Sophia , Marcellus Capucine De , Guyot Alexis , Gaillard Stephan , Raffin-Sanson Marie Laure , Cazabat Laure

Background: Somatostatin analogues are the mainstay medical treatment of acromegaly. Side effect of this treatment includes gastrointestinal disturbances, cholelithiasis, and local reactions at injection sites. Herein we report an unusual case of local myofascitis after one-year treatment with deep subcutaneous injections of lanreotide Autogel in a patient with acromegalo-gigantism.Clinical case: A 25-year-old man was found to have an invasive macroadeno...

ea0063p1075 | Pituitary and Neuroendocrinology 3 | ECE2019

Emotional disorders in the clinic of the thyrotropinoma

Sidneva Yuliya , Astafyeva Ludmila , Zaitsev Oleg , Kalinin Pavel , Kadashev Boris

Thyrotropinoma (TSH-secreting pituitary adenomas, TSH-AG) are rare tumor of the pituitary (0.5–2% of all pituitary adenomas). Localization of the tumor with the appropriate neuroendocrine disorders has features in the clinic. This is due to the direct damage to the nucleus and structures of the pituitary with hypersecretion of TSH, which leads to overstimulation of the thyroid gland and the emergence of the clinical picture of ‘central’ hyperthyroidism. Differen...

ea0063p1076 | Pituitary and Neuroendocrinology 3 | ECE2019

Prolactinoma – is there a relationship between T2W signal intensity in MRI and response to treatment with dopamine agonists?

Ferreira Ana , Oliveira Guilherme , Bastos Filipa , Carlos Cordeiro Maria , Duarte Julia , Portugal Jorge

Introduction: Prolactinomas are mostly benign tumours usually managed with pharmacological treatment. Some, however, seem to be resistant to dopamine agonists (DA) for unclear reasons. The relationship between T2W signal intensity (T2WSI) and response to treatment with somatostatin analogs is well described in acromegaly patients. Some evidence suggests that prolactinoma’s T2W hypointensity might be related to higher baseline prolactin levels and more resistance to DA.</p...

ea0063p1077 | Pituitary and Neuroendocrinology 3 | ECE2019

Long term observation of patients with pituitary stalk lesions – single center experience

Kluczyński Łukasz , Gilis-Januszewska Aleksandra , Rogoziński Damian , Pantofliński Jacek , Żabicka Katarzyna , Zygmunt-Gorska Agata , Wojcik Małgorzata , Starzyk Jerzy , Hubalewska-Dydejczyk Alicja

Background: Pituitary stalk lesions (PSL) are various changes located in the pituitary infundibulum. The underlying pathology and exact diagnosis are difficult to establish due to their difficult anatomical locus.Aim: To present the etiological spectrum of pituitary stalk lesions and their clinical and hormonal characteristics on the basis of long term observation in the pediatric/adult endocrinology departments of our university.M...

ea0063p1078 | Pituitary and Neuroendocrinology 3 | ECE2019

Pituitary stalk interruption syndrome with late revelation: about 5 cases

Chadli Asma , El Aziz Siham , sephora Lygie , Odiki Kibhat

Introduction: Pituitary Stalk Interruption Syndrome (PSIS) is a distinct and rare clinical entity responsible for isolated or combined anterior pituitary insufficiency. The objective of this work is to describe the clinical, hormonal and radiological aspects of PSIS.Patients and methods: Observational descriptive study of the files of 5 patients including 4 cases of congenital PSIS and one acquired, followed in the endocrinology and diabetology departmen...

ea0063p1079 | Pituitary and Neuroendocrinology 3 | ECE2019

Familial hypogonadotropic hypogonadism: about a family

Meryam ELbahi , Sana Rafi , Ghizlane Elmghari , Nawal Elansari

Introduction: Congenital idiopathic hypogonadotropic hypogonadism is a rare genetic disorder caused by an isolated defect in GnRH secretion by the hypothalamus or, less frequently, by a defect in the action of GnRH on pituitary gonadotropes. The majority of cases are sporadic but there are also family forms. We report a case of one family.Case report: These are 2 brothers with a family history of primary infertility in the maternal uncle. An 18-year-old ...

ea0063p1080 | Pituitary and Neuroendocrinology 3 | ECE2019

Impairment of glucose tolerance in children and adolescentstreated for medulloblastoma

Natalia Strebkova , Kalinin Alexey , Vasyukova Olga , Okorokov Pavel , Kareva Maria , Zheludkova Olga

Children and adolescents treated for solid brain tumors with chemotherapy and craniospinal irradiation are at increased risk of metabolic changes development. Current follow-up guidelines for cancer survivors recommend to monitor fasting glucose and HbA1 levels for diabetes/impaired glucose tolerance screening in these patients. The aim of our study was to evaluate metabolic changes in children treated for medulloblastoma with oral glucose tolerance test (OGTT). We examined 63...

ea0063p1081 | Pituitary and Neuroendocrinology 3 | ECE2019

ACTH-positive diffuse idiopathic neuroendocrine cell hyperplasia (DIPNECH)

Ferreira Ana , Bastos Filipa , Pedro Paula , Lopes Miguel , Carlos Cordeiro Maria , Portugal Jorge

Introduction: DIPNECH is a preinvasive condition in which there is an idiopathic generalised proliferation of pulmonary neuroendocrine cells that can form tumourlets. There are very few cases described of ACTH secretion by these cells causing Cushing’s syndrome, some of them cyclic.Case report: A 41 year-old woman was sent to our Endocrinology outpatient clinic for menstrual disturbance, acne and excessive sweating. She had a recent diagnosis of DIP...

ea0063p1082 | Pituitary and Neuroendocrinology 3 | ECE2019

Nasopharyngeal carcinoma revealing acromegaly on pituitary adenoma

Ijdda Sara , Bouizammarne Ilhame , Rafi Sana , Elmghari Ghizlane , El Ansari Nawal

Introduction: Acromegaly is a clinical syndrome caused by excessive production of growth hormone (GH). It is associated with an increase in the incidence of cancers. Through this observation, we illustrate the rare association of a somatotropic adenoma with a nasopharyngeal carcinoma.Case report: 57-year-old woman, having hypertension, followed for an undifferentiated nasopharyngeal carcinoma since 2011 under radio-chemotherapy, having recurred in Januar...

ea0063p1083 | Pituitary and Neuroendocrinology 3 | ECE2019

Diabetes mellitus and metabolic syndrome in acromegaly

Dumitriu Roxana , Petrova Eugenia , Cocolos Andra

Acromegaly is a rare endocrine disorder, caused by hypersecretion of growth hormone. Cardiovascular and metabolic complications reduce life expectancy. Early carbohydrate metabolism disorders and diabetes mellitus are frequently associated with acromegaly.Objective: The objective of this study was to evaluate the glycemic profile and cardiovascular complications in acromegaly.Methods: We performed a retrospective study. We included...

ea0063p1084 | Pituitary and Neuroendocrinology 3 | ECE2019

Case report: polynodular goiter and pituitary macroadenoma co-secreting growth hormone and thyroid stimulating hormone

Maria Hrisca Ana , Christina Ungureanu Maria , Chiriac Anca E. , Potorac Iulia

Purpose: The purpose is to draw attention to rare cases of Pituitary Macroadenoma co-secreting Growth Hormone and Thyroid Stimulating Hormone with Polynodular Goiter and their importance and approach in current practice.Background: Pituitary adenomas with no hormonal clinical picture are known as ‘silent’ tumors. They are rarely reported and lacking pathogenic explanations.Method: We describe a case of Pituitary Macroaden...

ea0063p1085 | Pituitary and Neuroendocrinology 3 | ECE2019

Idiopathic Fanconi anemia and growth retardation: do not miss GH deficiency

El Guich Dorra , Jemel Manel , Kandara Hajer , Mimita Wafa , Nagi Sonia , Kammoun Ines

Introduction: Fanconi anemia (FA) is an autosomal recessive disease associated with chromosomal instability, it is marked by phenotypic heterogeneity. Patients with FS often exhibit growth retardation due to complex factors such as hypophosphatemia, metabolic acidosis, disturbed vitamin D metabolism. On the other hand, endocrinopathies are a common feature of FA specially such as Growth hormone deficiency (GHD). We report here two cases of Fanconi disease associated to GH defi...

ea0063p1086 | Pituitary and Neuroendocrinology 3 | ECE2019

Predictive factors of surgical outcomes in acromegaly

Wafa Badr , Hasni Yosra , Chermiti Sondes , Abdelkarim Asma Ben , Kacem Maha , Chaieb Molka , Maaroufi Amel , Ach Koussay

Introduction: Acromegaly is a chronic disorder usually caused by growth hormone (GH)-secreting pituitary adenomas. Transsphenoidal surgery remains a treatment of choice for restoring GH to normal levels. The aim of this study was to illustrate the relationship between some factors and transsphenoidal surgery outcomes.Patients and methods: We retrospectively analysed the outcome of 31 patients with acromegaly after initial endoscopic transsphenoidal surge...

ea0063p1087 | Pituitary and Neuroendocrinology 3 | ECE2019

Surgical outcomes in cushing disease: Endoscopic transsphenoidal pituitary surgery

Remon-Ruiz Pablo , Dios-Fuentes Elena , Venegas Eva , Cozar-Duenas Miriam , Kaen Ariel , Cardenas Eugenio , Gonzalez Natividad , Martin Ignacio , Roldan Florinda , Fajardo Elena , Cano David , Soto-Moreno Alfonso

Introduction: Endoscopic transsphenoidal pituitary surgery has become the first line method for removal pituitary tumours. A new way to see the surgical field and the cooperation of two neurosurgeons has supposed a revolution in the area.Objetives: Analyse surgical outcomes and complications of a cohort of patients from a single center who underwent ETPS for Cushing disease.Methods: Descriptive prospective-retrospective study inclu...

ea0063p1088 | Pituitary and Neuroendocrinology 3 | ECE2019

Acromegaly and papillary carcinoma of the thyroid: a case report

Pangui-Ntsam Henricia Laurinda , El Aziz Siham , Mjabber Amal , Chadli Asma

Introduction: The pituitary adenoma is a benign hyperplasia of the pituitary gland; it often implies the presence of pathologies of the thyroid gland. The relation between the thyroid volume, the rate of IGF1 and the duration of the disease is not well specific, long time the secretion of GH and IGF1 have been associated with disorders of thyroid function.Presentation of the case: We report the observation of a 37-year-old woman operated on in 2016 with ...

ea0063p1089 | Pituitary and Neuroendocrinology 3 | ECE2019

Modification of breast in hyperprolactenemic conditions

Khalimova Zamira , Gumarova Aliya , Safarova Mijgona

Objective: Evaluate effect of hyperprolactinemia on breast’s conditions.Methods: Investigated 2 groups of patients with average age 34.9±7.5. The first group is 30 women with hyperprolactinemia. Inclusion criterion was an increase in prolactin level above 1000 mU/l with a double determination, as well as duration of at least 6 month, lack of taking antidepressants and oral contraceptives for last 3 month before the start of study, absence of co...

ea0063p1090 | Pituitary and Neuroendocrinology 3 | ECE2019

Growth retardation and brain imaging

Bouzid Aicha , Meskine Djamila

The diagnostic strategy in the face of stunted growth currently leaves an important place for brain imaging, which looks for growth hormone deficiency, a ‘craniopharyngioma’ tumor, or a malformation of the midline or pituitary region. The purpose of our work is to look for abnormalities of the pituitary area in case of stunted growth.Patients and methods: A retrospective descriptive and analytical study involving 69 patients (30 girls/9 boys) w...

ea0063p1091 | Pituitary and Neuroendocrinology 3 | ECE2019

Surgical outcomes in acromegaly disease: endoscopic transsphenoidal pituitary surgery

Cozar Miriam , Remon-Ruiz Pablo , Dios-Fuentes Elena , Cozar Miriam , Kaen Ariel , Cardenas Eugenio , Gonzalez Natividad , Martin Ignacio , Roldan Florinda , Fajardo Elena , Cano David , Soto-Moreno Alfonso

Introduction: Endoscopic transsphenoidal pituitary surgery has become the first line method for removal pituitary tumours. A new way to see the surgical field and the cooperation of two neurosurgeons has supposed a revolution in the area.Objetives: Analyse surgical outcomes and complications of a cohort of patients from a single center who underwent ETPS for GH secreting pituitary tumours.Methods: Descriptive prospective-retrospect...

ea0063p1092 | Pituitary and Neuroendocrinology 3 | ECE2019

Factors predicting dopamine agonist treatment withdrawal in prolactinoma patients

Solak Mirsala , Haxhiu Arta , Haxhiu Arita , Kraljevic Ivana , Dusek Tina , Leskovar Dunja , Polovina Tanja Skoric , Balasko Annemarie , Kastelan Darko

Aim: Dopamine agonist (DA) therapy is recommended as first-line treatment for prolactinomas, albeit with long treatment duration and high recurrence rate after treatment withdrawal. The aim of this retrospective study was to evaluate predictors for successful DA withdrawal.Methods: The study included 59 prolactinoma patients (39 female, 20 male; age 34 (18–82) years) that were treated with DA (35.6% on cabergoline); the duration of treatment was 71 ...

ea0063p1093 | Pituitary and Neuroendocrinology 3 | ECE2019

Medical treatment of cushing’s disease during pregnancy with Ketoconazole and Cabergoline – Report of 3 cases

Vilar Lucio , Vilar Clarice , Albuquerque Luciano , Gadelha Patricia , The Ana Carolina , Trovao Erik , Sampaio Icaro , Ferreira Liana , Lyra Ruy

Abstract: Cushing’s syndrome (CS) during pregnancy is a rare condition with fewer an 200 cases reported in the literature, However, because CS results in increased fetal and maternal complications, its early diagnosis and treatment are critical. During pregnancy, 40-50% of cases are caused by adrenal adenomas, while Cushing’s disease (CD) accounts for only one third of the cases. We describe here 3 patients with CD who needed to be treated during pregnancy.<p cla...

ea0063p1094 | Pituitary and Neuroendocrinology 3 | ECE2019

GH Deficiency in children: clinical, biological and radiological characteristics an experience of a tertiary care center

El Guiche Dorra , Jemel Manel , Kandar Hajer , Safa Chelbi , Nagi Sonia , Jemni Houda , Kammoun Ines

Introduction: GH deficiency (GHD) represents less than 20% of short stature in children, the clinical, biological and radiological characteristics differ from one population to another.Methods: Our retrospective study describe 59 children (37 boys and 22 girls) with confirmed GHD. The average age of discovery was 95 months. About 20.3% of these children were born from a consanguineous marriage. Family history of anterior pituitary insufficiency was prese...

ea0063p1095 | Pituitary and Neuroendocrinology 3 | ECE2019

Poor response to pre-surgical treatment with Somatostatin Receptor Ligands is associated with diabetes in patients with acromegaly

Tecilazich Francesco , Frara Stefano , Losa Marco , Formenti Anna Maria , Resmini Eugenia , Doga Mauro , Mortini Pietro , Giustina Andrea

Purpose: To evaluate whether the degree of response to surgical pre-treatment with somatostatin receptor ligands (SRL) predicts alterations in blood glucose levels.Patients and methods: We retrospectively studied 181 patients attending the Unit of Neurosurgery of our Hospital prior to transsphenoidal surgery. All patients had a diagnosis of acromegaly (nadir GH during OGTT >0.4 ng/ml; and IGF-I above age-standardized UNL); diagnosis of diabetes (DM) ...

ea0063p1096 | Pituitary and Neuroendocrinology 3 | ECE2019

Partial hypopituitarism and primary hypotiroidism associated with Diamond-Blackfan Anemia

Almendros Rosa Gomez , Aragon Ignacio Nocete , Coca Lucia Prieto , Miravalles Maria Soledad Segurado , Kanaan Laura Kanaan , Carvalho Rui Ferreira , Iglesias Pedro

Introduction: Diamond-Blackfan anemia (DBA) is a severe congenital erythroid aplastic anemia with autosomal dominant inheritance. It is a rare disease (incidence 1/150000) and usually is discovered during the 2 first years after birth. Treatment includes steroids, blood transfusions and bone-marrow transplantation.Case report: A 31 year-old woman with DBA had received multiple treatments including transfusion support since birth. Consequently, she had de...

ea0063p1097 | Pituitary and Neuroendocrinology 3 | ECE2019

Predictive factor of hypopituitarism in prolactinoma

Elleuch Mouna , Loukil Fatma , Mnif Fatma , Salah Dhouha Ben , Hadjkacem Faten , Mnif Mouna , Charfi Nedia , Rekik Nabila , Abid Mohamed

Intoduction: Pitiutary tumor is considered as the first etiology responsable of secondary hypopituitarism. Hypogonadotropic hypogonadism is the most commonly reported lesion.Meterials and methods: It is a retrospective study including 77 cases of prolactinoma. The data collection was done over 17 years, between 2000 and 2017.Results: Gonadotropic deficiency was confirmed in 48 patients (63.6%). A significant negative correlation wa...

ea0063p1098 | Pituitary and Neuroendocrinology 3 | ECE2019

The long time observation, treatment modalities and outcomes in patients with childhood/adult onset of craniopharyngioma

Gilis-Januszewska Aleksandra , Kluczyński Łukasz , Rogoziński Damian , Pantofliński Jacek , Zygmunt-Gorska Agata , Wojcik Małgorzata , Starzyk Jerzy , Hubalewska-Dydejczyk Alicja

Background: Craniopharyngiomas are rare, relatively benign, slowly growing intracranial tumors originating in pituitary gland embryonic tissue. They may present at any age, with two peaks of occurrence in children and in older adults. Clinical symptoms are the result of mass effects. Treatment options include surgery, radio- and chemotherapy and unfortunately are connected with a high ratio of postoperative pituitary insufficiency.Aim: To present the lon...

ea0063p1099 | Pituitary and Neuroendocrinology 3 | ECE2019

Pituitary apoplexy (PA) – a relatively rare condition requiring early recognition, individualized treatment and longterm follow-up

Vladan Andreea , Baranga Iuliana , Niculescu Dan , Radian Serban , Radian Serban , Poiana Catalina

Background: PA is a clinical syndrome secondary to hemorrhage or infarction of pituitary tumour, presenting with sudden onset headache and oculomotor palsy. PA may be managed conservatively in patients without visual disturbances.Aim: To describe PA patients illustrating typical aspects and peculiarities.Results: Case 1, a 49 years old (yo) male, presented for loss of consciousness in the ER. MRI showed a giant pituitary tumour, wh...

ea0063p1100 | Pituitary and Neuroendocrinology 3 | ECE2019

Outcome of prolactinoma during pregnancy

Elleuch Mouna , Loukil Fatma , Salah Dhouha Ben , Sahnoun Randa , Charfi Nedia , Mnif Fatma , Hadjkacem Faten , Mnif Mouna , Rekik Nabila , Abid Mohamed

Introduction: Infertility is a classic consequence of prolactinoma in women. The treatment of hyperprolactinemia allows the restoration of ovulatory cycles and therefore of fertility in 80–90% of cases.Methods and materials: The study is a retrospective cohort study done over 17 years from 2000 to 2017. It includes 77 cases of prolactinomas among which 12 women had one or more pregnancies after the diagnosis of prolactinoma.Re...

ea0063p1101 | Pituitary and Neuroendocrinology 3 | ECE2019

Pegvisomant: daily versus non daily administration a single centre real life study

Dassie Francesca , Rosson Marco , Parolin Matteo , Russo Lucia , Mazzocut Sara , Martini Chiara , De Carlo Eugenio , Mioni Roberto , Fallo Francesco , Vettor Roberto , Maffei Pietro

Background: Pegvisomant (PEG) is a second line medical treatment for active acromegalic patients. PEG efficacy is between 61.5 and 92% and even if it is administered daily its long half-life suggests a possible use with a non-daily regime.Aim: We aim to compare acromegalic patients on daily PEG administration (DP) with patients on non-daily PEG administration (NDP).Methods: We studied 43 acromegalic patients under PEG treatment bet...

ea0063p1102 | Pituitary and Neuroendocrinology 3 | ECE2019

The significance of low TSH value – case report

Vlad Mihaela , Amzar Daniela , Sotanga Lavinia , Toma Andreea

Introduction: Suppression of TSH usually indicates hyperthyroidism. But the etiology of low TSH is very wide, including pituitary pathology. In this report we describe a case diagnosed and treated for hyperthyroidism. Later on, the persistence of suppressed TSH after therapy of hyperthyroidism was due to a GH-secreting pituitary adenoma.Case presentation: A 47-year old woman was referred to our clinic for investigations, due to thyroid pathology. The pat...

ea0063p1103 | Pituitary and Neuroendocrinology 3 | ECE2019

Mild weakness as an only symptom for panhypopituitarism with empty sella syndrome: case report

Jagucianskaite Greta , Naskauskiene Gintare , Bagdziuniene Airida , Petraviciute Modesta , Visockiene Zydrune

Introduction: Weakness is one of the most common complaints among the patients. Clinical manifestations of a hypopituitarism depend on the extent of hormone deficiency and may be non-specific and thus the diagnosis is often missed. The progressive loss of pituitary hormone secretion is usually a slow process, which can occur over a period of months or years.Clinical case: A 62 years old women who complained of mild weakness mostly in the evenings in the ...

ea0063p1104 | Pituitary and Neuroendocrinology 3 | ECE2019

Prevalence and study of neuroendocrine deficits in a series of 75 patients following traumatic brain injury

Daniel Sara , Bonneville Jean-Francois , Beckers Albert , Valdes-Socin Hernan

Introduction: Clinical research studies over the last 15 years have reported a significant burden of hypopituitarism in survivors of traumatic brain injury (TBI). However, these endocrine anomalies remain underdiagnosed.Patients and methods: We are studying data from a series of 75 TBI patients. They had a basal hormonal test, and dynamic confirmation tests if necessary. Somatotropic deficiency was defined by growth hormone (GH) remaining under 3 μg...

ea0063p1105 | Pituitary and Neuroendocrinology 3 | ECE2019

Aggressive corticotroph adenoma

Stancu Cristina , Enculescu Augustina , Caragheorgheopol Andra , Badiu Corin

Aggressive pituitary tumors (APT) causing Cushing’s Disease are very rare, difficult to treat. The majority of Crooke’s corticotropinomas are macroadenomas, exhibiting rapid growth, resistance to conventional treatments, a high recurrence rate. To date, there is no fully effective method of treatment for these tumors. Pituitary carcinomas (PC) are defined by distant metastasis. PC is exceedingly rare, comprising only 0.1–0.2% of all pituitary neoplasms but APT m...

ea0063p1106 | Pituitary and Neuroendocrinology 3 | ECE2019

Analysis of gender-related differences in clinically non-functioning pituitary adenomas

Aguirre Moreno Nerea , Sampedro-Nunez Miguel , Levi Ana Ramos , Centeno Rogelio Garcia , Carrera Concepcion Blanco , Escola Cristina Alvarez , Novoa Paz de Miguel , Gutierrez Maria Calatayud , Librizzi Soledad , Azpiroz Monica Marazuela

Introduction: Clinically non-functioning pituitary adenomas (NFPA) are heterogeneous group. Some previous research has found that this type of pituitary adenomas may be smaller and have better prognostic in men. The aim of this study is to analyze if there are gender-related differences in NFPA.Material and methods: Retrospective study of patients with NFPA followed up in regional hospitals (Community of Madrid, Spain). All NFPA had molecular analysis. T...

ea0063p1107 | Pituitary and Neuroendocrinology 3 | ECE2019

European observational study of ketoconazole for endogenous cushing’s syndrome in collaboration with European registry on cushing’s syndrome ERCUSYN: PASS ketoconazole study design and rationale

Bostnavaron Martine , Marsault Pauline , Arosio Maura , Bertherat Jerome , Brue Thierry , Chabre Olivier , Chanson Philippe , Duarte Joao Sequeira , Fajardo Carmen , Feelders Richard , Alexandra Hanzu Felicia , Kastelan Darko , Netea-Maier Romana , Newell-Price John , Pereira Alberto , Ragnarsson Oskar , Reincke Martin , Strasburger Christian , Tabarin Antoine , Touraine Philippe , Trainer Peter , Pal Aparna , Zopf Kathrin , Franz Holger , Stalla Gunter , Santos Alicia , Valassi Elena , Werner Sandy , Webb Susan

Introduction and rationale: Cushing’s syndrome (CS) is a rare disease with hypercortisolism caused either by ACTH excess from a pituitary or non-pituitary tumor or by an ACTH-independent primary adrenal overproduction of cortisol. It is associated with significant comorbidities potentially lethal: hypertension, diabetes, coagulopathy, cardiovascular disease, infections, and osteoporotic fractures. It is usually managed by surgery and/or medical treatment with steroidogene...

ea0063p1108 | Pituitary and Neuroendocrinology 3 | ECE2019

Variability of momentarily measured fatigue in patients with pituitary insufficiency receiving hydrocortisone replacement therapy

Boesen Victor Brun , Watt Torquil , Borresen Stina Willemoes , Klose Marianne , Feldt-Rasmussen Ulla

Background: Secondary adrenal insufficiency is usually treated with hydrocortisone replacement therapy twice or thrice daily in varying doses to mimic the physiological rhythm of cortisol release. However, despite efforts to optimize treatment regimens patients report impaired quality of life (QoL), including important aspects such as fatigue. A possible explanation is a suboptimal imitation of cortisol release resulting in an inadequate substitution at certain times during th...

ea0063p1109 | Pituitary and Neuroendocrinology 3 | ECE2019

HPA axis function in patients with clinically non-functioning pituitary adenomas: effects of surgery and risk factors for HPA failure

Kolnes Anders Jensen , Oystese Kristin Astrid , Dahlberg Daniel , Bollerslev Jens , Jorgensen Anders Palmstrom

Introduction: Patients planned for first time surgery for clinically non-functioning pituitary adenoma (NFPA) were included in this prospective study.Aims: – To study the prevalence of hypothalamic-pituitary-adrenal (HPA) axis failure preoperatively and 3 months after surgery for clinically NFPA.– To investigate factors predicting risk of HPA axis failure postoperatively.Hypotheses<p class="abst...

ea0063p1110 | Pituitary and Neuroendocrinology 3 | ECE2019

Isolated central hypothyroidism as a clue for empty sella syndrome

Gouveia Sofia

Introduction: Isolated central hypothyroidism is a rare disease. Acquired causes for central hypothyroidism include iatrogenic, traumatic, immunologic, infiltrative, infectious, vascular or space-occupying lesions. Empty sella may present with endocrine dysfunction, mainly hyperprolactinemia and growth hormone or gonadotropin deficiency. Few cases of empty sella associated with isolated TSH deficiency were published.Case report: A 66-years-old female wit...

ea0063p1111 | Pituitary and Neuroendocrinology 3 | ECE2019

Hypoglycemic coma revealing sheehan syndrome: a case reported

Mahroug Ikram , Cheikh Sidi Mohammed Ould , Elmir Siham , Ouladamar Asmae , Kamaoui Imane , Latrech Hanane

Introduction: Sheehan’s syndrome is a rare postpartum complication. Recurrent hypoglycaemia,though described is a rare complication of Sheehan syndrome. Here we report a case of Sheehan syndrome which presented with hypoglycemic coma.Case Presentation: We report the case of a 47-year-old woman who presented to the medical emergency unit with coma. There was no history of chest pain, fever, headache, vomiting, trauma, or seizures. She had no history ...

ea0063p1112 | Pituitary and Neuroendocrinology 3 | ECE2019

Metabolic phenotype in acromegaly

Djurdjevic Sandra Pekic , Prpic MIlica , Doknic Mirjana , Miljic Dragana , Stojanovic Marko , Jemuovic Zvezdana , Djurovic Marina Nikolic , Petakov Milan

Introduction: Previous studies reported increased unfavorable metabolic phenotype in patients with active acromegaly.Aim of the study: We studied the metabolic phenotype in unselected cohort of 133 patients with active acromegaly (83 female, 62.4%), diagnosed at Clinic of Endocrinology, University Clinical Center, Belgrade, Serbia in the period 2007–2018. Mean age at diagnosis of acromegaly was 50.5±1.2 years and mean BMI was 28.4±0.4 kg/m...

ea0063p1113 | Pituitary and Neuroendocrinology 3 | ECE2019

The impact of clomiphene citrate as add-on therapy in male acromegalic patients non-responsive to combined medical therapy

Vilar Lucio , Vilar Clarice , Albuquerque Luciano , Trovao Erik , The Ana Carolina , Gadelha Patricia , Campos Renata , Cardoso Izabela , Borges Thaise , Lyra Ruy

Introduction: Clomiphene citrate (CC), a selective estrogen receptor modulator that increases LH and FSH secretion, improves hypogonadism and fertility outcomes. Moreover, there is limited evidence that it may also be helpful as add-on therapy to normalize IGF-1 levels in male acromegalic patients.Objective: To assess the effect impact of CC on serum IGF-1 and testosterone levels in male acromegalic patients not controlled by the combination of lanreotid...

ea0063p1114 | Pituitary and Neuroendocrinology 3 | ECE2019

Evolution of patients with discordance between growth hormone and insulin-like growth factor-1 after pituitary surgery for acromegaly

Olariu Cristina , Bojoga Andreea , Badiu Corin

Introduction: Persistent or intermittent postoperative discordance between growth hormone (GH) after OGTT and insulin-like growth factor-1 adjusted for age and gender (IGF-1) is up to 39% according to different studies. The aim of this study was to evaluate the impact of this discrepancy (normal GH and elevated IGF1 or vice versa) over the risk of biochemical and tumour recurrence after initial successful surgery for acromegaly.Methods: In this retrospec...

ea0063p1115 | Pituitary and Neuroendocrinology 3 | ECE2019

Pituitary apoplexy occurs more frequently in the morning

Faustini-Fustini Marco , Guaraldi Federica , Zoli Matteo , Asioli Sofia , Mazzatenta Diego , Provini Federica

Pituitary apoplexy (PA) is a rare clinical syndrome due to sudden haemorrhage and/or infarction of the pituitary gland, usually within a pre-existent pituitary tumour. Even though some sporadic cases of PA associated with rare sellar lesions (such as Rathke cleft cysts) have been reported, in the vast majority of cases the syndrome occurs within a pituitary adenoma. At presentation, patients with PA usually complain of sudden and severe headache, often associated with visual l...

ea0063p1116 | Pituitary and Neuroendocrinology 3 | ECE2019

Giant cerebral aneurysm a rare cause of hypopituitarism: a case report

Huerta Yolanda Zambrano , Marquez Pilar Olvera , Arranz Maria Teresa Herrera , Gonzalez Cristina Lorenzo , Fernandez Javier Garcia , Izquierdo Marcos Perera , Abizanda Enrique Palacio

Introduction: Hypophysary aneurysms are rare, they account for 1% to 2% of all intracranial aneurysms (1) and can be mistaken for pituitary adenomas, since they can have similar symptoms and even radiological signs especially if it’s an aneurysm completely thrombosed as angiography will show only avascular mass (2).Clinical case: A 84 year old female with past medical history of hypertension, dyslipidemia and depressive disorder, presents to emergen...

ea0063p1117 | Pituitary and Neuroendocrinology 3 | ECE2019

Epidemiology of acromegaly in Russian Federation: evaluation of National registry-based data

Lutsenko Alexander , Przhiyalkovskaya Elena , Pigarova Ekaterina , Belaya Zhanna , Rozhinskaya Liudmila

According to state statistics service, Russia’s population in 2018 is more than 146.8 mil people. The total prevalence of acromegaly may range between 2.8 and 13.7 cases per 100,000 people and the annual incidence rates vary between 0.2 and 1.1 cases per 100,000 people (Lavrentaki A, et al. 2016). The epidemiological data for acromegaly in Russian population is lacking. The Russian hypothalamic and pituitary tumors registry was founded in 2004 and for 2018 it con...

ea0063p1118 | Pituitary and Neuroendocrinology 3 | ECE2019

Diagnostic evaluation of a large cohort of Brazilian patients with endogenous Cushing’s syndrome

Vilar Lucio , Freitas Maria da Conceicao , Vilar Clarice , Albuquerque Luciano , The Ana Carolina , Trovao Erik , Gadelha Patricia , Sampaio Icaro , Ferreira Liana , Ibiapina George , Lyra Ruy

Introduction: Cushing’s syndrome (CS) is certainly one of the most challenging disorders to physicians due to the difficulties that often appear during its investigation. The diagnosis of CS involves two steps: confirmation of hypercortisolism and determination of its etiology. Biochemical confirmation of the hypercortisolemic state must be established before any attempt for differential diagnosis. Failure to do so will result in misdiagnosis, inappropriate treatment, and...