Reproductive Endocrinology 2

Introduction: Omentin is a visceral fat tissue adipokine which regulates metabolism (insulin sensitivity) and presents an anti-inflammatory activities, by lowering C-reactive protein concentration, in obesity and diabetes mellitus type 2. Polycystic ovary syndrome is the most common endocrinopathy in women of childbearing age. One of the major disorders in the PCOS metabolic phenotype is obesity and hyperinsulinaemia. The anthropometric indicators are useful tools for carbohyd...

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ea0063p1120 | Reproductive Endocrinology 2 | ECE2019

Immunomodulatory effects of dihydrotestosterone (DHT) in rat vaginal smooth muscle cells

Maseroli Elisa , Cellai Ilaria , Corno Chiara , Filippi Sandra , Comeglio Paolo , Sarchielli Erica , Rastrelli Giulia , Morelli Annamaria , Maggi Mario , Vignozzi Linda

Pathologies of the female reproductive system, characterized by chronic pain, are frequent and it has been hypothesized that inflammation may play an essential role in their pathogenesis. It is known that androgens, including dihydrotestosterone (DHT), have shown immunomodulatory effects in experimental models of chronic inflammation. The aim of this study was to evaluate the immunomodulatory effects of DHT in smooth muscle cells (rSMCs) isolated from vagina of intact Sprague-...

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ea0063p1121 | Reproductive Endocrinology 2 | ECE2019

Clinical and diagnostic criteria for patients with thyroid diseases in disturbances of the menstrual cycle

Nasirova Khurshida , Amilova Aziza

The project study thyroid diseases which are common endocrine pathology in Uzbekistan appearing in women of reproductive age. We study thyroid hormones, since its close relation with the female reproductive hormones (estrogen and progesterone), ensure the normal functioning of the ovaries and the maturation of the eggs or its disorder. The study evaluated thyroid dysfunction such as thyrotoxicosis or hypothyroidism that might lead to an imbalance of reproductive ...

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ea0063p1122 | Reproductive Endocrinology 2 | ECE2019

Severely elevated testosterone in a woman with ovarian hyperthecosis

Mumdzic Enis , Merza Zayd

A 73-year-old lady presented to our department with a 6-month history of facial hirsutism and frontal hair loss. Her past medical history comprised of type 2 diabetes and hypertension. Initial blood tests showed testosterone 15.9 nmol/l (normal range 01.7), SHBG 123.6 nmol/l, LH 23.1 iu/l (normal range 1664), FSH 33.5 iu/l (normal range 1664), oestradiol 281 pmol/l (normal <43), mild erythrocytosis, mild hyperbilirubinaemia and HbA1c 56 mmol/mol (normal &...

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ea0063p1123 | Reproductive Endocrinology 2 | ECE2019

Study of the anti-inflammatory effects of dihydrotestosterone in human vaginal smooth muscle cells

Maseroli Elisa , Cellai Ilaria , Corno Chiara , Rastrelli Giulia , Filippi Sandra , Comeglio Paolo , Amoriello Roberta , Ballerini Clara , Sarchielli Erica , Morelli Annamaria , Maggi Mario , Vignozzi Linda

Inflammation is hypothesized to play an important role in several diseases associated to the female genital tract and dihydrotestosterone (DHT) has shown immunomodulatory protective effects in experimental models of chronic inflammation. In the present study we aimed to evaluate the potential anti-inflammatory effects of DHT in a model of smooth muscle cells (hSMCs) isolated from human vagina biopsies and their potential role as APCs (Antigen Presenting Cells), crucial for the...

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ea0063p1124 | Reproductive Endocrinology 2 | ECE2019

Evaluation of insulin resistance and endocrine hormone parameters on etiopathogenesis of acne vulgaris, analyzing whether there is a change in insulin resistance and hormonal parameters after oral isotretinoin treatment

Kocyigit Suleyman Emre , Sahin Mustafa , Corapcioglu Demet

Introduction: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit and it can be seen on postadolescence period. Several studies show that adrenal and pituitary hormones have an important role in the pathogenesis. The studies which show the isotretinoin treatment takes effect on hormones are phenomenal in the literature. The aim of our study is to identify a hormonal alteration in the etiopathogenesis of acne vulgaris and to observe whether there is an alt...

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ea0063p1125 | Reproductive Endocrinology 2 | ECE2019

Both comorbidity burden and low testosterone can explain symptoms and signs of testosterone deficiency in men consulting for sexual dysfunction

Rastrelli Giulia , Corona Giovanni , Maggi Mario

Background: Low testosterone (T) is frequent in men with chronical illnesses. The clinical features of T deficiency (TD) overlap with those of chronic diseases. The aim of this study is to evaluate the relative contribution of chronic disease score (CDS) and low T to the presence of TD symptoms.Methods: A consecutive series of 3862 men (aged 52.1±13.1 years) consulting for sexual dysfunction was studied. Several clinical and biochemical parameters w...

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ea0063p1126 | Reproductive Endocrinology 2 | ECE2019

Hormonal predictors of pathologic findings at magnetic resonance imaging in secondary hypogonadal men

Cipriani Sarah , Corona Giovanni , Maggi Mario , Rastrelli Giulia

Introduction: Secondary hypogonadism (sHG) is the most common form of hypogonadism. sHG can arise from any dysregulation of hypothalamic-pituitary (HP) axis due to functional or organic disorders. HP organic disorders are often diagnosed using pituitary magnetic resonance imaging (MRI). However, MRI is an expensive and not widespread exam and it cannot be routinely offered to all sHG patient. The Endocrine Society guidelines suggest MRI scan in sHG men with total testosterone ...

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ea0063p1127 | Reproductive Endocrinology 2 | ECE2019

If insulin resistance lowering therapy is effective in polycystic ovary syndrome patients with androgen excess, why to start with various symptom-oriented treatment forms?

Petranyi Gyula

Insulin resistance (IR) is a dominant feature in polycystic ovary syndrome (PCOS). The author could treat more patients of comparable effect on hyperandrogenic symptoms with metformin than with the contraceptive pill because of less contraindication and side effects. Since 2004, combining metformin with lifestyle modification, he has observed also reduction in BMI and waist-to-hip circumference ratio (WH). Guidelines recommend different treatment options according to the pheno...

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ea0063p1128 | Reproductive Endocrinology 2 | ECE2019

Turner’s syndrome: adult life’s implications

Guiomar Joana Reis , Moreno Carolina , Cunha Nelson , Marques Bernardo , Catarino Diana , Fadiga Lucia , Silva Diana Festas , Bastos Margarida

Introduction: Turner syndrome (TS) is one of the most common chromosomal abnormalities, characterized by systemic involvement and susceptibility to some disorders that begin or progress in adult life. These lead to an increase in morbidity and mortality and a decrease in quality of life. The aim of this study was to analyse the profile of women with TS, who are currently followed in endocrinology, regarding: karyotype, age, final height and weight, puberty and fertility, and m...

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ea0063p1129 | Reproductive Endocrinology 2 | ECE2019

Features of the clinical course of prolactinomas in women

Safarova Mijgona , Khalimova Zamira , Issaeva Saodat , Alimova Kamola , Gumarova Aliya

Aim: To study the course of clinical symptoms in women with prolactinomas.Material and research methods: The study included the results of clinical examination and treatment of 73 patients with prolactin-secreting pituitary adenomas. In the main group, 84.9% (62 women) and 15.1% (11 men) aged from 17 to 74 years old, the average age was (38.5±12.6 years). All patients were divided into 2 groups depending on the size of the education. Group I consist...

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ea0063p1130 | Reproductive Endocrinology 2 | ECE2019

The metabolic effects of metformin, cyproterone-acetate and their combination in women with polycystic ovary syndrome

Bozic-Antic Ivana , Ilic Dusan , Bogavac Tamara , Erceg Snjezana , Lacmanovic Mirjana , Popovic Bojana , Isailovic Tatjana , Elezovic-Kovacevic Valentina , Ognjanovic Sanja , Vojnovic-Milutinovic Danijela , Macut Djuro

Introduction: Metformin and oral contraceptive pills (OCP) are the most commonly prescribed medications among women with polycystic ovary syndrome (PCOS). The aim of this study was to compare effects of pill containing cyproterone-acetate (CPA) and metformin (METF) in women with PCOS during six months of follow-up.Methods: Group of 60 women with PCOS diagnosed by ESHRE/ASRM criteria were divided into 3 subgroups (20 women each), which were treated with d...

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ea0063p1131 | Reproductive Endocrinology 2 | ECE2019

Influence of kidney function on sex hormone profile in postmenopausal women

Franz Marcel , Mulling Nils , Benson Sven , Tan Susanne , Reimhardt Walter

Introduction: Disturbances in menstruation and fertility are often reported in women with chronic kidney disease (CKD), particularly in women undergoing dialysis treatment (CKD stage 5). Prolactin (Prl) seems to play a major role in this pathomechanism. However, there are only very few data on the gonadal axis and the androgen status in postmenopausal women with mild to moderate renal failure and in dialysis patients. Therefore, we prospectively studied the sex hormone profile...

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ea0063p1132 | Reproductive Endocrinology 2 | ECE2019

Optimization of hyperproliferative syndrome treatment in woman on the background of obesity

Kondratiuk Kateryna , Kondratiuk Valentyna , Dziuba Galyna

Nowadays fat tissue is considered as endocrine organ responsible for metabolism of sex hormones. Obesity is accompanied by a decrease in biosynthesis of 17β-estradiol (2-hydroxyestrone) inactive metabolites and increased production of aggressive metabolites (16-hydroxyestrone). This factor leads to hyperproliferative syndrome, which includes hormonal-dependent lesions of target organs: uterine leiomyomas, adenomyosis, hyperplasia of endometrium, tumor-like lesions of the ...

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ea0063p1133 | Reproductive Endocrinology 2 | ECE2019

Serum anti-Müllerian hormone is significantly associated with higher luteinizing hormone level in polycystic ovary syndrome

Baculescu Nicoleta , Leonte Laura , Radian Serban , Gheorghiu Monica , Muresan Andrei , Biban Bianca , Baleanu Maria , Grigorescu Florin , Poiana Catalina

Background: Recent data highlight the role of anti-Müllerian hormone (AMH) to trigger the neuroendocrine abnormalities involving GnRH and secretion of gonadotropins in polycystic ovary syndrome (PCOS).Aim: To study factors significantly correlated with neuroendocrine dysfunction in PCOS, with focus on AMH.Subjects and methods: We performed a cross-sectional study in 137 patients with PCOS selected by Rotterdam 2003 criteria an...

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ea0063p1134 | Reproductive Endocrinology 2 | ECE2019

Hyperandrogenism in postmenopausal women

Zunzunegui Nerea Egana , Garay Ismene Bilbao , Calafell Maite Aramburu , Delgado Cristina Garcia , Agea Leire , Cordeu Maite Perez de Ciriza , Arrieta Alfredo Yoldi , Iregui Izaskun Olaizola , Iglesias Miguel Maria Goena

Introduction: The presentation of new onset hyperandrogenism is extremely rare in postmenopausal women. In premenopausal women, the most common cause of androgen excess is polycystic ovary syndrome. In contrast, when hyperandrogenism develops in postmenopausal women, it is usually associated with other causes, such as ovarian hyperthecosis or an androgen secreting tumor. We describe 5 patients with hyperandrogenism (Table 1). Total Testosterone 0.060.86 ng/ml, free testo...

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ea0063p1135 | Reproductive Endocrinology 2 | ECE2019

Assessment of the feasibility and safety of a novel transvaginal ovarian drilling method in a bovine model: ovarian rebalancing

Bongrani Alice , Dupont Mickael , Rame Christelle , Amer Saad , Briant Eric , Dupont Joelle

Polycystic Ovary Syndrome (PCOS), the most common endocrinopathy affecting reproductive-aged women, is characterized by oligo-/anovulation, hyperandrogenism and polycystic ovaries. In PCOS women with anovulatory infertility, the accepted first-line treatment is clomiphene citrate (CC). For patients resistant to CC, laparoscopic ovarian drilling (LOD) is recommended as a second-line therapy. Whilst very effective, LOD is an invasive technique requiring general anaesthesia and a...

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ea0063p1136 | Reproductive Endocrinology 2 | ECE2019

Kisspeptin in regulation of menstrual function in patients with resistant hyperprolactinemia

Vorotnikova Svetlana , Pigarova Ekaterina , Dzeranova Larisa , Fedorova Natal'ya

Introduction: Patients with resistant prolactinomas have reduced fertility todue to chronic anovulation and hypoplasia of uterus and ovaries. SERM tamoxifen demonstrates a recovery of menstrual function and ovulation and reverses the hypoplasia of the uterus. The mechanism of its action in case of hyperprolactinemia is not clear yet.Aim: To study the role of kisspeptin in restoration of reproductive function in patients with prolactinomas treated by tamo...

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ea0063p1137 | Reproductive Endocrinology 2 | ECE2019

Clinical and para-clinical characteristics of Klinefelter syndrome diagnosed in adulthood

Khaldi Safa , Hasni Yosra , Sarra Dimassi , Ach Koussay , Saad Ali

Klinefelter syndrome (KS) is the most frequent sex chromosomal disorder and affects approximately one in 660 newborn boys. The phenotype is variable ranging from nearnormal to a significantly affected individual. Typically, diagnosis is delayed with the majority of patients identified during fertility workup in adulthood, and only 10% of patients diagnosed prior to puberty.Patients and methods: This is an 8-year retrospective study of the cli...

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ea0063p1138 | Reproductive Endocrinology 2 | ECE2019

Abstract Unavailable....

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ea0063p1139 | Reproductive Endocrinology 2 | ECE2019

Androgen steroids profile in follicular fluid of Polycystic Ovary Syndrome (PCOS) women

Bongrani Alice , Plotton Ingrid , Rame Christelle , Guerif Fabrice , Fromenty Pascal , Dupont Joelle

Polycystic Ovary Syndrome (PCOS), the most common endocrinopathy of reproductive-age women, was initially defined by the association of anovulation and clinical and/or biochemical hyperandrogenism (1990 NIH). Since Rotterdam Consensus Conference in 2003, its diagnosis requires the presence of at least two of the following features: oligo-/anovulation, hyperandrogenism and polycystic ovaries on ultrasound. However, since its introduction, this definition was strongly challenged...

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ea0063p1140 | Reproductive Endocrinology 2 | ECE2019

Low levels of kisspeptin in patients with acromegaly

Vorotnikova Svetlana , Pigarova Ekaterina , Dzeranova Larisa , Masenko Valeriy

Introduction: Acromegaly impairs the hypothalamic-pituitary-gonadal (HPG) axis and reproductive function that causes amenorrhea and infertility. The mechanism of these disturbances is not clear. Kisspeptin and neurokinin B are very important neuropeptides regulating cyclic LH release from pituitary due to stimulation of GnRH.Aim: The purpose of this study was to assess the role of key reproductive neuropeptides in regulation of menstrual function in pati...

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ea0063p1141 | Reproductive Endocrinology 2 | ECE2019

Ovarian expression of adipokines in polycystic ovary syndrome: characterisation of the ‘ECHO’ condition

Bongrani Alice , Mellouk Namya , Rame Christelle , Cornuau Marion , Guerif Fabrice , Froment Pascal , Dupont Joelle

Introduction: Polycystic Ovary Syndrome (PCOS) is a very common endocrinopathy affecting 6 to 13% of women of reproductive age and one of the leading causes of female poor fertility. It was initially defined by the association of anovulation and clinical and/or biochemical hyperandrogenism (1990 National Institutes of Health-sponsored conference). Since Rotterdam ESHRE/ASRM Consensus Conference in 2003, polycystic ovaries morphology on ultrasound (ECHO condition) was added as ...

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ea0063p1142 | Reproductive Endocrinology 2 | ECE2019

Changes of steroid hormones in pregnant ex-smokers and their newborns

Jandikova Hana , Adamcova Karolina , Kolatorova Lucie , Skodova Tereza , Simkova Marketa , Parizek Antonin , Starka Luboslav , Duskova Michaela

Smoking has many effects on human health and reproduction. Women are generally recommended to quit smoking before conception. Cessation improves fertility and helps avoid many health risks for the mother and the child and plays an important role in the future development and health of the offspring. We have decided to perform a study following changes in the production of steroid hormones in pregnant smokers and ex-smokers compared to non-smokers. In physiological pregnancies,...

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ea0063p1143 | Reproductive Endocrinology 2 | ECE2019

AdipoRon, an adiponectin receptor agonist, reduces the proliferation and secretion of steroids by human granulosa cells

Grandhaye Jeremy , Plotton Ingrid , Hmadeh Sandy , Bongrani Alice , LeGuevel Remy , Rame Christelle , Dupont Joelle , Froment Pascal

Diet, and especially metabolic dysregulation such as obesity can influence the ovarian activity. Adipose tissue plays an important role since it is known to be one of the most important endocrine organs producing hundreds of cytokines, such as adiponectin. Our team has observed that adiponectin modulated steroid secretion by the ovarian granulosa cells and its concentration in the follicular fluid was influenced by the metabolic status. Recently, a small adiponectin mimetic sy...

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ea0063p1144 | Reproductive Endocrinology 2 | ECE2019

The impact of vitamin D supplementation on HOMA IR and ovulation in patients with polycystic ovarian syndrome

Muzurovic Emir , Vujosevic Snezana

Introduction: Polycystic ovarian syndrome (PCOs) is a common cause of ovarian dysfunction in women with anovulation. Vitamin D plays a physiologic role in reproduction including ovarian follicular development and luteinization via altering anti-müllerian hormone (AMH) signalling, follicle-stimulating hormone sensitivity and progesterone production in human granulosa cells. Low vitamin D levels may exacerbate the symptoms of PCOS, including insulin resistance, ovulatory, m...

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ea0063p1145 | Reproductive Endocrinology 2 | ECE2019

Prevalence of equol production capacity in women with polycystic ovary syndrome (PCOS) and association with reproductive, hormonal and metagenomic parameters before and 3 days after isoflavone challenge

Lindheim Lisa , Haudum Christoph , Ascani Angelo , Trummer Christian , Munzker Julia , Horvath Angela , Obermayer-Pietsch Barbara

Objective: Polycystic ovary syndrome (PCOS) is characterized by biochemical and clinical androgen excess and disturbed ovarian function and is associated with disorders of glucose and lipid metabolism. Isoflavones are phytoestrogens exerting endocrine effects on human hormone and metabolic signaling and may influence symptom penetrance in PCOS. We investigated whether women with PCOS and healthy controls have alterations in their capacity to metabolize hormonally active dietar...

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ea0063p1146 | Reproductive Endocrinology 2 | ECE2019

Recurrent reversal of male congenital hypogonadotropic hypogonadism and atypical fertility: A case report.

Renck Alessandra , Rocha Michelle , Amato Lorena , Schnoll Caroline , Sales Priscila , Latronico Ana , Mendonca Berenice , Costa Elaine , Silveira Leticia

Abstract: Congenital hypogonadotropic hypogonadism (CHH) is characterized by isolated GnRH deficiency in the absence of central anatomical causes. Classically considered to be a permanent disorder, CHH reversal has been reported in up to 15% of cases. However, reversal may not always be life-long, as hypogonadism relapse can occur in a subset of patients. Criteria for reversal normalization of circulating sex steroids, and spontaneous fertility. We report a 26-yrs-old man, who...

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ea0063p1147 | Reproductive Endocrinology 2 | ECE2019

Acne in girls and young women with hyperandrogenism

Sowinska-Przepiera Elzbieta , Patalong-Wojcik Martyna , Andrysiak-Mamos Elzbieta , Kiedrowicz Bartosz , Syrenicz Anhelli

Introduction: Acne vulgaris is the most common skin disorder, which may be sometimes the only early clinical manifestation of hyperandrogenemia. Main role in its pathogenesis play: genetical predisposition as well as hormonal and environmental disturbances, which may begin in puberty. It has been widely discussed at what age and what kind of diagnostics should be performed in this area.Aim of the study: Was to evaluate concentrations of selected hormones...

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ea0063p1148 | Reproductive Endocrinology 2 | ECE2019

Improvement of bone microarchitecture after 30 months of testosterone substitution therapy in young patients with Klinefelter Syndrome

Piot Anne , Plotton Ingrid , Dancer Benoite , Bacchetta Justine , Ailloud Sylviane , Lejeune Herve , Chapurlat Roland , Szulc Pawel , Confavreux Cyrille

Background: Klinefelter Syndrome (KS) patients, defined by a 47 XXY karyotype, suffer from osteoporosis, with an increased risk of mortality after femoral neck fracture. The mechanisms underlying this bone alteration remain unclear.Patients and methods: In KS patients naïve from testosterone substitution therapy (TST), we assessed bone microarchitecture at distal radius and tibia by High Resolution peripheral Computed Quantitative Tomography, and bo...

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ea0063p1149 | Reproductive Endocrinology 2 | ECE2019

Predictive factors of testosterone-induced erythrocytosis on transgender males

Perez-Luis Jesus , Gomez-Alvarez Beatriz , Guirado-Pelaez Patricia

Background: Testosterone therapy (TTh) may produce various side effects, particularly erythrocytosis, with short-acting testosterone (T) injections presenting the greatest risk. Other causes are smoking and obesity. Erythrocytosis increases blood viscosity, which may lead to thromboembolic complications. Aim: to study the frequency of erythrocytosis induced by TTh and its predictive factors on transgender males (TM) in the Gender Unit of our hospital.Met...

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ea0063p1150 | Reproductive Endocrinology 2 | ECE2019

Evolution of referrals for gender dysphoria and trends in the sex ratio: Data from the Trans’Est Gender Identity Centre of the University Hospital of Nancy (2002–2018)

Feigerlova Eva , Pascal Veronique , Ganne-Devonec Marie-Odile , Consolandi Pierre , Klein Marc , Guerci Bruno

Background: During the last decennium, an increase in the number of persons referred to gender identity centres has been observed. Epidemiological data have not yet been formally studied in France. Here we report the experience from the TransEst Gender Identity Centre of the University Hospital of Nancy.Aim: To study the number of people seeking transgender care, the age at referral and the trends in the sex ratio.Methods: Th...

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ea0063p1151 | Reproductive Endocrinology 2 | ECE2019

Psychological issues in turner syndrome

Calanchini Matilde , Fabbri Andrea , Turner Helen E

Introduction: Turner syndrome (TS) affects 1/1700 female, is due to total/partial lack of an X chromosome and besides short stature and gonadal dysgenesis, is associated with several comorbidities. No defined psychiatric condition has been related to TS. However, several case-reports have appeared in psychiatric literature, and TS is reported to be three times more prevalent in schizophrenia compared with the general female population.Aim: To evaluate th...

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ea0063p1152 | Reproductive Endocrinology 2 | ECE2019

Effects of paroxitine on biochemical parameters and reproductive function in male rats

Mosbah Rachid , Chettoum Aziz , Djerrou Zohir , Mantovani Alberto

Selective serotonin reuptake inhibitors (SSRI) are a class of molecules used in treating depression, anxiety, and mood disorders. Paroxetine (PRT) is one of the mostly prescribed antidepressant which has attracted great attention regarding its side effects in recent years. This study was planned to assess the adverse effects of paroxitine on the biochemical parameters and reproductive system. Fourteen male wistar rats were randomly allocated into two groups (7...

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ea0063p1153 | Reproductive Endocrinology 2 | ECE2019

Relationship and sexual experiences in young women with oestrogen deficiency: comparison between women with Turner syndrome and premature ovarian insufficiency

Attard Carol Cardona , Pimblett Antoinette , Puri Davina , Talaulikar Vikram , Davies Melanie , Conway Gerard

Background: Ages at first date and sexual encounter have been observed to be delayed in women with Turners syndrome (TS), with late presentation and delayed puberty induction being the main culprits. There is no equivalent data in women with premature ovarian insufficiency (POI).Objectives: We sought to assess whether age at start of oestrogen replacement therapy (ERT) and amenorrhoea status affected the age at first relationship and sexual experie...

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ea0063p1154 | Reproductive Endocrinology 2 | ECE2019

A rare cause of secondary amenorrhea in a patient with non-classical CAH due to a uterine middle-line developmental defect: Case report

Outas Mariana Costache , Costache Raluca

Introduction: The female genital developmental defects are not common in non-classical congenital adrenal hyperplasia (CAH). The causes of amenorrhea are multifactorial and are due to the incomplete control of hyperandrogenism as well as the increased progesterone, acting in various modes: blunted LH mid-cycle surge, lack of progestin withdrawal action and antagonise the estradiol action on the endometrium. The overtreatment with glucocorticoid results in the suppression of go...

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ea0063p1155 | Reproductive Endocrinology 2 | ECE2019

Metabolic and hormonal improvement after ketogenic VLCD diet (VLCK): Case report

Renck Alessandra , Sajoux Ignacio , Hallak Jorge , Costa Elaine

Obesity has become one of the most important public health problems. Considered as one of the many adverse consequences of overweight and obesity, the maleobesity-associatedsecondary hypogonadism (MOSH) is a very prevalent and undervalued condition. Is characterized by low total testosterone (TT) levels associated to low or inappropriately normal luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Increased aromatase activity, imbalance in the testosterone/estradi...

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ea0063p1156 | Reproductive Endocrinology 2 | ECE2019

Sex hormone-binding globulin (SHBG) as a marker of aggressive prostate cancer

Gyawali Prabin , Selth Luke A , Butler Lisa M , Vincent Andrew D , Hanson Adrienne R , Irani Swati , Ryan Natalie K , Martin Sean A , Heilbronn Leonie K , Wittert Gary A

Background: Sex hormone-binding globulin (SHBG) is a dimeric glycoprotein synthesized in, and secreted from, hepatocytes. SHBG is also expressed in, but not secreted from, the prostate, where its role is unclear. The expression of SHBG is linked to lipid metabolism, and it also modulates transport and availability of androgen. Given its expression in the prostate and role in the androgen signalling axis, we postulated that expression of SHBG will increase in prostate cancer (P...

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ea0063p1157 | Reproductive Endocrinology 2 | ECE2019

Klinefelter syndrome in adults: variability in clinical findings

Barbosa Mariana , Matta-Coelho Claudia , Souto Selma B

Introduction: Klinefelter syndrome (KS) is the most common congenital abnormality causing primary hypogonadism. It occurs in about 1 in 660 live male births. The clinical manifestations include tall stature, small testes, gynecomastia and neurocognitive impairment. Nevertheless, the KS phenotype varies greatly, which might be one of the reasons why the syndrome is highly underdiagnosed. KS is associated with several clinical conditions and increased morbidity/mortality. Testos...

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21st European Congress of Endocrinology

BiosciAbstracts