ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P257 | DOI: 10.1530/endoabs.63.P257

Radiation therapy in patients with pituitary somatotropinomas

Saodat Issaeva, Zamira Khalimova, Adliya Khalikova, Shokhsanam Safarova & Mijgona Safarova


Republican Specialized Scientific and Practical Medical Center of Endocrinology, Tashkent, Uzbekistan.


Purpose: To assess the effect of radiation therapy (RT) in patients with acromegaly, depending on the age of the patients and the activity of the formation.

Materials and methods: The object of the study was 50 patients (36 women and 14 men) with acromegaly who received gamma-therapy in a total dose of 45-60 Gr. The age of patients ranged from 29 to 77 years. By age, the patients were divided into 3 groups: 1st age group-29–44years old-23patients (46%), 2nd group-45–59years old-16 patients (32%), 3rd group-60-79years old-11patients (22%). All patients underwent hormonal (GH, IGF-I) studies in the dynamics of treatment.

Results: The hormone levels of GH and IGF-1 remain high in group I in 22% of patients, and in group III in 9%. Remissions reached 64% in the III group. The highest levels of GH were in the age range from 45 to 59 years old and amounted to 77.5±9.68 mMe/l, and from 26 to 44 years old was 68.1±6.84 mMe/l. After RT, this indicator in both age groups was almost equally depressed, but not to the norm. At the same time, in the Igroup, a decrease in the level of GH is observed in 10 patients, and in the II age group in 9patients it was 9.99±6.2 mMe/l. As the results of the study showed, the use of RT leads to a significant decrease in the level of GH and IGF-1 in all age periods and a particularly significant decrease was observed in age group III.

Conclusions: Thus, the analysis of the results of studying the relationship between the age of patients and the activity of the process at different periods of observation after RT showed that in all age periods, RT is a fairly effective method of treatment and gives positive results in most cases.

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