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Endocrine Abstracts (2019) 63 P980 | DOI: 10.1530/endoabs.63.P980

Diabetes, Obesity and Metabolism 3

The influence of the prediabetes phenotype on the efficacy of lifestyle interventions to improve glycemia, insulin resistance and postprandial hyperinsulinaemia

Zelija Velija Asimi1,2, Almira Hadzovic Dzuvo1,2 & Djinan Al-Tawil2


1University of Sarajevo, Sarajevo, Bosnia and Herzegovina; 2Polyclinic and Daily Hospital ‘dr Al-Tawil’, Sarajevo, Bosnia and Herzegovina.

Three phenotypes of prediabetes are known: impaired fasting glucose (IFG), Impaired glucose tolerance (IGT), and combined IFG/IGT. IFG is associated with impaired early phase and normal second-phase of insulin secretion. IGT is associated with both impaired early and late phase of insulin secretion. Numerous studies have demonstrated efficacy of lifestyle intervention in improving 2-hr oral glucose tolerance and fasting plasma glucose (FPG) in individuals with prediabetes, while other studies have failed to demonstrate improvements in 2-hr oral glucose tolerance and FPG. The aim of this study was to determine the influence of prediabetes phenotype on improvements in glucose homeostasis with resistance training (RT) or low-carb diet.

Methods: Obese prediabetics were treat by resistance training (RT) (IFG=22, IGT=24, IFG/IGT=20; or with low-carb diet (LC) (IFG=23, IGT=25, IFG/IGT=20). RT group (aged 45±5 years.; BMI 34±3.5 kg/m2) completed a resistance training twice per week (approximately 150 minutes per week) for 12 weeks without diet. Low-carb group (aged 44±3.9 years.; BMI 35±4.2 kg/m2) achieved low-carb diet for 12 weeks without physical activity. Body weight and waist circumference, fasting plasma glucose, 2-hr oral glucose tolerance, baseline assessments homeostasis model of insulin resistance (HOMA-IR), estimated insulin sensitivity index (ISI) and oral glucose-induced insulin were examined before and after the intervention.

Results: Waist circumference and BMI were decreased in both group with no difference between phenotypes. Fasting glucose did not change (P>0.05) in RT group but it improved in LC group (6.64±0.32 mmol/l vs 5.65±0.41 mmol/l, P<0.05). However, 2-hr oral glucose tolerance in RT group improved in those with IGT (9.34±0.52 mmol/l vs 7.31±0.71 mmol/l, P<0.05) and IFG/IGT (9.86±0.71 mmol/l vs 8.20±0.81 mmol/l). In LC group 2-hr oral glucose tolerance improved in those with IGT and IFG/IGT; FPG improved in those with IFG. There were no significant changes in ISI and HOMA-IR following the RT program but there were following LC program (P<0.05). Oral glucose-induced insulin secretion was reduced only in the LC group (65±11 mU/l vs 29±9.2 mU/l, P<0.05).

Conclusions: Resistance training appears to improve 2-hr oral glucose tolerance in individuals with prediabetes but did not improve FPG. Low-carb diet affect 2-hr oral glucose tolerance and FPG, and postprandial hyperinsulinemia in obese prediabetic individuals. The individualized approach is suggested to clinician’s for better treatment of individuals with prediabetes.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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