Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2019) 63 EP124 | DOI: 10.1530/endoabs.63.EP124

Internal Medicine-Endocrinology Department, University Hospital-Monastir-Tunisia, Monastir, Tunisia.

Introduction: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that predominantly affects women. The coexisting Klinefelter’s syndrome (47,XXY) and SLE was rare.

Observations: We report a case of a middle-aged male had SLE discovered by arthralgia. He presented hypogonadism. Hormonal examinations showed a low serum testosterone level (0.3 ng/ml), and high follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels (24.1 mlU/ml and 20.2 mlU/ml. Chromosomal analysis revealed a 47,XXY. The diagnosis was therefore Klinefelter’s syndrome (KS) and systemic lupus erythematosus (SLE).

Discussion: This case illustrates that male with Klinefelter Sydrome (KS) may develop SLE manifestations. KS is occasionally associated with autoimmune diseases, such as SLE. A genetic polymorphism on the X chromosome might help explain the female predominance in SLE. This hypothesis could explain the co-existing Klinefelter’s syndrome (47,XXY) and SLE. This autoimmune disease could also be improved by testosterone administration.

Conclusion: Increased diagnostic vigilance of KS in male with SLE is important in order to recognize this diagnosis, the effects of hypogonadism and effects of replacement treatment. Screening for other autoimmune diseases should be recommended.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.