Endocrine Abstracts

Abstract: A 41-year-old woman admitted Ginekological Clinic to surgical intervention due to ovarial enlargement. It was suspected diagnoses of Acromegalia according to the clinical manifestations: amenorrhea, headache, dizziness, enlarged phalangeal digits. nose. The patient underwent laboratory and instrumental investigations. MRI showed the pituitary adenoma (1.4×1.0×1.0 cm), GH, Prolactin and TSH were sharply increased, Ultrasound revealed remarkably enlarged ovaries (Right- 53.4 cm³, left 50.3 cm³). The patient was diagnosed with: Acromegaly and Hyperprolactinemia. It was decided to start treatment with a one-month Radiotherapy, which was followed by Bromocriptine. and Levothyroxine. Furthermore, the patient had autoimmune thyroiditis, primary Hypothyroidism with multinodular goiter and Insulin resistance, which is why Metformin and Levothyroxine were also prescribed. During the 12 yaers dose of Bromocriptine has been reduced and at last, removed six months ago. The sizes of ovaries have remarkably reduced–right one from 53.4 cm³ to 7.2 cm³ and left one from 50.3 to 8.5 cm³. MRI imaging shows only residual disorders in Sella Turcica. There is no increase in pituitary Hormones.

Conclusion: This is rare outcome of Pituitary adenoma treatment The patient is under observation, This case outlines, that in some patients radiotherapy + conservative treatment can be as effective as Surgery.