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Endocrine Abstracts (2019) 63 EP28 | DOI: 10.1530/endoabs.63.EP28

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1Department of Endocrinology, Asclepeion Hospital, Voula, Athens, Greece; 2First Department of Medicine, Asclepeion Hospital, Voula, Athens, Greece; 3Department of Rheumatology, St. Paul’s Hospital, Thessaloniki, Greece.


Introduction: Diseases of the gastrointestinal tract may have on effect on bone quality manifesting either as osteomalacia or as osteoporosis. Gastritis may have an effect on bone as it requires long term treatment with proton pump inhibitors. Gastrointestinal neoplasms may be accompanied by nutrient malabsorption. These diseases may also be related with vitamin D deficiency.

Aim: The aim was to describe two cases of gastrointestinal diseases, namely chronic gastritis and colon cancer who developed osteoporosis.

Cases description: The cases of two patients with gastrointestinal disorders who developed vitamin D deficiency and osteoporosis and osteoporosis, respectively, are described. The first patient, a female aged 84 presented with epigastric pain. Gastroscopy was performed and chronic gastritis was diagnosed. Laboratory investigations revealed levels of 25(OH)D3 15 ng/ml. Bone mineral density of the left femur was measured and revealed a T score of −3.9. The second patient, a female aged 85 presented with right flank pain. Laboratory investigations revealed anemia. Gastroscopy was performed and showed gastritis. Radiology of the abdomen revealed a large malignant colon cancer in the area of the sigmoid. Bone mineral density of the left femur showed a T score of −3.1. In the first case gastritis was managed conservatively and vitamin D and antiosteoporotic treatment were administered. In the second case the colon cancer was surgically removed and antiosteoporotic treatment was given.

Conclusions: The cases of two patients with gastrointestinal disorders are described who presented with vitamin D deficiency and osteoporosis. Gastrointestinal disorders may have an effect on bone quality. They may cause malabsorption, due either to nutrition disorders or to loss of appetite and they may require long term treatment with proton pump inhibitors, which causes bone loss. Additionally, treatment for osteoporosis may be a problem, as some of the drugs for osteoporosis may be accompanied by adverse effects from the gastrointestinal tract, in particular, gastritis. In conclusion, patients with gastrointestinal disorders should be evaluated for osteoporosis and vitamin D deficiency.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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