ECE2019 ePoster Presentations Diabetes, Obesity and Metabolism (42 abstracts)
Insulin resistance and metabolic disorders in women with morbid obesity
Fatma Boukhayatia 1 , Ibtissem Oueslati 1 , Hana Belhadj Hassen 1 , Bassem Hammami 2 , Wafa Grira 1 , Moncef Feki 2 , Fatma Chaker 1 & Melika Chihaoui 1
1Department of Endocrinology, La Rabta hospital, Tunis, Tunisia; 2Laboratory of Biochemistry, La Rabta hospital, Tunis, Tunisia.
Introduction: Metabolic abnormalities are usually linked with obesity. However, a proportion of obese individuals might not be at an increased risk of metabolic complications of obesity and therefore their phenotype can be referred to as metabolically healthy obesity. The aim of our study was to evaluate the metabolic status in women with morbid obesity and to determine its association with insulin resistance.
Methods: In a cross sectional study, we enrolled 50 morbidly obese women. All participants had physical examination and metabolic investigations. Insulin resistance was assessed using the homeostasis model assessment (HOMA-IR) = fasting insulin (uU/ml) × fasting plasma glucose (mmol/l)/22.5.
Results: The average age of participants was 34.2±7.51 years. They had a mean body mass index (BMI) of 44.53±3.97 kg/m2 (range: 40–55.58) and a waist circumference (WC) of 123.38±10.89 cm (range: 100–155). Metabolic syndrome was diagnosed in 96% of cases. The average HOMA index was 4±4.15. Insulin resistance was present in 48% of patients. All cases had metabolic syndrome. BMI (r=0.34, P=0.01), WC (r=0.41, 0.003), Fasting blood glucose (r=0.37, 0.007), triglycerides (r=0.37, 0.008) and uric acid (r=0.34, P=0.01) were positively correlated with the HOMA index. Diabetes or prediabetes (OR=4.8, P=0.01) and hypoHDLemia (OR=2.1, P=0.006) were significantly associated with insulin resistance. However the presence of high blood pressure, hypertriglyceridemia, hypercholesterolemia and hyperuricemia were not associated with insulin resistance.
Conclusion: Our results demonstrated a high prevalence of metabolic syndrome and insulin resistance in morbidly obese women. Insulin resistance was significantly associated with diabetes or prediabestes and hypoHDLemia. Thus, adequate management of morbid obesity is mandatory to prevent the occurrence of these complications.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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