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Endocrine Abstracts (2019) 63 GP78 | DOI: 10.1530/endoabs.63.GP78

Thyroid Autoimmune Disorders

Autoimmune thyroiditis, Graves’ disease and adiponectin, resistin and plasminogen activator inhibitor-1 levels

Celestino Neves1,2,3, João Sérgio Neves1,2, Sofia Castro Oliveira1,2, Oksana Sokhatska2,4, Miguel Pereira1, Ana Oliveira1, José Luís Medina2, Luís Delgado2,4 & Davide Carvalho1,2,3


1Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, Porto, Portugal; 2Faculty of Medicine, University of Porto, Porto, Portugal; 3Institute for Research and Innovation in Health Sciences, University of Porto, Porto, Portugal; 4Service and Laboratory of Immunology, Centro Hospitalar Universitário de São João, Porto, Portugal.

Introduction: The interrelationship between autoimmune thyroiditis, Graves’ disease and plasma adipokines levels remains elusive.

Aims: We aimed to compare the levels of adiponectin, resistin and PAI-1 levels in patients with autoimmune thyroiditis and Graves’ disease.

Subjects and methods: We recorded thyroid function tests, BMI, the levels of total cholesterol (TC), HDL, LDL-cholesterol, triglycerides (TG), apolipoprotein B (ApoB), ApoA1, lipoprotein(a) (Lp[a]), homocysteine, CRP (C-reactive protein), folic acid, vitamin B12, adiponectin, resistin and plasminogen activator inhibitor-1 (PAI-1) in 98 patients with autoimmune thyroid disease (75.9% woman, with a mean age of 46.7±15.3 years). We considered three groups of patients based on their thyroid function: euthyroidism (n=30), hypothyroidism (n=35) or hyperthyroidism (n=33). Statistical analysis was performed with Mann-Whitney test and spearman correlations. The results are expressed as mean±S.D. A two-tailed P≤0.05 was considered significant.

Results: BMI values were significant higher in hypothyroidism compared to hyperthyroid subjects (30.3±9.3vs 25.3±4.7 kg/m2, P=0.03). Serum levels of CRP were significantly elevated in hyperthyroid compared to euthyroid subjects (0.56±0.55 vs 0.30±0.24 mg/dl, P<0.001). The levels of Lp(a) were significantly elevated in hypothyroid compared to hyperthyroid subjects (24.6±30.1 vs 18.6±17.8 mg/dl, P<0.001). When compared to hyperthyroid subjects, those with hypothyroidism showed higher levels of resistin (20.7±22.6 vs 12.7±10.9 ng/ml, P<0.01) and PAI-1 (27.3±25.1 vs 19.9±17.4 ng/ml, P<0.01), and lower levels of adiponectin (21.0±13.vs28.3±14.7 μg/ml, P<0.01). In both hypothyroid and hyperthyroid states the levels adiponectin, resistin and PAI-1 were not correlated with BMI. Adiponectin levels were negatively correlated with free T3 in hyperthyroid subjects (r=−0.35, P<0.05) and with TSH in euthyroid group (r=−0.61, P<0.001). Resistin levels were not correlated with TSH, free T3 or free T4. PAI-1 levels were negatively correlated with free T3 in both hypothyroid (r=−0.42, P<0.05) and hyperthyroid subjects (r=−0.36, P<0.05).

Conclusions: Patients with hypothyroidism due to autoimmune thyroiditis present higher levels of resistin and PAI-1 and lower levels of adiponectin comparing with patients with hyperthyroidism due to Graves’ disease. The interrelations between thyroid function and adiponectin, resistin and PAI-1 may be associated with the pathogenesis of autoimmune thyroid disease and may contribute to the increased cardiovascular risk observed in these patients.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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