Endocrine Abstracts

Introduction: Several studies suggest an association between primary hyperparathyroidism (HPTP) and vitamin D deficiency. Our goal is to study the clinical and biological consequences of vitamin D deficiency in patients with primary hyperparathyroidism, and to determine the impact of Vitamin D deficiency on bone, kidney and heart functions.

Materials and methods: It is a retrospective study of 17 cases with HPTP associated with a vitamin D deficiency. We collected clinical, paraclinical, management and evolution data. All patients underwent a biological and radiological assessment of bone, cardiac and renal functions.

Results and discussion: The mean age was 57.17 years, with a sex ratio (F/M) of 0.23. The mean vitamin D value was 11.37 ng/mL, with a mean PTH value of 391 ng/L. Patients with vitamin D deficiency had a significantly higher PTH rate than patients with normal vitamin D levels (P=0.04). Mean serum calcium value was 117 mg/l, with no significant association with vitamin D level. Bone assessment showed an abnormal ODM in 70% of patients, radiological abnormalities were found in 29.4% of patients, these abnormalities didn’t have any correlation to the rate of vitamin D. The assessment of renal function showed that 11% of patients had renal failure, while 35.6% had urolithiasis.

Conclusion: Our study suggests that vitamin D deficiency in patients with primary hyperparathyroidism is associated with a higher rate of PTH, and occurrence of bone complications.