ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P1218 | DOI: 10.1530/endoabs.63.P1218

Association of polycystic ovary syndrome and graves' disease - case report

Cristina Corina Pop Radu1,2

1University of Medicine, Pharmacy, Science and Technology, Department of Endocrinology, Tirgu Mures, Romania; 2Mures County Clinical Hospital, Compartment of Endocrinology, Tirgu Mures, Romania.

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine system disorder among women of reproductive age. Although some studies have suggested an association between PCOS and autoimmune thyroiditis, only a few cases indicating association between PCOS and Graves’ disease are reported.

Case report: We present a woman aged 29 with Graves' disease certified by suppressed TSH (0.001 mUI/l), high FT4 (6.6 ng/dl) associated with elevated TRAb (32 IU/l) and elevated TPOAb (476 IU/l). BMI was 21.33 kg/m2, menarche at 12.6 years, oligomenorrhea for about 1 year, waist circumference 76 cm, Ferriman - Gallwey score was 15. Total testosterone was 77.02 ng/dl (25.0–65), LH and FSH was 19 IU/l (2–19) and 7.33 IU/l (4.5–9.31) respectively with LH/FSH ratio 2.59. Prolactin and 17-hydroxyprogesterone was in the normal range. The transabdominal USG was suggestive for PCOS by presence of 10–11 peripheral follicles each 2–7 mm in diameter in both ovaries.

Conclusions: The association of a Graves’ disease with PCOS is unlikely to be because of a chance alone and may point to a common aetiopathogenic linkage.

Keywords: Autoimmunity, Graves’ disease, polycystic ovary syndrome

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