Background: Measurement of thyroglobulin (Tg) in the washout fluid of fine-needle aspirates (FNA-Tg) is useful for diagnosis of Cevical lymph node (CLN) metastasis in papillary thyroid carcinoma (PTC).
Objective: The aim of this study was to evaluate the relationship between FNA-Tg levels and Sonographic findings in CLN in patients with PTC.
Methods: Since January 2017 until December 2018, an ultrasound-guided fine-needle aspiration was done in 34 patients with suspicious CLNs to obtain material for cytology and FNA-Tg.
Results: Data from 34 subjects with suspicious CLN were evaluated. 20 had a cytological diagnosis compatible with PTC lymph node metastases and the median value of FNA-Tg was 2801 μg/L (20420600). While the other 14, had Tg-PAAF levels of 0.04 μg/L (0.040.04) and the cytology results were compatible with lymphoid hyperplasia in 13 patients and 1 compatible with lymph node metastasis of undifferentiated thyroid carcinoma. In the group with Tg-FNA> 1 μg/L the short axis of the adenopathy was larger (0.80 cm vs 0.46 cm, P<0.05), with a higher frequency of: microcalcifications (50% vs 7%, P< 0.05), cystic changes (60% vs 7%, P<0.05) and presence of more than one suspicious Sonographic findings (100% vs 10%, P<0.05).
Conclusion: FNA-Tg measurement is a simple and effective technique, as a complement to cytology and thyroid ultrasound in the diagnosis of lymph node metastases in the patient with PTC.
18 - 21 May 2019
European Society of Endocrinology