ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P1226 | DOI: 10.1530/endoabs.63.P1226

Thyroglobulin in the washout fluid from lymph node fine-needle aspiration and Ultrasound features

Beatriz Torres Torres1,2, Susana García Calvo1,2, Gonzalo Díaz Soto1,2, Juan José López Gómez1,2, Cristina Serrano Vallés1,2, Rebeca Jimenez Sahagún1,2, Ana Ortolá Buiges1,2, Esther Delgado García1,2, Emilia Gómez Hoyos1,3 & Daniel De Luis Román1,2


1Hospital Clínico de Valladolid, Valladolid, Spain; 2Instituto de Endocrinología y Nutrición, Universidad de Valladolid, Valladolid, Spain; 3Universidad de Valladolid, Valladolid, Spain.


Background: Measurement of thyroglobulin (Tg) in the washout fluid of fine-needle aspirates (FNA-Tg) is useful for diagnosis of Cevical lymph node (CLN) metastasis in papillary thyroid carcinoma (PTC).

Objective: The aim of this study was to evaluate the relationship between FNA-Tg levels and Sonographic findings in CLN in patients with PTC.

Methods: Since January 2017 until December 2018, an ultrasound-guided fine-needle aspiration was done in 34 patients with suspicious CLNs to obtain material for cytology and FNA-Tg.

Results: Data from 34 subjects with suspicious CLN were evaluated. 20 had a cytological diagnosis compatible with PTC lymph node metastases and the median value of FNA-Tg was 2801 μg/L (204–20600). While the other 14, had Tg-PAAF levels of 0.04 μg/L (0.04–0.04) and the cytology results were compatible with lymphoid hyperplasia in 13 patients and 1 compatible with lymph node metastasis of undifferentiated thyroid carcinoma. In the group with Tg-FNA> 1 μg/L the short axis of the adenopathy was larger (0.80 cm vs 0.46 cm, P<0.05), with a higher frequency of: microcalcifications (50% vs 7%, P< 0.05), cystic changes (60% vs 7%, P<0.05) and presence of more than one suspicious Sonographic findings (100% vs 10%, P<0.05).

Conclusion: FNA-Tg measurement is a simple and effective technique, as a complement to cytology and thyroid ultrasound in the diagnosis of lymph node metastases in the patient with PTC.