ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P45 | DOI: 10.1530/endoabs.63.P45

Pheochromocytoma and disorders of carbohydrate metabolism

Siham E lmir, Yousef Yaden, Siham Rouf & Hanene Latrech

Endocrinology and Diabetology Department, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, Oujda, Morocco.

Introduction: Pheochromocytoma is a rare tumor secreting catecholamines, which are part of the hormones of carbohydrate counter-regulation. The aim of our work is to evaluate the glycemic balance in patients in pre- and post-operative pheochromocytoma.

Material and methods: A retrospective study of 18 cases of pheochromocytoma over a period of 5 years. A pre- and post-operative metabolic assessment was performed as well as an evaluation of the other clinical parameters.

Results: The mean age of the patients was 47 years (Sex F/H ratio: 2.6). Diabetes is found in 50% of patients and had the following characteristics: the average evolution of 5.7 years, with a strong type II diabetic heredity in 67.1% of cases and an average body mass index of 26.4 kg/m2. One-third of patients had HBA1C greater than 8%. No diabetic patient had a ketoacidosis decompensation, and 55.5% of our diabetic patients were under INSULNE + oral anti-diabetic on admission. In postoperative: only 22% of our patients were on oral anti-diabetic + Insulin, blood glucose level normalized in 22% of cases under no treatment, improved in 33% of cases under the same treatment and average HBA1C decreased from 7.57% in pre-op to 6.65% in post-op.

Discussion: The glucoregulation disorder of pheochromocytoma is quite common in our series as in some literature results. The radical surgery of pheochromocytoma has a remarkable impact on the glycemic balance.

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