ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P486 | DOI: 10.1530/endoabs.63.P486

Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism

Arzu Or Koca1,2,3,4,5,6

1Murat, Dağdeviren, Turkey; 2Tolga, Akkan, Turkey; 3İhsan, Ateş, Turkey; 4Salim, Neşelioğlu, Turkey; 5Özcan, Erel, Turkey; 6Mustafa, Altay, Turkey.

Purpose: In this study, we aimed at determining the dynamic thiol/disulfide homeostasis and oxidant balance, and investigating the relation of these parameters to the severity of the disease and the serum calcium levels.

Material and method: 55 patients with iatrogenic hypoparathyroidism follow-ups, and 40 healthy volunteers were included in the study. The blood dynamic thiol/sulfide balance, Total Antioxidant Status (TAS), Total Oxidant Status (TOS), Paraoxonase Enzyme Activity (PON) levels were measured in serum samples.

Findings: In our study, it was found that the disulfide, disulfide/native thiol, disulfide/total thiol levels were higher in the hypoparathyroidism group. A negative correlation was found between 25 hydroxy vitamin D (25 – OH vitamin D) and disulfide, disulfide/native thiol and disulfide/total thiol, and a positive correlation was found between native thiol and total thiol ratio; and the corrected calcium levels and PON levels were negatively correlated.

Discussion: Consequently, a change in favor of disulfide was found in the dynamic thiol disulfide homeostasis in the hypoparathyroidism group in our study.

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