ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P509 | DOI: 10.1530/endoabs.63.P509

Association between 25 hydroxyvitamin D levels and insulin resistance in a cohort of obese subjects

Maria Hayón Ponce, Maria del Carmen Serrano Laguna, Sara León Utrero, Enrique Redondo Torres, Socorro Leyva Martín, Maria Luisa Fernández Soto & Elena Torres Vela

Hospital Universitario San Cecilio, Granada, Spain.

Objetive: Obesity is associated with lower serum vitamin D (25(OH)D3) levels through several mechanisms. The aim of the study was to determine the prevalence of vitamin D deficiency and to examine the association between insulin resistance and 25(OH)D3 levels in a cohort of obese subjects.

Materials and methods: 85 obese subjects were enrolled into the study from october to december 2018. Demographic, anthropometric and clinical parameters were assessed. Serum fasting levels of 25(OH)D3, insulin, glucose, uric acid and lipids (triglycerides, total, HDL and LDL cholesterol) were measured. Insulin resistance was assessed by using the homeostasis model assessment (HOMA2-IR, HOMA2-%S and HOMA2-%B). Vitamin D deficiency was defined by levels of 25OHD3 <10 ng/ml.

Results: 85 obese subjects (58 women and 27 men), mean age 43.8±14.5 years. BMI 43.6±8.2 Kg/m2, SBP 133.4±18.7 mmHg, DBP 84.6±11.1 mmHg, fasting glucose 100.8±30.6 mg/dl, HbA1c 6.01±1.05%, total cholesterol 18.4±33.8 mg/dl, HDL-c 47.8±10.4 mg/dl, LDL-c 111.5±28.2 mg/dl, triglycerides 152.8±84.8 mg/dl, 25OHD3 17.5±6.01 ngl/ml. Vitamin D deficiency was present in 5.88% of subjects. 25(OH)D3 levels were significantly and negatively correlated with HOMA2-% B (P=0.07) and serum insulin (P=0.09). 25(OH)D3 levels were also reported to be directly related to HOMA2-% S (P=0.01).

Conclusion: We found an association between vitamin D and hyperinsulinemia. These results suggest that serum vitamin D deficiency could be an insulin resistance marker.

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