Introduction: In obesity and overweight, inflammation is associated with a progressive infiltration of immune cells causing cytokine secretion into adipose tissue. Objective. Evaluation of adipocytokines derived from adipose tissue and immune cells (adiponectin, resistin, TNF-α and IL-6). Materials and methods. 150 adults divided up in 3 groups; obese, overweight and controls. Adipocytokines (adiponectin, resistin, TNF-α and IL-6) were quantified by ELISA, serum insulin concentrations were assessed by RIA, and were used to calculate HOMA-IR, metabolic parameters (glycemia, triglycerides, HDLc, LDLc, cholesterol) by spectrophotometry. Results. In overweight and obese subjects, a very pronounced state of insulin resistance has been observed associated with hyperinsulinism and an imbalance in the level of pro-/anti-inflammatory adipocytokines, characterized by an increase in TNF-α, IL-6 and resistin and a decrease in adiponectin. Conclusion. The imbalance in adipocytokines levels is a biomarker of inflammation and characterizes overweight and obesity.
Keywords: resistin, adiponectin, overweight, obesity, insulin resistance
18 - 21 May 2019
European Society of Endocrinology