ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P559 | DOI: 10.1530/endoabs.63.P559

Inflammation and adipocytokines in overweight and obesity

Hassiba Benbaibeche1,2 & Elhadj Ahmed Koceïr2

1Université Alger 1, Faculté des Sciences, Département des Sciences de la Nature et de la vie., Algiers, Algeria; 2Bioenergetics and Intermediary Metabolism Laboratory, Department of Biological Sciences and Physiology, Faculty of Biologic Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria.

Introduction: In obesity and overweight, inflammation is associated with a progressive infiltration of immune cells causing cytokine secretion into adipose tissue. Objective. Evaluation of adipocytokines derived from adipose tissue and immune cells (adiponectin, resistin, TNF-α and IL-6). Materials and methods. 150 adults divided up in 3 groups; obese, overweight and controls. Adipocytokines (adiponectin, resistin, TNF-α and IL-6) were quantified by ELISA, serum insulin concentrations were assessed by RIA, and were used to calculate HOMA-IR, metabolic parameters (glycemia, triglycerides, HDLc, LDLc, cholesterol) by spectrophotometry. Results. In overweight and obese subjects, a very pronounced state of insulin resistance has been observed associated with hyperinsulinism and an imbalance in the level of pro-/anti-inflammatory adipocytokines, characterized by an increase in TNF-α, IL-6 and resistin and a decrease in adiponectin. Conclusion. The imbalance in adipocytokines levels is a biomarker of inflammation and characterizes overweight and obesity.

Keywords: resistin, adiponectin, overweight, obesity, insulin resistance

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