Searchable abstracts of presentations at key conferences in endocrinology
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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Poster Presentations

Diabetes, Obesity and Metabolism 2

ea0063p526 | Diabetes, Obesity and Metabolism 2 | ECE2019

Hypoglycemia as a first symptom of fructosemia, complicated by gestational diabetes in III pregnancy and 26 years of delayed final diagnosis: a case report

Kederys Andrius , Pauliukiene Renata , Petrenko Vladimiras

Introduction: Fructosemia is a rare autosomal recessive genetic metabolic disorder, caused by mutations in the ALDOB (9q22.3) gene, encoding the enzyme aldolase B. This case shows that fructosemia typically causes hypoglycemia. This disorder should be included in differential diagnosis. Prevalence of GDM in women with fructosemia is unknown, but it is a rare condition1.Case: Five month old female baby arrived in 1976 to the Hospital o...

ea0063p527 | Diabetes, Obesity and Metabolism 2 | ECE2019

Artificial intelligence for the remote evaluation of gestational diabetes using a smartphone application (Sinedie©): Study design.

Albert Lara , Subias David , Casamitjana Laia , Mazarico Isabel , Caballero-Ruiz Estefania , Garcia-Saez Gema , Martin-Redondo Pablo , Hernando Elena , Rigla Mercedes

Background: Gestational diabetes (GD) prevalence is increasing as the obesity epidemic continues. Its management involves hospital visits every 1–2 weeks. In 2016 our team developed a web-based telemedicine platform (SineDie©). This tool operated as a clinical decision support system designed to manage the treatment of patients with GD. SineDie© automatically prescribed diet recommendations and identified the necessity of insulin treatment....

ea0063p528 | Diabetes, Obesity and Metabolism 2 | ECE2019

Adolescent type 1 diabetes self-management: what about dietary regimen?

Jemel Manel , Chelbi Safa , Kandara Hajer , Stambouli Islem , Mansouri Leila , Kammoun Ines

Introduction: Nutritional management and adequate food intake is one of the fundamental cornerstones in the treatment of Type 1Diabetes Mellitus (Type 1 DM) to achieve optimal diabetes control, and reduced risk of micro vascular complications. Despite this emphasis on the importance of dietary education and management, the actual dietary intake of Tunisian adolescents with diabetes is not well documented.Aim: The aims were to describe the food and nutrie...

ea0063p529 | Diabetes, Obesity and Metabolism 2 | ECE2019

Epicardial fat accumulation in non-alcoholic liver disease and impaired glucose metabolism

Zelaya Carolina Maria Perdomo , Vaamonde Javier Gargallo , Goni Marta Garcia , Cardenas Juana Karina Zapata , Kollozi Ina , Valero Maria Llavero , Santos Jose Ignacio Herrero , Aleman Gorka Bastarrika , Martin Francisco Javier Escalada San

Patients with impaired glucose metabolism, either prediabetes (preD) or type 2 Diabetes (T2D), and non-alcoholic fatty liver disease (NAFLD) have a higher prevalence of cardiovascular events. Recent studies have shown a relationship between epicardial fat and myocardial ischemia.Objective: To determine whether hepatic fibrosis assessed by liver elastography (LE) or Fibrosis-4 (FIB-4) score correlates with epicardial fat volume quantified by computed tomo...

ea0063p530 | Diabetes, Obesity and Metabolism 2 | ECE2019

Vitamin B12 and gestational diabetes mellitus

Kouroglou Eleni , Anagnostis Panagiotis , Daponte Alexandros , Bargiota Alexandra

Objective/Design: Gestational diabetes mellitus (GDM) has been associated with serious complications for both the pregnant woman and the newborn. Vitamin B12 is implicated in some important metabolic procedures such as methylation and one carbon cycle and its deficiency can cause serious health problems, such as hyperhomocysteinemia, defective synthesis of neurotransmitters and fatty acids and more. However, it is not known if there is a link between vitamin B12 deficiency and...

ea0063p531 | Diabetes, Obesity and Metabolism 2 | ECE2019

TRMA syndrome (thiamine-responsive megaloblastic anemia): a case report

Jemel Manel , Jemel Manel , Jemaa Maroua Ben , Kandara Hajer , Jemni Houda , Kammoun Ines

Introduction: Thiamine responsive megaloblastic anemia (TRMA) syndrome, also known Rogers syndrome is a rare autosomal recessive inherited disorder characterized by a triad features of megaloblastic anemia, sensorineural deafness and diabetes mellitus. TRMA manifestation is caused by mutations in the gene SLC19A2 encoding a high-affinity thiamine transporter, which disturbs the active thiamine uptake into cells.Case Presentation...

ea0063p532 | Diabetes, Obesity and Metabolism 2 | ECE2019

Study on efficacy of long-term education for achieving compensation of type 1 diabetes mellitus in children Almaty region of Kazakhstan

Tashmanova Akmaral , Rakhimova Gulnara , Berkinbaev Salim

Background: Education is a basic component – to assess achievement of compensation in children and adolescents with type 1 diabetes mellitus within a 3-year period after training.Aim: The work was initiated to assess level of knowledge and compensation degree in children and adolescents with type 1 diabetes mellitus in ‘Type 1 Diabetes School’.Materials and methods: A five-day training course was conducted in ‘T...

ea0063p533 | Diabetes, Obesity and Metabolism 2 | ECE2019

A novel oral pyruvate dehydrogenase kinase 4 inhibitor ameliorates various spectrum of metabolic diseases in mice

Jeon Jae-Han , Lee In-Kyu , Choi Yeon-Kyung , Park Keun-Gyu , Kim Na-Young , Park Sung Don , Ahn Jin Hee , Kim Min-Ji

Pyruvate dehydrogenase kinase 4 (PDK4) activation is associated with metabolic diseases including hyperglycemia, insulin resistance, allergies, and cancer. We report here a new series of allosteric PDK4 inhibitor modified from hit anthraquinone. A novel PDK4 inhibitor, namely compound 8c, improved glucose tolerance in diet-induced obese mice. PDH activity in muscle and liver was enhance d by compound 8c treatment. Given the importance of PDK4 in immune cells including mast cel...

ea0063p534 | Diabetes, Obesity and Metabolism 2 | ECE2019

Quality of life in patients undergoing bariatric surgery

Merino-Molina Sara , Rebollo-Roman Angel , Herrera-Martinez Aura-Dulcinea , Alcantara-Laguna Maria-Dolores , Munoz-Jimenez Concepcion , Manzano-Garcia Gregorio , Calanas-Continente Alfonso , Molina-Puerta Maria-Jose

Aim: Evaluate results of bariatric surgery by using the Bariatric analysis and reporting outcome system (BAROS) scoring systemPatients and methods: Observational clinical study of consecutive cases of patients undergoing bariatric surgery in Reina Sofia University Hospital (Córdoba, Spain) and clinical follow-up in the Endocrinology service between January and December 2018. Statistical analysis performed with SPSS 24th version.<p class="abstext...

ea0063p535 | Diabetes, Obesity and Metabolism 2 | ECE2019

Metabolic encephalopathy secondary to diabetic ketoacidosis

Tomkins Maria , McCormack Richard , O'Connell Karen , Agha Amar , Merwick Aine

Case presentation: A 35-year-old man presented to the emergency department (ED) in a confused and agitated state. His past medical history was significant for poorly controlled type 1 diabetes, complicated by background diabetic retinopathy. He was taking basal/bolus insulin and had a history of diabetic ketoacidosis (DKA) eleven years prior. He also had multiple sclerosis however disengaged with neurology services and was non-compliant with interferon therapy. Prior to admiss...

ea0063p536 | Diabetes, Obesity and Metabolism 2 | ECE2019

Maternal weight status and gestational diabetes

Alla Achwak , Benyakhlef Salma , Latrech Hanane

Introduction: Gestational diabetes and maternal obesity have long been regarded as risk factors for pregnancy. The amount of weight gained during pregnancy can affect the immediate and future health of a woman and her infant [1]. The objective of our study is to evaluate the impact of maternal weight status on the glycemic profile of women followed for gestational diabetes.Materials and methods: This is a retrospective study over three years, including 2...

ea0063p537 | Diabetes, Obesity and Metabolism 2 | ECE2019

Diabetic retinopathy: Prevalence and risk factors

Elmir Siham , Rouf Siham , Boujtat Khadija , Latrech Hanane

Intoduction: Diabetic retinopathy remains one of the major causes of blindness. The management of the diabetic patient is multidisciplinary. The objective is to study the prevalence of retinopathy in a group of type 2 diabetic patients and to update the risk factors.Patients and methods: This is a cross-sectional study during 3 years of 129 type 2 diabetic patients followed up for endocrinology and metabolic diseases at the Mohammed VI University Hospita...

ea0063p538 | Diabetes, Obesity and Metabolism 2 | ECE2019

Efficacy of plasmapheresis in the management of severe hypertriglyceridemia

Yazan Ceyda Dincer , Imre Eren , Yavuz Dilek Gogas

Objective: Severe hypertriglyceridemia is one of the leading causes of acute pancreatitis which is associated with increased mortality and morbidity. Here we evaluate the effectiveness of plasmapheresis on triglyceride levels in our group of patients who had plasmapheresis in our endocrinology clinic.Method: We retrospectively evaluate clinical and laboratory reports between 2016–2018, for demographic parameters and the lipid levels before and immed...

ea0063p539 | Diabetes, Obesity and Metabolism 2 | ECE2019

Insulin pump therapy in patients with type 1 diabetes in Morocco

Rouf Siham , Benyakhlef Salma , Latrech Hanane

Introduction: Strict metabolic control is the main purpose in the management of type 1 diabetes in order to prevent patients from macro or microvascular complications. The therapy of type 1 diabetes was optimized by the basal-bolus regimens with multiple daily injections in addition to the educational programs such as flexible insulin therapy. Nevertheless, despite all those therapeutic approaches, the metabolic control is not always obtained. The specific aim of our study is ...

ea0063p540 | Diabetes, Obesity and Metabolism 2 | ECE2019

Role of proinflammatory cytokines TNF-α and IL-6 in pathogenesis of type 2 diabetes mellitus in persons exposed to ionizing radiation after the Chernobyl NPP accident

Dombrovska Natalya , Kaminskyi Oleksii , Afanasyev Dmitrii , Pleskach Oksana , Bazyka Dimitrii

Contemporary research data indicate that pancreatic beta cells are sensitive to ionizing radiation. Our recent studies showed a significant (2–3-fold) increase in the type 2 diabetes mellitus (T2DM) incidence in adults exposed to ionizing radiation in a young age within 1986–1990 time period compared to the entire population of Ukraine. Currently there are no data on the time pattern of content of proinflammatory cytokines TNF-α and IL-6 in the clean-up workers ...

ea0063p541 | Diabetes, Obesity and Metabolism 2 | ECE2019

A case of DRESS syndrome associated with autoimmune type 1 diabetes

Mattei Isabella , Fernandez Elena Garcia , Lopez Gema Villa , Rodriguez Irene Hoyas , Guerra Guillermo Martinez Diaz , Sanz Miguel Leon

Introduction: DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome is a severe multiorgan drug reaction, often associated with the development of autoimmune diseases. Pathogenically it has been related to the reactivation or the primary infection of different herpes virus.Clinical case: A 33-year-old woman with a history of residual epilepsy, after resection of a cerebellar pleomorphic xantoastrocytoma, started treatment with Levetirace...

ea0063p542 | Diabetes, Obesity and Metabolism 2 | ECE2019

Examination of the care pathways of adults with diabetes undergoing haemodialysis for end stage renal failure

Collins Louise , Plant Liam

Background: Management of diabetes in patients with End Stage Renal Failure (ESRF) is complex, requiring intervention from multiple disciplines. The Joint British Diabetes Societies and Renal Association published the first ever guidelines for the management of patients with diabetes undergoing haemodialysis for ESRF in 2017.Aims and objectives: Assess Current Care Pathways of all patients with Diabetes undergoing Haemodialysis in Cork University Hospita...

ea0063p543 | Diabetes, Obesity and Metabolism 2 | ECE2019

Exploratory study into communication styles of diabetes healthcare professionals according to their patients numerical ability

Menon Vaishnavi , Harris Sophie , Brackenridge Anna , Amiel Stephanie

Background and aims: Type 1 diabetes mellitus (T1DM) requires daily self-management to mimic endocrine function, using numerical skills such as carbohydrate counting and interpreting nutritional information. Healthcare professionals (HCPs) rely on effective communication to relay information to people with T1DM to enable good self-care. Curricula for diabetes self-management education (DSME) courses require high-school level numerical skills. Eighty percent of adults in the Un...

ea0063p544 | Diabetes, Obesity and Metabolism 2 | ECE2019

Enterotypes of the gut microbiome in Russian population and their metabolic activity

Egshatyan Lilit , Tkacheva Olga , Popenko Anna , Doudinskaya Katharina

Background: Network analysis of species abundance across different individuals suggested that the overall structure of the human gut microbiota in each individual conforms to discrete and distinct patterns defined by interactions within community members. This hypothesis was investigated using a dataset of metagenomic sequences from American, European and Japanese individuals. Multidimensional cluster analysis and principal component analysis revealed that all individual sampl...

ea0063p545 | Diabetes, Obesity and Metabolism 2 | ECE2019

Lipid profile and cardiovascular risk in ankylosing spondylitis

Athanassiou Panagiotis , Tzanavari Aikaterini , Athanassiou Lambros , Dardavesis Theodoros , Ifigenia Kostoglou-Athanassiou

Introduction: Ankylosing spondylitis (AS) is a chronic systemic inflammatory disorder which affects the sacroiliac joints, the axial skeleton, peripheral joints as well as other organs. It develops in young adults causing significant mobility and functional disorders, with associated severe dysfunction or disability. Ankylosing spondylitis has serious adverse effects on the ability to work and quality of life. Biologic agents are used for the treatment of AS, this effect havin...

ea0063p546 | Diabetes, Obesity and Metabolism 2 | ECE2019

Diagnostics of carbohydrate metabolism according to the regularity of menstrual cycle

Makhlina Elena , Navmenova Yana

Objectives: To analyze the presence of correlation between DHEA-S level and glycemic indices at CGMS of intercellular fluid according to the regularity of menstrual cycle of women with type 1 diabetes mellitus.Methods: The study of daily dynamics of glucose has been performed with continuous glucose monitoring system (CGMS) Medtronik MINIMED company, the USA. The study involved 155 patients with type 1 diabetes mellitus. The patients were divided into 2 ...

ea0063p547 | Diabetes, Obesity and Metabolism 2 | ECE2019

Clinical characteristics and foot amputations rate in patients treated in a multidisciplinary diabetic foot unit

Avila-Rubio Veronica , Lopez-Ibarra-Lozano Pablo J , Serrano-Laguna Carmen , Herrera-Mingorance Jose Damian , Moreno-Escobar Jose , Torres-Vela Elena

Objective: This study reviews the clinical characteristics of patients treated in a Multidisciplinary Diabetic Foot Unit (MDFU) and analyzes the rate of diabetic foot amputations and the risk factors associated.Design and methods: A retrospective cohort study including data from all patients who attended the MDFU during December 2017-October 2018 period. The patients were followed until January 2019. Clinical, anthropometric, and biochemical parameters (...

ea0063p548 | Diabetes, Obesity and Metabolism 2 | ECE2019

Microbiota changes in type 2 diabetes patients intolerant to metformin after drug reintroduction

Munoz-Garach Araceli , Diaz-Perdigones Cristina Maria , Moreno-Indias Isabel , Molina-Vega Maria , Cornejo-Pareja Isabel , Tinahones Francisco J

Introduction and objectives: Metformin (MTF) is the most used oral antidiabetic drug for the treatment of type 2 diabetes (T2D). However, intolerance to drug is frequent and limits its use. There are controversies about the cause of this problem, the gut microbiota has been proposed to be responsible. The gradual introduction of MTF could exercise an adaptation of gut microbiota that would facilitate tolerance to MTF. In this study we evaluate the metabolic changes and gut mic...

ea0063p549 | Diabetes, Obesity and Metabolism 2 | ECE2019

PRIMAVERA study: sibutramine therapy safety monitoring in patients with obesity

Troshina Ekaterina , Mazurina Natalya , Galieva Marina , Melnichenko Galina , Dedov Ivan

Objective: The aim of the study was to assess the effectiveness and safety of long-term sibutramine therapy in routine clinical practice.Materials and methods: In total, 98 774 patients (82.3% women, 17.7% men), from 142 cities of the Russian Federation were enrolled in the PRIMAVERA program. The mean age of the patients was 39.39±10.38 years, the mean body weight was 99.1±14.28 kg, and the mean BMI was 35.7±4.41 kg/m2. Physicia...

ea0063p550 | Diabetes, Obesity and Metabolism 2 | ECE2019

Does therapeutic education really prevent lipodystrophy?

Laidi Soukaina , Elaziz Siham , Chadli Asmaa

Introduction: Therapeutic education (TE) on injection techniques and zooning is a key step for any insulin-treated patient. Our study’s objective was to evaluate the role of ET and the number of sessions required to prevent lipodystrophies (LD).Materials and methods: We conducted a prospective study including any diabetic insulin-treated patient for more than 6 months, followed in our unit between February 2015 and June 2017. Patients responded to a...

ea0063p551 | Diabetes, Obesity and Metabolism 2 | ECE2019

Insulin injection techniques: what do moroccan diabetic patients do?

Laidi Soukaina , Elaziz Siham , Chadli Asmaa

Introduction: A good injection technique is crucial to ensure that insulin is properly administered into the subcutaneous tissue and then released at the right time, to avoid some common complications such as lipodystrophies (LD). The objective of our study is to evaluate injection techniques in Moroccan diabetic patients.Materials and methods: We conducted a prospective study including any diabetic insulin-treated patient for more than 6 months, followe...

ea0063p552 | Diabetes, Obesity and Metabolism 2 | ECE2019

The reuse of insulin needles: a problem with consequences (about 1000 cases)

Laidi Soukaina , El Aziz Siham , Chadli Asmaa

Introduction: Changing needles and syringes when injecting insulin is often included in recommendations on injection techniques and in education sessions. The objective of our study was to evaluate the rate of insulin needle reuse and its consequences.Materials and methods: We conducted a prospective study including any diabetic insulin-treated patient for more than 6 months, followed up at the service between February 2015 and June 2017. Patients respon...

ea0063p553 | Diabetes, Obesity and Metabolism 2 | ECE2019

Polymorphisms of genes GNB3, SERT, NET, TPH2 and results of obesity treatment with sibutramine

Mazurina Natalya , Galieva Marina , Troshina Ekaterina , Volynkina Anna , Artyushin Andrey , Pavlova Anastasiya , Logvinova Oksana

Introduction: Results obtained from PRIMAVERA study have demonstrated that 7.5% of obese individuals does not respond to sibutramine therapy. The aim of the study was to evaluate if GNB3, SERT, NET, TPH2 genes polymorphisms are associated with the results of obesity treatment with sibutramine.Methods: 69810 obese patients took sibutramine for at least 3 months. According to the results of 3 months therapy, we formed two groups of patients: 1) &#...

ea0063p554 | Diabetes, Obesity and Metabolism 2 | ECE2019

Microcirculatory disorders in adolescents with tipe 1 diabetes mellitus

Nikolaeva Nataliia , Bolotova Nina , Averianov Andrei , Dronova Elena , Nikolaeva Nadezhda , Poliakov Vadim

Microcirculatory disorders play important role in pathogenesis of diabetic vascular complications.Aim: To study peculiarities of microcirculatory haemostasis (tromboresistance of vessel wall and functional activity of thrombocytes) in adolescents with type 1 diabetes mellitus (T1DM).Patients and methods: 80 adolescents (42 boys, 38 girls) 11–16 y.o. with T1DM were examined. The duration of the disease was: less than 1 year - i...

ea0063p555 | Diabetes, Obesity and Metabolism 2 | ECE2019

Therapeutic and nutritional compliance in diabetic patients in the Endocrinology-Diabetology-Nutrition Department of Mohammed VI University Hospital Center in Oujda

Bouali Houda , Assarrar Imane , Latrech Hanane

Introduction: The non-compliance to treatment is defined as the lack of adequacy between patients’ behaviors in taking medication, following a diet, and/or executing lifestyle changes, and medical prescriptions. It is a major cause of therapeutic failure that puts into question the real efficiency of medical care. The objective of this study was to evaluate the therapeutic compliance degree in diabetic patients and to determine the different factors and issues complicatin...

ea0063p556 | Diabetes, Obesity and Metabolism 2 | ECE2019

Diabetes increases liver fibroscan value regardless of steatosis

Hadj Kacem Faten , Loukil Fatma , Ben Othman Wafa , Boudabouss Mouna , Gdoura Hela , Feki Wiem , Fourati Hela , Abid Mouhamed , Tahri Nabil , Mnif Zaineb

Background: Fibroscan is a noninvasive medical dispositive for the evaluation of hepatic fibrosis based on the technique of pulse elastography. However, the interpretation of its value depends on several parameters.Objective: The purpose of our work is to study the impact of diabetes on the value of liver fibroscan and to identify possible factors influencing this value in diabetics.Materials and methodes: Our work is a cross-secti...

ea0063p557 | Diabetes, Obesity and Metabolism 2 | ECE2019

Tobacco and diabetes: a comparative study of smoking diabetic patients and non-smoking diabetic patients in the Endocrinology-Diabetology-Nutrition Department of Oujda’s University Hospital in Morocco

Assarrar Imane , Draoui Najat , Bouali Houda , Latrech Hanane

Introduction: Smoking is considered to be a cardiovascular risk for diabetic patients, as for the overall population. Its presence in diabetic patients increases significantly the risk of micro and macro vascular diseases. This study purpose is to compare and analyze the occurrence rate of degenerative complications in diabetic patients who smoke and those who don’t.Materials and methods: It is a descriptive and comparative study carried out in the ...

ea0063p558 | Diabetes, Obesity and Metabolism 2 | ECE2019

Endocrinopathies and diabetes: cardiovascular risk assessment

Khiari Marwa , Ben Nacef Ibtissem , Rojbi Imene , Mchirgui Nadia , Lakhoua Youssef , Khiari Karima

A large number of endocrine pathologies can be associated to abnormalities in carbohydrate tolerance up to diabetes. The latter participates in the high risk of cardiovascular morbidity and mortality during these pathologies. The aim of our study was to assess the cardiovascular risk in a diabetic population suffering from an endocrine pathology. This is a retrospective study conducted in the department of endocrinology at Charles Nicolle Hospital involving 54 patients hospita...

ea0063p559 | Diabetes, Obesity and Metabolism 2 | ECE2019

Inflammation and adipocytokines in overweight and obesity

Benbaibeche Hassiba , Ahmed Koceir Elhadj

Introduction: In obesity and overweight, inflammation is associated with a progressive infiltration of immune cells causing cytokine secretion into adipose tissue. Objective. Evaluation of adipocytokines derived from adipose tissue and immune cells (adiponectin, resistin, TNF-α and IL-6). Materials and methods. 150 adults divided up in 3 groups; obese, overweight and controls. Adipocytokines (adiponectin, resistin, TNF-α and IL-6) were quantified by ELISA, serum insu...

ea0063p560 | Diabetes, Obesity and Metabolism 2 | ECE2019

Free T3 correlates with iron metabolism indexes in patients with type 1 diabetes and diabetic kidney disease

Sazonava Alena , Mokhort Tatiana , Karlovich Natalia

Aims: Thyroid status disturbances are not rare among DKD patients. It is known that the genesis of anemia in DKD has a multifactorial nature, and the combination of DKD and anemia significantly impairs quality of life. In addition, anemia in diabetic patients with DKD occurs earlier and tends to be more severe compared with CKD patients without diabetes. The purpose of the study was to investigate potential relationship between thyroid status and iron metabolism profile in pat...

ea0063p561 | Diabetes, Obesity and Metabolism 2 | ECE2019

Features of type 2 diabetes mellitus in the elderly (Minsk)

Bilodid Irina , Shyshko Volha , Shalobyta N.

The article is devoted to one of the most pressing medical problems – diabetes mellitus type 2.Objective: To study the peculiarities of the course of diabetes mellitus type 2 in persons over 65 years of age; to evaluate the effectiveness of different therapy regimens for the level of HbA1C.Material and methods: The retrospective study included 100 patients with type 2 diabetes (T2D). The age of the patients: 65 to 82 years. Th...

ea0063p562 | Diabetes, Obesity and Metabolism 2 | ECE2019

The role of glucagon like peptide - 1 (GLP-1) receptor agonists in the treatment of type 2 diabetes mellitus

Menon Vaishnavi

Background and Aims: Type 2 diabetes mellitus (T2DM) is multifactorial, affected by obesity, blood pressure (BP) and cardiovascular disease (CVD). The therapeutic effects of GLP-1 in managing BP and increasing satiety promoting weight loss prove beneficial against these risk factors. This literature review aims to assess current evidence on the efficacy of GLP-1 receptor agonists (GLP-1RA) for T2DM treatment.Methods: A PubMed literature search over the p...

ea0063p563 | Diabetes, Obesity and Metabolism 2 | ECE2019

Autoimmune diabetes mellitus adult patients having latent autoimmune diabetes of adulthood (LADA) form exhibit different prevalence of accompanying autoimmune diseases than patients with conventional (juvenile) autoimmune type 1 diabetes: Furthermore, anti-GAD autoantibodies are strongly associated with accompanying autoimmune diseases in patients with autoimmune diabetes mellitus

Gougourelas Dimitrios , Tsentidis Charalampos , Koutsovasilis Anastasios , koufadaki Athina-Maria , Gougourela Efpraxia , Kassi Georgia , Sotiropoulos Alexios , Bousboulas Stavros , Karavanaki Kyriaki

Introduction: Autoimmune diabetes mellitus patients, either with Latent Autoimmune Diabetes of Adults (LADA) form or with conventional (juvenile) autoimmune type 1 diabetes (T1D) form, exhibit a higher prevalence of Accompanying Autoimmune Diseases (AADs). The aim of this study was to investigate possible differences in AADs, Familial Autoimmune Diseases (FADs) and metabolic profile between patients with LADA and T1D and between patients with or without anti-GAD (Anti-Glutamic...

ea0063p564 | Diabetes, Obesity and Metabolism 2 | ECE2019

Erythrocytes glucose uptake increases in rats with experimental induced obesity, diabetes and hyperinsulinemia

Shamansurova Zulaykho , Alieva Anna , Tashmanova Akmaral , Saatov Talat

Introduction: As were previously shown the erythrocytes glucose uptake is impaired in patients with the Diabetes Mellitus, obesity and polycystic ovarian syndrome due to insulin resistance. For further, study whether the erythrocytes glucose uptake will be impaired in rats with experimental metabolic syndrome were observed gradually.Material and methods: The 40 adult white male rats separated into 4 groups. In 10 rats diabetes were induced by injection o...

ea0063p565 | Diabetes, Obesity and Metabolism 2 | ECE2019

Giant prolactinoma associated with alopecia universalis (AU): a case report

Liesionyte Kristina , Pauliukiene Renata , Knispelis Robertas

Introduction: Giant prolactinomas are rare tumours, they represent range from 0.5 to 4.0% of all pituitary tumours. We are presenting a patient with giant prolactinoma without visual field defects and any obvious clinical symptoms related to hyperprolactinemia and probably associated with alopecia universalis.Case: 32 years old man has visited outpatient department of our hospital, complaining of severe headache for the last three years. He underwent bra...

ea0063p566 | Diabetes, Obesity and Metabolism 2 | ECE2019

Evaluation of the improvement in vascular endothelial function from raphanus sativus via activation of PI3K/Akt pathway

Hwang Kyung-A , Hwang Hye-Jeong , Lee Sung-Hyeon , Jang Hwan-Hee

This study investigated the role of muscarinic receptors and endothelial signaling pathways in the vascular relaxation promoted by Raphanus sativu. In our research for active constituents in Raphanus sativus with the potential for improving the vascular system, we evaluated the effect of Raphanus sativus on NO production in vascular endothelial cells. In the result, we found that the underlying mechanism for stimulating NO production by Raphanus ...

ea0063p567 | Diabetes, Obesity and Metabolism 2 | ECE2019

Cardiovascular risk in obese women with polycystic ovary syndrome using Framingham scoring system

Ilic Dusan , Bozic Antic Ivana , Popovic Bojana , Bogavac Tamara , Isailovic Tatjana , Elezovic Kovacevic Valentina , Ognjanovic Sanja , Macut Djuro

Objectives: Women with polycystic ovary syndrome (PCOS) are at increased risk for cardiovascular disease. Aim of our study was to determine the frequency of cardiovascular risk factors using Framingham Scoring system (FSS) in PCOS and controls.Methods: FFS included age, value of cholesterol and HDL (mmol/L), smoking and systolic blood pressure (sysBP, mmHg). We also determined LDL (mmol/l), oxidized LDL (OxLDL, U/l) and triglycerides (mmol/l). We studied...

ea0063p568 | Diabetes, Obesity and Metabolism 2 | ECE2019

Association Kidney Neoplasm and recent diabetes: think about MODY 5

Marmouch Hela , Mrabet Houssem , Jenzri Haythem , Sallem Omkalthoum , Khochtali Ines

Introduction: The association of kidney disease and diabetes mellitus is a classic feature evoking Maturity Onset Diabetes of the Young (MODY) 5 otherwise known as renal cysts and diabetes syndrome. Kidney Neoplasms are unusual feature of MODY 5. We report the case of a 45 year-old man diagnosed with kidney Neoplasm and DiabetesCase report: A 45 year-old man with a history of Diabetes Mellitus treated with lifestyle management 8 months ago, presented to ...

ea0063p569 | Diabetes, Obesity and Metabolism 2 | ECE2019

Body composition (DXA) and hormonal picture in obese children

Teodoriu Laura , Trandafir Laura , Ambarus-Popovici Ioana , Ioan Bianca , Ungureanu Maria-Christina , Preda Cristina

Introduction: Obesity in children is rising worldwide with premature development which could involve greater risk of complications and comorbidities in adult life. Central adiposity is a well known feature of glucocorticoid excess and there are some speculations that cortisol biosynthesis is involved in pathogenesis of metabolic syndrome. However the circadian rhythm of cortisol axis or incrimination of cortisol excess in obese children is less known. Our aim is to investigate...

ea0063p570 | Diabetes, Obesity and Metabolism 2 | ECE2019

Mineralocorticoid receptor and diabetes: in favour of other corticosteroids than aldosterone

Ackermann Daniel , Jamin Heidi , Klossner Rahel , Dick Bernhard , Mohaupt Markus , Gennari-Moser Carine

Background: Despite normal aldosterone levels, diabetics often profit from the treatment with mineralocorticoid receptor (MR) antagonists (MRAs). We therefore speculated if the expression of MR and 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) were changed in cells of glomerular origin under diabetic conditions and – if not - whether the synthesis of other corticosteroid hormones, that could act on MR, was increased in diabetics.Metho...

ea0063p572 | Diabetes, Obesity and Metabolism 2 | ECE2019

Erythrocytes membrane plasmalogens level in Diabetes Mellitus depends from Arterial Hypertension and nephropathy

Saatov Talat , Akhrarova Nilufar , Shamansurova Zulaykho

Introduction: Metabolic disturbances at the Diabetes Mellitus (DM) leads to structural and functional abnormalities of the cell plasma membrane due to changes in the lipid content and composition, especially phospholipids. Plasmalogens are unique group of phospholipids with alcohol and ether bounds, presented in a few papers. We hypothesis their involvement into pathogenesis of DM.Material and methods: We studied the content of Plasmalogens in blood plas...

ea0063p573 | Diabetes, Obesity and Metabolism 2 | ECE2019

A hyperglycemic crisis as a first appearance of newly onset diabetes mellitus in a patient using dexamethasone: Blame the usual suspect or accuse a new one?

Mertens Jonathan , Martens Caroline , Vermeulen Griet

We describe the case of a 60-year old woman admitted to the intensive care unit (ICU) for progressively diminishing consciousness and severe lethargy. The patient was recently diagnosed with small cell lung carcinoma with solitary cerebral metastasis. In order to shrink the metastasis-induced cerebral edema she was treated with dexamethasone. She was hospitalized four days before admission to the ICU to start carboplatin-etoposide based chemotherapy. The day of admission she h...

ea0063p574 | Diabetes, Obesity and Metabolism 2 | ECE2019

Use of insulin therapy in the treatment of gestational diabetes

Mizouri Ramla , Zahra Hajer , Sebai Imen , Belhaj Maha , Khiari Marwa , Boukhayatia Fatma , Othman Rym Ben , Mahjoub Faten , Berriche Olfa , Jamoussi Henda

Introduction: In most cases, the management of gestational diabetes is based on self-monitoring and dietary monitoring. The use of insulin therapy may be necessary if glycemic targets are not achieved. The aim of this work is to determine the factors involved in the use of insulin therapy during gestational diabetes.Methods: It was a descriptive study performed in 150 diabetic pregnant women hospitalized in our department for monthly metabolic control. E...

ea0063p575 | Diabetes, Obesity and Metabolism 2 | ECE2019

The fasting of diabetic patients during Ramadan: a dilemma of religious conviction and medical prohibition

Draoui Najat , Assarrar Imane , Rouf Siham , Latrech Hanane

Introduction: Ramadan is a holy month for Muslims where they have to fast from dawn until dark. It is a questionable issue in patients with chronic diseases who may experience or aggravate their metabolic complications, especially for diabetic patients. The purpose of this study is to assess diabetic patients, knowledge of fasting in a religious and medical point of view.Materials and methods: This is a cross-sectional study conducted after the holy mont...

ea0063p576 | Diabetes, Obesity and Metabolism 2 | ECE2019

Myocardial infarction in diabetic patients and cardiovascular risk factors control

Alcantara-Laguna Maria , Rebollo-Roman Angel , Moreno-Moreno Paloma , Leon-Idougourram Soraya , Barrera-Martin Ana , Galvez-Moreno Maria-Angeles

Aim: Describe the control of cardiovascular risk factors (CVRF) in patients with diabetes and myocardial infarction (MI) as well as their treatment and control.Patients and methods: Observational retrospective study of a cohort of patients with diabetes admitted to the cardiology department because of a MI between November 2015 and November 2016. Statistical analysis performed with SPSS 24th version.Results: 421 patients admitted b...

ea0063p577 | Diabetes, Obesity and Metabolism 2 | ECE2019

Comparison of effects of metformin used as a monotherapy or in combination with gliclazide MR on glycemic control and lipid profile in patients with type 2 diabetes mellitus

Vujosevic Snezana , Borozan Sanja , Kavaric Sreten , Boskovic Olivera , Krnjevic Djordjije , Cikic Elzana , Muzurovic Emir , Bjeladinovic Igor , Radovanic Snezana , Sparavalo Rada , Vukicevic Violeta , Ivanovic Suzana , Pupovic Enisa

Objective: To evaluate and compare the effects of metformin used as a single-agent therapy and in combination with gliclazide modified release (MR) on glycoregulation and lipid profile in patients with type 2 diabetes mellitus (T2DM).Methodology: A multi-center observational epidemiological study was carried out in patients with T2DM, divided in two groups according to the current type of treatment: first group was on monotherapy with metformin in daily ...

ea0063p578 | Diabetes, Obesity and Metabolism 2 | ECE2019

Factors affecting effective gestational diabetes mellitus management: six-year experience from a single tertiary center

Tsentidis Charalampos , Mitakidou Eleni , Bampilis Andreas , Fragkos Dimitrios , Panos Christos , Limniati Christina , Kassi Georgia

Introduction: Effective gestational diabetes mellitus (GDM) management is pivotal for reducing delivery complications for both mother and offspring, since a linear and continuous association between blood glucose and unfavorable outcomes has been extensively reported. The aim of present study was to investigate possible factors affecting GDM treatment goals.Methods: We retrospectively evaluated 136 consecutive patients with GDM, treated in our department...

ea0063p579 | Diabetes, Obesity and Metabolism 2 | ECE2019

Oral glucose tolerance test is recommended for screening for new-onset glucose metabolism impairment during chronic low-dose glucocorticoid therapy

Nowak Karolina , Rdzanek Monika , Łebek-Szatańska Agnieszka , Nowakowska-Płaza Anna , Zielińska Agnieszka , Romanowska-Prochnicka Katarzyna , Zgliczyński Wojciech , Papierska Lucyna

Introduction: Patients with connective tissue diseases are susceptible to the occurrence of side-effects of long term treatment with low-dose glucocorticoids as these medications often cannot be withdrawn due to exacerbation of the underlying disease. The new-onset of glucose metabolism impairment is not considered common in patients treated with low-dose glucocorticoids and the risk factors are thought to be the same as in general population: increasing age, obesity or family...

ea0063p580 | Diabetes, Obesity and Metabolism 2 | ECE2019

Incidence of diabetes and its predictive factors in cancer patients treated with phosphatidylinositol 3 kinase inhibitors

Lee Jae Hyuk , Lee Yong Ho

Background: Targeted therapy using phosphatidylinositol 3-kinase (PI3K) inhibitors has become widespread in the treatment of cancers. Although PI3K inhibitors raised concern about the alteration of glucose and lipid metabolism from animal studies, human clinical data have been rarely reported.Aim: We investigated the clinical manifestations, incidence of diabetes and its predictive factors in cancer patients who treated with PI3K inhibitors.<p class=...

ea0063p581 | Diabetes, Obesity and Metabolism 2 | ECE2019

Flash glucose monitoring: repercussions in glycemic control

Rebollo-Roman Angel , Alhambra-Exposito Maria-Rosa , Moreno-Moreno Paloma , Alcantara-Laguna Maria , Leon-Idougourram Soraya , Palomares-Ortega Rafael , Galvez-Moreno Maria-Angeles

Introduction: Flash glucose monitoring (FGM) allows non-invasive glucose level assessment. Studies have shown that patients using FGM test their glucose levels more often than those who use traditional blood glucose testing. Given that a higher rate of glucose testing has showed to improve glycemic control our objective was to describe the change in the glycemic control and time in euglycemic range in patients with FGM and the effect of the number of scans in this control....

ea0063p582 | Diabetes, Obesity and Metabolism 2 | ECE2019

The role of proper insulin injection technique to achieve optimal glycemic control

Orlova Marina , Dikht Natalia , Frolova Arina , Dudov Islam

Proper insulin injection technique is a prerequisite for achieving good diabetes control, reducing absorption variability, and getting the best effect from using the drug. At the same time, the rate of absorption of insulin depends on a number of technical features, which include the depth of needle insertion, the severity of blood flow and the presence of lipodystrophy in the injection zones. Compliance with a number of rules minimizes the variability of absorption of insulin...

ea0063p583 | Diabetes, Obesity and Metabolism 2 | ECE2019

Metabolic effects of a novel myokine, Follistatin like protein 1 (FSTL1), in human primary adipocytes

Kim Jung Hye , Choi Arim , Park Kahui , Lee Sang Bae , Kim YuSik , Nam Ji Sun , Kang Shinae , Park Jong Suk , Ahn Chul Woo

Object: FSTL1, an extracellular glycoprotein, is a novel myokine that is secreted by skeletal muscle. However, its functions in metabolism remain unclear, Adipose tissue is one of the important organs for maintaining energy homeostasis. FSTL1 is known to induce inflammatory response and inhibit insulin-mediated Akt signaling pathway, we aimed to investigate whether FSTL1 play metabolic roles in human adipose tissue. We hypothesized that FSTL1 increases lipolysis throu...

ea0063p584 | Diabetes, Obesity and Metabolism 2 | ECE2019

Discordance between body-mass index and body adiposity index in classification of adiposity status in the elderly

Nowak Justyna , Hudzik Bartosz , Kulik-Kupka Karolina , Zieleń-Zynek Iwona , Kowalska Joanna , Zubelewicz-Szkodzińska Barbara

Introduction: The prevalence of obesity in elderly population increased. Obesity leads to increased morbidity and mortality as well as worsens quality of life in older individuals. Body-mass index (BMI) is the most widely used adiposity index. BMI correlates with body fatness but this index does not account for fat mass versus fat-free mass. Recently a new index of body adiposity the body adiposity index (BAI) was introduced. This novel index correlates well (in comparison to ...

ea0063p585 | Diabetes, Obesity and Metabolism 2 | ECE2019

The effect of Iranian propolis on glucose metabolism, lipid profile, insulin resistance, renal function and inflammatory biomarkers in patients with type 2 diabetes mellitus: a randomized double blind clinical trial

Zaeemzadeh Narjes , Zakerkish Mehrnoosh , Jenabi Maryam , Hemmati Ali Asghar , Neisi Niloofar

Propolis is a natural product with many biological properties including hypoglycemic activity and modulating lipid profile. The present study was designed to evaluate the effect of Iranian propolis extract on glucose metabolism, Lipid profile, Insulin resistance, renal and liver function as well as inflammatory biomarkers in patients with type 2 diabetes mellitus (T2DM). A double-blind, placebo-controlled clinical trial was conducted. The duration of the study lasted 90 days. ...

ea0063p586 | Diabetes, Obesity and Metabolism 2 | ECE2019

Real-world experience of generalized and partial lipodystrophy patients enrolled in the metreleptin early access program

Cook Keziah , Stears Anna , Araujo-Vilar David , Santini Ferruccio , O'Rahilly Stephen , Ceccarini Giovanni , Tibrewala Shruti , Bradt Pamela , Vigouroux Corinne , Vatier Camille , Savage David B

Objective: To evaluate the real-world experience of patients with generalized (GL) and partial (PL) lipodystrophy initiating treatment with metreleptin as part of an early access program (EAP).Methods: A retrospective data collection was conducted from four countries for patients enrolled in the EAP. A descriptive analysis was performed on selected patient characteristics, baseline organ impairments and complications, and response to metreleptin therapy,...

ea0063p587 | Diabetes, Obesity and Metabolism 2 | ECE2019

Prevalence and characteristics of Nivolumab-induced diabetes: results from a monocentric observational study

Leclerc Helene , Drui Delphine , Mahot-Moreau Pascale , Pichelin Matthieu , Thomare Patrick , Landau Ester , Fournier Anne-Laure , Fronteau Clementine , Dresco Eric , Lucas-Pouliquen Bernadette , Cariou Bertrand

Introduction: Nivolumab is an anti-PD1 immunotherapy that restores the immune response against cancer cells, but can induce fulminant diabetes. The prevalence of such anti-PD1 induced diabetes is not clearly determined, but it has been recently estimated between 0.4% and 0.9% in recent studies. Here, we performed a monocentric epidemiological study in order to assess the prevalence and provide a description of Nivolumab-induced diabetes cases.Material an...

ea0063p588 | Diabetes, Obesity and Metabolism 2 | ECE2019

Genetic diagnosis of maturity-onset diabetes of the young (MODY): experience of diabetology-endocrinology department of Oujda’s Mohammed VI university hospital

Khlifi Asmaa , Ben Yakhlef Salma , Latrech Hanane

Introduction: Maturity Onset Diabetes of the Young (MODY) is a monogenic form of non-insulin-dependent diabetes that classically presents in a lean individual with non ketotic hyperglycaemia and an autosomal dominant inheritance pattern. The diagnosis remains a challenge and may be made by careful clinical evaluation, but exact sub-typing is possible only by genetic analysis.Materials and methods: This is a prospective data analysis in the diabetology-en...

ea0063p589 | Diabetes, Obesity and Metabolism 2 | ECE2019

Discrete choice and SF-36 estimates of patient quality of life and benefits of leptin replacement therapy (LRT) in generalized and partial lipodystrophy (GL, PL)

Ali Omer , Cook Keziah , Lee Don , Shampanier Kristina , Tuttle Edward , Bradt Pamela

We report new estimates of the disutility associated with GL and PL, and the quality of life (QoL) impact of leptin replacement therapy (LRT) based on two methods. The first approach estimates utility decrements associated with a range of impairments related to lipodystrophy through a discrete choice experiment (DCE) conducted with members of the general public; the second elicits QoL estimates from 8 PL patients using the SF-36 instrument. To characterize QoL consequences of ...

ea0063p590 | Diabetes, Obesity and Metabolism 2 | ECE2019

Are all hypoglycemic drugs similar for men with type 2 diabetes and testosterone deficiency?

Khripun Irina , Vorobyev Sergey , Petrovskaya Ekaterina , Kuzmenko Natalia

Background: To date, it has been established that appointment of testosterone replacement therapy (TRT) in men with type 2 diabetes mellitus (T2DM) and testosterone (T) deficiency improves control of carbohydrate metabolism. Although, studies of effectiveness of different hypoglycemic drugs in men with T2DM and T deficiency have not been conducted. The aim of this study was to compare the efficacy of various types of hypoglycemic therapy in patients with T2DM and late onset hy...

ea0063p591 | Diabetes, Obesity and Metabolism 2 | ECE2019

A 5-years postoperative upper digestive endoscopy in obesity surgery

Benvenga Rosa , Catheline Jean Marc , Bendacha Yasmina , Cohen Regis

Introduction: Postoperative upper digestive endoscopy seems to give conflicting results in literature after obesity surgery. Some stressed on the frequency of major digestive lesions such as esophagitis, cancer or endo brachy esophagus (EBO) especially after Sleeve Gastrectomy (SG). The incidence of EBO after SG was found in 1.2% to 15% at ten years of follow up. Accordingly to European Guidelines, it is mandatory to perform a routinely preoperative gastroscopy but not after s...

ea0063p592 | Diabetes, Obesity and Metabolism 2 | ECE2019

Occupational outcomes after bariatric surgery: relation to deprivation, satisfaction score

Benvenga Rosa , Fysekidis Marinos , Bendacha Yasmina , Catheline Jean-Marc , Cohen Regis

Many studies but not all showed an increase in employment after bariatric surgery by 17–29%. We analyzed the relation of this increase of employment rate with weight loss, satisfaction and deprivation score. In an observational study, we evaluated the rate of employment (mean±S.E.) 2.3 years ±0.1 after bariatric surgery. We mailed to 791 patients a simple self-questionnaire to assess the employment status deprivation, satisfaction scale and Barros...

ea0063p593 | Diabetes, Obesity and Metabolism 2 | ECE2019

Probiotic supplementation and β-cell function in type 2 diabetes: evidence from randomized clinical trial

Kobyliak Nazarii , Mykhalchyshyn Galyna , Kyriienko Dmytro , Kononenko Liudmyla , Komisarenko Iuliia

Background: Probiotics have beneficial effect on obesity, insulin resistance and associated metabolic disorders. However, effect of probiotics on β-cell function are inconsistent.Aim: In a double-blind single center randomized placebo-controlled trials (RCT), effect of alive multistrain probiotic vs. placebo on β-cell function in type 2 diabetes patient were assessed.Methods: A total of 54 patients met the criteria for in...

ea0063p594 | Diabetes, Obesity and Metabolism 2 | ECE2019

Relationship between lipid profile and uricemia in diabetic type 2

Mahroug Ikram , Bouali Houda , Latrech Hanane

Introduction: Hyperuricemia is associated with an increase in cardiovascular risk and complications of type 2 diabetes (1). The aim of this study is to establish a possible link between lipid profile and hyperuricemia.Method: A total of 321 patients with type 2 diabetes were included in our study. Clinical and par clinical data were collected from patients’ medical records. The lipid profile includes low density lipoprotein (LDL), high density lipop...

ea0063p595 | Diabetes, Obesity and Metabolism 2 | ECE2019

Insulin resistance, systemic and regional inflammation in subcutaneous adipose tissue during weight loss in a population with obesity

Velde Frederique Van de , Ouwens Margriet , Batens Arsene-Helene , Shadid Samyah , Lapauw Bruno , Nieuwenhove Yves Van

Background: Adipose tissue dysfunction, such as adipocyte hypertrophy and secretion of pro-inflammatory cytokines, develops in obese subjects and goes hand in hand with obesity-related complications, especially insulin resistance (IR) and systemic inflammation. The exact mechanisms underlying adipose tissue dysfunction and consequently the obesity-related complications are not yet fully understood.Aim: Investigate the association between systemic IR and ...

ea0063p596 | Diabetes, Obesity and Metabolism 2 | ECE2019

The effect of 3 months of daily consumption of sugar-sweetened beverages on liver, adipose tissue, and glucose metabolism in an animal study

Lee Ghayoung , Han Ji Hye , Maeng Hyo Jin , Lim Soo

Background: Growing evidence suggests a link between sugar-sweetened beverages (SSBs) and metabolic disorders. We investigated the effect of SSBs that are commonly consumed by adolescents on glucose metabolism and fatty liver.Methods: We treated 7-week old male C57BL/6 mice with water (control) or either of SSBs: carbonated soda (Coca-Cola®), sweetened milk coffee (Maxwell®), or chocolate-added cocoa (Choco-Latte&#174...

ea0063p597 | Diabetes, Obesity and Metabolism 2 | ECE2019

A new neurocognitive phenotype in Alstrom sindrome

Lorusso Riccardina , Dassie Francesca , Benavides-Varela Silvia , Milan Gabriella , Favaretto Francesca , Vettor Roberto , Semenza Carlo , Maffei Pietro

Background: Alstrom syndrome (AS; OMIM#203800) is a rare (<1:100.000) autosomal recessive monogenic ciliopathy and it is caused by mutations in ALMS1 (chromosome 2p13), which function is still unknown. AS is characterized by multisystemic fibrosis, cone-rod retinal dystrophy leading to blindness, hearing loss, obesity, type 2 diabetes mellitus (T2DM), dilated cardiomyopathy, and progressive hepatic and renal failure. Most patients present neurological issue on developmenta...

ea0063p598 | Diabetes, Obesity and Metabolism 2 | ECE2019

Physical activity counteracts metabolic syndrome-induced hypogonadotropic hypogonadism and erectile dysfunction in the rabbit

Morelli Annamaria , Filippi Sandra , Comeglio Paolo , Sarchielli Erica , Cellai Ilaria , Danza Giovanna , Rastrelli Giulia , Corno Chiara , Zizza Michela , Guarnieri Giulia , Vignozzi Linda , Maggi Mario

Metabolic syndrome (MetS) clusters cardiovascular and metabolic risk factors, along with hypogonadism (HG) and erectile dysfunction (ED). Lifestyle modifications, including physical exercise (PhyEx), are well-known treatments for this condition. We previously established a non-genomic, high-fat diet (HFD)-induced rabbit model of MetS that recapitulates the human phenotype, including HG and ED. We now report studies on the effect of PhyEx on hypothalamus-pituitary-testis (HPT) ...

ea0063p599 | Diabetes, Obesity and Metabolism 2 | ECE2019

Testosterone restores metabolic syndrome-induced impairement in physical activity by ameliorating skeletal muscle fiber metabolism

Morelli Annamaria , Sarchielli Erica , Comeglio Paolo , Filippi Sandra , Cellai Ilaria , Guarnieri Giulia , Rastrelli Giulia , Vignozzi Linda , Maggi Mario

Background: Metabolic syndrome (MetS) is a clustering of metabolic and cardiovascular risk factors, with insulin resistance being one of the main components. In male, MetS is also associated to hypogonadotropic hypogonadism. Lifestyle modifications (e.g. physical activity) could prevent or considerably reduce MetS progression, however the ability to perform physical activity is often impaired in MetS subjects.Aim: Considering the known trophic role of T ...

ea0063p600 | Diabetes, Obesity and Metabolism 2 | ECE2019

Compliance with gestational weight gain in women with gestational diabetes mellitus

Dimitriadou Despoina , Mintziori Gesthimani , Neofytidou Ourania , Mousiolis Athanasios , Kotsa Kalliopi , Kazakos Kyriakos , Goulis Dimitrios

Introduction: The present study aimed to investigate whether women who developed gestational diabetes mellitus (GDM) comply with the guidelines for gestational weight gain (GWG) according to their pre-pregnancy Body Mass Index (BMI).Methods: A retrospective study was conducted involving 195 pregnant women with GDM, aged 25–45 years, attending an academic hospital outpatient clinic. These women were divided into three groups according to pre-pregnanc...

ea0063p601 | Diabetes, Obesity and Metabolism 2 | ECE2019

Clinical and ultrasonographic characteristics of women with co-existing gestational diabetes mellitus and thyroid disease

Neofytidou Ourania , Mintziori Gesthimani , Dimitriadou Despoina , Mousiolis Athanasios , Kotsa Kalliopi , Kazakos Kyriakos , Goulis Dimitrios G

Introduction: Gestational Diabetes Mellitus (GDM) is a disorder of glucose tolerance which is diagnosed for the first time during pregnancy. Thyroid disease is common in women of reproductive age and during gestation; both diseases have an adverse impact on pregnancy outcomes. The aim of this study was to assess the clinical and ultrasonographic characteristics in women with co-existing GDM and thyroid disease.Material and methods: In total, 112 pregnant...

ea0063p602 | Diabetes, Obesity and Metabolism 2 | ECE2019

Platelet reactivity in patients with type 2 diabetes mellitus after treatment intensification with DPP-4i, SGLT-2i and GLP-1RA

Siasos Gerasimos , Paschou Stavroula A , Stampouloglou Panagiota K , Bletsa Evanthia , Batzias Konstantinos , Tsigkou Vasiliki , Antonopoulos Alexis , Oikonomou Evangelos , Gouliopoulos Nikolaos , Thanopoulou Anastasia , Noutsou Marina , Vryonidou Andromachi , Tentolouris Nikolaos , Tousoulis Dimitrios

Introduction: Patients with type 2 diabetes mellitus (T2DM) exert a higher risk for thrombotic events. Platelet reactivity may be used to assess prothrombotic state in such patients. The aim of this study was to investigate whether the administration of novel antidiabetic agents could influence the platelet reactivity in T2DM patients.Patients and methods: We enrolled 99 consecutive patients (males=63.3%), 64.92±8.3 years old, receiving metformin fo...

ea0063p603 | Diabetes, Obesity and Metabolism 2 | ECE2019

Renoprotective effects of weekly dulaglutide in type 2 diabetes patients: A routine clinical practice study

Cayon-Blanco Manuel , Garcia-Figueras-Mateos Carolina

Introduction: Data from several clinical trials have shown positive effects of GLP1 analogue drugs on renal function in patients with type 2 diabetes (T2DM). However, there are very few reported results on its potential renoprotective effect in routine clinical practice. Our aim is to evaluate the effects of the addition of weekly dulaglutide (a GLP-1 analogue) to the normoglycemic treatment of patients with T2DM on renal function in a real-world cohort of patients.<p clas...

ea0063p604 | Diabetes, Obesity and Metabolism 2 | ECE2019

The effects of testosterone treatment on fat tissue dysfunction and nonalcoholic fatty liver disease in obese men undergoing bariatric surgery

Maseroli Elisa , Corno Chiara , Comeglio Paolo , Cellai Ilaria , Filippi Sandra , Mello Tommaso , Galli Andrea , Facchiano Enrico , Beltrame Benedetta , Lucchese Marcello , Rastrelli Giulia , Maggi Mario , Vignozzi Linda

Objective: Substitution treatment of hypogonadism in clinical and experimental models has shown beneficial effects on insulin sensitivity and accumulation of visceral and liver fat. Aim of the study was to analyze the effects of testosterone replacement therapy on benign prostatic hyperplasia/lower urinary tract symptoms (BPH/LUTS) clinical parameters, adipose tissue dysfunction and nonalcoholic fatty liver disease (NAFLD) in obese patients candidates for bariatric surgery.</p...

ea0063p605 | Diabetes, Obesity and Metabolism 2 | ECE2019

Parabens and their relationship to obesity

Šramkova Monika , Kolatorova Lucie , Vitků Jana , Včelak Josef , Lischkova Olga , Starka Luboslav , Duškova Michaela

Introduction: Parabens are a group of chemicals used as preservatives in the food, cosmetic and pharmaceutical industries. They are known to possess estrogenic effects, and therefore have been classified as endocrine disruptors. In addition to the classical endocrine organs, other tissues have endocrine activity, including adipose tissue. Several chemicals are known to cause obesogenic effects, and parabens are currently being studied in this context. The aim of this study was...

ea0063p606 | Diabetes, Obesity and Metabolism 2 | ECE2019

Complex use of noninvasive methods for estimating microcirculation of the blood and oxidative metabolism on the big sting finger in patients with diabetes, such as permeable diagnostic diagnostics diagnostics, patients with diable diagnosis

Mikhail 6/5000 Michael Shinkin , Ashot Mktrumyan , Larisa Zvenigorodskaya

Purpose of the study: Assess the criteria for early diagnosis of the risk of developing diabetic foot syndrome as a microvasculature using laser Doppler flowmetry and tissue metabolism using fluorescence spectroscopy in diabetic patients.Materials and methods: The studies are carried out with the help of the Laser Diagnostic LASMA ST Apparatus ‘(OOO NPP’ LAZMA’, Moscow) on the plantar surface of the big toe in three stages: resting state -...

ea0063p607 | Diabetes, Obesity and Metabolism 2 | ECE2019

Liver fibrosis and steatosis severity evaluation in patients with chronic hepatitis C and type 2 diabetes mellitus

Irina Morozova , Beliy PA , Axelrod AG , Rodnikova EM , Dudina KR , Safiullina NH , Znoyko OO

Background: Non-alcoholic fatty liver disease and chronic hepatitis C (CHC) are systemic diseases with a broad spectrum of coexisting disorders, but their common features are insulin resistance and higher frequency of concomitant type 2 diabetes mellitus (DM). According to recent studies, a higher frequency of CHC in patients with DM is not associated with this cohort exposure to multiple medical interventions, but with CHC being a possible risk factor for developing DM. CHC m...

ea0063p608 | Diabetes, Obesity and Metabolism 2 | ECE2019

Determinant factors for prescription of antidiabetic drugs with beneficial effects on weight

Cayon-Blanco Manuel , Garcia-Figueras-Mateos Carolina

Introduction: Sodium glucose cotransporter 2 inhibitors (SGT2-i) and glucagon-like peptide-1 receptor agonists (GLP-1-ra) conform two families of drugs with beneficial effects on weight and glycemia. Our aim is to identify epidemiological and clinical characteristics of patients, candidates to receive one of these classes of drugs, that can influence on physician’s decisions.Methods/design: Retrospective observational research. Data from patients wi...

ea0063p609 | Diabetes, Obesity and Metabolism 2 | ECE2019

Gut microbiota pattern in relation to diet, physical activity and malnutrition in patients with inflammatory bowel disease: cases-control study

Cornejo-Pareja Isabel , Garcia-Munoz Beatriz , Romero-Perez Eduardo , Garcia-Fuentes Eduardo , Tapia-Paniagua S , Morinigo-Gutierrez MA , Alcain-Martinez Guillermo , Manuel Garcia-Almeida Jose

Introduction: Modifications of gut microbiota have been described in relation to inflammatory bowel disease (IBD), dietary habits and nutritional status.Objective: To relate gut microbial pattern of patients with IBD compared to healthy individuals; and link gut microbial pattern with activity of the disease, nutritional status and dietary habit.Material and methods: Observational study of 56 subjects (44 with IBD and 12 controls)....

ea0063p610 | Diabetes, Obesity and Metabolism 2 | ECE2019

Description of a novel AGPAT2 gene mutation (R159C) responsible for congenital generalized lipoatrophy type 1 (Berardinelli-Seip Syndrome)

Magno Silvia , Ceccarini Giovanni , Pelosini Caterina , Ferrari Federica , Scabia Gaia , Maffei Margherita , Vitti Paolo , Santini Ferruccio

Berardinelli-Seip congenital lipoatrophy type 1 (BSCL1) is a rare autosomal recessive disease caused by mutations in the AGPAT2 gene. This syndrome is characterized by near total absence of adipose tissue since birth, associated with the progressive development of metabolic complications. The AGPAT2 gene encodes for 1-acylglycerol-3phosphate-O-acyltransferase highly expressed in white adipocytes that catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a...

ea0063p611 | Diabetes, Obesity and Metabolism 2 | ECE2019

Prenatal metformin treatment in obese rats: Evaluation of liver norepinephrine and lipogenic enzymes in offspring

Valero Viviana , Fernandois Daniela , Alvarez Daniela , Cruz Gonzalo

Maternal obesity during pregnancy is associated with several metabolic impairments in offspring, some of them evidenced from early infancy. Some reports have demonstrated that offspring of obese rats, whose obesity was induced by high fat diet consumption, have an increase sympathetic tone and increased norepinephrine (NE) content in kidney, liver and ovary. We recently reported that maternal administration of metformin prevents the increase in ovarian NE in offspring when the...

ea0063p612 | Diabetes, Obesity and Metabolism 2 | ECE2019

Profile of celiac disease in diabetic children

Lassoued Najoua , Wannes Salmane , Jammeli Nessrine , Wardani Asma , Hammouda Hechmi Ben , Soua Habib , Mahjoub Bahri

Introduction: Celiac disease (CD) is a common condition in children with type 1 diabetes (T1D). This condition is often asymptomatic and predisposes to severe complications of diabetes. The aim of this work was to study the clinical, biological, and evolutionary features of CD in diabetic children compared to a control group of non-celiac diabetic children.Patients and methods: Retrospective study of a cohort of 10 T1D children with CD compared to a cont...

ea0063p613 | Diabetes, Obesity and Metabolism 2 | ECE2019

A common but forgotten cause of electrolyte disturbances in patients with cachexia

Christidis Grigorios , Garaiman Alexandru , Holz Robert , Krawczyk Marcin , Lammert Frank

Fluid and electrolyte disturbances are a challenging problem of inpatients, especially in those subpopulations, in whom the electrolyte imbalance is involved in the pathogenesis of the primary disease. Here we present the case of a 58 year old woman, with ongoing alcohol abuse on a daily basis, who was admitted with progressive fatigue and dysphagia. At the admission BMI was 17.8 kg/m2, and the patient presented deficiency of vitamins A, B, and D. The diagnostic pro...

ea0063p614 | Diabetes, Obesity and Metabolism 2 | ECE2019

Vitamin D status and bone metabolism in adult patients with Type 1 diabetes mellitus

Barmpa Eleftheria , Karamagiolis Spyros , Tigas Stelios , Koukoulis Georgios N , Bargiota Alexandra

Introduction: Vitamin D is essential for calcium metabolism and is involved in bone turnover. The purpose of this study was to examine vitamin D status and its relation with bone metabolism in adult patients with T1DM.Methods/Design: We studied 118 patients with T1DM (Group-D) (mean age: 35.4+10.3 years) and 94 healthy controls (Group-C) matched for age, sex and body mass index (BMI). In both groups HbA1c, 25(OH)Vitamin D (Vit-D), serum calcium (Ca), pho...

ea0063p615 | Diabetes, Obesity and Metabolism 2 | ECE2019

The effect of antidiabetic drugs on serum 25-hydroxyvitamin D level: A preliminary report

Zelinska Nataliya , Maslii Kateryna

Objective: This study aimed to assess the early results of the effect of antidiabetic drugs on serum 25-hydroxyvitamin D (25(OH)D) level in patients with type 2 diabetes mellitus (T2DM).Methods: Thirty-five patients with T2DM having vitamin D deficiency (<20 ng/ml) or insufficiency (<30 ng/ml) were included. They were divided into 5 groups according to the drug therapy (metformin alone (n=9), metformin in combination with insulin (n<...

ea0063p616 | Diabetes, Obesity and Metabolism 2 | ECE2019

Serum total and bioactive fibroblast growth factor 21 levels are similar in patients with gestational diabetes mellitus and healthy pregnant controls

Celik Ali Osman , Kiyici Sinem , Ustundag Yasemin , Sigirli Deniz , Guclu Metin , Ustunyurt Emin

Aim: Fibroblast growth factor (FGF) 21 is a hormone which plays an important role in metabolic diseases such as diabetes, obesity and dyslipidemia. In this study; we aimed to investigate the serum total and bioactive FGF21 levels in patients with gestational diabetes mellitus (GDM) and compared with healthy pregnant controls.Material and Methods: A two-step screening method and Carpenter and Coustan criteria were used in the diagnosis of...

ea0063p617 | Diabetes, Obesity and Metabolism 2 | ECE2019

Liraglutide restores the hyperglycemic oxidative imbalance and induces the expression of CRH, UCN1, UCN2 AND UCN3 neuropeptides in macroendothelial cells

Gougoura Sofia , Bargiota Alexandra , Koukoulis Georgos N.

Introduction: Liraglutide treatment reduces cardiovascular complications in patients with diabetes mellitus (DM), which may imply a favorable impact on the endothelial function. The aim of the present study was to investigate in vitro the effect of liraglutide on endothelial redox balance and the parallel expression of CRH, UCN1, 2 and 3 neuropeptides, under normoglycemic and hyperglycemic conditions.Methods: Macroendothelial cell line EAhy926 w...

ea0063p618 | Diabetes, Obesity and Metabolism 2 | ECE2019

The effects of hyperinsulinemia on cochlear functions

Koca Arzu Or

Purpose: Hyperinsulinemia is the metabolic change, which is related to the cochleovestibular diseases the most. It is thought that undiagnosed deafness is highly probable in individuals with prediabetic hyperinsulinemia. We aimed at investigating the results of hearing function test in hyperinsulinemic individuals.Material and Method: 164 patients were included in the study, which was designed as a prospective research, 76 of which were in case group and...

ea0063p619 | Diabetes, Obesity and Metabolism 2 | ECE2019

Trial-in-progress: ZEPHYR, a pivotal phase 2b/3 randomized, placebo-controlled study of livoletide, a novel unacylated ghrelin analog, for the treatment of hyperphagia and food-related behaviors in patients with Prader-Willi syndrome

Allas Soraya , Mohideen Pharis , Delale Thomas , Lin Vivian , Yeh Michael , Tremel Nadege , Tauber Maithe

Background: Prader-Willi syndrome (PWS) is a rare disease characterized by hyperphagia and abnormal food-related behaviors that contribute to severe morbidity and early mortality and to a significant burden on patients and caregivers. There is no approved treatment for hyperphagia in PWS. Patients with PWS have increased circulating levels of the orexigenic hormone acylated ghrelin (AG) with a relative deficit of unacylated ghrelin (UAG). Livoletide (AZP-531) is a first-in-cla...

ea0063p620 | Diabetes, Obesity and Metabolism 2 | ECE2019

Next generation sequencing reveals ABCC8 (MODY 12) variants in two families with diabetes mellitus (DM)

Markou Athina , Sertedaki Amalia , Tatsi Elizabeth , Piaditis George , Kounadi Theodora , Kanaka-Gantenbein Christina

Introduction: Maturity Onset Diabetes of the Young (MODY) constitutes a genetically and clinically heterogeneous type of Monogenic Diabetes (MD). It is characterized by autosomal dominant inheritance, early onset diabetes, defect in the β-cell insulin secretion, positive family history, absence of diabetic ketoacidosis, auto-antibodies and insulin resistance. To date, 14 different MODY subtypes have been reported each one with distinct genetic etiology, however MODY patie...

ea0063p621 | Diabetes, Obesity and Metabolism 2 | ECE2019

Nonclinical development of livoletide (AZP-531), a peptide analog of unacylated ghrelin for the treatment of hyperphagia in Prader-Willi syndrome

Milano Stephane , Allas Soraya , Cade Didier , Briffaux Jean-Paul , Spencer Andrew

Prader-Willi syndrome (PWS) is a rare complex endocrine disease characterized by hyperphagia and abnormal food-related behaviors that contribute to severe morbidity and early mortality and to a significant burden on patients and caregivers. There are no approved treatments for hyperphagia in PWS. Patients with PWS have increased circulating levels of the orexigenic hormone acylated ghrelin (AG) with a relative deficit of unacylated ghrelin (UAG). These abnormalities in AG and ...

ea0063p622 | Diabetes, Obesity and Metabolism 2 | ECE2019

Assessment of materno-fetal complications in pregnant women with type 1 diabetes exposed to insulin degludec

Martinez Montoro Jose Ignacio , Hernandez Garcia Carmen , Jose Picon Cesar Maria , Molina Vega Maria , Maria Diaz Perdigones Cristina , Damas Fuentes Miguel , Jose Tinahones Madueno Francisco

Introduction: Pregnancy in women with type 1 diabetes mellitus (T1DM) is associated with an increased risk of adverse outcomes, so pregnancy planning in order to achieve an optimal glycemic control is essential. This control has been made possible, in part, by the widespread use of insulin analogues, especially the long-acting ones, glargine and detemir. Insulin degludec, an ultra-long-acting insulin is not currently approved for pregnant women due to the lack of randomized co...

ea0063p623 | Diabetes, Obesity and Metabolism 2 | ECE2019

Myeloproliferative disorder: a rare cause of insulin auto-immune syndrome leading to recurrent severe hypoglycaemia

Emna Jelloul , Fontaine Benedicte , Vanderbecken Stephane , Meliani Pascal , Kembellec Candice , Flaus-Furmaniuk Ania , Debussche Xavier

Insulin autoimmune syndrome (IAS; Hirata syndrome) is a rare cause of hypoglycemia. It seems to be related to specific HLA class II alleles. Rarely, monoclonal antibody acts as an insulin-binding autoantibody: until now 10 cases have been described in association with a myeloproliferative disorder. In June 2015, a 60-year-old patient presented in a local hospital in Mayotte with confusion, sweating and severe hypoglycemia (blood glucose as low as 20 mg/dl). He was suffering of...

ea0063p624 | Diabetes, Obesity and Metabolism 2 | ECE2019

Augmented Mitophagy and Inflammasome Activation with Metformin therapy in patients with T2DM

Bhansali Shipra , Bhansali Anil , Dhawan Veena

Background: Impaired mitophagy (mitochondrial autophagy) and NLRP3 inflammasome activation have been implicated in the etiopathogenesis of insulin resistance and T2DM. Metformin beside being an insulin-sensitizer, also induces autophagy. However, further research is warranted in elucidating its effect on mitophagy and NLRP3 activation in patients with T2DM.Methods: 45 drug-naïve, newly diagnosed T2DM patients, with HbA1C 53–75 mmol/m...

ea0063p625 | Diabetes, Obesity and Metabolism 2 | ECE2019

Features of IL-17 expression in focus of inflammation modulating in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease

Kondratiuk Kateryna , Kondratiuk Valentyna , Lysianyj Mykola , Mykhalchyschyn Galyna

According to recent views, underlying cause and characteristic of type 2 diabetes mellitus (DM2), complicated by non-alcoholic fatty liver disease (NAFLD) is chronic systemic low-gradient inflammation, in which the leading role in liver damage and DM2 decompensation is given to the cytokine production. The purpose of this study was to compare the levels of interleukin 17 (IL-17) expression in patients with DM2 and NAFLD, as well as to assess the relationship between IL-17 and ...