Searchable abstracts of presentations at key conferences in endocrinology
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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Poster Presentations

Interdisciplinary Endocrinology 1

ea0063p626 | Interdisciplinary Endocrinology 1 | ECE2019

Autoimmune thyroiditis (AIT) and diet – the patients’ and medical professionals’ view

Trofimiuk-Muldner Małgorzata , Czubek Ewa , Sztorc Jan , Skalniak Anna , Hubalewska-Dydejczyk Alicja

An increasing interest in improving the quality of life of patients with autoimmune thyroid disorders has been noted during recent years. Although there is little scientific evidence, many patient-oriented publications, websites and support groups recommend changes in diet as well as nutritional supplement use as a cure for thyroid disease and the mean for ailments reduction. The presented survey aimed to explore the patients’ and medical professionals’ approach to n...

ea0063p628 | Interdisciplinary Endocrinology 1 | ECE2019

Diabetes and dementia in the geriatric population – The icing on the cake

Wong Jim , New Ru , Chan Kok

Background: The association between diabetes and dementia has been well documented (1, 2, 3) and with Australia’s aging population, the already significant disease burden of both pathologies will inevitably progress over time. Despite both being progressive pathologies which escalate over time, there have not been any studies pertaining to degree of glycaemic control and the extent to which this relates to prevalence of dementia.Aims: To determine a...

ea0063p629 | Interdisciplinary Endocrinology 1 | ECE2019

Gender affirming therapy in Female to Male individuals – lipid profile alterations

Miletic Marija , Gajic Milina Tancic , Stojanovic Milos , Vujovic Svetlana

Background: Individuals with gender incongruence receive gender affirming therapy which is fundamental to sex reassignment. Cross sex hormone treatment both improves and impairs several surrogate markers of cardiovascular risk. In the aging population of transsexual persons, we are called to address clinical endpoints of the long-term gender affirming hormone therapy.Aim: Aim was to assess changes in the fasting serum lipid profile during gender affirmin...

ea0063p630 | Interdisciplinary Endocrinology 1 | ECE2019

Therapeutic education specifically dedicated to patients being followed for stunting with somatotropin

Askaoui Sara , Rafi Sana , Lmghari Guizlane , Ansari Nawal El

Introduction: Therapeutic education is one of the cornerstones in the management of various chronic diseases in children and adults. Several models of therapeutic education have been well developed (obesity, type 1 diabetes…); nevertheless, it remains less common and less developed in certain endocrine diseases. The purpose of this work is to present the therapeutic approach designed for children requiring treatment with growth hormone.Materials an...

ea0063p631 | Interdisciplinary Endocrinology 1 | ECE2019

Mobile technologies for nutritional support and exercise for improving life of a patient with HIV: Case report

Krylov Vadim , Dobreva Ekaterina

Introduction: There are a lot of conditions associated with human immunodeficiency viri such as lipodystrophy, fat atrophy, insulin resistance, low levels of high-density lipoprotein cholesterol, and hypertriglyceridemia. A diet program combined with exercises can help to treat patients with HIV.Methods: We used an online system for patient education based on video lessons, full of humor, pictures, and cartoons to convey the necessary information on good...

ea0063p632 | Interdisciplinary Endocrinology 1 | ECE2019

Alleviation of Autoimmune phenomena in Hashimoto’s thyroiditis after Thyroidectomy: Is this an additional surgical indication?

Panchangam Ramakanth Bhargav , Sabaretnam M , Chakrapani B , Ramesh B , Rajesh B

Introduction: Hashimoto’s thyroiditis (HT) is one of the commonest endocrine disorder. Often, HT is associated with a plethora of autoimmune co-morbidities (AIC) such as vitiligo, arthitides, pernicious anaemia, skin allergy, thrombocytopenia, addison’s disease, type 1 diabetes, celiac disease, eosinophilia etc., The etiology of these AIC in HT is enigmatically idiopathic and hypothesized to be autoimmune in origin. Many studies suggests that thyroid specific antibod...

ea0063p633 | Interdisciplinary Endocrinology 1 | ECE2019

Is Hashimoto’s encephalopathy Reversible with Surgical Thyroidectomy: A South Indian experience

Panchangam Ramakanth Bhargav , Mayilvaganan Sabaretnam , Bangariahgari Chakrapani , Rajesh B , Ramesh B

Introduction: Hashimoto’s thyroiditis (HT) is one of the frequent endocrine disorder. Clinical picture in Hashimoto’s thyroiditis is predominantly due to associated hypothyroidism and/or goiter related neck complaints. Rarely, HT can be associated with recurrent encephalopathy characterized by seizures, amnesia and comatose episodes. The etiology of this Hashimoto’s encephalopathy (HE) is enigmatically idiopathic and hypothesized to be autoimmune in origin. The ...

ea0063p635 | Interdisciplinary Endocrinology 1 | ECE2019

Hypothyroidism and Down syndrome

Kavecan Ivana , Privrodski Jadranka Jovanovic , Obrenovic Milan , Privrodski Boris , Mudrinic Tatjana Redzek

Background and Aims: Individuals with Down syndrome have an increased risk of developing hypothyroidism, autoimmune etiology. Prevalence of hypothyroidism in Down syndrome people is from 15% to 65%. Congenital hypothyroidism is about 25 times more common among newborns and infants with Down syndrome in comparison with the general population with incidence of 0.7% permanent cases and 0.3% transient congenital hypothyroidism cases, detected by newborn screening. Beyond the newbo...

ea0063p636 | Interdisciplinary Endocrinology 1 | ECE2019

Helicobacter pylori infection in patients with celiac disease

Mrabet Soumaya , Jemni Imen , Akkari Imen , Jazia Elhem Ben

Introduction: Different studies indicated the possible association between celiac disease and Helicobacter pylori (HP) infection, although this evidence is not consistently accepted. The aim of our study was to determine whether HP infection and celiac disease were associated among patients undergoing upper gastrointestinal endoscopy.Methods: Between January 2017 and June 2018, patients undergoing upper gastrointestinal endoscopy with both gastric and du...

ea0063p637 | Interdisciplinary Endocrinology 1 | ECE2019

Polyphenol health effects on cardiovascular and neurodegenerative disorders: a meta-analysis

Spaggiari Giorgia , Poti Francesco , Zimetti Francesca , Zanotti Ilaria , Santi Daniele

Background: Polyphenols are proposed as protective factors against the occurrence of degenerative diseases affecting several systems, such as cardiovascular and neurocognitive ones. The beneficial effect of polyphenol-enriched diets is assumed to be multifactorial, including direct antioxidant and anti-inflammatory properties, as well as the polyphenol-related capability to modulate lipid metabolism and gut microbiota function. However, the prediction of polyphenols’ impa...

ea0063p638 | Interdisciplinary Endocrinology 1 | ECE2019

Causes and outcomes of hyponatraemia at Mater Dei Hospital, Malta

Seguna Desiree , Magro Abigail , Gauci Paula , Moore Gillian Pace , Gruppetta Mark

Context: Hyponatraemia is the most common electrolyte balance disorder in clinical practice, amounting to 15–20% of casualty visits. While there is general agreement that associated mortality rates are high, most studies are uncontrolled.Objective: To determine the characteristics, causes and outcome of severe hyponatraemia (<125 mmol/l) in hospitalised patients and to indentify mortality predictors.Design: This is a retro...

ea0063p639 | Interdisciplinary Endocrinology 1 | ECE2019

Constitutive activity of human RXFP2

Suteau Valentine , Gourdin Louis , Briet Clairee , Lebeault Maylis , Rodien Patrice , Munier Mathilde

Introduction: The relaxin family peptide receptor 2 (RXFP2) is the receptor for Insulin-like peptide-3 (INSL3). The INSL3/RXFP2 signaling is necessary in the first stage of testis descent. Besides, it is proposed that RXFP2 has a role in bone metabolism or in development of cancers (thyroid, prostate). RXFP2 is a rhodopsin-like G protein-coupled receptors (GPCR). Recently, it has been demonstrated that Drosophila RXFP2 had constitutive activity, i.e., a ligand-independent sign...

ea0063p640 | Interdisciplinary Endocrinology 1 | ECE2019

Different regulation of erythropoietin and VEGF in clear renal cell carcinoma

Cokic Bojana Beleslin , Macut Djuro , Milicevic Ivana , Rodic Gordana , Bankovic Jovana , Antic Jadranka , Noguchi Constance , Damjanovic Svetozar

Clear renal cell carcinoma (ccRCC) is a highly vascularized and proliferative tumor. ccRCC can be sporadic or familiar, usually associated with von Hippel-Lindau (VHL) gene mutations. VHL protein is part of the E3 ubiquitin ligase complex that regulates hypoxia-inducible factor (HIF). When a defective and inactive VHL protein is produced, HIF is not degraded, resulting in over-expression of hypoxia related genes including erythropoietin (EPO) and vascular endothelial growth fa...

ea0063p641 | Interdisciplinary Endocrinology 1 | ECE2019

Digital epidemiology of hypothyroidism: pilot study

Ilias Ioannis , Kakoulidis Ioannis , Koukkou Eftychia

Introduction: Digital epidemiology uses digital data which was not generated with the primary goal of serving epidemiological research (Life Sci Soc Pol 2018; 14:1). Recently, time and geographical correlation was noted between Google Trends findings and the prevalence of coronary artery disease (JACC, 2018, 71:98). Furthermore, using Google Trends, we have noted that the search terms ‘fatigue/weakness’ were correlated with the terms ‘hypothyroidism/thyroiditis&...

ea0063p642 | Interdisciplinary Endocrinology 1 | ECE2019

To what extend biotin interferes with hormones immunoassays?

Bouzerara Amina , Pavard Juliette , Bonnet-Serrano Fideline , Jaoude Mathieu Abou , Guibourdenche Jean

Introduction: Biotin (vitamin B8) is a coenzyme of carboxylases involved in many metabolic pathways and also used in therapeutics as a dietary supplement (diffuse alopecia)(<30 mg/day), in the treatment of rare congenital enzymatic deficiencies (5–40 mg/day) or more recently in the treatment of progressive multiple sclerosis at higher doses (300 mg/day). At such high doses, interferences with thyroid hormones assays using biotin-streptavidin amplification system were ...

ea0063p643 | Interdisciplinary Endocrinology 1 | ECE2019

Unexpected manifestation of autoimmune thyroid disease in a lipoid proteinosis patient

Uygur Meliha Melin , Eskiocak Ali Haydar

Extracellular matrix protein 1 (ECM1) is an 85 kDa glycoprotein that plays an important role in skin physiology, angiogenesis, tumor progression and malignancies. However, the function of ECM-1 in regulation of the immune responses has not been identified. Recent studies showed ECM-1 deficiency lowers the capacity of T helper 2 (Th2) cells to emigrate from draining lymph nodes to an inflamatory site. Lipoid proteinosis (LiP) and Licken Sclerosus (LS) are immunogenetic counterp...

ea0063p644 | Interdisciplinary Endocrinology 1 | ECE2019

Dominance of ovarian follicles is determined by follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) heteromers

Casarini Livio , Lazzaretti Clara , Paradiso Elia , Riccetti Laura , Sperduti Samantha , Marcozzi Serena , Sayers Niamh , Brigante Giulia , Poti Francesco , La Marca Antonio , Valli Barbara , Falbo Angela , Villani Maria Teresa , Klinger Francesca Gioia , Fane Francesca , Hanyaloglu Aylin Carla , Simoni Manuela

Mechanisms regulating the selection of antral ovarian follicles are poorly understood and supposed to rely on low estrogen levels, decline of follicle-stimulating hormone (FSH) levels and receptor (FSHR) expression on the surface of granulosa cells. These concepts are challenged in-vitro, where apoptosis of human granulosa cells (hGLC) and transfected cell lines is induced by high doses of FSH or FSHR overexpression, while estrogens induce anti-apoptotic signals via n...

ea0063p645 | Interdisciplinary Endocrinology 1 | ECE2019

Demonstration of follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) heterodimerization by bioluminescence resonance energy transfer (BRET)

Lazzaretti Clara , Paradiso Elia , Riccetti Laura , Sperduti Samantha , Brigante Giulia , Poti Francesco , Fanelli Francesca , Simoni Manuela , Hanyaloglu Aylin Carla , Casarini Livio

During the menstrual cycle, selection of the dominant follicle is characterized by changes of gonadotropin and steroid hormone receptor expression. We aim to evaluate whether co-existing follicle-stimulating hormone receptor (FSHR) and G protein-coupled estrogen receptor (GPER) form heterodimers, suggesting their role in ovarian follicle selection. FSHR-GPER dimerization was evaluated in transfected HEK293 cells in vitro by bioluminescence resonance energy transfer (B...

ea0063p646 | Interdisciplinary Endocrinology 1 | ECE2019

Spingosine-1-phosphate induces cAMP/PKA-independent pCREB activation, but not steroidogenesis, in human granulosa cells

Paradiso Elia , Lazzaretti Clara , Riccetti Laura , Sperduti Samantha , Antoniani Francesco , Brigante Giulia , Feo Gaetano De , Morini Daria , Iannotti Francesca , Simoni Manuela , Poti Francesco , Casarini Livio

Sphingosine-1 phosphate (S1P) is a lysosphingolipid present in the ovarian follicular fluid at the nanomolar concentration. The physiological functions of S1P are mediated through five specific G protein-coupled receptors (GPCRs), known as S1PR1-5. S1PR1 and S1PR3 are expressed in human primary granulosa lutein cells (hGLC), as well as in the immortalized human primary granulosa cell line hGL5. S1PRs are activated at nanomolar concentrations inducing specific activation or inh...

ea0063p647 | Interdisciplinary Endocrinology 1 | ECE2019

5-Beta-reductase (AKR1D1) deletion leads to increased insulin sensitivity in mature male mice

Arvaniti Anastasia , Harris Shelley , Nikolaou Nikolaos , Hazlehurst Jonathan , Moolla Ahmad , Dempster Niall , Cox Roger , Gathercole Laura , Tomlinson Jeremy

Bile acids (BA) are potent steroid hormones that mediate a variety of metabolic effects. They play a pivotal role in cholesterol catabolism, intestine nutrient absorption, and regulate lipid, glucose and energy metabolism. 5-Beta-Reductase (AKR1D1) is a key enzyme in the BA synthesis pathway, required for cholesterol metabolism into bile acids. We generated a novel global AKR1D1 knockout (KO) mouse which, as expected, has decreased total serum and hepatic BAs and altered BA co...

ea0063p648 | Interdisciplinary Endocrinology 1 | ECE2019

Ghrelin expression in breast carcinomas

Armasu Ioana , Ciobanu Delia-Gabriela , Ianole Victor , Vasiliu Ioana , Hristov Ioana , Leustean Letita , Lupascu Cristian , Mocanu Veronica , Serban Ionela Lacramioara , Preda Cristina

Introduction: Breast cancer is, by far, the most frequent cancer among women. Local and systemic factors have been shown to drive growth in breast cancer cells. There is increasing evidence that hormone ghrelin, known for the growth hormone releasing effect and food intake modulator, may also influence cancer growth. Ghrelin has been shown to be produced by some tumor cells, including breast cancer cells.Objective: To analyze ghrelin expression in correl...

ea0063p649 | Interdisciplinary Endocrinology 1 | ECE2019

Polydispia can reveal underlying non-osmotic arginine-vasopressin secretion

Pazos Mario , Pallares Raquel , Cuesta Martin , Barrio Elvira , Ramos Elvira , Herraiz Lorea , Azcutia Ane , Miguel Maria Paz De , Runkle Isabelle , Calle Alfonso

Inroduction: Polydipsia -excessive oral intake of liquids, with/without thirst- can induce euvolemic hyponatremia. Adequate inhibition of AVP secretion induced by low plasma osmolality (POsm) is reflected in a urinary osmolality (UOsm) ≤100 mOsm/kg. However, increased fluid intake can also reveal underlying non-osmotic AVP secretion, induced by pain, nausea, and/or SIADH, with UOsm >100. Iatrogenic polydipsia is characterized by increased liquid intake without thirst...

ea0063p650 | Interdisciplinary Endocrinology 1 | ECE2019

Helicobacter pylori infection in patients with celiac disease

Jazia Elhem Ben , Mrabet Soumaya , Akkari Imen , Jemni Imen

Different studies indicated the possible association between lymphocytic gastritis and both celiac disease and Helicobacter pylori infection, although this evidence is not consistently accepted.Objective: We aimed to determine whether Helicobacter pylori infection and celiac disease were associated among patients undergoing upper gastrointestinal endoscopy.Methods: Between January 2016 and June 2017, patients over...

ea0063p651 | Interdisciplinary Endocrinology 1 | ECE2019

Biguanides exert antitumoral actions in pituitary tumor cells through AMPK-dependent and -independent mechanisms

Herrera-Martinez Aura D , Vazquez-Borrego Mari C , Fuentes-Fayos Antonio C , L-Lopez Fernando , Ibanez-Costa Alejandro , Moreno Paloma Moreno , Alhambra-Exposito Maria R , Barrera-Martin Ana , Blanco-Acevedo Cristobal , Dios Elena , Venegas-Moreno Eva , Solivera Juan , Gahete Manuel D , Soto-Moreno Alfonso , Galvez-Moreno Maria A , Castano Justo P , Luque Raul M

Background: Pituitary adenomas represent a commonly underestimated pathology in terms of incidence and associated morbimortality. Additionally, some patients poorly respond or develop resistance to current medical treatments [i.e. somatostatin analogues (SSAs) and dopamine agonists]. In this context, it is necessary to develop novel and/or optimize currently available medical therapies. Biguanides (metformin, buformin and phenformin) are antidiabetic drugs that have been descr...

ea0063p652 | Interdisciplinary Endocrinology 1 | ECE2019

Restoring the sleep disruption by blue light emitting screen use in adolescents: a randomized controlled trial

Meijden Wisse P van der , Stenvers Dirk Jan , Kerkhof Linda van , Nierop Lotte van , Steeg Harry van , Bisschop Peter H , Someren Eus J van , Kalsbeek Andries

Introduction: Adolescents spend much time using blue-light emitting screen devices such as smartphones, tablets and computers. Blue light affects the central circadian clock in the suprachiasmatic nucleus (SCN) as well as melatonin secretion by the pineal gland. Screen use in adolescents strongly associates with reduced sleep quality and sleep duration. However, there is a lack of intervention studies that reduce blue light exposure due to screen use in adolescents.<p clas...

ea0063p653 | Interdisciplinary Endocrinology 1 | ECE2019

Dietary glycemic index and dietary glycemic load is associated with apelin gene expression from visceral and subcutaneous adipose tissues of adults

Yuzbashian Emad , Asghari Golaleh , Zarkesh Maryam , Aghayan Maryam , Mirmiran Parvin , Hedayati Mehdi , Khalaj Alireza

Background and aim: Apelin, as an adipokine, is encoded by the APLN gene. It is a key regulator in glucose and lipid metabolism and plays an important role in the pathogenesis of insulin resistance and type 2 diabetes. It seems that habitual dietary intake of carbohydrates including quality and quantity by chronic manipulating insulin concentration might have a distinguishing role in the prediction of apelin gene expression in adipose tissue, but there is no evidence in this r...

ea0063p654 | Interdisciplinary Endocrinology 1 | ECE2019

Habitual physical activity are associated with fat mass and obesity-associated gene (FTO) gene expression in visceral and subcutaneous adipose tissues among non-diabetic people

Mahmoodi Behnaz , Yuzbashian Emad , Zarkesh Maryam , Asghari Golaleh , Hedayati Mehdi , Mirmiran Parvin , Khalaj Alireza

Introduction: Human fat mass and obesity-associated gene (FTO) gene expression are associated with body mass index and type 2 diabetes. It is unknown whether lifestyle factors, such as physical activity, can attenuate weight gain and obesity by contribution to the FTO gene regulation. The objective of the present study was to investigate the association between habitual physical activity and the FTO gene expression among morbid obese and non-obese subjects.<p class="abstex...

ea0063p655 | Interdisciplinary Endocrinology 1 | ECE2019

Meningiomas and hormone therapy: a multicenter, epidemiological, retrospective, uncontrolled study

Lugat Alexandre , Samarut Edouard , Thillays Francois , Buffenoir Kevin , Roualdes Vincent , Cariou Bertrand , Drui Delphine

Meningiomas are the most common intracranial tumors accounting for 20 to 30% of central nervous system tumors. Currently, only two risk factors have been highlighted: the history of exposure (therapeutic or accidental) to ionizing radiation, and some genetic predispositions syndromes in particular Neurofibromatosis type 2. Given the feminine predominance and the presence of progesterone receptors expression in meningiomas, authors began to focus on hormonal factors as a risk f...

ea0063p656 | Interdisciplinary Endocrinology 1 | ECE2019

Epidemiological characteristics of transsexual people referred to a single-center during its first fifteen years in Catania (Italy)

Vetri Mario , Cataldi Alessia , Naselli Adriano

Gender Dysphoria (GD) is defined as incongruence between gender identity and physical phenotype. This condition exists in different psychological typologies: male-to-female (MtF) and female-to-male (FtM) transsexualism. In most cases the first manifestations can occur even during childhood. The transition project is a long and difficult path that involves a multidisciplinary team including endocrinologists, psychologist and plastic surgeons. Our study aims to describe socio-de...

ea0063p657 | Interdisciplinary Endocrinology 1 | ECE2019

Endocrinological management of male-to-female (MtF) transgender persons: a single center experience during the last decade

Vetri Mario , Naselli Adriano , Cataldi Alessia

In MtFs therapy with oestrogens and antiandrogens, actually considered the best strategy, requires a careful baseline and follow-up hormonal evaluation. We conducted a retrospective analysis to define the most frequent hormonal treatment prescribed and the relationship between the dosage and patients’ hormonal changes. Among 85 pts referring to us between March 2003 and June 2018 with a mean age of 28.4 years we have selected 42 treated with Oestradiol Valerate (OV) and C...

ea0063p658 | Interdisciplinary Endocrinology 1 | ECE2019

Endocrinological management of female-to-male (FtM) transgender persons: a single center experience during the last decade

Vetri Mario , Naselli Adriano , Cataldi Alessia

In FtMs testosterone (TE) therapy is used to pursue the dual objective of suppressing female secondary sex characteristics and inducing a male phenotype to the patient. Between October 2001 and December 2018, an heterogeneous group of 32 patients (Pts) with a mean age of 27.7 years presented to our Center for FtM Gender Dysphoria. We analyzed Body Mass Index (BMI), haemochrome and hormonal (LH, FSH, Prolactin) measurements comparing baseline levels to post-therapy. A total of ...

ea0063p659 | Interdisciplinary Endocrinology 1 | ECE2019

Long-term outcome in young women treated for central precocious puberty

Improda Nicola , Barbieri Flavia , Moracas Cristina , Paolo Ciccarelli Gian , Capalbo Donatella , Santamaria Fabiana , Salerno Mariacarolina

Background: GnRH-analogs (GnRHa) are the recommended treatment for Central Precocious Puberty (CPP). Despite a normal long-term outcome is generally reported, reproductive function and emotional sphere in adulthood are still poorly evaluated.Objective: To evaluate the general long-term outcome of young women with previous CPP treated with GnRHa.Patients and methods: A cohort of 63 young women (25.5±5.31 years) with history of ...

ea0063p660 | Interdisciplinary Endocrinology 1 | ECE2019

Neurofibromatosis type 2 revealed by hypertension in a young woman: is there a link?

Marmouch Hela , Jenzri Haythem , Mrabet Houssem , Fekih Hamza , Khochtali Ines

Introduction: Neurofibromatosis 2 (NF2) is a rare genetic disease characterized by the development of multiple schwannomas and meningiomas. It has a very variable phenotype but the most common type of tumor to develop is the vestibular schwannoma. We report clinical case of NF2 which has been revealed by hypertension.Observation: We report the case of a 25-year-old woman referred to our institution for evaluation of hypertension. She had no family histor...

ea0063p661 | Interdisciplinary Endocrinology 1 | ECE2019

MiRNA-342-3p as a potential diagnostic biomarker in parathyroid carcinomas

Krupinova Julia , Mokrysheva Natalia , Petrov Vasiliy , Pigarova Ekaterina , Tiulpakov Anatoliy , Eremkina Anna , Dzeranova Larisa , Melnichenko Galina

Introduction: Despite recent developments in biochemical, radiological and molecular techniques, a preoperative diagnosis of parathyroid carcinoma (PC) remains a difficult task. The main challenge of all studies in this area is a small number of cases based on retrospective data. The search for new blood biomarkers associated with PC could be important for early diagnosis and prognosis. Dysregulated microRNA (miRNA) levels are involved in tumorigenesis and may serve as diagnos...

ea0063p662 | Interdisciplinary Endocrinology 1 | ECE2019

Adaptation of hypothalamo-pituitary-adrenal axis and cardio-metabolic parameters to physical stress in professional athletes

Popovic Bojana , Macut Djuro , Popovic Dejana , Banovic Marko , Bozic Antic Ivana , Isailovic Tatjana , Ognjanovic Sanja , Bogavac Tamara , Elezovic Kovacevic Valentina , Ilic Dusan , Damjanovic Svetozar

Introduction: Although intensive, repeated and perennial, physical stress of training generally does not represent a health hazard to professional athletes. Adaptation to such stress is presumed on multiple levels, but still not fully defined. Our aim was to analyze specificities of hypothalamic-pituitary-adrenal (HPA) axis response and adaptation to physical stress in professional athletes.Subjects and methods: We exposed 55 professional male athletes t...

ea0063p663 | Interdisciplinary Endocrinology 1 | ECE2019

Diagnotic value of Shear Wave Elastography in differentiating parathyroid adenomas from thyroid nodules

Vlad Mihaela , Golu Ioana , Oprea Maria , Amzar Daniela , Balas Melania , Sporea Ioan

Parathyroid adenomas are situated nearby thyroid gland or even intrathyroidal and could be confounded with thyroid nodules. Ultrasound elastography is a noninvasive technique that explores the elasticity and stiffness of different tissue.Aim: To assess the value of 2D-shear wave elastography (2D-SWE), a new technique of sonoelastography, in the differentiation of parathyroid adenomas from thyroid nodules.Subjects and methods: We st...

ea0063p664 | Interdisciplinary Endocrinology 1 | ECE2019

Differential regulation of 5β-reductase (AKR1D1) expression and activity by glucocorticoids in human and rodent liver

Nikolaou Nikolaos , Morgan Stuart , Larner Dean , Sharp Anna , Raouf Zachariah , Hughes Beverly , Digweed Dena , Whitaker Martin , Ross Richard , Lavery Gareth , Arlt Wiebke , Gathercole Laura , Tomlinson Jeremy

The prevalence of metabolic syndrome and its hepatic manifestation, non-alcoholic fatty liver disease (NAFLD), continues to escalate. Glucocorticoids (GCs) and bile acids (BAs) are established regulators of metabolic phenotype. 5β-reductase (AKR1D1) is highly expressed in human and rodent liver, where it inactivates steroid hormones and catalyses a fundamental step in BA synthesis. We have previously demonstrated that AKR1D1 modulates hepatic GC availability and GC recept...

ea0063p665 | Interdisciplinary Endocrinology 1 | ECE2019

CD27-IgD- memory B cells studied in polycystic ovary syndrome

Ascani Angelo , Gumpold Roswitha , Borzan Valentin , Flieszer Elisabeth , Weber Jennifer , Prietl Barbara , Helmut Stradner Martin , Obermayer-Pietsch Barbara

Background: Age-associated double negative (DN) B memory cells lacking surface expression of CD27 and IgD have been associated with proinflammatory characteristics, higher disease activity in autoimmune diseases and disease-specific autoantibodies. We studied the distribution of DN B cells in Polycystic Ovary Syndrome (PCOS), their surface markers and cytokine production.Methods: CD19+ cell subpopulations on the basis of IgD and CD27 expression were phen...

ea0063p666 | Interdisciplinary Endocrinology 1 | ECE2019

Pan-cancer analysis of thyroid hormone signaling pathway reveals new possible targets for combinations therapy

Hanusek Karolina , Popławski Piotr , Piekiełko-Witkowska Agnieszka

Introduction: Published studies suggest links between altered actions of thyroid hormones (TH) and cancer development and progression. It is not clear, however, whether these links are specific to cancer types or whether TH can globally affect cancerogenesis. Here, we performed PanCancer analysis of TH signaling pathway.Material/methods: 79 genes linked with TH signaling pathway, including genes encoding proteins involved in TH synthesis, transport, rece...

ea0063p667 | Interdisciplinary Endocrinology 1 | ECE2019

CYP11A1 inhibition as a therapeutic approach for the treatment of castration resistant prostate cancer

Riikonen Reetta , Karimaa Mari , Rasanen Kati , Ramela Meri , Vehmaan-Kreula Pirjo , Rummakko Petteri , Wohlfahrt Gerd , Mustonen Mika V.J. , Oksala Riikka

Background: Prostate cancer is a major global challenge due to the increasing number of aging population and frequency of diagnosis. During the past decade new treatments have been targeted to the androgen signaling axis either by inhibiting the binding of androgens to androgen receptor (AR) and AR nuclear translocation, or by inhibiting androgen production via CYP17A1 enzyme. Despite the significant progress on the research and new therapies, CRPC is still incurable and there...

ea0063p668 | Interdisciplinary Endocrinology 1 | ECE2019

Neuroendocrine effects of stereotactic hypothalamotomy in humans

Ludecke Dieter K , Crock Patricia A , Muller Emeritus Dieter

Stereotactic hypothalamotomy in the treatment of morbid sexual deviation was first performed by Prof. Dr. Fritz Roeder 1966 in Univ. Göttingen and installed in University Hamburg-Eppendorf (UKE) by Neuropathologist Dr. Dieter Müller (DM) in the late 1970s. Dr. Dieter Lüdecke (DKL) agreed with Prof. Herrmann, Director of Neurosurgery, to give the Professor position to DM to join the Unit. It was known that the sex behaviour centre in the ventromedial nucleus of C...

ea0063p669 | Interdisciplinary Endocrinology 1 | ECE2019

Dyslipidaemia and altered hepatic function in males - consequences of androgen excess in fetal life

Siemienowicz Katarzyna , Filis Panagiotis , Shaw Sophie , Douglas Alex , Thomas Jennifer , Howie Forbes , Fowler Paul , Duncan Colin , Rae Mick

Introduction: Adult male offspring of women with PCOS have increased dyslipidaemia, characterised by elevated triglycerides (TG), increased total and LDL-cholesterol (LDL-C), and hyperinsulinaemia. As altered intrauterine endocrine environments can ‘programme’ adverse health outcomes in adulthood we hypothesised that this dyslipidaemia was a consequence of a hyperandrogenic intrauterine environment. We used an outbred large animal model to identify if prenatal androg...

ea0063p670 | Interdisciplinary Endocrinology 1 | ECE2019

The impact of new technologies in the future of health somatotropin: 100% therapeutic adhesion in oncological pediatric age survivors in the Ipolfg

Sonia Andrade , Filipa Matos , Joana Simoes-Pereira , Conceicao Pereira Maria da

Introduction: The somatotropin deficit is one of the late consequences of cancer treatments. The administration of somatotropin implies treatment with daily injections, which hinders therapeutic adherence. This goal is a challenge for survivors and health professionals. Therapeutic education and new technologies are instruments that favor the training and development of control mechanisms that promote and motivate the behavior’s change.Objective: To...

ea0063p671 | Interdisciplinary Endocrinology 1 | ECE2019

Clinical, malformative profile of turnersyndrome at mohammed VI university hospital centre oujda-morroco

Mahroug Ikram , Rbiai Najwa , Latrech Hanane

Introduction: Turner syndrome occurs in one out of every 2,500 to 3,000 live female births. The syndrome is characterized by the partial or complete absence of one X chromosome (45,X karyotype)(1). Patients with Turner syndrome are at risk of congenital heart defects, and is defined by the association of a dysmorphic and malformative syndrome, the main elements of which are small size and gonadal dysgenesis(2).Methodology: Descripti...