ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P760 | DOI: 10.1530/endoabs.63.P760

NMR-measured subfractions of HDL-cholesterol through thyroid function spectrum

Carolina Castro Porto Silva Janovsky1, Marcio Sommer Bittencourt1,2, Alessandra Goulart1, Paulo A Lotufo1,3 & Isabela M Bensenor1,3

1Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de Sao Paulo, Sao Paulo, Brazil; 2Hospital Israelita Albert Einstein & School of Medicine, Faculdade Israelita de Ciencia da Saude Albert Einstein, Sao Paulo, Brazil; 3Department of Internal Medicine, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Thyroid dysfunction has been traditionally related to several lipid abnormalities. Indeed, even within the normal range of thyroid-stimulating hormone (TSH) values, a linear increase in total cholesterol, low-density lipoprotein cholesterol and triglycerides and a linear decrease in high-density lipoprotein cholesterol (HDL-C) levels has been observed with increasing TSH. With respect to serum high-density lipoprotein (HDL) cholesterol concentrations, high, normal, or low values have been reported in different series. The aim of this report is to evaluate HDL-cholesterol subfractions analysed through nuclear magnetic resonance (NMR) through thyroid function spectrum in a Brazilian population.

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