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Endocrine Abstracts (2019) 63 P763 | DOI: 10.1530/endoabs.63.P763

Thyroid 2

Antinuclear antibodies, chronic autoimmune thyroiditis, periodontal disease – pathological correlations

Razvan Circo, Victoria Badea, Cristina Gosu & Eduard Circo


Department of Endocrinology, ‘Ovidius’ University, Constanta, Romania.

Aims: To evaluate the prevalence of antinuclear antibodies (ANA) in patients with chronic autoimmune thyroiditis (CAT) associated with periodontal disease (P.D).

Material and methods: 42 patients with TCA and BP were tested for ANA (Group 1) and 50 patients with TCA without BP (Group 2). Inclusion criterias – absence of other autoimmune diseases associated with positive ANA patients. Thyroid hormone deficiency has established thyroid function. Patients with B.P were differentiated: initial lesion - gingivitis, aggravated lesion - loss of dental attachment/endodontic lesions.

Results: Incidence of ANA: Group 1–36 (85.7%), Group 2–15 (30%). ANA/PD distribution – initial lesions – 10 (23.8%), advanced lesions – 26 (32%). ANA distribution/thyroid function: hypothyroidism – 21 (50%); normothyroid – 4 (9.5%), thyrotoxicosis – 11 (27%). Hypothyroidism associated to PD: inward lesions – 3 (30%); advanced lesions – 17 (5.3%).

Conclusions: There may be common pathogenic mechanisms for TCA and PD. Hypothyroidism produces an intensified lesional effect at periodontal level.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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