Neuroendocrine tumors (NETs) are a class of rare and heterogeneous neoplasms derived from the neuroendocrine system. Animal models are indispensable tools for investigating the pathogenesis, mechanisms for tumour invasion and metastasis and new therapeutic approaches for cancer. Unfortunately, only few models are available for NETs, probably due to the rarity and heterogeneity of this group of neoplasms. The tropical teleost zebrafish (Danio rerio) is a popular vertebrate model system that offers unique advantages for the study of a variety of biological processes. The small size and low cost of maintenance, together with the high prolific nature, the external fertilization and the rapid development of its transparent embryos have led to the first emergence of the zebrafish as reliable and suitable embryological model. Moreover, due to the proved conservation in genetic programs and physiology between fish and mammals, zebrafish has become a powerful model for studying human diseases, including cancer. This presentation provides an overview of the state of the art of zebrafish model in the cancer research with a main focus on NETs, highlighting future developments in this field.
18 - 21 May 2019
European Society of Endocrinology