ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 S5.1 | DOI: 10.1530/endoabs.63.S5.1

Human gut microbiome: hopes, threats and promises

Hubert VIDAL


France.


The gut microbiota is now the subject of considerable investigation and our knowledge of its composition and understanding of functions are rapidly growing.Gut microbiota has profound impact on host physiology and it is now well-established that dysbiosis is associated with altered glycemic control and type 2 diabetes development. Targeting microbiota appears therefore as a promising strategy for the treatment of diabetic patients. Using probiotics in order to modulate blood glucose has been considered for a long time. However, the low efficacy of currently available probiotics highlights the lack of well-defined and standardized methodology to identify and select bacterial strains with real anti-diabetic properties. A better understanding of the mechanisms by which gut microbiota impacts host physiology is needed to identify such probiotic strains. In this presentation, we will discuss some innovative strategies to identify bona fide probiotic strains with anti-diabetic potential.

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