Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2019

Brighton, United Kingdom
11 Nov 2019 - 13 Nov 2019

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Come and exchange knowledge, share experiences and strengthen collaborations across our global community of endocrinologists!


Reproductive Endocrinology and Biology

ea0065oc6.1 | Reproductive Endocrinology and Biology | SFEBES2019

Effect of MVT-602, a potent kisspeptin receptor agonist, on LH levels in healthy pre-menopausal women undergoing a minimal controlled ovarian stimulation protocol

Abbara Ali , Duijkers Ingrid , Ezzati Max , Voors Christine , Romeijn Christel , Berman Lance , Fan Xiaolin , Migoya Elizabeth , Dhillo Waljit S

Background: Kisspeptin is an endogenous neuropeptide that regulates GnRH release from the hypothalamus. Kisspeptin-54 has been shown to effectively trigger oocyte maturation during in vitro fertilisation (IVF) treatment, but with markedly reduced rates of ovarian hyperstimulation syndrome (OHSS). The kisspeptin receptor agonist, MVT-602, has a longer half-life than native kisspeptin-54 (1.5–2.2 h vs. 0.5 h) and has potential for development as a novel trigger of oocyte ma...

ea0065oc6.2 | Reproductive Endocrinology and Biology | SFEBES2019

Differential follicle stimulating hormone glycosylation modulates follicle growth and survival rates

Johnson Gillian , Bousfield George , Hardy Kate , Jonas Kim

Ovarian aging is a naturally occurring physiological process, marked by dynamic changes in ovarian function and hormone secretion. Ovarian ageing is associated with several co-morbidities, including; osteoporosis, diabetes, cardiovascular disease and impaired cognitive function, therefore, understanding the physiological processes regulating this is imperative for identifying novel treatment modalities. A key endocrine regulatory of ovarian function is the heterodimer glycopro...

ea0065oc6.3 | Reproductive Endocrinology and Biology | SFEBES2019

Investigating the impact of altered maternal extracellular vesicle miRNAs on placental function in women with gestational diabetes complicated by large for gestational age infants

Timms Kate , Cartland Sarah J , Ntostis Panagiotis , Saravanan Ponnusamy , Simpson Nigel , Scott Eleanor , Forbes Karen

Gestational diabetes mellitus (GDM) increases fetal morbidity/mortality, and is associated with elevated risks of offspring cardiometabolic disease. These risks are compounded in infants born large for gestational age (LGA) rather than appropriate size (AGA), a common complication of GDM associated with altered placental function. Circulating extracellular vesicle (EV)-associated miRNAs are internalised into the placenta and are emerging as key GDM mediators, with their role i...

ea0065oc6.4 | Reproductive Endocrinology and Biology | SFEBES2019

Kallmann syndrome-associated WDR11 regulates primordial germ cell development

Lee Ji Young , Kim Yeon Joo , Ataliotis Paris , Bennett Dorothy , Brown Nigel , Kim Soo Hyun

The primary cilium, a non-motile microtubule-based organelle protruding from most vertebrate cells, serves as a specialized compartment for signal transduction. Any disruption of ciliogenesis leads to ciliopathy-spectrum disorder with multiple signalling failure in development and homeostasis. Several ciliopathies including Bardet–Biedl syndrome associate with infertility and hormone imbalances, but the role of primary cilia in reproductive disorders is not clear. Congeni...

ea0065oc6.5 | Reproductive Endocrinology and Biology | SFEBES2019

Placental expression of estrogen related receptor γ (ERRγ) is hypoxia-sensitive and is altered in pregnancies complicated by fetal growth restriction

Zou Zhiyong , Heazell Alexander , Harris Lynda , Forbes Karen

Fetal growth restriction (FGR) defines a fetus which does not achieve its intrauterine growth potential. FGR is linked to placental dysfunction and hypoxia and is associated with a high risk of stillbirth, neonatal death and long-term complications; there are no treatments. Estrogen related receptor γ (ERRγ) is a nuclear receptor that is regulated by hypoxia in other systems; it is expressed in the placenta, thus we propose that it may be an important regulator of hy...

ea0065oc6.6 | Reproductive Endocrinology and Biology | SFEBES2019

Kisspeptin enhances the brain processing of attraction in men

Yang Lisa , Demetriou Lysia , Wall Matt , Mills Edouard , Zargaran David , Sykes Mark , Prague Julia , Abbara Ali , Owen Bryn , Bassett Paul , Rabiner Eugenii , Comninos Alexander , Dhillo Waljit

Background: Successful reproduction relies on integration of sensory cues of attraction with corresponding emotions and behaviours. However, the intrinsic factors integrating these fundamental aspects of human attraction with limbic and reproductive pathways have not been fully identified. Kisspeptin is a crucial activator of the reproductive axis and together with its receptor is widely expressed throughout the limbic and olfactory systems in humans suggesting a potential rol...