Endocrine Abstracts

New targeted drug strategies are urgently needed to improve radioiodine uptake and efficiently ablate thyroid cancer cells thereby minimising the risk of recurrent disease. High-throughput screening (HTS) offers a promising approach to identify new candidate drugs that will induce sodium iodide symporter (NIS) function to promote iodide uptake. However, significant progress has been limited by a lack of thyroid cell-based assays amenable to HTS. Here, we constructed a thyroid ...

Background: High risk patients with differentiated thyroid cancer (DTC) undergoing radioiodine (I-131) treatment can be prepared by thyroid hormone withdrawal (THW) or with parenteral recombinant TSH (rhTSH). We compared two centres predominantly using THW or rhTSH to study the impact on radioiodine retention and length of hospital stay (LoHS).Methods: We retrospectively compared radioactivity at discharge following high dose I-131 therapy (3–5 GBq ...

The potential health threat posed by endocrine-disrupting chemicals has come to the forefront of environmental health in previous years and nowadays represents a major concern among scientific, regulatory and public communities. Different groups of environmental chemicals appear to have thyroid-disrupting properties. The lifelong exposure to these chemicals raises concerns about their deleterious effects on human health, having in mind that even subtle changes in the individua...

Background: Alemtuzumab is an anti-CD52 monoclonal antibody used in the treatment of relapsing-remitting multiple sclerosis (MS). Between 20 and 40% of Alemtuzumab-treated MS patients develop autoimmune thyroid disease (AITD) as a side effect. It is currently unknown whether development of AITD correlates with MS disease activity following Alemtuzumab treatment.Aims: To characterise the types and frequency of AITD that MS patients develop following Alemt...

Thyroid dysfunction and autoimmunity are associated with adverse fertility and pregnancy outcomes. International bodies recommend routine thyroid function screening in women with history of subfertility or miscarriage. Knowledge about the frequency of, and risk factors for, thyroid disease is limited in the asymptomatic preconception population. A prospective multi-centre study of women with history of miscarriage or subfertility conducted at 49 hospitals across the United Kin...

Thyroid cancer is increasing in incidence worldwide. While outcomes are generally good, up to 25% of patients suffer recurrence, and this has a significant impact on their quality of life and life expectancy. We hypothesised that thyroid tumours which recur display a distinct pattern of driver events, present on initial histology. Controlled-access TCGA data on thyroid cancer were downloaded and whole exome sequencing data analysed. An analysis pipeline utilising Platypus, Ann...