Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2019

Brighton, United Kingdom
11 Nov 2019 - 13 Nov 2019

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Come and exchange knowledge, share experiences and strengthen collaborations across our global community of endocrinologists!


Metabolism and Obesity

ea0065op3.1 | Metabolism and Obesity | SFEBES2019

Intermittent cold exposure ameliorates fatty liver disease

Mitchell Alice , Alawi Khadija , Aubdool Aisah , Papacleovoulou Georgia , Jansen Eugene , Brain Susan , Abu-Hayyeh Shadi , Williamson Catherine

Background: Non-alcoholic fatty liver disease (NAFLD) is now the most common liver disease in children and young people. NAFLD can progress to cirrhosis and is associated with cardiometabolic morbidity and mortality, often requiring liver transplant. Brown adipose tissue (BAT) expends energy for thermogenesis when activated by pharmacological agents, e.g. β3-adrenergic receptor agonists, or environmental signals such as cold exposure. We hypothesise that intermittent cold...

ea0065op3.2 | Metabolism and Obesity | SFEBES2019

Intestinal injury and evidence of increased gut permeability in female AKR1D1 knockout mice

Arvaniti Anastasia , Harris Shelley , Nikolaou Nikolaos , Cox Roger , Odermatt Alex Alex , Tomlinson Jeremy , Gathercole Laura

Disruption of the gut-liver axis contributes to metabolic syndrome and the progression of non-alcoholic fatty liver disease (NAFLD). Bile acids (BAs) are potent antimicrobials that support gastrointestinal health and dysregulation of BA homeostasis in NAFLD is thought to contribute to gut dysbiosis. Furthermore, an increase in hydrophobic (cytotoxic) BA species may directly affect gut health. We have previously shown that bile acid synthesis enzyme, 5β-reductase (AKR1D1),...

ea0065op3.3 | Metabolism and Obesity | SFEBES2019

The impact of subcutaneous infusions of three anorexigenic gut hormones glucagon-like peptide-1, oxyntomodulin and peptide YY (GOP) on the psychological health of obese diabetic patients

Alessimii Haya , Behary Preeshila , Tharakan George , Alexiadou Kleopatra , Chedie Doyle , Bloom Stephen , Tan Tricia , Scholtz Samantha

Introduction: Obesity-associated psychopathological co-morbidities have a negative impact on quality of life. Roux-en-Y gastric bypass surgery (RYGB) has been shown to ameliorate psychological health, however, the underlying mechanisms are not fully understood. Changes in gastrointestinal and central neuroendocrine signalling have been postulated as mediators of psychological and eating behaviour changes following RYGB. Here we assess the impact of subcutaneous infusions of th...

ea0065op3.4 | Metabolism and Obesity | SFEBES2019

Mice with a gain-of function Gα11 mutation have autosomal dominant hypocalcaemia, but not impaired glucose metabolism

Gluck Anna , Lines Kate , Gorvin Caroline , Babinsky Valerie , Piret Sian , Sarbu Stefan , Stewart Michelle , Bentley Liz , Wells Sara , Cox Roger , Ecker Rupert , Ellinger Isabella , Hannan Fadil , Thakker Rajesh

The calcium-sensing-receptor (CaSR) is a G-protein-coupled receptor that plays a fundamental role in extracellular calcium homeostasis, but is also implicated in non-calcitropic disorders including colon cancer and asthma. In addition, CaSR is highly expressed in pancreatic islets where it has a role in insulin secretion. Patients with gain-of-function CaSR mutations, and mice (referred to as Nuf) with a gain-of-function CaSR mutation (Leu723Gln), develop autosomal dominant hy...