Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2019

Brighton, United Kingdom
11 Nov 2019 - 13 Nov 2019

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Come and exchange knowledge, share experiences and strengthen collaborations across our global community of endocrinologists!


Reproductive Endocrinology and Biology

ea0065op5.1 | Reproductive Endocrinology and Biology | SFEBES2019

Hypothalamic-pituitary-gonadal (HPG) axis suppression during basic military training in women despite increased adiposity and insulin resistance

Gifford Robert M , O'Leary Thomas J , Wardle Sophie L , Greeves Julie P , Anderson Richard A , Woods David R , Reynolds Rebecca M

Background: Low energy availability (LEA) in female athletes can result in HPG axis suppression. Basic military training (BMT) is physically arduous and associated with amenorrhoea and low-trauma fractures. We hypothesised that women undergoing BMT would demonstrate evidence of LEA and suppressed HPG function.Design: Prospective study of 61 women undertaking 11-month BMT. Subjects acted as their own controls at baseline (all measures). Body composition m...

ea0065op5.2 | Reproductive Endocrinology and Biology | SFEBES2019

Profiling the expression and function of the truncated oestrogen receptor isoform ER46 in human endometrium

Gibson Douglas , Esnal-Zufiaurre Arantza , Bajo-Santos Cristina , Collins Frances , Critchley Hilary , Saunders Philippa

Introduction: Oestrogen receptors (ER) are essential for reproductive function and fertility. ER46 is a 46 kDa truncated isoform of full length ERĪ± (ER66) that binds oestradiol (E2) and can signal via nuclear or membrane-initiated signalling pathways. ER46 has been detected in breast cancer cell lines but expression in endometrial tissues has not been documented. The aims of this study were a) to determine whether endometrial cells express ER46, and b) to investigate a po...

ea0065op5.3 | Reproductive Endocrinology and Biology | SFEBES2019

Stress is implicated in programming metabolic disorders in the offspring of fructose-induced diabetic rats

Iranloye Bolanle , Ogunsola Bimbo , Adegoke Olufeyisipe

Foetal exposure to a diabetic intra-uterine environment is known to impair metabolic processes with long term consequences, a phenomenon termed foetal programming. However, the mechanisms involved has not been completely understood. Fructose feeding has been used to induce type 2 diabetes in animal models. This study aims to investigate if stress mechanism is involved in the foetal programming of diabetic pregnancies. Twenty-four female rats were randomly divided into two grou...

ea0065op5.4 | Reproductive Endocrinology and Biology | SFEBES2019

Kisspeptin as a novel biomarker for pregnancy complications

Phylactou Maria , Abbara Ali , Al-Memar Maya , Eng Pei Chia , Comninos Alexander N , Izzi-Engbeaya Chioma , Clarke Sophie A , Mills Edouard , Nadir Rans , Sykes Mark , Pacuszka Ewa , Yang Lisa , Fourie Hanine , Bech Paul , Kelsey Tom W , Bourne Tom , Dhillo Waljit S

Background: Placentation (invasion of the placenta into the maternal endometrium) is hypothesised to be critical for healthy placental function and is abnormal in two thirds of miscarriages. Kisspeptin has emerged as a putative regulator of physiological placentation; it is highly expressed in placental syncytiotrophoblasts and could play an important paracrine role in the regulation of placentation. Circulating kisspeptin levels are considerably raised during healthy pregnanc...