Endocrine Abstracts

In both spontaneous and iatrogenic Cushing’s syndrome, chronic glucocorticoid excess causes obesity, hyperglycaemia, hypertension and accelerated cardiovascular disease. We have pursued the global hypothesis that elevation of cortisol causes cardiovascular disease in the general population, and that the underlying mechanisms will reveal new therapies for cardiometabolic diseases. Circumstantial support is provided by cohort studies, in which higher plasma cortisol is asso...