Metabolism and Obesity

Obesity-induced changes in hepatocyte and skeletal myocyte expression of mRNAs encoding islet GPCR peptide ligands

Atanes Patricio Smith Lorna Bowe James Persaud Shanta

King’s College London, London, UK

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Sarcopenic phenotypes are associated with an increased risk of type 2 diabetes: findings from the Korean Genome and Epidemiology Study (KoGES)

Son Jang Won Lee Won Young Yoo Soon Jib

¹The Catholic University of Korea, Seoul, Republic of Korea; ²Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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Long term impact of sleeve gastrectomy on metabolic parameters in morbidly obese patients

Sirbu Anca Soare Iulia Martin Sorina Popa Miruna Barbu Carmen Copaescu Catalin Fica Simona

¹Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; ²Elias University Hospital, Bucharest, Romania; ³Ponderas Hospital, Bucharest, Romania

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Intravascular subcutaneous adipose tissue blood flow measured with Doppler ultrasound for experimental medicine studies

Lempesis Ioannis Goossens Gijs Manolopoulos Konstantinos

¹Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Birmingham, UK; ²Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK; ³Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre+, Maastricht, Netherlands

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Chronic disruption of endothelial Insulin/IGF1 signaling pathway enhances whole body insulin sensitivity

Viswambharan Hema Yuldasheva Nadira Imrie Helen Cubbon Richard Bridge Katherine Haywood Natalie Skromna Anna Porter Karen Hemmings Karen Clark Emily Gatenby Victoria Abudushalamu Yilizila Cordell Paul Simmons Katie Makava Natallia Walker Andrew Futers Simon Shah Ajay Beech David Wheatcroft Stephen Kearney Mark Sukumar Piruthivi

¹Leeds Institute for Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK; ²British Heart Foundation Centre of Research Excellence, London, UK

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5[beta]-reductase (AKR1D1) isoforms differentially regulate natural and synthetic glucocorticoid clearance and glucocorticoid receptor activation in vitro

Appanna Nathan Arvaniti Anastasia Gangitano Elena Morris Karen George Sherly Keevil Brian Tomlinson Jeremy Nikolaou Nikolaos

¹University of Oxford, Oxford, UK; ²University of Manchester, Manchester, UK

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Physicochemical optimization of dermal insulin patches: effects on selected metabolic parameters in STZ-induced diabetic rats

Mfayela Nokuphiwa Mabandla Musa Musabayane Cephas Tagumirwa Hadebe Silindile Innocentia

¹University of KwaZulu-Natal, Durban, South Africa; ²Walter Sisulu University, Mthatha, South Africa

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Effect of maternal obesity on offspring metabolic indices

Adekunbi Daniel Morakinyo Femi Adegoke Feyi

University of Lagos, Lagos, Nigeria

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Impact of free fatty acid 4 receptor internalization on signalling

Tripp Emma O'Brien Shannon Calebiro Davide

University of Birmingham, Birmingham, UK

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The effect of tumour necrosis factor-alpha on myogenesis in immortalised human myoblasts

Frampton James Chang Hanna Chambers Edward Murphy Kevin

Imperial College London, London, UK

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Brain derived neurotrophic factor (BDNF) methylation in patients with impaired glucose regulation: implications progression to type 2 diabetes mellitus (T2DM)

Fachim Helene Siddals Kirk Malipatil Nagaraj Cortes Gabriela Donn Rachelle Dalton Caroline Reynolds Gavin Gibson Martin Heald Adrian

¹Salford Royal Foundation Trust, Salford, UK; ²The University of Manchester, Manchester, UK; ³High Speciality Regional Hospital of Ixtapaluca, Ixtapaluca, Mexico; ⁴Sheffield Hallam University, Sheffield, UK

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Investigating the role of GPR119 in the vagus nerve

Cheng Sijing Roberts Anna Norton Mariana Owen Bryn Hanyaloglu Aylin Murphy Kevin

Imperial College Londo, London, UK

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Glycaemic response to a mixed meal challenge: does camel milk preload confer an advantage?

Moriarty Maura Buckley Adam Ashraf Tanveer Barakat Maha T Lessan Nader

Imperial College London Diabetes Centre, Abu Dhabi, UAE

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Continuous subcutaneous insulin infusion (CSII): a trust-wide audit

Tauni Rahat Ali Marath Haris Shipp Maxine Griggs Susan Orriss Karen Davey Larissa Hunt Mandy

West Suffolk NHS Foundation Trust, Bury St Edmunds, UK

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Very low calorie diet (VLCD) in obese patients with longstanding type 2 diabetes mellitus: real-world outcomes with twelve months follow-up

Nana Melanie Moore Sacha Loganathan Ria Williams Victoria Rahman Mohammad Jennings Elaine Dixon Anthony Bondugulapati LN Rao

Wrexham Maelor Hospital, Wrexham, UK

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The progesterone metabolite epiallopregnanolone sulphate induces glucose-stimulated insulin secretion from human and mouse islets and is reduced in gestational diabetes mellitus

Fan Hei Man Bellafante Elena Mitchell Alice Ovadia Caroline Martineau Marcus Jones Peter McCance David Marschall Hanns-Ulrich Hunt Kate Bewick Gavin Bowe James Williamson Catherine

¹King’s College London, London, UK; ²Imperial College London, London, UK; ³Queens University, Belfast, UK; ⁴University of Gothenburg, Gothenburg, Sweden

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Oral chenodeoxycholic acid increases post-prandial anorectic gut hormone levels and increases indices of insulin sensitivity

McGlone Emma Rose Malallah Khalefah Bloom Stephen Tan Tricia

Imperial College London, London, UK

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Hepatic effects of new anti-diabetic drugs: real world data from a retrospective study

Colosimo Santo Brodosi Lucia Marchignoli Francesca Barbanti Francesca A Marchesini Giulio Petroni Maria Letizia

Unit of Metabolic Diseases – University of Bologna, Bologna, Italy

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Vitamin B12 deficiency leads to fatty acid metabolism dysregulation and increased pro-inflammatory cytokine production in human adipocytes and in maternal subcutaneous and omental adipose tissue

Samavat Jinous Adaikalakoteswari Antonysunil Boachie Joseph Jackisch Laura McTernan Philip Christian Mark Saravanan Ponnusamy

¹University of Warwick, Coventry, UK; ²Nottingham Trent University, Nottingham, UK

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Endotoxin and adiposity as mediators of down-regulating the BRITE fat phenotype

Omran Farah Murphy Alice Jackisch Laura Samavat Jinus McTernan Philip G Christian Mark

¹University of Warwick, Coventry, UK; ²Nottingham Trent University, Nottingham, UK

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AKR1D1 (5[beta]-reductase) deletion drives hepatic inflammation, fibrosis and tumour development in vivo

Harris Shelley Nikolaou Nikolaos Arvaniti Anastasia Cox Roger Gathercole Laura Tomlinson Jeremy

¹University of Oxford, Oxford, UK; ²Oxford Brookes University, Oxford, UK; ³MRC Harwell Institute, Didcot, UK

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Low B12 is associated with increased de novo synthesis of 'unsafe' fatty acids in the liver

Boachie Joseph Adaikalakoteswari Antonysunil Samavat Jinus Saravanan Ponnusamy

¹Division of Metabolic and Vascular Health, Clinical Sciences Research Laboratories, Warwick Medical School, University of Warwick, Coventry, UK; ²Interdisciplinary Science and Technology Centre, School of Science and Technology, Nottingham Trent University, Clifton, Nottingham, UK; ³Diabetes Centre, George Eliot Hospital NHS Trust College Street, Nuneaton, Warwickshire, Nuneaton, UK

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Insulin signalling in kidney podocytes: an information theoretic approach

Pope Robert JP Welsh Gavin I Coward Richard JM McArdle Craig A

Bristol Renal, Department of Translational Health, Bristol Medical School, University of Bristol, Bristol, UK

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The FreeStyle libre flash glucose monitoring system: how it has improved glycaemic control for people with type 1 diabetes (T1DM) in Eastern Cheshire, UK

Dwived Shivangi Heald Adrian Naseem Asma Kochhar Rupinder Khan Inamullah Leivesley Kate Metters Ann Horne Linda Steele Tom

¹New Cross Hospital, Wolverhampton, UK; ²Salford Royal Hospital, Salford, UK; ³University of Manchester, Manchester, UK; ⁴Watersgreen Medical Centre, Macclesfield, UK

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Androgen receptor reduced sensitivity is associated with increased mortality, poor glycemic control and BMI in men with type 2 diabetes - a 14-year follow up study

Heald Adrian Yadegarfar Ghasem Livingston Mark Fachim Helene Lunt Mark Narayanan Ram Prakash Siddals Kirk Cortes Gabriela Hackett Geoff Naseem Asma Kochhar Rupinder Inamullah Khan Donn Rachelle Gibson Martin Jones Hugh

¹Salford Royal Hospital, Salford, UK; ²University of Manchester, Manchester, UK; ³Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran; ⁴Walsall Manor Hospital, Walsall, UK; ⁵University of Liverpool, Liverpool, UK; ⁶High Speciality Regional Hospital of Ixtapaluca, Mexico City, Mexico; ⁷Heartlands Hospital Birmingham, Birmingham, UK; ⁸University of Sheffield, Sheffield, United Kingtom

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Male testosterone levels and laboratory practice: a need for a standardised approach to measurement and reporting

Livingston Mark Downie Paul Hackett Geoffrey Marrington Rachel Heald Adrian Ramachandran Sudarshan

¹Department of Clinical Biochemistry, Black Country Pathology Services, Walsall Manor Hospital, Walsall, UK; ²The School of Medicine and Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK; ³Department of Clinical Biochemistry, Bristol Royal Infirmary, Bristol, UK; ⁴School of Health and Life Sciences, Aston University, Birmingham, UK; ⁵Birmingham Quality (UK NEQAS), University Hospitals NHS Foundation Trust, Birmingham, UK; ⁶Department of Endocrinology and Diabetes, Salford Royal Hospital, Manchester, UK; ⁷Department of Clinical Biochemistry, University Hospitals Birmingham NHS Foundation Trust, Sutton Coldfield, UK; ⁸Department of Clinical Biochemistry, University Hospitals of North Midlands/ Institute of Science and Technology, Keele University / Faculty of Health Sciences, Staffordshire University, Staffordshire, UK; ⁹College of Engineering, Design and Physical Sciences, Brunel University, London, UK

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Lipoprotein(a) as a predictive biomarker for subclinical coronary atherosclerosis

Trivedi Namrata Loh Wann David Alessia Cegla Jaimini

¹Imperial College London, London, UK; ²Changi General Hospital, Singapore; ³Imperial College Healthcare NHS Trust, London, UK

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Modulation of vagal afferent signalling by the amino acid metabolite sensor GPR35

Roberts Anna Cheng Sijing Norton Mariana Mohamed Omer Cork Simon C Salem Victoria Hanyaloglu Aylin Murphy Kevin

Imperial College, London, UK

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Efficacy of liraglutide in weight management post bariatric surgery patients: data from an Emirati cohort

Alnuaimi Abdulla Radha Saradalekshmi Koramannil AlAmeri Majid Barakat Maha T Lessan Nader

Imperial College London Diabetes Centre, Abu Dhabi, UAE

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ISX-9 preferentially induces enterochromaffin and I-cell enteroendocrine lineages in human small intestinal organoids

Pedro Patricia Fonseca Tsakmaki Anastasia Bewick Gavin

King’s College London, London, UK

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The differential effects of weight loss by RYGB versus very-low calorie diet (VLCD) on gut hormone levels and appetite: potential contribution to sustained weight loss

Behary Preeshila Tharakan George Alexiadou Kleopatra Hope David Anyiam Oluwaseun Choudhury Sirazum Alessimii Haya Doyle Chedie Miras Alexander Chahal Harvinder Purkayastha Sanjay Moorthy Krishna Ahmed Ahmed Bloom Stephen Tan Tricia

Imperial NHS Trust, London, UK

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Immature [beta]-cells are required for normal islet function and insulin release

Nasteska Daniela Fine Nicholas H F Ashford Fiona B Smith Gabrielle Bakhti Mostafa Bastidas-Ponce Aimee Rutter Guy A Lickert Heiko Zhou Qiao Akerman Ildem Hodson David J

¹Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK; ²Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK; ³Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany; ⁴Section of Cell Biology and Functional Genomics, Imperial College London, London, UK; ⁵Division of Regenerative Medicine, Department of Medicine, Weill Cornell Medical College, New York, USA

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Modulation of EGFR expression to increase islet transplantation success

Ali Usama Suba Kinga Bitsi Stavroula Alonso Aldara Martin Patel Yateen Leclerc Isabelle Rutter Guy A Rothery Stephen Salem Victoria Tomas Alejandra

Imperial College London, London, UK

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Systemic and femoral adipose tissue-specific nontargeted plasma metabolome during acute hypercortisolaemia

Prete Alessandro Dunn Warwick B Manolopoulos Konstantinos

¹Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; ²Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK; ³School of Biosciences, University of Birmingham, Birmingham, UK; ⁴Phenome Centre Birmingham, University of Birmingham, Birmingham, UK

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A role for kisspeptin in long-term islet function in females

Smith Lorna Hill Thomas Simpson Sian Jones Peter Bowe James

¹King’s College London, London, UK; ²University of Oxford, Oxford, UK

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Vitamin D-binding protein is required for the maintenance of [alpha]-cell identity and function

Viloria Katrina Nasteska Daniela Larner Dean Fine Nicholas Ashford Fiona Heising Silke Xavier Gabriela da Silva Briant Linford Flaxman Christine Morgan Noel Richardson Sarah Hewison Martin Hodson David

¹Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; ²Oxford Centre for Diabetes, University of Oxford, Oxford, UK; ³Institute of Biomedical and Clinical Science, Medical School, University of Exeter, Exeter, UK; ⁴Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Endoplasmic reticulum stress directly impacts mitochondrial function in human adipocytes

Jackisch Laura Murphy Alice Kumar Sudhesh Randeva Harpal Tripathi Gyanendra McTernan Philip

¹Warwick University, Warwick, UK; ²Nottingham Trent University, Nottingham, UK

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The track-pump study

Johnson Agnes Oliver Nick Godsland Ian Hill Neil

Imperial College Healthcare NHS Trust, London, UK

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Glucocorticoid regulation of the PEPITEM pathway

Chosgora Ailbhe Ni Hopkin Sophie Hardy Rowan Rainger Ed Chimen Myriam

University of Birmingham, Birmingham, UK

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The American lifestyle induced obesity syndrome diet (ALIOS) in rodents recapitulates the clinical features and sexual dimorphism of NAFLD and NASH

Harris Shelley Arvaniti Anastasia Cox Roger Gathercole Laura Tomlinson Jeremy

¹University of Oxford, Oxford, UK; ²Oxford Brookes University, Oxford, UK; ³MRC Harwell Institute, Didcot, UK

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Role of palmitoylation on GLP-1 receptor responses in pancreatic beta cells

Lyu Zekun Piedade Carolina Bitsi Stavroula Jones Ben Tomas Alejandra

Imperial College London, London, UK

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Visfatin and resistin as predictors of poor pain outcome in total hip and knee joint replacement in patients with osteoarthritis

Nanus Dominika E Davis Edward T Jones Simon

¹University of Birmingham, Birmingham, UK; ²The Royal Orthopaedic Hospital NHS Foundation Trust, Birmingham, UK

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Assessment of cardiovascular disease risk in subjects with pre-diabetes

Petkovic Milica Marjanovic Vuksanovic Miljanka Sasic Ivana Zivkovic Teodora Beljic

¹Belgrade School of Medicine and Zvezdara University Medical Center, Belgrade, Serbia; ²Cardiovascular Institute Dedinje, Belgrade, Serbia

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Maternal diet-induced cholestasis programmes murine offspring metabolic impairment on feeding a Western diet, with altered intestinal metabolites and microbiota in the female offspring

Ovadia Caroline Spagou Konstantina Perdones-Montero Alvaro Smith Ann Papacleovoulou Georgia Dixon Peter Holmes Elaine Marchesi Julian Williamson Catherine

¹King’s College London, London, UK; ²Imperial College London, London, UK; ³Cardiff University, Cardiff, UK

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All cause and cardiovascular mortality in adults with schizophrenia and diabetes - a retrospective matched study

Morrison Deborah Frize Ryan Sainsbury Christopher A Wilson Ruairi Jones Gregory C

¹Gartnavel General Hospital, Glasgow, UK; ²University of Glasgow, Glasgow, UK

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Glycated haemoglobin and obstetric outcomes among patients with gestational diabetes mellitus: a single center study

Awofisoye Oyindamola Osaji Nicole

¹Cadiocare Cardiovascular Hospital, Abuja, Nigeria; ²Limi Hospital, Abuja, Nigeria

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An audit of SGLT2-inhibitors in the management of type 2 diabetes in Sligo University Hospital Ireland: metabolic and haemodynamic outcomes

Radhakrishna Avinash Mchugh Catherine

Sligo University Hospital, Sligo, Ireland

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Determinants for developing foot ulcer among persons with diabetes mellitus attending outpatient clinic in a tertiary hospital in Nigeria

Olopade Oluwarotimi Odeniyi Ifedayo Olusanya Adedunni Fasanmade Olufemi Sowemimo Oluwadamilola Akinsola Clement

¹Lagos University Teaching Hospital, Lagos, Nigeria; ²College of Medicine, University of Lagos, Lagos, Nigeria

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Hypoglycaemia screen (hypopak) quality improvement audit

Spence Kirsty Beckett Rachel Hamilton Gillian Alcheikh Mohammad Heffernan Emmeline Abid Noina O'Sullivan Siobhan Connolly Grainne McDonnell Margaret

¹Regional Endocrine Laboratory, Belfast Health and Social Care Trust, Belfast, UK; ²Paediatric Endocrinology and Diabetes Unit, Royal Belfast Hospital for Sick Children, Belfast Health and Social Care Trust, Belfast, UK; ³Regional Metabolic Laboratory, Belfast Health and Social Care Trust, Belfast, UK; ⁴Paediatric Metabolic Unit, Royal Belfast Hospital for Sick Children, Belfast Health and Social Care Trust, Belfast, UK

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Bariatric surgery outcomes amongst older obese patients: data from an Emirati cohort

Radha Saradalekshmi Koramannil Barakat Maha T Lessan Nader

Imperial College London Diabetes Centre, Abu Dhabi, UAE

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Risk of sleep apnoea among Emirati patients with type 2 diabetes

Hassan Sama Buckley Adam Al Tameemi T Fojas Esphie Grace Barakat Maha T Lessan Nader

Imperial College London Diabetes Centre, Abu Dhabi, UAE

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A novel method for analysis of 11 oestrogens using high-throughput liquid chromatography tandem mass spectrometry

Gilligan Lorna Goymer Lauren Toor Harjeavon Cox Grace Shaheen Fozia Arlt Wiebke Taylor Angela

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK

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Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) prevents cytokine-mediated beta cell dysfunction

Egbase Daniel Sayers Sophie Evans Elizabeth Butterworth Sam Greally Joshua Bewick Gavin Tsakmaki Anastasia Persaud Shanta Caton Paul

¹King’s College London, London, UK; ²University of Manchester, Manchester, UK

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Predicting mortality in both diabetes and open-source clinical datasets from free text entries using machine learning (natural language processing)

Sainsbury Christopher Conkie Andrew Buchner Mark Wales Ann Jones Gregory

¹Diabetes Centre, Gartnavel General Hospital, Glasgow, UK; ²Redstar Consulting, Glasgow, UK; ³Tactuum Ltd, Glasgow, UK; ⁴Scottish Government Digital Health and Care Division, Edinburgh, UK

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GLP-1/Glucagon dual agonist affects amino acid metabolism

Scott Rebecca Hope David Owen Bryn Bloom Steve Tan Tricia

Imperial College, London, UK

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A digital lifestyle programme to support outpatient treatment of type 2 diabetes: a randomised controlled trial

Hilmarsdottir Eva Sigurðardottir Arun Kristin Arnardottir Ragnheiður Harpa

¹Akureyri Hospital, Akureyri, Iceland; ²University of Akureyri, Akureyri, Iceland; ³Uppsala University, Uppsala, Sweden

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FSH levels are adversely associated with markers of regional adiposity in postmenopausal women

Armeni Eleni Augoulea Areti Rizos Demetrios Kaparos George Panoulis Konstantinos Lambrinoudaki Irene

¹2nd Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens, Athens, Greece; ²Hormonal and Biochemical Laboratory, National and Kapodistrian Univeristy of Athens, Aretaieio Hospital, Athens, Greece

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Untreated pre-operative mental illness is associated with poorer bariatric surgery outcomes

Sultman David Whitelaw Benjamin

King’s College Hospital, London, UK

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Regulation and role of MiR-125b in [beta]-cells

Pizza Grazia Cheung Rebecca Rolando Delphine Nguyen-Tu Marie-Sophie Cebola Ines Chabosseau Pauline Marchetti Piero Shapiro James Piemonti Lorenzo Sakamoto Kei Smith David M Rutter Guy A Martinez-Sanchez Aida

¹Imperial College London, London, UK; ²University of Pisa, Pisa, Italy; ³University of Alberta, Edmonton, Canada; ⁴Vita-Salute San Raffaele, Milan, Italy; ⁵Nestle Institute of Health Sciences, Lausanne, Swaziland; ⁶Astrazeneca, Cambridge, UK

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Refeeding syndrome induced hypertriglyceridemia

Boharoon Hessa AlJaberi Asma

Tawam, Abu Dhabi, UAE

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Are PCSK9 inhibitors delivering as promised?

Bashir Bilal Bharaj Harnovdeep Hutchesson Andrew Banerjee Moulinath

Royal Bolton Hospital, Bolton, UK

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Bariatric surgery outcomes in super obese Emirati patients

Radha Saradalekshmi Koramannil Fojas Esphie Grace Barakat Maha T Lessan Nader

Imperial College London Diabetes Centre, Abu Dhabi, UAE

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Investigating mesenchymal stromal cell mediated support of islets after exposure to transplantation related stressors

Hubber Ella Rackham Chloe Pullen Timothy Jones Peter

King’s College London, London, UK

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Steroid deconjugation by helix pomatia - can we overcome snail speed?

Shaheen Fozia Gilligan Lorna Berner Camila Callejas Jose Luis Shackleton Cedric Arlt Wiebke Taylor Angela

¹Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; ²KuraBiotec, Puerto Vara, Chile; ³Children’s Hospital and Research Center at Oakland, Oakland, USA

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Acute changes in steroid biosynthesis in patients following severe trauma: the golden hour study

Taylor Angela Bentley Conor Foster Mark Lord Janet Hazeldine Jon Arlt Wiebke

¹Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK; ²NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospital Birmingham, Birmingham, UK; ³Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK

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Mammary adipose tissue steroid activation and its relevance for breast cancer prognosis

Laforest Sofia Denver Nina Homer Natalie ZM Durocher Francine Walker Brian R Andrew Ruth Tchernof Andre

¹CRCHU-UL, Quebec, Canada; ²IUCPQ, Quebec, Canada; ³BHF/CVS, QMRI, U of Edinburgh, Edinburgh, UK; ⁴ICAMS, U of Glasgow, Glasgow, UK; ⁵MS Core, Edinburgh CRF, Edinburgh, UK; ⁶SIPBS, U of Strathclyde, Glasgow, UK; ⁷IGM, Newcastle University, Newcastle, UK

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Anti thrombin activity in newly diagnosed Type 2 diabetes subjects in a Tertiary Hospital in Calabar, Nigeria

Enang Ofem Akaba Kingsley

¹University of Calabar, Calabar, Nigeria; ²University of Calabar Teaching Hospitalal, Calabar, Nigeria

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L-Phenylalanine simulates the secretion of pancreatic hormones via vagal CaSR

Norton Mariana Cork Simon C Roberts Anna Patel Yateen Cheng Sijing Hansford Robert Cao Ye Hanyaloglu Aylin Chang Wenhan Murphy Kevin G

¹Imperial College, London, UK; ²Kings College, London, UK; ³University of Auckland, Auckland, New Zealand; ⁴University of California, San Francisco, USA

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Adhesion G-protein coupled receptors as novel players in islet development

Olaniru Oladapo Edward Atanes Patricio Toczyska Klaudia Piao Xianhua Persaud Shanta

¹King’s College London, London, UK; ²Children’s Hospital and Harvard Medical School, Boston, USA

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Insights into the mechanisms underpinning the physiological effects of biased GLP-1 receptor agonists

Lucey Maria Pickford Phil Ma Yue Shchepinova Maria Tate Ed McGinty James French Paul Davies Samuel Xavier Gabriela Da Silva Stolarczyk Emilie Minnion James Rutter Guy Bloom Steve Tomas Alejandra Jones Ben

¹Imperial College London, London, UK; ²University of Birmingham, Birmingham, UK

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Case reports of immunosuppression therapy for anti-insulin receptor and anti-insulin antibodies in patients attending the national severe insulin resistance service

Liu Charlotte Jenkins Adams Claire Church David Flanagan Catherine Gaff Lisa Jayne David Melvin Audrey O'Rahilly Stephen Pizirtzidou Eirini Savage David Semple Robert Withers Elaine Stears Anna

¹Addenbrookes Hospital, Cambridge, UK; ²University of Edinburgh, Edinburgh, UK

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Obesity induces cardiac hypertrophy without functional or fibrotic alterations

Villalobos Elisa Criollo Alfredo Schiattarella Gabriele Altamirano Francisco Gillette Thomas Lavandero Sergio Hill Joseph

¹Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA; ²Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK; ³Instituto de Investigación en Ciencias Odontológicas, Facultad Odontología, Universidad de Chile, Santiago, Chile; ⁴Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Quimicas y Farmaceuticas & Facultad Medicina, Santiago, Chile; ⁵Department of Internal Medicine and Molecular Biology, University of Texas Southwestern Medical Center, Dallas, USA

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Idiopathic gigantomastia: newer mechanistic insights implicating the paracrine milieu

Das Liza Dutta Pinaki Rai Ashutosh Bhansali Anil Tripathy Satyaswarup Vaiphei Kim Garg Akhil Mohsina Subair

PGIMER, Chandigarh, India

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Weight loss and change in obesity related comorbidities in patients undergoing laparoscopic adjustable gastric banding at UHCW between 2009 and 2012

Leca Bianca Dimitriadis Georgios K Khan Uzma Abraham Jenny Halder Louise Shuttlewood Emma Shah Neha Barber Thomas M Menon Vinod Randeva Harpal S

¹Department of Endocrinology, Diabetes and Metabolism – WISDEM Centre, University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK; ²University of Warwick Medical School, Clinical Sciences Research Laboratories, Coventry, UK

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Safe use of variable rate intravenous insulin infusion: a trust wide audit

Siddique Rana Tauni Rahat Ali

West Suffolk NHS Foundation Trust UK, Bury St Edmunds, UK

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Investigating the role of microRNA-7 in pancreatic islet development

Kane Eva Mak Tracy C S Latreille Mathieu

¹MRC London Institute of Medical Sciences (LMS), London, UK; ²Imperial College London, London, UK

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Glucocorticoid treatment is associated with dose-dependent effects in healthy male volunteers

Pofi Riccardo Bonaventura Ilaria Othonos Nanthia Marjot Thomas Moolla Ahmed Isidori Andrea M Hodson Leanne Tomlinson Jeremy W

¹Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM) and NIHR Oxford Biomedical Research Centre, Churchill Hospital, University of Oxford, Oxford, UK; ²Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, Rome, Italy

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Mass spectrometric characterisation of circulating proinsulin-derived peptides in insulin autoimmune syndrome

Church David Halsall David Gribble Fiona Reimann Frank Semple Robert Kay Richard

¹Cambridge University Hospitals, NHS Foundation Trust, Cambridge, UK; ²University of Cambridge Metabolic Research Laboratories, Cambridge, UK; ³National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, UK; ⁴Centre for Cardiovascular Science, Edinburgh, UK

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Hepatic steatosis in rats with dexamethasone-induced metabolic syndrome: a role for Ocimum gratissimum leaf extract

Shittu Shehu-Tijani Adeoye Tolulope Shittu Seyyid Lasisi Taye

University of Ibadan, Ibadan, Nigeria

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Glycaemic control in patients with diabetes mellitus in a Tertiary Hospital in South-West, Nigeria

Owolabi Funmilayo Soyoye David Imarhiagbe Laura Adepoju Ayanbola Kolawole Babatope Ikem Rosemary

¹Obafemi Awolowo University Teaching Hospital Complex, Ile Ife, Nigeria; ²Obafemi Awolowo University, Ile Ife, Nigeria

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Presentation, investigations and management of suspected Gitelman syndrome in pregnancy

Silveira Maria Haynes Shelly Bujanova Jana

University Hospital Southampton, Southampton, UK

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Audit on initial investigation and management of hyponatraemia in inpatients

Alabaf Setareh Soong Elaine Misra Sushil Majeed Joohi

¹West Suffolk NHS Foundation Trust, Bury St Edmunds, UK; ²University of Gothenburg, Sweden

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Using problem-based learning (PBL) to engage undergraduate medical students in endocrinology at Edinburgh Medical School

Pender Frederic T Morley Steven D

¹Medical Education, University of Edinburgh Medical School, Edinburgh, EH16 4SB, UK; ²Division of Health Sciences, University of Edinburgh Medical School, Edinburgh, EH16 4SB, UK

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'H' syndrome; a rare case with novel symptoms

Shah Shanty DSilva Deborah Arunachalam Col. Ganesh MK Shenoy Ram Sudeep K

Father Muller Medical College, Mangalore, India

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Abstract unavailable

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Five-year review of diabetic foot ulcer admissions at Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigera

Adesegun Tajudin Yusuff Olaoluwatomi Ezekpo Okechukwu Soyoye David Kolawole Babatope Ikem Rosemary

Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria

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Molecular interactions of cashew leaf (Anacardium occidentale) derived compounds with anti-diabetic targets: in silico and in vivo studies

Ukwenya Victor Omotuyi Olaposi Enejo Ojochenemi Alese Olutayo

¹Federal University of Technology, Akure, Akure, Nigeria; ²Centre for Biocomputing and Drug Development, Adekunle Ajasin University, Akungba-Akoko, Nigeria; ³Centre for Genomics Research Initiative, National Biotechnology Agency, Abuja, Nigeria; ⁴Department of Anatomy, College of Medicine, Ekiti State University, Ado-Ekiti, Nigeria

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Juvenile type 2 diabetes and Klinefelter syndrome

Lang Ailidh Stirling Angus Maitland Rahat

Queen Elizabeth University Hospital, Glasgow, UK

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St James's Hospital intensive care unit insulin discharge policy - A quality improvement project

Quinn Mark Courtney Ashling Smyth Coilin-Collins Healy Marie-Louise Pazderska Agnieszka O'Connor Enda

St. James’s Hospital, Dublin, Ireland

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Ten years type 2 diabetes risks among doctors in Ondo State, South West Nigeria

Enikuomehin Adenike Adejumo Oludamola Ajiboye John Junaid Oladimeji Muhammad Fakhraddeen Kolawole Babatope Ikem Rosemary Lawal Oluwatoyin

¹University of Medical Science Teaching Hospital Complex, Akure, Nigeria; ²University of Medical Science Teaching Hospital Complex, Ondo, Nigeria; ³College of Health Science, Bayero University, Kano, Nigeria; ⁴Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Nigeria

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Diabetic lipemia − acute pancreatitis and new diagnosis of diabetes

Ventress Luke Ahmad Waqar Artham Satish

University Hospital of North Tees, Stockton on Tees, UK

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Life threatening hypoglycaemia associated with illicit benzodiazepines

Naasan Adeeb Connelly Paul Brown Chris Stevenson Richard Carty David

¹Department of Diabetes, Endocrinology and Clinical Pharmacology, Glasgow Royal Infirmary, Glasgow, UK; ²Emergency Department, Glasgow Royal Infirmary, Glasgow, UK

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Severe peri-partum hyponatraemia: is oxytocin always the culprit?

Ali Tauni Rahat

West Suffolk NHS Foundation Trust, Bury St Edmunds, UK

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Effectiveness of bariatric surgery - impact and metabolic outcome in different co-morbidities - a single center study in UK

Rafai Wajid Ester Dubiwa Beck Lana Faraj Grive Anne Hollywood Amelia Aung Theingi

¹Royal Berkshire Hospital, Reading, UK; ²University of Reading, Reading, UK

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Muhammad Fakhraddeen Enikuomehin Adenike

¹Muhammad Abdullahi Wase Specialist Hospital, Kano, Nigeria; ²State Specialist Hospital, AKURE, Nigeria

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