Endocrine Abstracts (2019) 65 P326 | DOI: 10.1530/endoabs.65.P326

A rare pituitary tumour mimicking an adenoma - spindle cell oncocytoma

Janki Panicker1, Pallavi Hegde1, Anubhav Sinha2, Nitika Rati2, Dushyant Sharma1 & Tejpal Purewal1

1Royal Liverpool and Broadgreen University Hospital, Liverpool, UK; 2Walton centre NHS foundation Trust, Liverpool, UK

Spindle cell oncocytoma (SCO) is a rare nonfunctioning neoplasm of the anterior pituitary gland .This tumour is often misdiagnosed as pituitary adenoma or pituitcytoma due to it’s location and symptoms. Such tumours are highly vascular radiologically and histologically. We report a 54 year old gentleman who was found to have pituitary adenoma on CT head performed after a fall. Subsequent Pituitary MRI showed 25×18 mm pituitary macroadenoma with optic chiasm compression without cavernous sinus invasion. Biochemically it was nonfunctioning . Visual field assessment showed loss of colour vision in the left eye and a bitemporal visual field defect. He underwent transsphenoidal surgery and had an uncomplicated recovery. Histology results confirmed the diagnosis of spindle cell oncocytoma on immunohistochemistry and electron microscopy. Post transsphenoidal surgery patient developed partial anterior hypopituitarism and was commenced on levothyroxine, testosterone and hydrocortisone. Literature search shows that these tumours are rare and long term follow up is required as these tumours tend to reoccur. One case reported of malignant pituitary spindle cell oncocytoma requiring three surgeries and radiotherapy showing they can have potential to be malignant.

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