Endocrine Abstracts

Abstract unavailable...

Both genetic and environmental factors determine whether individuals who have a predisposition to the development of type 1 diabetes actually develop the disease. Although we now know a considerable amount about the genetics through genome wide scans, and diabetes risk scores have been developed, the actual environmental triggers or perpetuating factors are not clearly defined. There has been considerable interest in recent years in investigation of these possible environmenta...

It is over 17 years since the randomised controlled trial of metformin showed efficacy in childhood type 2 diabetes. Since that time, despite much investment in paediatric investigation plans, very few interventional clinical trials have reported. This presentation reviews the evidence for childhood type 2 diabetes being different to adult type 2 diabetes. Childhood type 2 diabetes is a more aggressive disease; children have lower insulin sensitivity than adults; and complicat...