Endocrine Abstracts

Polycystic Ovary Syndrome (PCOS) is the commonest endocrine disorder in young women, affecting up to 10% of the premenopausal population. In addition to its reproductive sequelae, PCOS is now established as a metabolic disorder, characterised by defects in insulin secretion and action. These disturbances, along with comorbidities such as obesity and dyslipidaemia, may predispose to an increased risk of cardiometabolic disease in later life. Our studies confirm a higher prevale...

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The foetus relies on placental transfer of maternal thyroid hormones, until the thyroid matures fully, at ˜36 weeks gestation. Studies in animals, and the cognitive impairment experienced by children born in areas of iodine deficiency or to mothers with hypothyroidism, highlight the importance of thyroid hormone in brain development. The impact of less severe thyroid dysfunction remained controversial until two large-scale trials investigated the effect on child IQ of thy...