Endocrine Abstracts

Introduction: Precocious puberty occurs is associated with initial increase in linear growth and acceleration of bone maturity presenting as advanced bone age with early epiphyseal fusion which ultimately results in short stature. ‘Van Wyk Grumbach Syndrome’ (VWGS) is a rare syndrome associated with incomplete isosexual precocious puberty and macroadenoma seen in cases of longstanding, untreated hypothyroidism is associated with a delayed bone age. Complete resolutio...

Introduction: Hypothyroidism is one of the major causes of preventable mental retardation. Neonatal screening aids in the prompt diagnosis of newborns with congenital hypothyroidism. There are other clinical conditions that can alter thyroid function during the newborn period, including exposure of high iodine concentrations.Case presentation: One day old female born at 37 3/7 weeks of gestational age by C-section with imperforated anus and congenital he...

Introduction: It has been documented that autoimmune thyroiditis (AT) predisposes to the development of papillary thyroid cancer (PTC). The presence of chronic inflammation was thought to act as an initiating factor in carcinogenesis. Moreover elevated levels of TSH found in hypothyroid patients with AT were speculated to stimulate follicular epithelial proliferation and thereby promote the development of PCT.Case: We describe a case of two sisters aged ...

Background: Screening for Congenital hypothyroidism is part of National New-born screening program. Each District General Hospital is required to have a Congenital Hypothyroidism Service with a Lead Paediatrician and a Deputy to provide seamless service to babies with suspected congenital hypothyroidism and their families. National guidelines and service standards exist to guide setup, operation and auditing of this service.Aim: We aim to benchmark the p...

Goal: To determine the level of vitamin D and its pathogenetic role in children with Grave’s disease living in the territory of Uzbekistan. The study included 16 children and adolescents of 9–17 years old with the first time identified Grave’s disease. The control group included 12 children without thyroid pathology. The concentration of total vitamin D, TSH, fT4 and Antibodies to TSH receptors (TRAb) in serum was determined using a Cobas e 411 Hitachi closed-ty...

Background: Graves disease is the most common cause of hyperthyroidism or thyrotoxicosis in children. The prevalance is 1 in 10 000 among children. It is important to reinforce the awareness amongst clinicians as patients can present with wide range of clinical symptoms. The range of presentations in our study included a child treated for one year for Attention Deficit Hyperactivity Disorder (ADHD) to a child who had diarrhoea and abdominal pain and presented as appendicitis i...