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Endocrine Abstracts (2019) 66 P38 | DOI: 10.1530/endoabs.66.P38

BSPED2019 Poster Presentations Diabetes 3 (8 abstracts)

Remission rates, demographics and outcomes of paediatric patients with type 2 diabetes at a single centre: 2006–2018

Elizabeth Procter , James Law , Jennifer Calvert & Pooja Sachdev


Nottingham Children’s Hospital, Nottingham, UK


Background: Incidence of type 2 diabetes (T2DM) is increasing in children and young people under the age of 18 years. This group has a higher risk of microvascular complications and a more adverse cardiovascular risk profile than those diagnosed later. Weight loss is essential for remission, but intensive input is often required to achieve this.

Aims: 1. Describe the demographics of our T2DM population

2. Look at our remission rates

Methods: Patients were identified from a local database of patients with T2DM. Their hospital records were reviewed to identify baseline characteristics, treatment, progress and whether remission was achieved (n=34).

Results: Patients were most commonly female (38% male, 62% female), white (53% White, 35% Asian, 12% Black) and 75% had a family history of T2DM. Co-morbidities at baseline included polycystic ovary syndrome (n=4) and hypertension (n=7). Remission was achieved in nine and maintained in five (relapsed: n=3; unknown: n=1). Weight loss at remission was 8.0±3.3% and remains below baseline (7.6±4.2%, n=7) compared to the non-remission group, who have gained weight (1.8±11.2%, n=16). Patients who achieved remission most commonly opted for healthy eating and lifestyle management. One patient followed a supervised very low-calorie diet (<800 kcal/day) for six weeks followed by introduction of regular balanced meals.

Table 1 Characteristics of patients with T2DM at baseline, remission and present.
RemissionNon-RemissionP
N925
Age (years)15.5±0.814.7±2.00.08
Baseline BMI SDS3.29±3.9 (n=4)3.37±3.8 (n=10)
Baseline HbA1C77±2974±280.82
Remission BMI SDS1.48±1.07N/A
Current BMI SDS1.55±0.652.97±2.47
Current HbA1c39±5 mmol/l (n=8)73±28 mmol/l (n=20)

Conclusions: Remission is achieved in a minority of patients despite intensive input from hospital teams. Patients who achieved remission maintain a lower HbA1c and BMI SDS in comparison to the non-remission group, even if they have experienced a relapse. This demonstrates the importance and positive impact of weight loss, even if relapse occurs.

Volume 66

47th Meeting of the British Society for Paediatric Endocrinology and Diabetes

Cardiff, UK
27 Nov 2019 - 29 Nov 2019

British Society for Paediatric Endocrinology and Diabetes 

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