Endocrine Abstracts

Pregnant women are at risk of developing diseases associated with deficiency of essential micronutrients.

Objective: To assess the prevalence of vitamin D deficiency among pregnant women and its dependence on the trimester of pregnancy.

Methods: We examined 476 pregnant women at different gestational periods from three regions of Russia (Moscow, Ivanovo, Smolensk). Concentration of 25(OH)vitamin D (ng/ml) was estimated by immunometric method. We collect information about intake of vitamin supplements.

Results: Median of vit.D in Moscow was 14.9 ng/ml, in Ivanovo - 17.3 ng/ml, in Smolensk - 15.8 ng/ml. In Moscow only 5.6% of all women have level above 30 ng/ml, 76% have vitamin D deficiency (below 20 ng/ml). 17% of patients have insufficiency of this element (20−30 ng/ml). In Ivanovo: 6% – optimal level, 66% – deficiency, 28% – insufficiency. In Smolensk: 4.7% – optimal level, 76% – deficiency, 19% – insufficiency. Women who have optimal level of vit.D was on therapy with native vit.D. When assessed dependence of concentration of vit.D on the trimester of pregnancy, a significant decrease was found with an increase in gestational age.

Conclusions: We revealed the presence of vitamin D deficiency in pregnant women in Russia. It was also found that vit.D deficiency increases with increasing gestational age. Now there are no long-term data on the safe dosage of vitamin D preparations during pregnancy, so further research is needed on this topic. These results must be considered for adjusting vitamin-containing supplements prescribed to pregnant women.

Work was supported by RSF grant Nº 17-75-30035.