EYES2019 7th ESE Young Endocrinologists and Scientists (EYES) Meeting Oral Presentations (67 abstracts)
Bone health and final height in craniopharyngioma patients
Selveta S van Santen 1, , Daniel S Olsson 2, , Casper Hammarstrand 2, , Mark Wijnen 1 , Gudmundur Johannsson 2, , Aart J van der Lely 1 , MM van den Heuvel-Eibrink 4 & Sebastian JCMM Neggers 1,
1Department of Medicine, Endocrinology; Erasmus Medical Center, Rotterdam, The Netherlands; 2Department of Endocrinology; Sahlgrenska University Hospital, Gothenburg, Sweden; 3Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; 4Princess Máxima Centre for Paediatric Oncology, Utrecht, The Netherlands.
Objective: Craniopharyngioma (CP) is a benign tumor of the sellar/hypothalamic region. It is associated with endocrinopathies, which may potentially impair bone health. Our objective was to determine bone health status in CP patients.
Methods: In this retrospective study, Dutch/Swedish CP patients were included if data was available on fractures, bone mineral density (BMD) (T/Z-score), or final height (age >18 years). Data is presented as mean±S.D. Standardized deviation scores (SDS) of final height were calculated based on sex/country of origin. A logistic regression model was developed to evaluate determinants for fractures.
Results: We included 177 patients (48% female, mean age at diagnosis 28±20 years). Fractures occurred in 31 patients (18%). In a multivariable logistic regression model for fractures, significant determinants were female sex (OR 0.3 P=0.004), surgery (OR 0.1, P=0.009), and use of anti-epileptics (OR 3.0, P=0.07). Osteoporosis was not an explanatory variable (OR 2.1, P=0.21). Mean BMD T- and Z-scores were normal: Z-scores for total body, femur neck and L2L4 were 0.1±1.5 (range −4.1–3.5), −0.1±1.3 (range −2.7–4.7) and 0.0±2.0 (range −3.5–6.8), respectively. Low BMD occurred in 47 patients (50%). Final height SDS was −0.3±1.2 (no difference between adulthood- or childhood-onset disease (P=0.67)).
Conclusions: CP seem to result in a high rate of fractures. Epilepsy treatment was a risk factor and female sex a protective factor for fractures. Mean BMD Z-score was normal, but with a very wide range, resulting in low BMD in 50%. Osteoporosis does not explain fracture risk well. Final height is normal.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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