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17th Annual Meeting of the UK and Ireland Neuroendocrine Tumour Society 2019

Birmingham, UK
02 Dec 2019 - 02 Dec 2019

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The Conference is your opportunity to join fellow clinicians, scientists, nurses and allied health care workers involved in the care and service of neuroendocrine tumour (NET) patients.

ea0068oc1 | Abstracts | UKINETS2019

Longitudinal biomarker changes during treatment of functional midgut neuroendocrine tumours with lanreotide autogel: CALM-NET study results

Shah Tahir , Caplin Martyn , Khan Mohid S , Houchard Aude , Higgs Kate , Meyer Tim

Background: CALM-NET (EudraCT 2013-002194-22; NCT02075606), a prospective, exploratory study, evaluated enumeration of pre-treatment circulating tumour cells as a predictor of symptomatic response to lanreotide autogel (LAN) in patients with functional midgut neuroendocrine tumours (NETs). Here, we describe the effect of LAN on biomarkers.Methods: Patients, ≥18 years, with functional, well- or moderately-differentiated midgut NETs were treated with...

ea0068oc2 | Abstracts | UKINETS2019

Development of ex-vivo models of metastatic neuroendocrine neoplasms

Doornebal Ewald , Harris Nicola , Edwards Helen , Miquel Rosa , Zen Yoh , Pizanias Michail , Prachalias Andreas , Menon Krishna , Zamalloa Ane , Preziosi Melissa , Heaton Nigel , Ramage John K , Williams Roger , Palma Elena , Chokshi Shilpa , Srirajaskanthan Raj

Background: The lack of relevant in-vivo and in-vitro models has precluded investigations of the pathophysiology of metastatic NENs. Organotypic tumour slices retain the complexity of tumours in-vivo without extensive manipulation of the tissue. The aims of this study are to understand the utility of precision cut slice technology to develop an immunocompetent model of metastatic GEP NENs to test new therapeutics and elucidate immunological, molecula...

ea0068oc3 | Abstracts | UKINETS2019

Incidence and prevalence of neuroendocrine neoplasms reported in England from 2015 to 2017

White Benjamin E , Bouvier Catherine , Genus Tracey , Rous Brian , Srirajaskanthan Rajaventhan , Chandrakumaran Kandiah , Ramage John K

Introduction: Previously published UK Cancer Registry data showed incidence of Neuroendocrine Neoplasms rising between 2001 and 2015. This was higher than had been thought (Genus et al.). We report more recent data with more accurate coding (ICD-O-3).Aim: To analyse National Cancer Registration and Analysis Service (NCRAS) data on Neuroendocrine Neoplasias (NENs) in England including years 2015–2017.Methods: Public He...