Endocrine Abstracts (2019) 68 P25 | DOI: 10.1530/endoabs.68.P25

(Non)Functioning neuroendocrine tumours in 18F-FDG PET-CT

Clara Ferreira & James Cullis


University Hospital of Coventry and Warwickshire, Coventry, UK


Neuroendocrine tumours (NETs) are distinctive tumours which arise from cells which have neural and hormonal origins. Gastroenteropancreatic tumours (GEP) are the most common clinically encountered NETs. Imaging has a lead role in the evaluation of these tumours – detection, staging and follow-up. It is also known that PET–CT with 18F-FDG has a limited value in well-differentiated NETs. This study was performed to evaluate the clinical value of 18F-FDG PET–CT in assessing functioning and non-functioning NETs. From September 2008 to August 2019, a retrospective observational study of patients (31 cases) with GEP-NETs from University Hospital of Coventry and Warwickshire underwent 18F-FDG PET–CT scan. Demographics and clinical characteristics were retrospectively collected and analysed. Therefore, 31 patients (16 females, 15 males), the average age of 64±11.7 years were scanned in the GE Discovery PET–CT 710 using a standard protocol (Boellaard et al., 2015). From the 31 patients, there are 20 patients with non-functioning and 11 patients with functioning NETs. The functional tumours show the following SUVmax values for T, N and M of 7.23±3.81 g/ml, 8.70±7.06 g/ml and 10.43±7.62 g/ml, respectively. On the other hand, non-functional NETs present a SUVmax for T, N and M of 7.54±2.52 g/ml, 7.24±3.57 g/ml and 7.20±7.62 g/ml. The differences evaluated in the N and M staging have significant value (P<0.005). In addition, 18F-FDG uptake had a significant association with tumour size (P<0.005) and Ki-67 index (P<0.005). The evaluation of the 18F-FDG PET–CT scan has changed the management in 9 of the 31 cases (29%). In conclusion, PET–CT with 18F-FDG has an important role in detecting and contributing to the staging of functional and non-functional NETs.

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